How many days will it take for hCG 1500 to disappear? HCG injection to stimulate ovulation

Chorionic gonadotropin 1500 is a drug that, due to its gonadotropic effect, stimulates the maturation of follicles in the ovaries and also maintains the corpus luteum phase. The medicine is produced in the form of a lyophilisate, on the basis of which a solution for intramuscular administration is prepared. One bottle contains the active substance human chorionic gonadotropin 1500 units.

The drug is packaged in glass bottles. The lyophilisate itself has the appearance of a white powder. Each package also contains a special component with which the active substance is diluted - sodium chloride, in a volume of 1 milliliter. During production, the drug is placed in cellular blisters, and five such sets are placed in each pack.

Chorionic gonadotropin (1500 units) instructions for use classify it as a gonadotropic-type hormone, which is naturally produced by the placenta and is then released into urine. Subsequently, when the hormone is extracted, it is sent for purification.

HCG is necessary to maintain the process of development and formation of the placenta in a normal state, and also stimulates the corpus luteum to begin to produce the hormone estrogen. As mentioned earlier, the drug is characterized by a luteinizing and gonadotropic effect.

1500 gonadotropin is a powerful stimulator of estrogen and progesterone production in female patients, and also provokes ovulation. If the drug is prescribed to representatives of the stronger sex, then their process of spermatogenesis improves, and the production of sex hormones of the steroid group is stimulated at a higher level. In cryptorchidism, the drug has the ability to provoke testicular prolapse.

The drug is characterized by a high degree of absorption after intramuscular injection. According to some data, before being eliminated, the active component passes through the kidneys, where it is modified in the body. Answering the question: how long does it take for hCG 1500 to be removed from the body, doctors call a period from five days to a week.

Pharmacokinetic properties

Patients are often interested in how long it takes for an injection of hCG 1500 to be removed from the body. The manufacturer indicates that the half-life is 8 hours. The maximum level of concentration of the active substance in the blood plasma can be monitored 4-12 hours after injection.

If you regularly inject 1500 units of hCG, how long it takes to be removed from the body, you will need to check with your doctor, since on average this process takes 29-30 hours, but the active component tends to accumulate. About 10-20% of human chorionic gonadotropin can be found unchanged in the urine, the rest is excreted by the kidneys in the form of beta chain fragments.

Indications

There are certain conditions of the body, when identified, doctors can prescribe intramuscular administration of human chorionic gonadotropin in the dosage under consideration, among them:

1. Insufficiency of the luteal phase - this is necessary in order to be able to maintain the functioning of the corpus luteum of the ovary;
2. Provoking the onset of ovulation is often practiced when solving infertility problems, as well as when it is necessary to stabilize the cycle.

Representatives of the stronger sex are also prescribed hCG 1500 units. The drug will have a certain therapeutic effectiveness in the presence of the following diseases: with gonadotropic gonadism, as part of complex therapy, when a human menopausal gonadotropin drug is taken, with cryptorchidism, to assess the functionality of the testicles, and also if it is necessary to conduct a functional Leydig test.

Contraindications

Like most medications, hCG has 1500 units. instructions for use contain certain contraindications. For example, the medication should not be taken if the patient has been diagnosed with neoplasms that can change when certain hormones enter the body.

It is also unacceptable to prescribe the drug for organic cryptorchidism, when the patient has an anatomically incorrect location of the testicles, their location has changed after surgery, or due to the presence of an inguinal hernia. Also, a contraindication to starting therapy is individual intolerance to the medication by the body.

Dosage

The drug is intended for intramuscular administration. Initially, the lyophilisate is diluted in the form of a powder with a special filler, after which the solution is drawn into a syringe and a slow injection is made. The dosage can be adjusted by the attending physician depending on the purpose of the drug.

During menstrual cycles in women who pass without ovulation, 6-7 injections of Chorionic Gonadotropin are indicated, with an interval of one day. To carry out maintenance therapy for the corpus luteum phase, the scheme provides for 2-3 injections within nine days after ovulation or embryo transfer.

If delayed puberty is observed in adolescents, which occurs due to insufficiency of the gonadotropic function of the pituitary gland, injections of the drug are indicated at a frequency of 2-3 times a week for six months.

For cryptorchidism, which is not caused by anatomical obstruction, patients aged 3-6 years are administered the medicine 2 times a week. If necessary, the treatment can be repeated.

