Sorbifer application. Instructions for use sorbifer durules

Preparations containing iron.

Composition of Sorbifer Durules

The active ingredients are iron sulfate and ascorbic acid.

Manufacturers

Astra (Sweden), Egis pharmaceutical plant (Hungary)

pharmachologic effect

Antianemic.

Provides the body's need for iron; increases its absorption (vitamin C).

Side effects of Sorbifer Durules

From the gastrointestinal tract:

• anorexic,
• nausea, nausea
• vomiting
• diarrhea.

Allergic reactions:

• skin rash,

Indications for use

Iron deficiency and iron deficiency anemia of various origins (hypochromic anemia, chronic gastritis, condition after gastrectomy, acute and chronic bleeding, peptic ulcer stomach and duodenum).

Prevention iron deficiency anemia in pregnant women and newborn children; hypochromic anemia and decreased resistance to infections in children and adolescents.

Contraindications Sorbifer Durules

Diseases accompanied by the accumulation of iron in the body:

• aplastic and hemolytic anemia,
• hemochromato,
• transfusion siderosis.

Directions for use and dosage

Orally, after meals, prevention of iron deficiency, moderate anemia - 1 table. per day, severe iron deficiency anemia - 1 table. 2 times a day.

The duration of treatment is determined individually, under the control of hemoglobin and iron levels in the blood serum.

After normalization of hemoglobin content, continue taking until the iron depot is saturated (within 1-3 months).

Pregnant and breastfeeding women:

• in the first 6 months of pregnancy - 1 tablet. per day,
• in the last trimester and during breastfeeding - 1 tablet. 2 times a day.

Overdose

No data.

Interaction

Interferes with the absorption of tetracyclines in the gastrointestinal tract.

Absorption is increased by ascorbic acid, reduced by antacids.

Chloramphenicol slows down the development of the effect (stimulation of erythropoiesis).

Film-coated tablets yellow ocher coloured, lenticular, slightly biconvex, with a "Z" engraving on one side, with a characteristic odor.

Excipients: povidone (K-25), polyethylene powder, carbomer 934P, magnesium stearate, hypromellose, macrogol 6000, titanium dioxide (E171), yellow iron oxide (E172), solid paraffin.

30 pcs. - dark glass bottles (1) - cardboard packs.
50 pcs. - dark glass bottles (1) - cardboard packs.

Description medicinal product SORBIFER DURULES based on officially approved instructions for use of the drug and made in 2007. Update date: 03/06/2007

pharmachologic effect

Iron supplement. Iron is an essential component of the body, necessary for the formation of hemoglobin and oxidative processes in living tissues. The drug is used to eliminate iron deficiency. Long-term release of iron ions is ensured by the film coating of the tablet.

Pharmacokinetics

Durules is a dosage form that gradually releases the active substance, ensuring a uniform supply of the drug. When taking Sorbifer Durules 100 mg 2 times a day, iron absorption is 30% greater than with usual dosage forms iron preparations.

Dosage regimen

For adults and teenagers Usually prescribed 1 tablet. in the morning and in the evening.

At iron deficiency anemia the dose can, if necessary, be increased to 3-4 tablets/day in 2 doses (morning and evening).

At pregnancy with for the purpose of prevention, 1 tablet/day is prescribed.

During treatment iron deficiency- 1 tab. in the morning and in the evening.

The tablet must not be split or chewed. The tablet should be swallowed whole with at least half a glass of liquid. Do not give tablets to a patient in a horizontal position.

Treatment should be continued until the optimal hemoglobin level is achieved. To further replenish the depot, you may need to continue taking the drug for another month.

Long-term therapy (continuously or intermittently) can be carried out if significant iron loss occurs regularly (for example, with heavy menstruation).

Side effects

From the outside digestive system: >1% - nausea, abdominal pain, diarrhea, constipation;

The incidence of side effects from the digestive system increases with increasing doses and is 7-20% at doses of 100 to 400 mg of iron per day.

Dermatological reactions: <1% - сыпь.

special instructions

During the use of iron supplements, darkening of the stool is possible.

The patient should be warned that iron supplements can cause poisoning in children.

