An effective antitussive drug for oral administration - Sinekod drops for children: instructions for use and contraindications. Dosage and composition of children's drops, tablets and syrup Sinecode - indications, side effects and price Sinecode types

When a cough with sputum occurs, which is called wet, various drugs with an expectorant effect are used. But in some cases, the cough is dry and makes the sick person suffer both day and night, without bringing relief.

To eliminate it, medications that can affect the cough reflex are used. One of them is Sinekod. This medicine in the form of drops is in demand in adults for laryngitis, whooping cough and other diseases with a strong non-productive cough. But can it be used in childhood and how to do it correctly? How can exceeding the dose cause harm and are there any analogues of such medication?

Release form

Sinekod drops are produced in small glass bottles that have a dropper dispenser. One bottle contains 20 ml of solution, which smells pleasantly of vanilla. It is transparent and often colorless, but can also have a yellowish tint. In addition to drops, Sinekod is also available in syrup, and this medication does not have such forms as tablets, injections or capsules.

Compound

The active substance due to which the drops can influence the cough reflex is called butamirate citrate. Each milliliter of solution contains this ingredient in a dose of 1.5 mg.

Among the excipients in the medicine are glycerol, 96% ethyl alcohol, benzoic acid, water, 70% sorbitol and sodium hydroxide. They help the medication remain in liquid form and not deteriorate during storage. For a sweet taste, sodium saccharinate is added to the preparation, and the aroma of the drops is due to the presence of vanillin in its composition.

Mechanism of action

Sinekod has a central effect, because butamirate can affect the cough center in the brain. In many respiratory diseases, the cause of coughing is the formation of sputum, which needs to be expelled. When it appears, receptors begin to send signals to the brain to activate the cough reflex and eliminate the irritant.

But if the cough is dry, then there is practically no sputum, and the cause of signals from receptors located in the mucous membrane is the inflammatory process and irritation of the respiratory tract. And when, in response to increased activity of the cough center, a dry cough begins, it does not bring relief, because there is no sputum, no signals are received about its removal from the respiratory tract, and the reflex remains active.

As a result, the brain continues to receive signals about irritation of the mucous membrane and the need to remove sputum, which is not there, so the cough does not end. And in this case, there is a need for Sinecode, as in a medicine that will suppress the cough reflex, due to which the patient’s condition will improve.

Drops not only help get rid of coughing attacks, but also reduce the resistance of the respiratory tract, and also promote greater oxygen supply to the bloodstream.

In addition, they also have some bronchodilating effects, that is, the use of Sinecod helps to expand the lumen of the bronchi. All these effects simultaneously make breathing easier and eliminate oxygen starvation of tissues, which speeds up recovery

Indications

Since Sinekod in drops affects the cough reflex, it is prescribed in situations where a child is tormented by a dry cough that worsens his condition. This symptom especially often appears at night, disrupting the baby’s sleep. The medicine is in demand for the following diseases:

• whooping cough;
• tracheitis;
• laryngotracheitis;
• bronchopneumonia;
• bronchitis;
• tracheobronchitis;
• laryngitis;
• pharyngitis;
• emphysema;
• pleurisy;
• bronchial asthma

Drops can also be used before various manipulations on the respiratory tract (for example, before bronchoscopy) or before surgical treatment. If a child has an acute respiratory viral infection, Sinekod is usually not prescribed, because with such problems, a dry cough quickly turns into a wet one. Nevertheless, if one of the symptoms is a painful dry cough, you can use drops, but only as prescribed by a doctor and only until the sick baby begins to produce and cough up sputum.

At what age is it prescribed to children?

Sinekod drops can be used from an early age, because the instructions for this form of medication indicate contraindications for children under 2 months of age. If the baby is already two months old, it is permissible to give him the solution, but only after examination by a doctor. Although the medicine is considered safe, is not a narcotic and rarely causes side effects, its use without a pediatrician’s prescription in children in the first years of life is unacceptable.

