After the hCG injection, 2 corpora lutea. The effect of hCG injection on the follicle

Human (or hCG for short) begins to be produced by the female body immediately after fertilization of the egg and plays a critical role in the proper growth and development of the embryo. Thanks to the achievements of modern medicine, it has become possible to synthesize this hormone artificially. It is used to treat ovulatory disorders in women that prevent conception. The hormone is administered using a special injection. We will tell you in our article what a hCG injection is and when they resort to using this method.

Why is an injection of human chorionic gonadotropin prescribed?

If a woman who seeks medical help is diagnosed, in most cases it is recommended to stimulate this process. For this, a hCG injection is often used, which not only “starts” the process of ovulation in the female body, but also prevents the regression of follicles, which can develop into follicular cysts. The injection dose is usually 5,000 or 10,000 units, and ovulation after an hCG injection occurs after 24-36 hours.

HCG injections during pregnancy

The production of human chorionic gonadotropin begins from the moment the embryo enters the uterine cavity and continues until the end of pregnancy. In the first few months after conception, the level of this hormone constantly increases, and, based on its quantitative content at certain periods, one can judge whether the pregnancy is proceeding normally. The main function of hCG is to ensure normal fetal growth and control production in the first trimester. If for some reason the synthesis of this hormone ceases, then the production of substances vital to the fetus is disrupted, which can lead to termination of pregnancy. Such problems can be solved by hCG, designed to compensate for the deficiency of this important hormone. Such injections are prescribed in the following cases:

• in order to preserve the viability of the corpus luteum until the placenta takes over the production of all hormones that contribute to the normal course of pregnancy;
• to help the formation of the placenta.

HCG injection: indications

Thus, the indications for injections of this hormone are the following conditions:

• insufficient production of the corpus luteum by the female body during pregnancy;
• lack of ovulation, which entails the impossibility of conception;
• habitual;
• threatened miscarriage;
• preparation for IVF.

Contraindications for hCG injection

Injections of this hormone also have contraindications, which include the following conditions: early menopause, lactation, thrombophlebitis, ovarian cancer, hypothyroidism, fallopian tube obstruction, hypersensitivity to the components of the drug, hyperprolactinemia.

Women planning to have a baby are faced with many unfamiliar medical terms. Their meaning remains a mystery until you experience them in person. These include the hCG hormone, which is produced by the female body after fertilization and is responsible for the proper development of the fetus. But sometimes a failure occurs and its artificial introduction is required. This is possible with the help of special injections that contain a substance - human chorionic gonadotropin. It is given during pregnancy planning to women who do not ovulate.

Under what circumstances is an HCG injection needed?

The ability to become pregnant occurs only when the egg is released from the ovary. This occurs somewhere in the middle of the menstrual cycle. Sometimes the fertilized egg does not attach to the wall of the uterus. The couple tries for a long time, but nothing works, since the long-awaited ovulation does not occur. It can be caused by stimulation, but to do this it is necessary to find out the causes of the failure and eliminate them.

An injection of hCG can restore ovulation, but the choice of drug and its dosage is prescribed only by a doctor based on the characteristics of each woman individually. After the administration of the chosen remedy, the favorable period should occur in a day or a day and a half, but this is an approximate time, because sometimes ovulation occurs much later.

• to stimulate the egg and prevent the formation of a cyst, which can occur when the follicle does not burst, but begins to decrease in size;
• in cases where the placenta is not developing well. An HCG injection is administered to help her. He contributes to its formation;
• to preserve the functionality of the corpus luteum. In the initial stage of pregnancy, the body really needs its support, then the placenta can take over this function;
• at risk of miscarriage. Especially if they have already been present in previous cases of pregnancy;
• in case of artificial insemination.

Important! During stimulation, the success of follicle development must be monitored by ultrasound. In case of male infertility, injections with hCG are useless.

If after all the examinations it turns out that such a procedure cannot be done without, then it is necessary to provide the doctor not only with the results of the woman’s tests, but also with her partner. He is required to take a spermogram to accurately verify the man’s ability to conceive. This can be understood by the quality of his seminal fluid. Many representatives of the stronger half believe that if they have not had problems before and their older children are proof of this, then they are deeply mistaken. The situation may change within a year and it does not matter how many children there were before.

In what cases should you not do hCG?

Before stimulation, you need to take tests to check your hormones. This is necessary to clarify their exact indicators; it is better to do this several times. After discovering the problem, the doctor will probably prescribe a course of normalizing hormone levels, and if this therapy does not help, then you will need to resort to an injection of hCG.

