Indications for use acc. ACC: instructions for use, contraindications, indications, side effects, dosage for children syrup, granules, effervescent tablets ACC sandoz powder instructions for use

Description of the dosage form

Effervescent tablets, 100 mg: round flat-cylindrical white, with a smell of blackberry. There may be a slight sulfur odor. Reconstituted Solution: colorless transparent with blackberry smell. There may be a slight sulfur odor.

Granules for oral solution preparation (orange): homogeneous, white, without agglomerates, with an orange smell.

Syrup: clear, colorless, slightly viscous solution with a cherry smell.

pharmachologic effect

Pharmacodynamics

Acetylcysteine ​​is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates sputum discharge due to a direct effect on the rheological properties of sputum. The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause depolymerization of sputum mucoproteins, which leads to a decrease in its viscosity. The drug remains active in the presence of purulent sputum.

It has an antioxidant effect based on the ability of its reactive sulfhydryl groups (SH-groups) to bind to oxidizing radicals and thus neutralize them.

In addition, acetylcysteine ​​promotes the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine ​​increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction.

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.

Pharmacokinetics

Absorption is high. It is rapidly metabolized in the liver with the formation of a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides. Bioavailability when taken orally is 10% (due to the presence of a pronounced effect of the first passage through the liver). Tmax in plasma is 1-3 hours. Communication with plasma proteins is 50%. It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine). T 1 / 2 is about 1 hour, liver dysfunction leads to an extension of T 1 / 2 to 8 hours. Penetrates through the placental barrier. There are no data on the ability of acetylcysteine ​​to penetrate the BBB and be excreted in breast milk.

Indications for ACC ®

For all dosage forms

diseases of the respiratory system, accompanied by the formation of viscous sputum difficult to separate:

Acute and chronic bronchitis;

Obstructive bronchitis;

Tracheitis;

laryngotracheitis;

Pneumonia;

lung abscess;

bronchiectasis;

Bronchial asthma;

Chronic obstructive pulmonary disease;

bronchiolitis;

cystic fibrosis;

acute and chronic sinusitis;

inflammation of the middle ear (otitis media).

Contraindications

For all dosage forms

hypersensitivity to acetylcysteine ​​or other components of the drug;

peptic ulcer stomach and duodenum in the acute stage;

hemoptysis, pulmonary bleeding;

pregnancy;

period breastfeeding;

children's age up to 2 years.

For effervescent tablets, 100 mg, optional

lactase deficiency, lactose intolerance, glucose-galactose malabsorption.

Carefully: peptic ulcer of the stomach and duodenum in history; bronchial asthma; obstructive bronchitis; hepatic and / or renal failure; histamine intolerance (long-term use of the drug should be avoided, because acetylcysteine ​​affects the metabolism of histamine and can lead to signs of intolerance, such as headache, vasomotor rhinitis, itching); varicose veins of the esophagus; diseases of the adrenal glands; arterial hypertension.

For mortar pellets optional

sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose deficiency.

Carefully: peptic ulcer of the stomach and duodenum in history; arterial hypertension; varicose veins of the esophagus; bronchial asthma; obstructive bronchitis; diseases of the adrenal glands; hepatic and / or renal failure; histamine intolerance (long-term use of the drug should be avoided, because acetylcysteine ​​affects the metabolism of histamine and can lead to signs of intolerance, such as headache, vasomotor rhinitis, itching).

extra for syrup

Carefully: peptic ulcer of the stomach and duodenum in history; bronchial asthma; hepatic and / or renal failure; histamine intolerance (long-term use of the drug should be avoided, since acetylcysteine ​​affects the metabolism of histamine and can lead to signs of intolerance, such as headache, vasomotor rhinitis, itching); varicose veins of the esophagus; diseases of the adrenal glands; arterial hypertension.

Use during pregnancy and lactation

Data on the use of acetylcysteine ​​during pregnancy and breastfeeding are limited. The use of the drug during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.

If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.

Side effects

According to WHO, adverse reactions are classified according to their frequency of development as follows: very often (≥1 / 10); often (≥1/100,<1/10); нечасто (≥1/1000, <1/100); редко (≥1/10000, <1/1000); очень редко (<1/10000); частота неизвестна — по имеющимся данным установить частоту возникновения не представлялось возможным.

Allergic reactions: infrequently - pruritus, rash, exanthema, urticaria, angioedema, decreased blood pressure, tachycardia; very rarely - anaphylactic reactions up to shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).

From the respiratory system: rarely - shortness of breath, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).

From the gastrointestinal tract: infrequently - stomatitis, abdominal pain, nausea, vomiting, diarrhea; heartburn, dyspepsia (except syrup).

From the sense organs: infrequently - tinnitus.

Others: very rarely - headache, fever, isolated reports of the development of bleeding due to the presence of a hypersensitivity reaction, a decrease in platelet aggregation.

Interaction

For all dosage forms

With the simultaneous use of acetylcysteine ​​and antitussives, due to the suppression of the cough reflex, sputum stagnation may occur. Therefore, such combinations should be chosen with caution.