The syrup contains much more active substance per 1 ml, so it is not used until 3 years of age.

Children under three years of age are allowed to give Sinekod exclusively in drops.

Contraindications

The medicine is not used in the treatment of children who are intolerant to any ingredient in the drops. In addition, the drug is not given for diseases of the respiratory tract that occur with a wet cough.

Side effects

Occasionally, when treated with Sinekod, the following occurs:

• allergic rash;
• feeling of nausea;
• stool liquefaction;
• dizziness;
• drowsy state.

If any of these ailments occur, stop using the drops and consult your doctor.

Instructions for use

The medication is prescribed to be taken before meals four times a day. Before each use, shake the bottle so that the components of the solution are well mixed. It is recommended to drip Sinekod into a clean spoon or other small container.

To measure the required number of drops, turn the bottle vertically over a spoon and count the drops falling into the container. Next, the drug is given to the child to drink without diluting it with water. As soon as the baby swallows the medicine, you can offer it with a small amount of water.

The single dosage of Sinecode depends on the age of the small patient:

• If the baby is not yet a year old, then he should be given 10 drops per dose.
• If the baby’s age is between one and three years, then for such a patient a single dose of the medication is 15 drops.
• For children 3 years of age and older, 25 drops are measured per dose.

When giving Sinekod to a child, you need to make sure that the sick child drinks the drops in the right dose. If the patient spits out the medicine, it should not be given again immediately afterwards, as this will increase the risk of overdose. In such a situation, you need to wait until the next scheduled dose and give the baby the full dose.

The duration of Sinecode therapy for each child is determined by the attending physician, but the medication is usually used in short courses, not exceeding seven days.

If after a week of use the cough still bothers the baby, a repeated examination by a doctor and other treatment is needed.

Overdose

Although the drug is considered relatively safe in childhood, even a slight overdose can cause drowsiness, dizziness, severe nausea or diarrhea. In some children, excess drops cause vomiting or lower blood pressure. With such symptoms, they resort to gastric lavage and give the patient a medicine from the group of sorbents.

Interaction with other medications

Since the main effect of Sinecod is to suppress cough, such drops should not be prescribed simultaneously with mucolytic drugs and expectorants. If such drugs are used together, sputum will become more liquid and at the same time will accumulate in the respiratory tract. This can provoke bronchospasm and mucus stagnation in the respiratory tract, which often causes secondary infection.

Sinekod can be prescribed with any other medications. This drug is often prescribed together with antibacterial agents (Macropen, Sumamed, Ospamox, etc.), antiviral and anti-inflammatory drugs.

Terms of sale

Sinekod drops are sold in pharmacies without a prescription, but a doctor’s examination before purchasing this drug for a child is mandatory, especially for patients under three years of age. For one bottle of medicine you need to pay an average of 350 rubles.

Storage Features

It is necessary to keep a bottle of drops at home out of the reach of children, because this product has a sweet taste and pleasant aroma, which, if easily accessible, can lead to an overdose. The storage temperature of Sinecode should not exceed +30 degrees Celsius.

Sealed drops have a fairly long shelf life of 5 years. An opened bottle does not require special conditions (it does not need to be kept in the refrigerator), and the expiration date does not change after the first use.

Reviews

Parents speak mostly positively about Sinekod drops, calling this medication a highly effective remedy for dry and barking cough. According to many reviews from mothers, this medicine quickly helped with tracheitis, laryngitis, whooping cough and other respiratory diseases, easing the condition of the little patient.

The main advantages of the drops are that parents include the possibility of treating infants with this drug, the sweet taste and ease of use. Among the disadvantages of this Sinecode, the high price is often mentioned, because the syrup is cheaper and there are less expensive analogues based on butamirate.

Also, some patients complain of an unpleasant aftertaste of the medication. In addition, although rare, the drops can cause negative side effects, such as a feeling of nausea or the appearance of rashes on the body.