But there are hormones in violation of which stimulation cannot be carried out, these are:

• prolactin;
• thyroid gland;
• and almost all of them are male.

They can interfere with the process, and it will be inconclusive.

It is strictly forbidden to give injections with hCG if the following diseases are observed:

• tumors of the ovaries and pituitary gland;
• hypothyroidism – lack of thyroid hormones;
• existing blood clots in the vessels or a predisposition to their appearance;
• early menopause;
• sensitivity to the ingredients of the injection.

Important! If tubal obstruction is detected, then stimulation of ovulation can lead to ectopic conception. Therefore, before the procedure it is necessary to undergo laparoscopy and metrosalpingography.

Indications for ultrasound monitoring for hCG

On average, a woman's monthly cycle lasts 28 days, so the first ultrasound can be done 10 days after the last menstruation. The procedure should be carried out every three days until the ovulation period is established or the next “women’s days” begin.

The results of observations can be:

• lack of ovulation because the ovaries do not work and the follicles do not mature;
• the main follicle matures, but does not grow to the required size and ovulation does not occur;
• the follicular sac develops normally, but then does not rupture.

Stimulation is not required only if ovulation occurs and the corpus luteum forms in the follicle. And if it does not open in time, you can help it do so with a timely injection of hCG, after which a corpus luteum will appear in place of the follicle.

Stimulation procedure

The doctor usually prescribes an injection with human chorionic gonadotropin on the second day of the cycle. It must be done daily, and after ten days the stimulation stops. The whole process takes place under the supervision of a doctor, who also prescribes how many days the injections should be given and what should be the dose of the administered medication.

Important! There is no need to rely on averages or performing stimulation on friends. For each patient, everything goes individually, this is due to the structural features of the ovaries and uterus of an individual woman.

Treatment is accompanied by constant monitoring by ultrasound every three days. The first is carried out after stimulation on the fifth day. And when the follicles grow to the required size (approximately 20-25 mm), then a final examination is carried out, checking their opening. To complete it successfully, an injection of hCG is administered; during this period, it provokes the start of ovulation.

If all circumstances are favorable, the injection will take effect within 36 hours and ovulation will begin. After this is confirmed by ultrasound, hormonal injections with utrogestan and progesterone, which are needed to support the activity of the ovaries, will be prescribed.

How much and when sexual intercourse should be performed during stimulation is prescribed by the doctor; this is influenced by the male factor. After completing the injection, you can try again the next day. They must be repeated until the corpus luteum appears, that is, until the period when ovulation occurs.

An increase in hCG begins to be observed already on the third day, and every 3 days it doubles. Under the influence of the administered injection, the body begins to produce progesterone and estrogen at double speed, and they promote conception.

The hCG injection is often used in gynecology to stimulate ovulation; it effectively helps with infertility and promotes the speedy conception of a long-awaited baby. After its administration, you do not have to wait long for results, and in most cases they are positive.

In the proposed video, a specialist will clearly explain the significance and effect of the hCG injection.

Injections at home - review of prices and quality from professionals

An injection of hCG to stimulate ovulation is one of the most effective methods for promoting pregnancy. He helps women who have been trying to conceive a baby for a long time and to no avail. So, what is hCG and when is it prescribed in injections?

Indications for hCG injection

During a normal monthly female cycle, a biologically active substance such as human chorionic gonadotropin (hCG) begins to be synthesized in a woman’s body only after conception. But sometimes hCG injections are prescribed not only to pregnant women, but also to those women who need to stimulate ovulation.

As you know, in order for an egg to be fertilized, it must be released from the follicle, which bursts during ovulation. Unfortunately, for some girls this process is disrupted. Their ovaries do not produce eggs. Either the mature follicle does not burst and the egg does not come out. Therefore, their menstrual cycle is defined by experts as anovulatory.

What to do if the long-awaited ovulation does not occur? In such cases, doctors may suggest that patients stimulate the process of egg release by intramuscular injection of human chorionic gonadotropin. Naturally, the specialist must first find out the reasons for the possible disruption of the normal menstrual cycle and try to eliminate them.

One of the most effective methods for stimulating ovulation is an injection of hCG, which promotes the maturation of the follicle and allows it to successfully burst, giving the woman the opportunity to experience all the joys of motherhood.

HCG injections are prescribed in the following cases:

• to stimulate the release of an egg from the ovary;
• to prevent the formation of a cyst at the site of a follicle that did not burst and began to regress;
• to preserve the functionality of the corpus luteum;
• artificial insemination;
• to reduce the risk of miscarriage and maintain pregnancy.