Impact on the ability to drive vehicles and operate machinery

Sorbifer Durules does not affect the ability to drive a car or operate machinery, or this effect is insignificant.

Overdose

Symptoms: abdominal pain, vomiting, diarrhea (sometimes bloody), dehydration, acidosis, drowsiness and shock. The patient's condition may improve, but after an asymptomatic period of 6-24 hours, symptoms may resume:

• coagulopathy, cardiovascular collapse (heart failure due to myocardial damage), hyperthermia, hypoglycemia, liver damage, renal failure, muscle cramps and coma;
• risk of intestinal perforation. In the future, liver cirrhosis and pyloric stenosis may develop. Septicemia caused by Yersinia enterocolitica is possible.

Treatment: urgent measures - taking milk and raw eggs to form an iron-protein complex, inducing vomiting. Then you should do a gastric lavage, preferably with a 1% solution of sodium bicarbonate. Specific therapy is carried out with deferoxamine:

• gastric lavage at a concentration of 2 g/l, then 5-10 g of deferoxamine dissolved in 50-100 ml of drinking water is left in the stomach. To remove absorbed iron, deferoxamine is administered intramuscularly at a dose of 1-2 g. In severe cases, accompanied by the development of shock, a long-term intravenous infusion of deferoxamine is performed at a rate of 15 mg/kg/h (maximum 80 mg/kg in 24 hours), and also symptomatic therapy.

Recipe (international)

Rp.:Tab."Sorbifer-durules"No. 50
D.S. 1 t. 2 rub. morning and evening in 30 min. before meals.

Recipe (Russia)

Rp.:Tab. Ferri sulfatis 320 mg

Acidi ascorbinici 60 mg

S. 1 tablet 2 times a day, 30 minutes in advance. before meals.

Prescription form - 107-1/у

Active substance

Ferrous sulfate, Ascorbic acid (Ferrous sulfate, Ascorbic acid)

pharmachologic effect

Ferrous iron (Fe(II)), as a component of the protoporphyrin prosthetic group of hemoglobin (Hb), plays an important role in the binding and transport of oxygen and carbon dioxide.

Iron of the protoporphyrin group of cytochromes plays a key role in the process of electron transport. In these processes, the capture and release of electrons is possible due to the reversible transition reaction Fe (II) ↔ Fe (III).

Iron is also found in significant quantities in muscle myoglobin.

Ascorbic acid promotes the absorption and absorption of iron (it stabilizes the Fe (II) ion, preventing its conversion to Fe (III) ion.

Mechanism of action

The sustained release of Fe(II) ions is the result of Durules tablet technology. During passage through the gastrointestinal tract, Fe (II) ions are continuously released from the porous matrix of the Durules tablet over a period of 6 hours. The slow release of the active substance prevents the development of pathologically high local iron concentrations. Thus, the use of the drug Sorbifer Durules avoids damage to the mucous membrane.

Iron is an essential component of the body, necessary for the formation of Hb and the occurrence of oxidative processes in living tissues. The drug is used to eliminate iron deficiency. The plastic matrix of Sorbifer Durules tablets is completely inert in the digestive juice, but completely disintegrates under the action of intestinal peristalsis, when the active ingredient is completely released.

Pharmacokinetics

Suction and distribution

Iron is absorbed from the duodenum and proximal small intestine. The degree of absorption of heme-bound iron is approximately 20%, and that of non-heme-bound iron is 10%. For effective absorption, iron must be in the form of Fe(II).

After oral administration, ascorbic acid is completely absorbed from the gastrointestinal tract. Hydrochloric acid of the stomach stimulates the absorption of iron, reducing it from Fe (III) to Fe (II). Ascorbic acid improves iron absorption and increases the bioavailability of the drug.

About 1/3 of the iron entering the blood binds to apotransferrin, the molecule of which is converted into transferrin. The iron-transferrin complex is transported to target organs and, after binding to receptors located on the surface of their cells, enters the cytoplasm via endocytosis. In the cytoplasm, iron is separated and recombined with apoferritin. Apoferritin oxidizes iron to Fe(III), and flavoproteins participate in the reduction of iron.