After women have been given an injection of hCG 1500, the attending physician should tell them when to do the test. The day may vary depending on how long the drug was administered and for what purpose it was prescribed. On average, the test after an hCG injection is 1500 units. done for 3-6 days. In some cases, if there is no pregnancy, a second, barely noticeable stripe may appear. If conception is successful, on the eighth day it will gradually begin to become brighter. To confirm pregnancy, tests are done and blood is donated for hCG over time.

Side effects

Depending on gender and age, negative reactions can take different forms. Least often, doctors recorded the presence of generalized rashes and fever in patients. Local reactions were observed much more often, including: pain and bruising at the injection site, itching, redness, swelling of the skin, and increased fatigue.

In women, after injections, reactions may occur from the nervous system, which manifests itself in the form of dizziness and pain. The development of depression, irritability and anxiety is also possible. In certain cases, swelling may occur.

In representatives of the stronger sex, after injections of Human Chorionic Gonadotropin, rashes in the form of acne often appear on the skin of the face. In certain cases, the process of puberty accelerates, the penis enlarges, prostate hyperplasia is observed, the sensitivity of the nipples increases, and the testicles in the inguinal canal enlarge.

Overdose

The drug in question has a low level of toxicity. If the permissible dose of the medication has been exceeded, then representatives of the fairer sex may develop signs of ovarian hyperstimulation syndrome.

Representatives of the stronger sex, when using the drug incorrectly, can also observe symptoms of an overdose: a change in the anatomical appearance of the pectoral muscle (breast gland), if treatment has been carried out for a long time aimed at eliminating such a pathology as the absence of a testicle in the scrotum, boys begin to behave as if again experience the first stage of puberty, a decrease in the number of sperm, the initial stage of the process of destruction of the seminiferous tubules.

special instructions

During treatment with this drug, doctors note an increased risk of developing pathologies such as thromboembolism of veins or arteries, as well as their combination. That is why, those women who are at risk, before starting therapy, should carefully evaluate its advantages over possible dangers, especially if in vitro fertilization is to be performed. Gynecologists themselves draw the attention of women to the fact that the process of bearing a child is itself associated with an increased risk of developing varicose veins and thrombosis.

It is also possible that after treatment a woman may have a multiple pregnancy. During the entire course of drug administration, as well as for one and a half weeks after completion of therapy, the drug affects immunological tests. Due to the fact that the concentration of the hCG hormone in the blood plasma increases, a false-positive determination of pregnancy is possible.

When treating stronger sex patients, there is a possibility of increasing the body’s own production of androgens, therefore those men who are at risk should take the drug only for medical reasons and under medical supervision.

Therapy may not give adequate results if a woman has a high concentration of follicle-stimulating hormone in the body. With long-term treatment, antibodies to the drug are formed. If the treatment of cryptorchidism is unreasonably long, then degeneration of the mammary glands will occur.

During the treatment period, you should refrain from driving vehicles, as well as from working with complex mechanisms. During pregnancy and lactation, the medication is contraindicated for use. The medicine is not prescribed to patients who have not reached the age of three.

Chorionic gonadotropin: instructions for use and reviews

Latin name: Gonadotrophin chorionic

ATX code: G03GA01

Active substance: Chorionic Gonadotropin

Manufacturer: Moscow Endocrine Plant (Russia)

Updating the description and photo: 22.10.2018

Human chorionic gonadotropin is a pharmacological agent and belongs to the group of hormonal agents. Most often it is known as a pregnancy hormone. After successful conception, this hormone begins to be intensely released. Determining the level of hCG is one of the accurate diagnostic methods.

The topic of human chorionic gonadotropin remains relevant today. This hormone is actively used to stimulate ovulation, that is, the release of an egg from the ovary into the fallopian tube, due to a burst follicle. It is used in both sexes for medical reasons. What problems are solved thanks to this hormone and what effect it has on the body - this will be discussed in more detail in the article.

Release form and composition

The main component of the drug is human chorionic gonadotropin, which is produced by the human placenta and excreted in the urine of pregnant women.

The product consists of:

1. White powder for intramuscular injection. The drug is available in bottles containing 500IU, 1000IU, 1500IU and 5000IU - action units. Additionally, the substance mannitol has been added to the composition.
2. The solvent used is 0.9% physiological sodium chloride solution in an amount of 1 ml. The product is sold in 5 bottles in a paper box.

Action of the medication

When ingested, the drug has the following therapeutic effect:

Among women:

• normalizes ovarian function;
• increases the biosynthesis of sex hormones ─ progesterone and estrogen;
• participates in the development of the placenta;
• participates in the process of ovulation;
• at the beginning of pregnancy, it stimulates the corpus luteum to produce progesterone.