If the follicle does not mature

It often happens that the reason for anovulatory cycles is not only that the follicle does not burst. But also that it does not grow to the required size. Then doctors prescribe drugs that stimulate the growth and maturation of follicles. And only when the dominant follicle grows to the desired size, an hCG injection is given.

The classic scheme is as follows. First, the process of follicle maturation is activated using the drug “Clostilbegit” (clomiphene citrate). It is taken in tablet form from the 5th to the 9th day of the menstrual cycle. And only then is an injection of human chorionic gonadotropin prescribed. Stimulation of ovulation with Clostilbegit is not suitable for everyone. Therefore, gynecologists often choose other drugs for this purpose.

How does he work

An hCG injection is given if a dominant follicle measuring about 2 cm in diameter is visible on ultrasound. After the injection, the follicle successfully bursts and a new egg is born.

When does ovulation occur after injection? According to the instructions for the use of human chorionic gonadotropin, ovulation after an hCG injection should occur one to two days after the manipulation. The process may take a long time. This depends on the woman’s hormonal background, her individual constitutional characteristics and the dose of the drug administered.

How it works? The fact is that hCG affects the function of follicles in much the same way as luteinizing hormone (LH). It is under the influence of LH that ovulation occurs successfully and the egg is released from the ovary. It is important that hCG injections not only allow the follicles to burst, but also prevent their cystic degeneration.

Also, the prescribed human chorionic gonadotropin promotes the development of the placenta, so it is used after conception.

Basic principles of the procedure

Injections to stimulate ovulation based on human chorionic gonadotropin are available in the form of a solution or components for its preparation. According to the instructions for use, the drug must be injected intramuscularly in the abdominal area using an insulin syringe. Naturally, only a doctor can give an injection. And only an obstetrician-gynecologist can prescribe adequate dosages and correctly determine the time of the procedure. Only in this case will the injection be as effective and safe as possible.

“Pregnil”, “Menogon”, “Humagon”, “Ovidrel” and many others are used as an injection drug. Their action is aimed at stimulating ovarian function by increasing the level of human chorionic gonadotropin in the blood. Recommendations for the use of these dosage forms are given exclusively by the attending physician during the examination of the patient, taking into account all the characteristics of the body and the state of her hormonal sphere.

As a rule, in case of disturbances in the normal ovulation process, a single injection of hCG 5000-10000 subunits is prescribed. During IVF, women need to receive an injection of 10,000 units of hCG, which is also prescribed once after stimulating follicle growth. In gynecological practice, doctors most often use an injection of hCG 5000 units, since it is optimally safe for the expectant mother.

Contraindications and side effects

HCG injections have a number of contraindications, including:

• early menopause;
• malignant neoplasms of the ovaries;
• diagnosed obstruction of the fallopian tubes;
• bleeding disorders with an increased risk of blood clots;
• lactation period;
• imbalance of adrenal hormones;
• individual intolerance to the components of the drug.

HCG injection, if used incorrectly, has a number of unpleasant side effects. Therefore, before using the drug, it is so important to be examined by a competent specialist.

Violation of the order of use, an overdose of human chorionic gonadotropin can contribute to the occurrence of symptoms of ascites, polycystic disease, thromboembolism, acne, and allergies. Very often, after an injection of hCG, patients’ general health deteriorates, weakness and lethargy appear, it becomes difficult for a woman to stand, and sometimes fainting can occur.

When to take an ovulation test?

Ovulation after an hCG injection should occur 24-36 hours after the injection. Sometimes it happens that the release of the egg at the specified time does not occur or is postponed to a later date. That is why this process takes place under strict ultrasound control. After ovulation has occurred after the hCG injection, the patient is prescribed hormones that help maintain ovarian function. For example, utrozhestan or duphaston.

A woman can find out that ovulation has occurred after an hCG injection using not only an ultrasound examination, but also a special test.

So, at what time after the injection of human chorionic gonadotropin is it best to determine the release of the egg from the follicle?

When can I do a pregnancy test

Some women are interested in when they can take a pregnancy test after an hCG injection. If conception has occurred, the pregnancy test will be positive after the first day of absence of the expected menstruation. Although most doctors doubt its reliability. After all, since human chorionic gonadotropin was artificially introduced into the body, it can be present in the urine for up to two weeks after the injection. Only from this moment is it considered reliable.