Non-narcotic antitussives.

Composition of Sinecode

Active substance:

• butamirate citrate 5 mg/ml.

Manufacturers

Novartis Consumer Health S.A. (Switzerland)

pharmachologic effect

Pharmacological properties.

Butamirat. The active substance of the drug is a centrally acting antitussive agent.

It is not classified as an opium alkaloid either chemically or pharmacologically.

Suppresses cough, having a direct effect on the cough center.

Has a bronchodilator effect (expands the bronchi).

Helps make breathing easier by improving spirometry (reduces airway resistance) and blood oxygenation (saturates the blood with oxygen).

Pharmacokinetics.

Butamirate is quickly and completely absorbed when taken orally.

After taking 150 mg of butamirate, the maximum plasma concentration of the main metabolite (2-phenylbutyric acid) is reached after approximately 1.5 hours and is 3.4 μg/ml.

When the drug is re-administered, its concentration in the blood remains linear and no accumulation is observed.

Hydrolysis of butamirate:

• initially to 2-phenylbutyric acid and diethylaminoethoxyethanol,
• starts in the blood.

These metabolites also have antitussive activity.

Like butamirate, the metabolites have an almost maximum (about 95%) degree of binding to plasma proteins, which, among other things, determines their long half-life from plasma.

Metabolites are excreted primarily by the kidneys, with acidic metabolites largely associated with glucuronic acid.

The half-life is 6 hours.

Side effects of Sinekod

From the central nervous system:

• sleepy,
• dizziness.

From the gastrointestinal tract:

• nausea, nausea
• diarrhea.

From the skin:

• exanthema.

Rarely, allergic reactions may develop.

Indications for use

Symptomatic treatment of dry cough of various etiologies:

• cough in the preoperative and postoperative period,
• during surgical interventions,
• bronchoscopy,
• with whooping cough.

Contraindications Sinekod

Hypersensitivity to the components of the drug, children under 2 months of age, pregnancy (first trimester), lactation period.

Directions for use and dosage

Inside, before meals.

Children from 3 to 6 years old - 5 ml 3 times a day; from 6 to 12 years - 10 ml 3 times a day; 12 years and older - 15 ml 3 times a day; adults - 15 ml 4 times a day.

Use a measuring cap.

The measuring cap should be washed and dried after each use.

If the cough persists for more than 7 days, you should consult a doctor.

Overdose

Symptoms:

• sleepy,
• nausea, nausea
• vomiting
• diarrhea,
• dizziness and decreased blood pressure.

Treatment:

• gastric lavage: taking activated carbon: maintaining vital body functions.

There is no special antidote.

Interaction

No drug interactions have been reported for butamirate.

special instructions

Carefully.

Pregnancy (II and III trimesters).

Use during pregnancy and lactation.

In studies conducted in animals, no adverse effects on the fetus were noted.

There have been no controlled studies in pregnant women.

In this regard, the drug should not be used in the first trimester of pregnancy.

In the second and third trimesters, the use of the drug is possible taking into account the benefits for the mother and the potential risk for the fetus.

Considering the lack of data on the excretion of butamirate in breast milk:

• Prescribing the drug during lactation is not recommended.

Due to the fact that butamirate suppresses the cough reflex, the simultaneous use of expectorants should be avoided to avoid the accumulation of sputum in the respiratory tract with the risk of developing bronchospasm and respiratory tract infection.

The syrup contains saccharinate and sorbitol as sweeteners, so it can be prescribed to patients with diabetes.

Impact on the ability to drive vehicles or operate machinery.

The drug may cause drowsiness, so caution should be exercised when driving or performing work that requires concentration (for example, when operating machinery) after taking the drug.

Sinekod (form - drops) (pharmacological group - drugs used for coughs and colds). The instructions for use highlight the following features of the drug:

• During pregnancy: contraindicated
• When breastfeeding: contraindicated
• In childhood: with caution
• In old age: with caution

Package

Compound

Sinekod syrup:

• in 1 ml - 1.5 mg of butamirate citrate.