For men:

• participates in the formation of male germ cells - sperm;
• stimulates the production and disruption of the biosynthesis of steroid hormones;
• improves the formation of secondary sexual characteristics.

Pharmacokinetics

Chorionic gonadotropin, after entering the body, is well absorbed and then excreted within 8 hours by the kidneys. With daily use, accumulation of the drug is observed. The maximum concentration in the blood occurs from 4 to 12 hours.

Advantages and disadvantages of the drug:

• despite the fact that the drug is used for infertility and impaired impotence, scientists have proven that human chorionic gonadotropin can be used in weight loss, as it allows you to reduce the fat layer;
• In some cases, analysis of this hormone can detect tumors several months before symptoms appear. This helps to begin the fight against the disease earlier and increase the effectiveness of treatment.

Indications for use of Gonadotropin

The product is used in the treatment of both men and women.

• infertility in women associated with impaired ovarian function ─ disruption of the process of release of the egg from the ovary;
• late sexual development of boys and girls, impaired biosynthesis of the gonads due to damage to the pituitary gland and hypothalamus;
• recurrent miscarriage or a woman’s inability to bear a fetus;
• spontaneous miscarriage.

For boys and men:

• delayed sexual development associated with dysfunction of the pituitary gland;
• congenital underdevelopment or decreased function of the gonads and genital organs;
• a disease associated with decreased function of the gonads, obesity and underdevelopment of the genital organs;
• testicular hypoplasia – the disease is the underdevelopment of one of the male gonads;
• congenital pathology, which is associated with the absence of testicles in the scrotum;
• a disease characterized by impaired biosynthesis of sex hormones: androgens;
• a pathological condition of sexual underdevelopment, in which there is deposition of fat in the shoulder girdle, abdomen, buttocks and thighs. This occurs in childhood.

Use of medication and dosage

Instructions for use of hg:

The medication is prescribed to be injected into the gluteal muscle, that is, intramuscularly. HCG injection is prescribed by a doctor for a long period. It is important that this is done by a specially trained person who knows how to give intramuscular injections, or by a nurse in the treatment room.

The dosage and course of therapy are adjusted by the doctor individually depending on the disease.

The medication is available in the following dosages:

• Chorionic gonadotropin 500 units;
• Chorionic gonadotropin 1 thousand units;
• Chorionic gonadotropin 5000 units;
• Chorionic gonadotropin 1500 units;
• Chorionic gonadotropin 10,000 units.

The duration of therapy is 45 days, but there are some peculiarities.

Prescription of the drug depending on the specific disease:

1. An injection of hCG to stimulate ovulation is given once at a dosage of 10,000 units.
2. If there is a threat of miscarriage, 10 thousand IU is administered once, then 5000 IU twice a week.
3. In case of ovarian dysfunction and elevated estrogen levels, the dosage is 3000 IU at intervals of several days and 2-3 injections on days 10-12 of the menstrual cycle.
4. For regular production of the corpus luteum, 5000 units of hCG are injected on days 3, 6, 9 after ovulation.
5. The medication is prescribed to boys in the absence of testicles in the scrotum with a course of 1.5 months, 2 times a week and a dosage of 1000 IU
6. Men are prescribed treatment with the drug for 30 days, 3 times a week at a dosage of 3000 IU. The new course is continued with a break after 6 weeks. This course can be conducted three times during the year.

How to dilute the medication Gonadotropin?

Before injecting the drug, you need to dilute it correctly. It is recommended to use a freshly prepared solution before injecting:

• Without opening the bottle, remove the plastic cap and wipe it with alcohol;
• measure the required amount of solvent specified in the instructions with a syringe and pour it into the bottle with the powder;
• The diluted drug should not be shaken vigorously, as its effectiveness may be reduced.

How to inject Gonadotropin?

When stimulating ovulation, hCG injections are recommended by experts to be given in the abdominal area, as this is much more convenient and less painful. You can master this simple procedure and do it yourself at home:

Procedure method:

• Wash your hands before giving the injection;
• combine and carefully mix the powder and solvent in one bottle;
• draw the medicine into the syringe and select the injection site, at the level or under the navel, stepping back 2 fingers;
• wipe the abdominal area with an alcohol wipe;
• grasping a fold of skin, insert the needle straight at an angle of 90 or 45 degrees and slowly pour in the medicine;
• Remove the needle and wipe the injection site with an alcohol wipe.

How long does it take for the hCG injection to come out?