Therefore, a more accurate and informative method of diagnosing pregnancy is usually prescribed - ultrasound examination of the pelvic organs. Or you need to donate blood for hCG in dynamics.

Important nuances

Those who have been helped by an hCG injection to get pregnant know that successful conception is impossible without strict adherence to all the recommendations of the attending physician. It is a competent specialist who will help you figure out whether a woman with an anovulatory cycle really needs the administration of human chorionic gonadotropin. He will also answer the question of how long after an unsuccessful injection you can try again. When to take an ovulation and pregnancy test and much more.

In any case, women need to remember:

• Chorionic gonadotropin preparations should be prescribed by a doctor after a comprehensive examination of the patient and clarification of all the characteristics of her body;
• it is necessary to strictly observe the timing of the administration of hCG and do an ultrasound on time;
• the technique does not guarantee 100% results;
• not all forms of anovulatory disorders are equally sensitive to treatment with hCG drugs;
• ovulation should be monitored using ultrasound, since the test is not a sufficiently informative diagnostic method;
• For successful conception, you need not only a full-fledged egg, but also high-quality sperm, therefore, when planning a pregnancy, both partners should be examined for infertility.

One of the most popular methods of treating infertility is ovulation stimulation. It is used for women with problems with the maturation of the egg and the absence of its release from the ovary. To stimulate ovulation, hormonal drugs are used, thanks to the action of which one or more eggs capable of fertilization are formed in the female body.

In our Remedial Practice we will test you step by step. Once a gestational carrier has been selected, she must undergo a thorough examination. Once all assessments are completed, the treatment cycle can begin. Both the gestational carrier and the donor mother begin taking pills and injections to synchronize their cycles and prepare for embryo transfer. The donor mother takes the eggs to stimulate her ovaries to produce eggs, and at the same time the carrier takes medications to prepare the uterus for implantation.

After embryo transfer, the gestational carrier asked to reduce excessive physical activity for several days. After the transfer you will be given and a pregnancy test will be done approximately 10 days later. If it is positive, it indicates that implantation has been achieved.

Methods to restore ovulation are selected taking into account the reason for its absence. Achieving a positive effect from the use of ovulation stimulation is possible only if the cause that disrupts the ovulatory process is established.

Reasons for the development of anovulation

The reasons that provoke the development of anovulation can be physiological and pathological (chronic). Physiological anovulation is considered normal and does not require seeking medical help and may occur during the following periods in a woman’s life:

The first ultrasound to evaluate pregnancy is scheduled approximately 3-4 weeks after the transfer. If the pregnancy test is negative, all treatment is stopped and menstruation usually begins within three to ten days. If frozen embryos exist, the process can be started again.

Preimplantation genetic diagnosis

These cells and embryos freeze. The biopsy cells are analyzed and we get a report that tells us if the embryos have a normal number of chromosomes or not. We also learn about fetal sex. This process significantly increases the chances of pregnancy, reducing the incidence of multiple pregnancies and abortions. This also reduces the number of embryos that are saved, since only normal ones remain frozen. These embryos, without genetic defects, are transferred into a future cycle.

Puberty: In teenage girls, ovulation may not occur for the first two years after menarche;
period of pregnancy and breastfeeding;
menopause;
“rest” period: 1-2 menstrual cycles per year; women of reproductive age may not ovulate.

Pathological anovulation can be caused by a violation of the structure of organs or diseases of the endocrine system. Most often, the presence of this particular condition is the cause of infertility.

Not all methods offer this procedure. Laparoscopy is a minimally invasive surgical procedure that allows for a complete examination and evaluation of the female pelvic region and abdominal structure. This is an outpatient surgery performed under general anesthesia. The incisions are half a centimeter, so the patient can go home the same day and work within a few days. Pelvic adhesions, endometriosis, tubal, ovarian and uterine abnormalities, evidence of past infections, are some of the things we can diagnose with these procedures.

Pathological reasons for the lack of ovulation may be the presence of the following conditions:

Hypothalamic dysfunction;
oncological diseases of the pituitary gland;
circulatory disorders in the brain;
hyperprolactinemia;
hyperandrogenism;
frequent stress;
injuries of the reproductive system;
inflammatory diseases of the appendages;
obesity;
anorexia;
premature menopause;
(polycystic ovary syndrome, endometriosis, uterine fibroids, etc.);
diseases of the thyroid gland and liver;
when taking hormonal contraceptives.