Excipients:

• sodium saccharinate;
• glycerol;
• vanillin;
• benzoic acid;
• water.

Composition of drops:

• in 1 ml - 5 mg of butamirate citrate.

Excipients:

• sodium saccharinate;
• glycerol;
• vanillin;
• benzoic acid;
• water.

Dragees (many people mistakenly believe that these are tablets):

• the main substance is butamirate dihydrogen citrate (50 mg in one tablet);
• lactose;
• Excipients.

Release form

• One bottle of drops contains 20 ml, a pack contains one bottle.
• One bottle of syrup contains 200 ml, one bottle per pack.
• In one package of dragees - 10 pcs.

pharmachologic effect

The cough medicine Sinecod (lat. Sinecod) has a bronchodilator effect, making breathing easier when coughing. Reduces the central action of the cough center. Improves spirometric indicators. It is important that Sinekod is a medicine for dry cough.

Pharmacodynamics and pharmacokinetics

Sinekod is a cough medicine that has a central effect and is not an opium alkaloid. Airway resistance decreases when taking the medication.

After administration, it is absorbed very quickly, the effect is achieved 1.5 hours after administration. There is no accumulation of substances in the body (cumulation). Exits through the urinary system.

Indications for use

• for the treatment of dry cough;
• for cough caused by smoking;
• with whooping cough;
• with bronchitis;
• with tracheitis.

Contraindications

• This drug should not be taken by people with hypersensitivity to the components of the drug;
• during pregnancy (first trimester);
• with pulmonary hemorrhages;
• children under 3 years of age should not take syrup;
• drops are contraindicated for children under 2 months of age;
• tablets are contraindicated for children under 6 years of age.

Side effects

Side effects of this drug are described extremely rarely in the annotations, however, the following are possible:

• dizziness;
• headache;
• nausea;
• drowsiness;
• various allergic reactions.

Instructions for use of Sinecode (Method and dosage)

Sinekod in cough drops:

• 2 months - 1 year - 10 drops 4 times a day (necessarily before meals);
• 1 year - 3 years - 15 drops 4 times a day (necessarily before meals);
• From 3 years - 25 drops 4 times a day (necessarily before meals).

Sinekod syrup, instructions for use:

Syrup for dry cough should be taken in different dosages depending on age:

• 3 years - 6 years - 5 ml 3 times a day;
• 6-12 years - 10 ml 3 times a day;
• From 12 years - 15 ml 3 times a day.

Adults can also use this medicine; it is not just children's syrup, as many believe. Adults need to take this drug 4 times a day, 15 ml.

Instructions for using dragees:

• 6-12 - 1 tablet 2 times a day;
• After 12 years - 3 tablets per day;
• For adults - 2 tablets 3 times a day.

You can't chew it!

How many days should I take this medicine? Up to 7 days; if there is no improvement, you should stop taking the drug and consult a doctor.

Overdose

In case of an overdose of the drug, the following symptoms appear:

• drowsiness;
• nausea;
• dizziness.

You should drink activated charcoal and consult a doctor immediately.

Interaction

The interaction of this drug with other drugs has not been described.

Terms of sale

Sinekod is available in pharmacies without a prescription.

Storage conditions

This medicine should be stored in a dark place at room temperature (but not higher than 30 degrees) and out of reach of children.

Best before date

Analogues of Sinecode

• Stoptussin
• Fluditek
• Erespal
• Ascoril
• Omnitus
• Panatus (Forte)

The price of Sinekod analogues is approximately the same, with the exception of Erespal, whose price is higher than all the others. This drug has no Russian analogues.

Which is better: Stoptussin or Sinekod?

These drugs have almost the same effect on the human body. The only difference is that Sinekod cough syrup treats only a dry cough, while Stoptussin also has an expectorant effect. Otherwise, there is no difference, so doctors very often prescribe these two medications to the patient to choose from.

