Pyrantel 250 instructions for use. Why is Pirantel prescribed? Instructions, reviews and analogues, price in pharmacies

Pyrantel is available as:

1. Tablets are round in shape, white or cream in color. Each contains 250 mg of pyrantel, xanthan gum, gelatin, corn starch, magnesium stearate, anhydrous silica, sodium carboxymethyl starch. Tablets are packaged in contour cells of 3 or 6 pieces. 1 blister is placed in a cardboard box along with instructions.
2. Suspensions for oral administration. The composition of 5 ml of the drug includes 250 mg of pyrantel, sucrose, sorbic acid, chocolate flavor, vanilla flavor, caramel coloring, distilled water, 70% sorbitol solution, acacia gum. The suspension is bottled in dark glass bottles of 10 or 15 ml.

Indications for use

The drug is used for the prevention and treatment of helminthic infestations caused by pinworms, roundworms, hookworms and other roundworms.

Benefits of Pirantel 250

How does it work?

Pyrantel blocks neuromuscular transmission in the bodies of sensitive helminths. Causes paralysis of the smooth muscles of worms, helping to expel worms from the intestines. Effective for diseases caused by:

• roundworms;
• hookworms;
• necators;
• whipworms;
• trichostrongyloidides.

The drug causes paralysis of muscle tissue in mature and immature worms of both sexes. Does not affect the life activity and migration of larvae. The drug acts within the intestinal lumen, practically without being absorbed into the blood. Minor concentrations of pyrantel in the blood are determined 1-3 hours after administration. The active substance entering the body is converted into inactive metabolites, which are excreted in feces and urine.

Contraindications to taking the drug Pirantel 250

How to take Pirantel 250?

Pills

The tablets are taken orally, chewing thoroughly. The dosage and duration of the therapeutic course depend on the type of helminthic infestation, age and weight of the patient:

1. Enterobiasis and ascariasis. Adults are prescribed 10 mg/kg (for example, with a body weight of 75 kg, a single dose is 750 mg).
2. Hookworm. 10 mg/kg is taken in the morning on an empty stomach. Treatment lasts 3 days.
3. Nekatoroz. Take 1000-1500 mg per day. Therapeutic course - 2 days.
4. Isolated ascariasis. 5 mg/kg is taken once.

Suspension

A child under 2 years of age is given 125 mg of pyrantel per day. The recommended daily dose for children 2-6 years old is 5 ml of suspension. The drug is taken once.

Treatment regimen for ascariasis and enterobiasis

For enterobiasis and ascariasis, the drug is used 2 times with a break of 21 days. This helps avoid re-infection. The treatment regimen includes vitamins and antihistamines that eliminate the consequences caused by the vital activity of helminths in the form of hypovitaminosis and allergic reactions.

Treatment regimen for hookworm and necatoriasis

Side effects

The following side effects may occur during treatment with Pirantel:

• neurological disorders (pain in the back of the head and forehead, dizziness, insomnia at night and daytime sleepiness, asthenic syndrome, decreased visual acuity and hearing, impaired consciousness, paresthesia, changes in taste, hallucinations);
• digestive disorders (attacks of nausea, vomiting, loss of appetite, pain in the epigastric region, inflammation of the pancreas, changes in the activity of liver enzymes, loose stools, a feeling of heaviness in the stomach, drooling);
• allergic manifestations (skin rashes such as erythema and urticaria, skin itching, fever, weeping erythema).

Overdose

Cases of acute overdose that could cause life-threatening and health-threatening consequences have not been recorded.

special instructions

Use during pregnancy and lactation

The effect of pyrantel on the body of the fetus and child feeding on mother's milk has not been studied. The use of the drug is possible only if there are strict indications. It is not recommended to take tablets and suspension when breastfeeding.

Use in childhood

Pyrantel is not prescribed to children under 6 months of age.

For impaired renal function

For liver dysfunction

Tablets and suspension are not prescribed for severe liver failure.