A large percentage of patients who have all normal fertility tests have problems in the pelvic area. Many times these anomalies can be repaired simultaneously. Thus, this operation serves as a diagnosis, helps us plan next steps, and often improves the chances of pregnancy. Photos are taken before, during and after surgery. Most patients are discharged and can return home after the procedure.

Hysteroscopy is an outpatient surgical procedure performed under anesthesia. A 4-6 mm camera is inserted behind the cervix to enter the uterine cavity. Using fine instruments such as tweezers and scissors, abnormalities such as polyps, fibroids, scars and septums are corrected. Typically, these abnormalities can be corrected in one session without making any incisions. Typically, patients can return to work the next day. Most patients are discharged within a couple of hours.

Diagnosis of anovulation

To diagnose anovulation, it is not enough to draw a basal temperature chart, since this method is not reliable enough. More informative ways to identify this pathology are: ultrasound examination, carried out over several menstrual cycles, as well as tests to determine the level of certain sex hormones.

Reversal of tubal ligation

To be able to perform this procedure, it is important that your tubes are blocked but not destroyed. We need at least 4-5 centimeters of a regular horn to use. It is also important that your partner has a normal sperm test so you can become pregnant after surgery. The operation itself takes about two hours. The incision measures 5-2 inches and is located in the pubic area covered by the “bikini”. The patient is discharged the same day and takes about two weeks to recover and return to daily life.

Tests for hormone levels in the blood

Stimulation of ovulation is not prescribed if there are deviations from the norm in the blood levels of thyroid hormones, prolactin and male sex hormones.

Ultrasound monitoring

In order to confirm or exclude the absence of ovulation, it is necessary to conduct multiple ultrasound examinations throughout the entire menstrual cycle.

Stages of ovulation stimulation

The chances of pregnancy depend on the type of tubal ligation, the woman's age, other female factors and the man's test sperm. However, since the middle of the last century, some weight management clinics have also administered the substance as an aid to weight loss. In recent years, this substance has increased in popularity for this purpose and is usually administered as an injection or sublingual drops.

History as a weight loss assistant

This hormone is an aid in the production of its hormonal compound progesterone, which dilates the uterus and helps nourish the fetus. While studying pregnant women in India, he realized that those in a calorie deficit lost fat instead of muscle. After a complete medical examination and pre-detoxification for detoxification, the patient receives daily injections or self-administers for the same number of days as the protocol lasts. The patient also follows a strict, extremely low calorie diet until the end of the program and then a high calorie maintenance diet.

If the cycle is 28 days, the first ultrasound is scheduled for 8-10 days after the last menstruation has ended. Then the study is repeated at intervals of 2-3 days until the onset of ovulation or the beginning of the next menstruation.

Stages of ovulation stimulation

Stimulation using clostilbelite begins on the fifth day of the menstrual cycle, with gonadotropins - on the second. The timing of the start and duration of taking the drugs is determined by the attending physician in accordance with the condition of the woman’s uterus and ovaries.

After this, the patient must stop the protocol, but must still follow a low-calorie diet for at least three weeks. However, the injections themselves last approximately three days each. This hormone begins to be produced immediately when the fertilized egg begins to run.

Although it is possible to take a pregnancy test before this time, the chances of getting a false positive result are extremely high if you decide to take your chances. With that in mind, there's no reason why he shouldn't take a pregnancy test around 12 days in advance.

The first ultrasound examination is carried out a few days after the start of the ovulation stimulation procedure. Then ultrasound is repeated every 2-3 days until the follicles reach a size of at least 20 mm. After this, the woman is given an injection of hCG (in a dosage of 5,000 to 10,000 units), which starts the ovulation process and prevents regression of the follicles and the risk of follicular cyst formation.

An hCG injection is an injection of a hormonal drug with the main active substance - human chorionic gonadotropin: pregnyl, prophasia, choragon, humegon, menogon, choriogonin, etc. With the help of these drugs, the ovulation process is restored, as well as an increase in the level of hCG in the blood, due to which yellow body and its activity increases.

The doctor selects the dosage of the hCG drug in each individual case in accordance with hormone levels, the size of the follicles and a number of other equally important factors. Excessive amounts of human chorionic gonadotropin can trigger the development of ovarian hyperstimulation syndrome.

An injection of hCG (human chorionic gonadotropin) triggers the onset of ovulation, which usually begins 24-36 hours after the injection. The release of the egg is recorded using ultrasound, after which the woman is prescribed additional support for the ovaries (corpus luteum) in the form of injections of utrogestan or progesterone.