Active substance: butamirate citrate 1.5 mg/ml.

Excipients: sorbitol, glycerin, sodium saccharin, benzoic acid (E210), vanillin, ethanol, sodium hydroxide, purified water.

Description

Transparent solution, colorless to pale brownish-yellow.

Pharmacotherapeutic group

Other antitussives. CodeATX: R05DB13.

Pharmacological properties

Pharmacodynamics

Butamirate, the active substance of the drug Sinecod®, is an antitussive agent that is not an opium alkaloid either chemically or pharmacologically.

It is believed that Sinekod® is a centrally acting antitussive drug. In addition to the antitussive effect, there is a trend towards a decrease in airway resistance, which is reflected in a slight increase in spirometry.

Pharmacokinetics

Butamirate citrate is rapidly absorbed after oral administration, with measurable blood concentrations detected within 5-10 minutes after administration of doses ranging from 22.5 mg to 90 mg. Maximum plasma concentration is achieved within 1 hour. The effect of food on absorption has not been studied.

Butamirate is hydrolyzed to 2-phenylbutyric acid and diethylaminoethoxyethanol. These butamirate metabolites have antitussive activity.

2-phenylbutyric acid undergoes further metabolism. All metabolites are excreted primarily through the kidneys.

Indications for use

For the symptomatic treatment of dry cough of various origins.

Contraindications

Hypersensitivity to the components of the drug, children under 3 years of age.

Use during pregnancy and breastfeeding

The use of the drug during pregnancy and breastfeeding is not recommended.

Directions for use and doses

For oral administration. Take before meals.

For adults and children over 3 years old.

Children from 3 to 6 years old - 5 ml 3 times a day; children from 6 to 12 years old - 10 ml 3 times a day; children aged 12 years and older - 15 ml 3 times a day; adults - 15 ml 4 times a day.

Use measuring cup (supplied). The measuring cup should be washed and dried after each use.

The maximum duration of treatment should not exceed 7 days (see information in the "Precautions" section). If the cough persists for more than 7 days, you should consult a doctor. The need for further use of the drug is determined by the doctor, taking into account the characteristics of the disease, tolerability of the drug and the achieved effect.

Side effects

When using the drug, the following side effects are possible:

From the nervous system:

Uncommon (0.1 to 1.0%): dizziness, drowsiness

From the gastrointestinal tract:

Uncommon (0.1 to 1.0%): nausea, diarrhea

From the skin:

Rarely (from 0.01 to 0.1%): rash, urticaria.

If an adverse event occurs, including one not listed in these instructions, you should stop taking the medicine and consult a doctor.

Overdose

Overdose may cause the following symptoms: drowsiness, nausea, dizziness, vomiting, diarrhea, hypotension.

Treatment: activated carbon, saline laxatives, if necessary, maintaining the functions of the cardiovascular and respiratory systems.

Interaction with other drugs

Due to the proposed mechanism of action on the central nervous system, a possible enhanced effect of drugs that depress the central nervous system, including ethanol-containing drugs, cannot be ruled out. The simultaneous use of other medications containing ethyl alcohol should be avoided. Concomitant use with expectorants should be avoided (see information in the "Precautions" section).

Precautionary measures

Due to the inhibition of the cough reflex by butamirate, concomitant use with expectorants should be avoided, as this may lead to mucus stagnation in the airways, which increases the risk of bronchospasm and respiratory tract infection.

The syrup contains saccharin and sorbitol as sweeteners, so it can be prescribed to patients with diabetes.

Due to the presence of sorbitol, the drug should not be taken by patients with rare hereditary disorders associated with fructose intolerance.

The maximum duration of treatment should not exceed 7 days. If symptoms persist for more than 7 days or the condition worsens, you should consult a doctor.