Drug interactions

Terms and conditions of storage

Tablets and suspension are stored in a cool place, away from moisture and direct sunlight. The drug is suitable for use for 36 months.

Conditions for dispensing from pharmacies

A doctor's prescription is required to purchase anthelmintic medication.

Price

The average price of the drug is 40 rubles.

Analogues

The following drugs have a similar effect:

• Nemocid;
• Helminthox;
• Nemozol;
• Vermox;
• Wormil.

pills

Owner/Registrar

M.J. BIOPHARM, Pvt. Ltd.

International Classification of Diseases (ICD-10)

B76 Hookworm disease B76.1 Necatoriasis B77 Ascariasis B79 Trichuriasis

Pharmacological group

Anthelmintic drug

pharmachologic effect

Anthelmintic. Causes neuromuscular blockade of sensitive helminths. Active against Enterobius vermicularis, Ancylostoma duodenale, Necator americanus and, to a lesser extent, Trichocephalus trichiurus. It affects both sexually mature and immature individuals of both sexes.

Pharmacokinetics

Practically not absorbed from the gastrointestinal tract. After taking a single dose of 10 mg/kg, the plasma concentration is 0.005-0.13 mcg/ml and is achieved within 1-3 hours. It is partially metabolized in the liver to N-methyl-1,3-propanediamine. It is excreted unchanged through the intestines (about 93%), 7% is excreted by the kidneys unchanged or as a metabolite.

Ascariasis, hookworm disease, necatoriasis, trichocephalosis.

Pregnancy, hypersensitivity to pyrantel, myasthenia gravis (treatment period).

From the digestive system: nausea, vomiting, diarrhea, anorexia, increased activity of liver transaminases.

From the central nervous system and peripheral nervous system: headache, hallucinations, confusion, paresthesia, dizziness, drowsiness or insomnia.

Dermatological reactions: skin rash, urticaria.

Others: hearing loss, hyperthermia.

special instructions

After taking pyrantel, laxatives are not prescribed.

Prescribe with caution to children under 6 months of age.

In case of liver dysfunction

Use with caution in case of liver failure.

Use during pregnancy and breastfeeding

Pyrantel is contraindicated for use during pregnancy.

If it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.

Drug interactions

Should not be administered concomitantly with piperazine (decreased effect).

With simultaneous use, pyrantel increases the concentration of theophylline in plasma.

For ascariasis and enterobiasis, use a single dose of 10 mg/kg. When necatoriasis is combined with ascariasis or other combined helminth infections, use for 3 consecutive days at a dose of 10 mg/kg/day or for 2 days at a dose of 20 mg/kg/day.

Latest update of the description by the manufacturer 27.07.2004

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Active substance:

ATX

Pharmacological group

Nosological classification (ICD-10)

3D images

Composition and release form

in dark glass bottles of 15 ml (with measuring cap); 1 bottle in a cardboard pack.

Description of the dosage form

The suspension is light yellow in color with a characteristic odor.

pharmachologic effect

pharmachologic effect- anthelmintic.

Blocks neuromuscular transmission in sensitive helminths.

Pharmacodynamics

It acts on helminths in the early phase of development and on mature forms, does not affect larvae in the migration stage. Active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis.

Pharmacokinetics

Practically not absorbed into the gastrointestinal tract. After oral administration in a single dose of 10 mg/kg body weight, Cmax is 0.005-0.13 mcg/ml and is achieved within 1-3 hours. Partially metabolized in the liver to N-methyl-1,3-propanediamine. It is excreted in feces (50% of the dose taken unchanged) and in urine (about 7% unchanged and in the form of a metabolite).

Indications for the drug Pirantel

Enterobiasis, ascariasis, hookworm disease, necatoriasis.

Contraindications

Hypersensitivity.

Use during pregnancy and breastfeeding

Use during pregnancy and breastfeeding is possible only under the strict supervision of a doctor.