The timing and frequency of sexual intercourse or artificial insemination when stimulating ovulation is prescribed by the doctor individually, depending on the results of the man’s spermogram. If the quality and quantity of sperm are good, it is recommended to have sexual intercourse every day or every other day, starting from the moment the woman received the hCG injection until the corpus luteum is formed.

What is an HCG injection?

The main factor influencing a woman’s ability to become a mother is the presence of ovulation - the process of release of mature eggs from the follicles and subsequent movement through the fallopian tubes, which determines readiness for fertilization. Sometimes, for one reason or another, a malfunction occurs in the body, as a result of which the membrane (follicle) does not rupture.

The success of conception largely depends on the level of the hormone human chorionic gonadotropin in a woman’s blood, the effect of which on the corpus luteum continues until the fertilized egg attaches to the wall of the uterus. In some cases, there is a need for artificial administration of human gonadotropin (hCG injection).

In what cases is an HCG injection indicated?

An hCG injection can be prescribed to women in the following cases:

In the absence of ovulation: an injection of hCG stimulates the release of the egg and prevents the reverse development of follicles (atresia). Unruptured follicles may regress, decreasing in size and forming follicular cysts;
to preserve the vital activity of the corpus luteum: an injection of hCG helps maintain the condition of the corpus luteum until these responsibilities are “transferred” to the placenta;
for the normal formation of the placenta and maintenance of its functions: when the development of the placenta is inhibited;
if the female body is unable to maintain pregnancy and has a history of miscarriages;
if there is a risk of miscarriage;
when planning in vitro fertilization.

HCG injection: contraindications for injection

HCG injection is not prescribed for women suffering from the following pathologies:

Malignant ovarian tumors;
pituitary tumor;
predisposition to the formation of blood clots in blood vessels;
violation of the patency of the fallopian tubes;
hypothyroidism (insufficient amount of thyroid hormones);
individual intolerance to one or another component of the drug to stimulate ovulation;
with early menopause;
during breastfeeding.

Pregnancy after hCG injection

An hCG injection can cause a false positive result if a pregnancy test is performed earlier than 14 days after ovulation. This is explained by the fact that these tests are based on determining the level of hCG, which is an indicator of the onset of conception, and the artificial introduction of this hormone increases its amount in the blood for a while. A more reliable method is dynamic monitoring of hCG, the level of which in pregnant women is constantly increasing until the end of the first semester. At the beginning of the second semester, it gradually decreases to a certain level, which remains unchanged until the end of pregnancy.

HCG is a hormone that is released into a woman’s blood immediately after the fertilized egg is implanted in the uterus.

The level of this substance in the blood is constantly growing, with its help you can find out whether everything is fine with the fetus. But this hormone is prescribed when planning a conception, so many women are interested in the question of whom the hCG injection helped to get pregnant.

How does the hCG injection work?

Usually this injection is prescribed only once when planning pregnancy. This hormone promotes the rupture of the dominant follicle and stimulates ovulation. This medicine is prescribed only after the woman takes hormones for the growth of the dominant follicle.

Every 2 days the follicle is monitored, and when it reaches the desired size, hCG is administered. After administration of the drug, ovulation occurs within 12-36 hours. It is during this period that you need to have sex during natural conception or introduce sperm through insemination. Reviews indicate that the injection helps to get pregnant.

When is an HCG injection prescribed?

There are two options for administering the hormone:

• stimulation of ovulation with Clostilbegit;
• with polycystic ovary syndrome, when the follicle grows, but does not burst, but develops into a cyst.

Therefore, an hCG injection is prescribed for anovulatory cycles, when the egg does not mature. Stimulation is carried out with Clostilbegit or Clomid. On days 14-20 of the cycle, the hCG hormone is administered. During insemination, sperm is injected only after follicle rupture is confirmed.

The hCG hormone helps to get pregnant and maintain pregnancy. When artificially inducing ovulation after administration of human chorionic gonadotropin, progesterone is prescribed. Usually this is the drug "Utrozhestan" or "Duphaston". They loosen the endometrium and promote the attachment of the fertilized egg.

Indications for the use of hCG:

• anovulation;
• corpus luteum deficiency during pregnancy;
• habitual abortion;
• risk of miscarriage.

When can I take a pregnancy test after an injection?

It is worth considering that pregnancy test strips react specifically to this hormone. Therefore, before the expected date of your period, you will receive false positive results. Only after a few days of delay does it make sense to do a test.

If you don’t have enough patience and want to find out about your pregnancy as soon as possible, then donate blood for hCG. Based on the amount of hormone in the laboratory, they can judge the absence or occurrence of pregnancy.