This medicine contains a small amount of ethanol (11.73 mg/5ml). Use in patients with impaired renal function and/orliver

No special studies have been conducted. Patients with impaired renal and/or liver function may be at greater risk of developing side effects due to the accumulation of butamirate or its metabolites.

(butamirate | butamirate)

Registration number:

Tradename: SINECODE®

International nonproprietary name: Butamirat.

Chemical structure: 2-ethyl-2-phenylbutyrate citrate

Dosage form:

Compound:

Excipients: sorbitol solution 70% w/w, glycerin (glycerol), sodium saccharin, benzoic acid, vanillin, ethanol 96% v/v, sodium hydroxide 30% m/w, purified water.

Description: colorless transparent liquid with vanilla odor

Pharmacotherapeutic group:

CodeATX: R05DB13.

Pharmacological properties

Butamirate, the active substance of the drug Sinekod, is a centrally acting antitussive agent, neither chemically nor pharmacologically related to opium alkaloids. It has an expectorant, moderate bronchodilator and anti-inflammatory effect, has a direct effect on the cough center, improves spirometry (reduces airway resistance) and blood oxygenation.

Pharmacokinetics
Butamirate is quickly and completely absorbed when taken orally. After taking 150 mg of butamirate, the maximum plasma concentration of the main metabolite (2-phenylbutyric acid) is reached after approximately 1.5 hours and is 6.4 μg/ml. The half-life is 6 hours. When the drug is re-administered, its concentration in the blood remains linear and no accumulation is observed. Hydrolysis of butamirate, initially to 2-phenylbutyric acid and diethylaminoethoxyethanol, begins in the blood. These metabolites also have antitussive activity. Like butamirate, the metabolites have an almost maximum (about 95%) degree of binding to plasma proteins, which, among other things, determines their long half-life from plasma. Metabolites are excreted primarily in the urine, with acidic metabolites largely associated with glucuronic acid.

Indications for use

Dry cough of any etiology (including whooping cough). Suppression of cough in the pre- and postoperative period during surgical interventions and bronchoscopy.

Contraindications
Hypersensitivity to the components of the drug, children under 3 years of age (for children under 3 years of age, Sinekod drops can be used for oral administration).

Use during pregnancy and lactation

In animal studies, no adverse effects on the fetus were observed. There have been no controlled studies in pregnant women. In this regard, Sinekod should not be used in the first trimester of pregnancy. In the second and third trimesters, the use of Sinekod is possible, taking into account the benefits for the mother and the potential risk to the fetus. Given the lack of data on the excretion of the active substance in breast milk, the use of Sinekod during lactation is not recommended.

Directions for use and doses
Inside, before meals.
Children from 3 to 6 years old - 5 ml 3 times a day;
6-12 years - 10 ml 3 times a day;
12 years and older - 15 ml 3 times a day;
adults - 15 ml 4 times a day.
Use the measuring cap (supplied).

Side effects
Skin rash, nausea, diarrhea, dizziness (frequency less than 1%), allergic reactions.

Overdose
Symptoms: drowsiness, nausea, vomiting, diarrhea, loss of balance and decreased blood pressure.

Treatment: activated charcoal, saline laxatives, maintaining the function of the cardiovascular and respiratory systems.

Interaction with other drugs
No drug interactions have been reported for butamirate.

special instructions

The syrup contains saccharin and sorbitol as sweeteners, so they can be prescribed to patients with diabetes.

Release form

100 ml and 200 ml of syrup in dark glass bottles with a lid made of polyethylene and polypropylene, equipped with a child tampering system and a measuring cap made of polypropylene. 1 bottle along with instructions for use is placed in a cardboard box.

Best before date
5 years. Do not use after expiration date.

Storage conditions
At a temperature not exceeding 30°C, out of the reach of children.

Conditions for dispensing from pharmacies.
Over the counter.

Manufacturer(All stages, including release quality control)
Novartis Consumer Health S.A.
Route de l`Etraz, 1260 Nyon, Switzerland Switzerland