"Durules" is a technology that ensures the gradual release of the active substance (iron ions) and a uniform supply of the drug. Taking 100 mg 2 times a day provides 30% greater absorption of iron from Sorbifer Durules compared to other iron preparations.

Deposited in the form of ferritin or hemosiderin in hepatocytes and cells of the phagocytic macrophage system, a small amount - in the form of myoglobin in muscles

Metabolism and excretion

Fe(II) entering the intestinal epithelial cells undergoes intracellular oxidation to Fe(III), which binds to apoferritin. Part of apoferritin enters the blood, the other part temporarily remains in the intestinal epithelial cells in the form of ferritin, which enters the blood after 1-2 days or is excreted from the body in feces during the desquamation of epithelial cells.

Mode of application

For adults: I take the drug orally.
Film-coated tablets should not be split or chewed.
The tablet should be swallowed whole and washed down with at least half a glass of liquid.

Adults and adolescents are prescribed 1 tablet. 1-2 times/day. If necessary, for patients with iron deficiency anemia, the dose can be increased to 3-4 tablets/day in 2 doses (morning and evening) for 3-4 months (until the iron depot in the body is replenished).
During pregnancy and lactation, for the purpose of prevention, 1 tablet/day is prescribed; For treatment, 1 tablet is prescribed. 2 times/day (morning and evening).

Treatment should be continued until the optimal hemoglobin level is achieved. To further replenish the depot, you may need to continue taking the drug for another 2 months.

Indications

- Iron-deficiency anemia;
- iron deficiency;
— prophylactic use during pregnancy, lactation, and in blood donors.

Contraindications

- stenosis of the esophagus and/or other obstructive changes in the digestive tract;

- increased iron content in the body (hemosiderosis, hemochromatosis);

- impaired iron utilization (lead anemia, sideroblastic anemia, hemolytic anemia);

- children under 12 years of age (due to lack of clinical data);
- hypersensitivity to the components of the drug.

The drug should be used with caution in case of gastric and duodenal ulcers, inflammatory bowel diseases (enteritis, diverticulitis, ulcerative colitis, Crohn's disease).

Side effects

- From the digestive system: nausea, vomiting, abdominal pain, diarrhea, constipation (the frequency of these side effects may increase with increasing dose from 100 mg to 400 mg); rarely - ulcerative lesions of the esophagus, stenosis of the esophagus.
— Allergic reactions: rarely - itching, rash.
- From the central nervous system: rarely - headache, dizziness.
Other: rarely - skin hyperthermia, weakness.

Release form

Tab., cover. coated, 320 mg+60 mg: 30 or 50 pcs.

Release form, composition and packaging
Light yellow, round, biconvex, film-coated tablets, engraved with “Z” on one side; at the break there is a gray kernel with a characteristic odor.
1 tab.
iron sulfate (II) 320 mg,
which is equivalent to Fe2+ content 100 mg

ascorbic acid (vit. C) 60 mg.

Excipients: magnesium stearate, povidone K-25, polyethylene powder, carbomer 934R.
Shell composition: hypromellose, macrogol 6000, titanium dioxide, yellow iron oxide, solid paraffin.
30 pcs. - dark glass bottles (1) - cardboard packs.
50 pcs. - dark glass bottles (1) - cardboard packs.

ATTENTION!

The information on the page you are viewing is created for informational purposes only and does not in any way promote self-medication. The resource is intended to provide healthcare workers with additional information about certain medications, thereby increasing their level of professionalism. The use of the drug "" necessarily requires consultation with a specialist, as well as his recommendations on the method of use and dosage of the medicine you have chosen.

Every third pregnant woman experiences iron deficiency in the body. According to official data from the World Health Organization, this pathological condition is considered almost the most common in the world and can pose a direct threat not only to the mother, but also to the fetus. Approximately 30-40% of women with obvious or hidden iron deficiency experience various complications during pregnancy. To prevent and treat iron deficiency, gynecologists often prescribe medications containing this important trace element. The most convenient and safest in this regard is Sorbifer during pregnancy. This drug contains the physiological form of iron and ascorbic acid, which further improves the absorption of the microelement in the intestine.