When does it make no sense to inject hCG?

This injection is not prescribed at random. It must be done on a certain day of the cycle when the follicle is fully mature. If you administer the medicine earlier, ovulation will occur, but you will receive an underdeveloped egg that is not capable of developing into pregnancy.

Therefore, the substance is administered only with constant folliculometry using ultrasound. If you have not been injected with drugs to stimulate the growth of the dominant follicle, then the injection is also useless, since there will be nothing to rupture due to the absence of the “main” follicle.

How to determine that pregnancy is developing by hCG levels?

This hormone is included in mandatory screening of pregnant women. The concentration of this substance is used to judge the health of the fetus. At 14-18 weeks, the pregnant woman donates blood for hCG. If it is reduced, it means that there is a threat of miscarriage or the presence of pathologies in the fetus.

What to do if hCG is low during pregnancy?

If during testing it turns out that the concentration of this substance is low, the hormone is administered by injection to preserve the embryo. The fact is that this substance controls the release of progestins and estrogens into the blood. If there are more or less of these hormones, there is a risk of miscarriage. In addition, human chorionic gonadotropin is prescribed for insufficiency of the corpus luteum, which supplies the fertilized egg with useful substances.

An increased concentration of hCG indicates:

• about multiple pregnancy;
• about maternal diabetes;
• about taking progestins;
• about Down syndrome in the fetus;
• about an incorrectly determined gestational age.

Therefore, if you are taking Duphaston or Utrozhestan when there is a threat of miscarriage, tell the laboratory about it. Usually, it is not the concentration of hCG itself that is analyzed, but its relationship to AFP and estriol. Based on the data obtained, a diagram of the risk of genetic defects in the fetus is constructed, since an increased level of the hormone is an indication for the analysis of amniotic fluid, which is collected by puncturing the mother’s abdomen. This increases the risk of infection and miscarriage.

When a woman has problems conceiving, treatment raises many questions and is often frightening with terminology. What is a hCG injection, in what cases is it used, how effective is it, what contraindications does it have - let's figure it out together.

Human chorionic gonadotropin (hCG) is a term used to describe a hormone that is produced in the body after fertilization of an egg and is responsible for the preservation and development of the fetus during pregnancy. It is the determination of the level of this hormone that underlies the pregnancy test.

HCG injection - instructions

• The hormonal drug hCG is synthesized from the urine of pregnant women or by genetically modified microbes with recombinant DNA. The pharmacological action is based on stimulation of the ovulatory cycle, spermatogenesis and the production of sex hormones in the ovaries
• Preparations based on hCG are effective in cases of corpus luteum deficiency, ovarian dysfunction, infertility caused by lack of ovulation, threat of miscarriage, and risk of premature birth. These hormonal drugs can also be prescribed for assisted reproductive techniques (in vitro fertilization)
• Chorionic gonadotropin is available in the form of a solution for intramuscular injection or lyophilisate (component for preparing the solution). In case of stimulation of ovulation, injections are made into the abdominal area using a syringe with a short (insulin) needle. This method is more effective and painless
• The dosage of the drug, as well as recommendations for its use, are prescribed by the attending physician based on multiple studies. The exact dose of the drug must be calculated strictly individually, based on the level of hormones, the size of the follicles, the thickness of the endometrial layer of the uterus and data from other tests
• Menogon, Pregnil, Humegon, Profasi, Novarel, Ovidrel, etc. are used as injection drugs. Their action is aimed at restoring ovulation function and stimulating hormonal activity caused by an increase in the level of hCG in the blood

HCG injection into the abdominal area

In general cases, the following doses of the drug are used:

• in case of disturbance of the ovulatory process, 5000-10000 IU is prescribed once
• if there is a risk of miscarriage, as well as the threat of miscarriage - no later than the 8th week of gestation for the first time 10,000 IU, then 2 times a week until the 14th week inclusive - 5,000 IU
• In the process of artificial insemination, after stimulating the development of follicles, 10,000 IU is prescribed once

The hCG injection has a number of contraindications that you need to pay attention to:

• low-quality tumor formation of the ovaries
• early onset of menopause
• lactation period
• thrombophlebitis or predisposition to this disease
• established obstruction of the fallopian tubes
• chronic inflammatory diseases of the adrenal glands
• individual sensitivity to components (allergy)

If the order of procedures is violated or the drug is overdosed, side effects may occur in the form of acne, polycystic disease, ascites, thromboembolism due to ovarian hyperstimulation.