Firstly, there is no definite answer to this question, since each organism is individual and the elimination period is different for everyone. The only way to confirm hormone levels is through a blood test.

Secondly, the injection of hCG 10,000 when it leaves the body during pregnancy is difficult to say, since natural gonadotropin begins to work.

Side effects

Self-treatment will lead to serious consequences:

• allergy to the components of the drug;
• Women develop an increase in ovarian activity, which can lead to the formation of cysts, with the possibility of their rupture.
• development of multiple pregnancy;
• in men and boys, there is an enlargement of the mammary glands, possibly an enlargement of the prostate gland, skin rashes in the form of acne, and early puberty.

Contraindications

The medication is contraindicated in the following cases:

1. Hypersensitivity to components.
2. The presence of a tumor in the genitals and breasts.
3. Vein disease, when a blood clot forms in the lumen of a vessel.
4. High blood pressure.
5. Lack of thyroid hormone.
6. Headache.
7. Sudden onset of seizures.

For women:

1. Lactation period.
2. Incorrect formation of the genital organs.
3. Bleeding of unknown origin.
4. Obesity ─ increase in body weight.

Features of use

1. The injection solution is used freshly prepared, as it is prepared before each procedure. Long-term storage reduces the effectiveness of the drug.
2. Possible increase in ovarian size.
3. Do not use the product after the expiration date.
4. With long-term treatment, antibodies to the drug are formed.
5. You should refrain from driving a vehicle until the end of the course.
6. Treatment with gonadotropin is not prescribed for children under 3 years of age.

Overdose

With an overdose in women, the ovaries increase in size.

Price

The average cost of the drug Chorionic Gonadotropin depends on the dosage:

• 500 units N5 powder and solvent ─ 415.30 rub.
• 1500 units N5 ─ 1087.80 rub.
• 5000 units N5 ─ 2652.50 rub.

Terms of sale

Dispensed from pharmacies only with a prescription indicating the dosage.

Storage period and conditions

The shelf life depends on the dosage of the drug.

Chorionic gonadotropin 1500 units, 1000 and 500 shelf life is 4 years, at a dosage of 5000 units - 3 years.

Store in a place protected from light, at room temperature no more than +20° C and out of reach of children.

Gonadotropin analogues

Sometimes the medication prescribed by the doctor is not suitable for the patient. Analogues of the drug come to the rescue:

• Chorale;
• Ecostimulin;
• Horagon;
• Rotten.

Ovulation stimulation

In the absence of ovulation, women who are planning a child need help with conception. In this situation, artificial hCG preparations come to the rescue - special injections containing a drug such as human chorionic gonadotropin.

An injection of hCG to stimulate ovulation is considered a safe and effective remedy.

So, an hCG injection for ovulation is prescribed by a specialist after a thorough examination of patients - hormone tests, semen analysis in men, which shows the ability to conceive, and a compatibility test in partners.

An injection of hCG to stimulate ovulation is prescribed:

1. In the absence of ovulation, due to hormonal imbalance or other elementary reasons, such as stress.
2. Habitual miscarriage. HCG injections are prescribed starting from the preparation stage and during gestation.
3. Insufficient production of the corpus luteum, which forms after ovulation and produces the hormone progesterone. In this case, a course of injections is prescribed before the formation of the placenta.
4. In preparation for in vitro fertilization.
5. To improve sperm quality and increase the possibility of conception.

HCG injections to stimulate ovulation with clostilbegit

The drug Clostilbegit is used as a stimulant, which causes the formation of one or more eggs. At the same time, the medication leads to an increase in the production of the hormone prolactin. Therapy is carried out under ultrasound control from days 5-9 of the cycle. Based on the examination, the dynamics of follicle growth to the desired size is assessed. When ovulation occurs, an hCG injection is prescribed to activate the process.

If after 3 stimulations there is no progress in treatment, it is worth resorting to other treatment regimens. If used incorrectly, early menopause is possible.

Unfortunately, ovulation after an hCG injection is not always successful. A reduced level of hCG can cause fetal death, frozen and ectopic pregnancy.

Contraindications to stimulation:

• Infectious diseases;
• Inflammatory processes;
• Hormone imbalance;
• Inflammatory liver diseases;
• Obstruction of the fallopian tubes;
• Male infertility;
• Poor semen analysis.