The leading clinical manifestation of iron deficiency is anemia. This is a complex of symptoms, the main cause of which is a decrease in the level of hemoglobin and/or red blood cells, which is determined by a simple blood test. For a more in-depth study of iron metabolism in a woman’s body, the doctor may prescribe additional studies, such as determining the level of transferrin and ferritin.

Leading symptoms of anemia during pregnancy:

• General weakness and fatigue.
• Dizziness, tinnitus, flashing “spots” before the eyes.
• Paleness of the skin and mucous membranes.
• Brittle hair and brittle nails.
• Increased heart rate.
• Unpleasant sensations in the mouth.
• Digestive problems, including unexplained diarrhea.

Anemia is diagnosed if the hemoglobin level in a pregnant woman's blood drops below 110 g/l. This is a direct indication for the prescription of iron supplements and changes in diet.

Composition of the drug Sorbifer Durules

The active component of Sorbifer Durules is divalent iron, which is easily absorbed by the body. The composition also includes ascorbic acid, which greatly facilitates the absorption of this trace element in the intestines.

Unlike other iron-containing drugs, Sorbifer tablets are produced using the unique Durules technology. It ensures not immediate, but gradual absorption of iron over a long period of time, which allows you to take the drug no more than 1-2 times a day. The combination of this technology with the complementary effect of ascorbic acid and ease of use make Sorbifer an ideal drug for the treatment and prevention of iron deficiency conditions.

Indications for use

During pregnancy, Sorbifer is prescribed to prevent iron deficiency and to treat existing anemia. Women expecting the birth of a child are a special risk group for iron deficiency, since during pregnancy the need for this microelement increases significantly. Iron is essential for the synthesis of hemoglobin and myoglobin (an important muscle protein), it participates in all redox reactions and ensures the normal functioning of the body.

Sorbifer is also used during breastfeeding, when iron is intensively excreted from a woman’s body along with milk. A special indication for the use of this drug is blood donation. Even in donors with extensive experience, Sorbifer allows you to completely normalize iron levels in a short time.

Contraindications during pregnancy

Like any other drug, Sorbifer has certain contraindications during pregnancy, when it is not recommended or even strictly forbidden to take it. This is due to both the nature of the active component itself and the structure of the tablets.

The main contraindications to the use of the drug Sorbifer:

• Increased iron content in the body (for example, with hemochromatosis). When detecting reduced hemoglobin, it is important to evaluate the level of transferrin, ferritin and serum iron, since not all anemia is caused by iron deficiency.
• Sideroblastic and hemolytic anemia.
• Obstructive changes in the gastrointestinal tract. In other words, the presence in the lumen of the esophagus, stomach or intestines of an obstacle to the advancement of the tablet.
• Hypersensitivity to individual components of the drug.

Fortunately, these contraindications are rare, and therefore in most cases Sorbifer Durules can be taken during pregnancy without any fear.

Instructions for use

In the early stages of pregnancy, doctors prescribe Sorbifer mainly for the prevention of iron deficiency conditions. During pregnancy, Sorbifer tablets should be swallowed whole, without breaking or chewing them, otherwise the effect of the drug will be unpredictable. They should be taken during meals with water. It is important to avoid consuming dairy products for two hours after taking the drug, since the calcium they contain slows down the absorption of iron.

1st trimester of pregnancy

In the 1st trimester, increased development of the placenta occurs, as well as changes in the functioning of the female body. This period also marks the most important stages of fetal development, which urgently needs iron. All this predisposes to the development of hidden iron deficiency. To prevent it, the recommended dose of Sorbifer during pregnancy, as stated in the instructions for use, is 1 tablet per day. This amount is usually sufficient to maintain normal iron levels in the body and prevent the development of anemia.

2nd and 3rd trimesters

In the second half of pregnancy, two important changes occur in the fetus's body - intensive growth of muscle fibers and active hematopoiesis, or the formation of blood cells.

In the later stages, Sorbifer Durules is prescribed primarily for the treatment of anemia that has already occurred. The standard dose is to take one tablet 1-2 times a day with meals, morning and evening. Therapy should be carried out with regular monitoring of a general blood test and under the strict supervision of a doctor, since irrational use of the drug and self-medication can lead to a number of unpleasant and dangerous side effects.