Side effects

From the nervous system and sensory organs: rarely - headache, dizziness, drowsiness, insomnia, weakness; in some cases - hearing loss, hallucinations, confusion, paresthesia.

From the gastrointestinal tract: nausea, vomiting, diarrhea, stomach pain; rarely - increased activity of liver transaminases.

Others: skin rash, fever.

Directions for use and doses

Inside, during or after meals.

Enterobiasis, ascariasis and mixed invasions: once 10 mg/kg.

Hookworm: 10 mg/kg/day for 3 days.

Necatoriasis: 20 mg/kg for 2 days (for severe forms).

Precautionary measures

In case of enterobiasis, simultaneous treatment of persons living together should be carried out. After completion of treatment, it is necessary to conduct a control stool test for worm eggs.

Storage conditions for the drug Pirantel

In a place protected from light, at a temperature of 15-25 °C.

Keep out of the reach of children.

Anthelmintic. Causes neuromuscular blockade of sensitive helminths. Active against Enterobius vermicularis, Ancylostoma duodenale, Necator americanus and, to a lesser extent, Trichocephalus trichiurus. It affects both sexually mature and immature individuals of both sexes.

Indications for use

Ascariasis, hookworm disease, necatoriasis, trichocephalosis.

Mode of application

For ascariasis and enterobiasis, use a single dose of 10 mg/kg. When necatoriasis is combined with ascariasis or other combined helminth infections, use for 3 consecutive days at a dose of 10 mg/kg/day or for 2 days at a dose of 20 mg/kg/day.
Pyrantel is contraindicated for use during pregnancy.
If it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.
Prescribe with caution to children under 6 months of age.

Interaction

Should not be administered concomitantly with piperazine (decreased effect).
With simultaneous use, pyrantel increases the concentration of theophylline in plasma.

Side effect

From the digestive system: nausea, vomiting, diarrhea, anorexia, increased activity of liver transaminases.
From the central nervous system and peripheral nervous system: headache, hallucinations, confusion, paresthesia, dizziness, drowsiness or insomnia.
Dermatological reactions: skin rash, urticaria.
Other: hearing loss, hyperthermia.

Contraindications

Pregnancy, hypersensitivity to pyrantel, myasthenia gravis (treatment period).

special instructions

Use with caution in case of liver failure.
After taking pyrantel, laxatives are not prescribed.
In case of enterobiasis, simultaneous treatment of all persons living together should be carried out. After completion of treatment, it is necessary to conduct a control stool examination for the presence of parasite eggs.
Prescribe with caution to children under 6 months of age.

Pirantel

International nonproprietary name

Pirantel

Dosage form

Tablets, 250 mg

Compound

One tablet contains

active substance - pyrantel embonate 720 mg (equivalent to pyrantel 250 mg),

Excipients: potato starch, povidone, colloidal silicon dioxide, ethylcellulose, magnesium stearate, orange flavor.

Description

The tablets are round, flat on both sides, with a scoring line, sandy-yellow in color with a gray-greenish tint with inconspicuous specks with an orange taste and smell. The tablets darken under the influence of light, changing color to yellow-brown.

Pharmacotherapeutic group

Anthelmintic drugs. Tetrahydropyrimidine derivatives. Pirantel.

ATX code P02C C01

Pharmacological properties

Pharmacokinetics

Absorption

Poorly absorbed from the gastrointestinal tract. The concentration of the drug in plasma after taking a single dose of 10 mg/kg body weight is 0.05 - 0.13 mcg/ml for 1 to 3 hours.

Distribution

There is no data on the penetration of the drug through the placenta and into breast milk, as well as on the location of the drug in biological tissues and fluids (theoretically, absorption of the drug is minimal).

Metabolism

The minimal amount of the drug absorbed in the gastrointestinal tract is partially metabolized in the liver to N-methyl-1,3-propanediamine (0.8-5.6%).