Simultaneous administration of acetylcysteine ​​with vasodilators and nitroglycerin may lead to increased vasodilating action.

With simultaneous use with antibiotics for oral administration (including penicillins, tetracyclines, cephalosporins), their interaction with the thiol group of acetylcysteine ​​is possible, which can lead to a decrease in their antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine ​​should be at least 2 hours (except for cefixime and loracarbene).

In contact with metals, rubber, sulfides are formed with a characteristic odor.

Dosage and administration

inside, after meal.

Mucolytic therapy

Adults and children over 14 years of age: 2 tab. effervescent 100 mg 2-3 times a day or 2 packs. ACC ® granules for the preparation of a solution of 100 mg 2-3 times a day, or 10 ml of syrup 2-3 times a day (400-600 mg of acetylcysteine ​​per day).

Children from 6 to 14 years old: 1 tab. effervescent 100 mg 3 times a day or 2 tablets. effervescent 2 times a day, or 1 pack. ACC ® granules for solution 3 times a day or 2 packs. 2 times a day, or 5 ml of syrup 3-4 times a day or 10 ml of syrup 2 times a day (300-400 mg of acetylcysteine ​​per day).

Children from 2 to 6 years old: 1 tab. effervescent 100 mg or 1 pack. ACC ® granules for the preparation of a solution of 100 mg 2-3 times a day, or 5 ml of syrup 2-3 times a day (200-300 mg of acetylcysteine ​​per day).

cystic fibrosis

For patients with cystic fibrosis (a congenital metabolic disorder with frequent infections of the bronchial tract) and weighing more than 30 kg, if necessary, it is possible to increase the dose to 800 mg of acetylcysteine ​​per day.

Children over 6 years old: 2 tab. effervescent 100 mg or 2 pak. ACC ® granules 100 mg for solution 3 times a day, or 10 ml syrup 3 times a day (600 mg acetylcysteine ​​per day).

Children from 2 to 6 years old: 1 tab. effervescent 100 mg or 1 pack. ACC ® granules 100 mg for solution, or 5 ml syrup 4 times a day (400 mg acetylcysteine ​​per day).

Effervescent tablets should be dissolved in 1 glass of water and taken immediately after dissolution, in exceptional cases, you can leave the solution ready for use for 2 hours.

Granules for oral solution (orange) should be dissolved in water, juice or iced tea and taken after meals.

Additional fluid intake enhances the mucolytic effect of the drug. With short-term colds, the duration of administration is 5-7 days.

In chronic bronchitis and cystic fibrosis, the drug should be taken for a longer time to achieve a preventive effect against infections.

ACC ® syrup is taken with a measuring syringe or a measuring cup, which is in the package. 10 ml of syrup corresponds to 1/2 measuring cup or 2 filled syringes.

Using a measuring syringe

1. Open the vial cap by pushing it in and turning it counterclockwise.

2. Remove the plug with a hole from the syringe, insert it into the neck of the vial and press it in until it stops. The stopper is designed to connect the syringe to the vial and remains in the neck of the vial.

3. Insert the syringe firmly into the stopper. Carefully turn the bottle upside down, pull the syringe plunger down and draw up the required amount of syrup. If air bubbles are visible in the syrup, press the plunger all the way down, then refill the syringe. Return the vial to its original position and remove the syringe.

4. The syrup from the syringe should be poured onto a spoon or directly into the child's mouth (into the buccal area, slowly, so that the child can swallow the syrup properly), while taking the syrup, the child should be in an upright position.

5. After use, rinse the syringe with clean water.

Note for diabetic patients: 1 effervescent tablet corresponds to 0.006 XE; 1 pack ACC ® granules for the preparation of a solution of 100 mg corresponds to 0.24 XE; 10 ml (2 measuring spoons) of ready-to-use syrup contain 3.7 g of D-glucitol (sorbitol), which corresponds to 0.31 XE.

Overdose

Symptoms: acetylcysteine ​​at doses up to 500 mg/kg did not cause any symptoms of intoxication. With an erroneous or deliberate overdose, such phenomena as diarrhea, vomiting, stomach pain, heartburn and nausea can be observed. Children may experience hypersecretion of sputum.

Treatment: symptomatic.

special instructions

When working with the drug, it is necessary to use glassware, avoid contact with metals, rubber, oxygen, easily oxidized substances.

When using acetylcysteine, cases of severe allergic reactions such as Stevens-Johnson syndrome and Lyell's syndrome have been reported very rarely. If there are changes in the skin and mucous membranes, you should immediately consult a doctor, the drug should be stopped.

In patients with bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be administered with caution under the systemic control of bronchial patency.

Do not take the drug immediately before bedtime (it is recommended to take the drug before 18:00).

Influence on the ability to drive vehicles and work with mechanisms. There are no data on the negative effect of the drug in recommended doses on the ability to drive vehicles, mechanisms.