Side effects

Clinical studies and patient reviews show that most often, while taking the drug Sorbifer, adverse events from the gastrointestinal tract occur, such as nausea, vomiting, discomfort and pain in the abdomen, as well as stool disorders. It has been proven that the higher the dose, the greater the frequency of these side effects, so if during therapy a pregnant woman notices at least one of these symptoms, she should immediately consult a doctor.

A specific side effect of all iron-containing drugs is black stool. This is due to the fact that part of the iron that is not absorbed in the intestines is oxidized under the action of hydrochloric acid in gastric juice and acquires a rich black tint. Typically, this side effect does not pose any danger. The exception is if the patient has had episodes of gastrointestinal bleeding that may resemble these symptoms.

Other side effects of Sorbifer during pregnancy are very rarely observed.:

• allergic reactions;
• headache and dizziness;
• temperature increase;
• stenosis, or narrowing of the esophagus;
• ulcers on the mucous membrane of the esophagus.

As a rule, the appearance of these symptoms does not require discontinuation of the drug - it is enough to just adjust the dose. The exception is allergic reactions - if they occur, you should stop taking Sorbifer.

Overdose

In extremely rare cases, an overdose of Sorbifer Durules is possible. Most often this happens when a woman takes the drug on her own, without a doctor’s recommendation.

Symptoms of overdose are:

• cutting pain in the abdomen;
• repeated vomiting;
• frequent loose stools mixed with blood;
• increased body temperature;
• cold and sticky sweat, pale skin;
• decrease in blood pressure.

If these symptoms develop, you should immediately call an ambulance. First aid for overdose includes gastric lavage with warm saline solution. To prevent further absorption of iron, you need to drink a raw egg and several glasses of milk.

Compatibility with other drugs

How to take Sorbifer during pregnancy to maximize its effectiveness? To do this, you should consider how this drug interacts with other medications.

In particular, you should not take iron supplements and antacids (medicines used to treat heartburn and abdominal pain) at the same time. The latter reduce or completely block the absorption of iron in the small intestine and, as a result, such therapy will simply be meaningless. It should be a rule that antacid medications can be taken no earlier than 2 hours after the last dose of Sorbifer, but it is best to avoid them altogether during the treatment of anemia.

It is also not recommended to take Sorbifer together with antibiotics from the fluoroquinolone group. Although these drugs are generally prohibited from being used during pregnancy due to the extremely negative effects on the fetus, this should also be kept in mind.

Analogs

During pregnancy, other iron-containing drugs are also used. They are recommended in cases where there is intolerance to Sorbifer.

It should be borne in mind that Sorbifer has a number of advantages over these drugs. Firstly, it contains divalent iron, which is easily absorbed by the body. Secondly, Durules technology provides long-term release of the active substance. Thirdly, the absorption of iron from Sorbifer is on average 30% greater than from other iron-containing preparations.

Sorbifer Durules is an effective and safe drug for the prevention and treatment of iron deficiency conditions in pregnant women. When used under the supervision of a specialist, the risk of complications and adverse events is significantly reduced. By maintaining normal iron levels in the body, a woman can be sure that her baby will be strong and healthy.

Useful video about anemia during pregnancy

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In this article you can read the instructions for use of the drug Sorbifer Durules. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Sorbifer Durules in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Sorbifer Durules in the presence of existing structural analogues. Use for the treatment of iron deficiency in the body, anemia and increasing hemoglobin levels in adults, children, as well as during pregnancy and lactation.

Sorbifer Durules- antianemic drug. Iron is an essential component of the body, necessary for the formation of hemoglobin and the occurrence of oxidative processes in living tissues.

Durules technology provides a gradual release of the active ingredient (iron ions) over a long period of time. The plastic matrix of Sorbifer Durules tablets is completely inert in the digestive juice, but completely disintegrates under the action of intestinal peristalsis, when the active ingredient is completely released.

Ascorbic acid helps improve iron absorption.

Compound

Iron sulfate + Ascorbic acid (vitamin C) + excipients.