Excretion from the body

More than 50% of a dose of the drug taken orally is excreted unchanged in the feces and less than 15% is excreted in the urine either unchanged or as a metabolite of N-methyl-1,3-propanediamine.

Pharmacodynamics

Can be used for hookworm infection; It has a more effective effect in the treatment of hookworm disease than in the treatment of necatoriasis.

Indications for use

Enterobiasis

Ascariasis

Hookworm

Necatoriasis

Directions for use and doses

The drug is taken orally, during or after meals, with water.

The tablet should be chewed or crushed thoroughly before swallowing.

For diseases caused Ascaris lumbricoides, Enterobius vermicularis, Ancylostoma duodenaleAndNecator americanus, depending on the age and body weight of the patient, the following doses are recommended:

For ascariasis and enterobiasis (as well as a combination of these diseases), the total therapeutic dose (10 mg/kg/day) is prescribed once.

For hookworm, the daily dose (10 mg/kg/day) is taken once a day for 3 days. In severe forms of necatoriasis (massive infestations Necator americanus) is prescribed 20 mg/kg/day once a day for 2 days or 10 mg/kg/day for 3 days.

Side effects

Side effects disappear after stopping treatment.

Rarely(≥1/10,000 to<1/1 000)

Nausea, vomiting, stomach pain and cramps, lack of appetite, diarrhea, transient increase in aminotransferase activity

Headache, dizziness, drowsiness, insomnia, weakness

Skin rash

With unknown frequency

Urge to defecate

Hallucinations, confusion, paresthesia, hearing impairment

Fever

Contraindications

Hypersensitivity to pyrantel or excipients

Concomitant use of piperazine

Myasthenia gravis (treatment period)

Drug interactions

Do not use simultaneously with piperazine. Concomitant use has an antagonistic effect.

Pyrantel may increase plasma theophylline concentrations.

special instructions

Pyrantel should be used with caution - special medical supervision is necessary for patients:

with liver failure, since during treatment the drug can increase the concentration of AspAT,

with malnutrition or anemia.

Attention

In case of enterobiasis, simultaneous treatment of all persons living together should be carried out.

It is necessary to strictly adhere to hygiene rules.

Pregnancy and lactation

There have been no controlled studies of the safety of the use of pyrantel during pregnancy, so the use of the drug during this period is possible only as a last resort, when the expected benefit to the mother outweighs the potential risk to the fetus.

Features of the influence on the ability to drive a vehicle or potentially dangerous mechanisms

In some cases, dizziness may occur; therefore, caution should be exercised when driving vehicles and servicing mechanical equipment.

Overdose

Symptoms: visual disturbances, disorientation, dizziness, fainting or dizziness when standing up from a lying or sitting position, increased sweating, previously unexperienced feelings of tiredness or weakness, irregular pulse; cramps, trembling and muscle weakness; feeling of exhaustion, asphyxia (suffocation, loss of consciousness).

Treatment: symptomatic and supportive (early gastric lavage, airway and breathing support, blood pressure support). There is no specific antidote.

Release form and packaging

3 tablets in a contour-free packaging made of aluminum foil.

1 package, along with instructions for use in the state and Russian languages, is placed in a cardboard pack.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children!

Shelf life

Do not use the drug after the expiration date

Conditions for dispensing from pharmacies

On prescription

Name and country of the organization - manufacturer

Pharmaceutical plant "Polpharma" JSC

st. Pelplinska 19, 83-200 Starogard Gdanski, Poland

Registration Certificate Holder

"Khimpharm" JSC, Republic of Kazakhstan

Name and country of the packing organization

Pharmaceutical plant "Polpharma" JSC, Poland

Address of the organization that accepts claims from consumers regarding the quality of products (products) on the territory of the Republic of Kazakhstan

JSC "Khimpharm", Shymkent, Republic of Kazakhstan,

st. Rashidova, 81

Phone number 7252 (561342)

Fax number 7252 (561342)

E-mail address [email protected]