It is important to remember that self-medication with hormones is unacceptable, as this can affect the condition of the body. In this regard, the medication chorionic gonadotropin and its analogues should be taken under the strict supervision of a specialist and monitor the hormonal levels and general condition of the patient. This will significantly increase your chances of recovery.

human chorionic gonadotropin reviews in women during stimulation:

• Elsa, Ekaterinburg

There were problems with ovulation, the follicles developed, but did not burst. The gynecologist prescribed an injection of hCG 5000 units in one of the cycles. The doctor monitored the development of the follicle using ultrasound and gave injections. Everything went well. The long-awaited pregnancy has arrived. With the injection, the chances of conception increase.

The only drawback is the price of the issue.

• Alena Petrozavodsk

I couldn’t get pregnant for a long time because I had hormonal problems. It was impossible to do without stimulation. The gynecologist prescribed a series of tests and prescribed a course of medications. Among them was Gonadotropin 1000 IU. Thanks to this remedy, I was able to conceive the first time.

I am grateful to the drug for the happiness of motherhood.

• Varvara Murom

My husband and I wanted a second child, but there was a frozen pregnancy in the early stages. The doctor said that the problem was endometriosis. After completing a course of treatment to improve the inner layer of the uterus, the result was obtained, and the gynecologist gave the go-ahead for conception. To enhance ovulation, he recommended an injection of hCG 5000 units. An ultrasound scan confirmed the presence of ovulation. Everything worked out, thanks to the medicine for a real chance!

Mom.life. The app for Modern Moms

Who received the hCG injection after IVF transfer? How many days does it take for the injection to leave the body? After the puncture - on February 28 and after the transplant - on March 5, I received hCG injections to support the endometrium, 1500 units. Today is the 9th day after replanting. Is it possible to do pregnancy tests? What if the injection hasn’t worn off yet and I’ll be happy in vain - //.

Comments

They didn't do it to me. For support, Krainon was prescribed from the day of the puncture, and it has not yet been canceled. And also Progynova, 4 tablets a day, after an HCG test they reduced it to 3, then gradually reduced it and stopped it. Regarding the tests, the doctor warned that they may not be informative, since hormonal support is strong. I didn't do any tests, I waited for the blood test

- @vorobievalubov, thank you. I take Proginova 2 tablets. per day and morning. HCG was done immediately after the transfer and that’s it

On the sixth day after the transfer, I showed a second faint line)

After the transfer, the doctor also told me not to do tests. It will show a negative result, and you will be upset, but it is false, for example

So it's better to be patient a little. Good luck to you🙏🏼

- @lina2501, did you have hCG done?

- @kazan yes, after the puncture and after the transfer, 1500 each

- @kazan where did you do eco?

- @olya666, on the contrary, I think that suddenly there will be // false

- @lina2501, and this was already your hCG, not from the injection?

- @lina2501, in Ava-Kazan

- @olya666, thank you 😊

Where did you do it with whom?

- @olya666, Ava-Kazan, Sabirova

- @kazan yes yours. Then every day it brightened

- @kazan I’m also in Ava Kazan with Yarullina)

- @lina2501, today I have //, the second one is dim. I'll repeat it tomorrow

- @kazan God forbid it shines. I donated blood for hCG on the 9th day and 12th))))

- @lina2501, I’m not going to donate blood, it’s a pity for the veins))) test tomorrow!!️ // I hope it’s bright

- @kazan I’ll wait for tomorrow’s result)))

- @lina2501, yeah, I’ll write

- @lina2501, I also took 9, 12 and tomorrow I’ll go to 14

- @pugovka92 what is the result? +++++?

- @lina2501, so far so good. Tttt

- @pugovka92 how many embryos were transferred?

- @pugovka92, @lina2501, @kazan, girls! Dear ones! My hCG is 17.5 on the 7th day after the transfer, I’m torturing myself (((is this normal?

- @madi_madi, it's hard to say. Not 0, already good. Watch in a day.

- @madi_madi, if you look at the table, then it’s normal. Submit in a day

- @kazan, am I getting ready? I don't quite understand

- @kazan, God forbid!!! When did you take it for the first time?)

- @madi_madi, the age of your embryo is 12 days (if the five-day period was postponed), then you fit within the norm (lower limit)

- @kazan, yes, five days)

- @kazan, when did you pass for the first time? What DPP?

I did it the first time, as the doctor said - on the 12th day. I don’t meet the standard, I’ll retake it tomorrow

- @kazan, what does the doctor think now?

- @madi_madi, ectopic or frozen 😔that will catch up with chanson very little

- @kazan, when to see the doctor?? Subscribe later! Let's keep our fingers crossed!!

- @madi_madi, ok

- @madi_madi, retested hCG - today at 14 dpp 113.0. In 48 hours the increase is 2 times