Pharmacokinetics

Durules is a technology that ensures a gradual release of the active substance (iron ions) and a uniform supply of the drug. Taking 100 mg 2 times a day provides 30% greater absorption of iron from Sorbifer Durules compared to conventional iron preparations. Absorption and bioavailability of iron are high. Iron is absorbed primarily in the duodenum and proximal jejunum. Plasma protein binding - 90% or more. Deposited in the form of ferritin or hemosiderin in hepatocytes and cells of the phagocytic macrophage system, a small amount - in the form of myoglobin in muscles.

Indications

• Iron-deficiency anemia;
• iron deficiency;
• prevention of iron deficiency anemia during pregnancy, lactation, and in blood donors.

Release forms

Film-coated tablets.

Instructions for use and dosage regimen

The drug is taken orally. Film-coated tablets should not be split or chewed. The tablet should be swallowed whole and washed down with at least half a glass of liquid.

Adults and adolescents are prescribed 1 tablet 1-2 times a day. If necessary, for patients with iron deficiency anemia, the dose can be increased to 3-4 tablets per day in 2 doses (morning and evening) for 3-4 months (until the iron depot in the body is replenished).

During pregnancy and lactation, for the purpose of prevention, 1 tablet per day is prescribed; For treatment, 1 tablet is prescribed 2 times a day (morning and evening).

Treatment should be continued until the optimal hemoglobin level is achieved. To further replenish the depot, you may need to continue taking the drug for another 2 months.

Side effect

• nausea, vomiting;
• stomach ache;
• diarrhea;
• constipation;
• ulcerative lesions of the esophagus;
• esophageal stenosis;
• rash;
• headache;
• dizziness;
• skin hyperthermia;
• weakness.

Contraindications

• esophageal stenosis and/or other obstructive changes in the digestive tract;
• increased iron content in the body (hemosiderosis, hemochromatosis);
• impaired iron utilization (lead anemia, sideroblastic anemia, hemolytic anemia);
• children under 12 years of age (due to lack of clinical data);
• hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

It is possible to use the drug Sorbifer Durules during pregnancy and lactation according to indications.

Use in children

The drug is contraindicated in children and adolescents under 12 years of age.

special instructions

When using the drug, darkening of the stool (black stool) is possible, which has no clinical significance.

The drug should be used with caution in case of gastric and duodenal ulcers, inflammatory bowel diseases (enteritis, diverticulitis, ulcerative colitis, Crohn's disease).

Drug interactions

Sorbifer Durules may reduce the absorption of concomitantly administered enoxacin, clodronate, grepafloxacin, levodopa, levofloxacin, methyldopa, penicillamine, tetracyclines and thyroid hormones.

The simultaneous use of Sorbifer Durules and antacid preparations containing aluminum hydroxide and magnesium carbonate may reduce the absorption of iron. The maximum possible time interval should be maintained between taking Sorbifer Durules and any of these drugs. The recommended minimum time interval between doses is 2 hours, except when taking tetracyclines, when the minimum interval should be 3 hours.

Sorbifer Durules should not be combined with the following drugs: ciprofloxacin, doxycycline, norfloxacin and ofloxacin.

Analogues of the drug Sorbifer Durules

Structural analogues of the active substance:

• Fenyuls 100;
• Ferroplex.

Analogs by pharmacological group (drugs for the treatment of iron deficiency):

• Actiferrin compositum;
• Aloe syrup with iron;
• Biovital elixir;
• Biofer;
• Venofer;
• Vitrum Superstress;
• Vitrum Circus;
• Hemofer;
• Gyno Tardiferon;
• Likferr 100;
• Maltofer;
• Maltofer Fall;
• Multi tabs Active;
• Pikovit Complex;
• Merz special dragee;
• Stress formula with iron;
• Supradin Kids Junior;
• Tardiferon;
• Totema;
• Ferlatum;
• Ferretab;
• Ferrinate;
• Ferro Folgamma;
• Ferrogrademet;
• Ferronal;
• Ferronal 35;
• Ferrum Lek;
• Heferol;
• Enfamil Premium 2;
• Enfamil with iron.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.