Consultation with a doctor to diagnose the condition of a woman’s body

HCG injection: what is it done for and when?

HCG injections are used as a medication for the prevention and treatment of female infertility, as well as preserving the fetus during pregnancy. Injections are given:

• to stimulate the egg and reduce the risk of cyst formation, which occurs when the follicle does not rupture, but shrinks in size
• to preserve the vital activity of the corpus luteum in early pregnancy
• to maintain the functions of the formation and development of the placenta
• at risk of miscarriage - especially if such pathologies have already occurred more than once
• in case of artificial insemination for the “superovulation” effect

HCG injection for ovulation

Most often, an hCG injection is used in the absence of ovulation, i.e. dysfunction of the maturation of an egg capable of fertilization. This condition may be due to various reasons:

• polycystic ovary syndrome
• tumor formations
• increased physical activity and fatigue
• stressful conditions
• taking certain medications

When diagnosing ovulatory dysfunction, a woman needs to be tested for hormone levels, regularly record basal temperature, and undergo an ultrasound examination of the pelvic organs.

• Such examinations should determine the need to stimulate ovulation by injection of hCG. In some cases, normalizing the levels of thyroid hormones, testosterone and prolactin can naturally restore the ovulation cycle
• To confirm the absence of ovulation, constant ultrasound monitoring of the development and growth of follicles is prescribed. The first study is carried out 8-10 days after the onset of the last menstruation, then repeated with an interval of 2-3 days until the start of the next one.

Carrying out hormone tests before hormone therapy

During the research process it can be established:

• Complete absence of ovulatory function due to improper functioning of the ovaries - follicles do not mature
• The main follicle matures, but does not develop to the required size
• The follicle develops normally, but the follicular sac does not open and the egg does not release

If during observations it is revealed that the follicle does not burst, an hCG injection may be prescribed to resume ovulation. 24-36 hours after the injection, an additional ultrasound is prescribed to confirm successful stimulation.

Continuous ultrasound monitoring to monitor changes during stimulation with hCG injections

How long after hCG injection does ovulation occur?

• If a problem is identified, infertility treatment should be carried out under constant supervision. The first injection is prescribed on the 2nd day of the cycle for 10 days
• The entire process of follicle maturation and growth is monitored using ultrasound. When the follicle size is 20-25 mm, their opening is stimulated; for this purpose, an injection of hCG is administered in the required dosage
• An increase in hormone levels occurs during the first day after the injection. Therefore, positive tests for ovulation during the first 3 days cannot reliably indicate its occurrence
• Typically, after an HCG injection, ovulation occurs within 24 to 36 hours. In some cases, ovulation may not occur or may occur much later. The onset of ovulation can be determined using ultrasound
• After confirmation of ovulation, injections of the hormones utrogestan and progesterone are usually prescribed to support ovarian function.

How long after the hCG injection should I take the test?

• It is recommended to carry out an ovulation test 3 days after the procedure. The increase in hormone levels after ovulation occurs gradually and doubles every 3 days
• An active increase is observed in the first trimester of gestation, since the woman’s body, under the influence of the administered drug, begins to actively produce hormones that promote conception - estrogen and progesterone
• Recommendations on the number and desired time of sexual intercourse during the period of stimulation are made by the attending physician, taking into account the examination and the results of the man’s spermogram. After the main injection, you can start trying the very next day with the necessary break before and some time after the formation of the corpus luteum - the actual onset of ovulation

It is recommended to carry out the test after the hCG injection no earlier than 72 hours later.

HCG injections during pregnancy

Hormonal injections are prescribed to pregnant women if a sharp drop in the level of human chorionic gonadotropin in the blood is diagnosed. Before prescribing hormone therapy, an additional examination of the hormone level is carried out.

If the deviation from the norm is significant and is up to 20% on the downside, hCG injections are prescribed without fail.

A decrease in hormone levels may signal the development of the following pregnancy pathologies:

• suspected ectopic pregnancy
• frozen pregnancy
• dysfunction of the placenta
• threat of interruption

Prescribing hCG injections to pregnant women to maintain the functions of the placenta and preserve the fetus

The presence of high levels of the hCG hormone in the absence of pregnancy may be an indicator of the development of a cancerous tumor. It has not yet been established whether the production of the hormone is a consequence or a cause of cancer, but since 2011, unlicensed homeopathic and food products containing hCG, which were advertised as auxiliary drugs for the treatment of infertility, have been prohibited for sale.

Video: Ovulation stimulation