Special precautions for the disposal of unused medicinal product. There is no need for special precautions when destroying unused product.

extra for syrup

The use of the drug in patients with renal and / or hepatic insufficiency should be avoided in order to avoid additional formation of nitrogenous compounds.

1 ml of syrup contains 41.02 mg of sodium. This should be taken into account when using the drug in patients on a diet aimed at limiting sodium intake (with a reduced sodium / salt content).

Release form

Effervescent tablets, 100 mg.

When packing Hermes Pharma Ges.m.b.Kh., Austria: 20 tab. effervescent in a plastic or aluminum tube. 1 tube of 20 tab. effervescent in a cardboard box.

Granules for oral solution (orange), 100 mg. 3 g granules in bags of combined material (aluminum foil/paper/PE). 20 pack in a cardboard box.

Syrup, 20 mg/ml. In dark glass bottles, sealed with white caps with a sealing membrane, child-resistant, with a protective ring, 100 ml.

Dosing devices:

Transparent measuring cup (cap), graduated at 2.5; 5 and 10 ml;

Transparent dosing syringe, graduated at 2.5 and 5 ml, with white plunger and adapter ring for attaching to the vial.

1 vial together with dosing devices in a cardboard box.

Manufacturer

Effervescent tablets

1. Hermes Pharma Ges.m.b.H., Austria.

2. Hermes Artsnaimittel GmbH, Germany.

Granules for solution preparation

Marketing authorization holder: Sandoz d.d., Verovshkova 57, 1000 Ljubljana, Slovenia.

Produced by: Lindopharm GmbH, Neustraße 82, 40721 Hilden, Germany.

Syrup

Pharma Wernigerode GmbH, Germany.

Marketing authorization holder: Sandoz d.d. Verovshkova 57, Ljubljana, Slovenia.

The composition of the tool ACC in tablets includes an active ingredient acetylcysteine , and also the medicine contains additional components: anhydrous citric acid, anhydrous sodium carbonate, sodium bicarbonate, mannitol, anhydrous lactose, sodium citrate, sodium saccharinate, flavoring.

ACC powder contains an active ingredient acetylcysteine , as well as additional components: sucrose, ascorbic acid, sodium saccharinate, flavoring.

Release form

The drug is produced ACC 100(ACC for children) and ACC 200(for adult patients).

The medicine is available in the form of effervescent tablets, as well as in the form of granules, which are used to apply the solution. Tablets are white, on one side of the risk, have a blackberry flavor. There may be a slight smell of sulfur. Tablets are used to prepare a solution - transparent, with the aroma of blackberries.

The granules are white, homogeneous, have the aroma of honey and lemon or orange. The granulate is contained in foil bags, in a carton pack of 20 bags.

pharmachologic effect

Wikipedia indicates that the substance acetylcysteine is an amino acid derivative . It produces a mucolytic effect, under its influence the process of sputum discharge is facilitated, since the substance directly affects the rheological properties of sputum. Its influence is associated with the ability to break the disulfide bonds of mucopolysaccharide chains, as a result of which depolymerization of sputum mucoproteins is noted. As a result, the viscosity of sputum decreases.

The drug is also active if the patient has purulent sputum.

The annotation also contains information about what ACC provides antioxidant action associated with the ability of reactive sulfhydryl groups to neutralize oxidative radicals by binding to them. In view of this, the protection of cells from oxidation, which often occurs during inflammatory reactions, increases.

Acetylcysteine ​​also activates , which is an important part of the antioxidant system and chemical detoxification of the body.

If ACC is used for prevention, the severity and frequency of exacerbations in people suffering from cystic fibrosis and chronic .

Pharmacokinetics and pharmacodynamics

There is a high level of absorption of the drug. occurs in the liver, with the formation of an active metabolite - cysteine , Also , diacetylcysteine , mixed disulfides.

When taken orally, the level of bioavailability is 10% (since a pronounced effect of the first passage through the liver is noted). The maximum concentration in plasma is observed after 1-3 hours. It binds to proteins by 50%.

It is excreted in the urine as inactive metabolites. The half-life is 1 hour, if the patient has impaired liver function, then it can be extended up to 8 hours.

It penetrates through the placenta, there is no data on penetration through the BBB.

Indications for use

The following indications for the use of this drug are noted:

• respiratory diseases, in which viscous sputum is formed, which is difficult to separate;
• bronchitis acute and chronic;
• tracheitis , ;
• bronchiectasis;
• cystic fibrosis;
• lung abscess;
• chronic obstructive pulmonary disease;
• acute and chronic;

Contraindications

There are such contraindications for all forms of the drug:

• high sensitivity to any of the components of the drug;
• period of exacerbation ;
• pulmonary bleeding;
• hemoptysis;
• and period.

Carefully prescribe the drug to patients with a history of gastric or duodenal ulcers, with intolerance histamine (cannot be used for a long time), with varicose veins of the esophagus, obstructive bronchitis, diseases of the adrenal glands, arterial hypertension, hepatic and / or.

Additional contraindications for effervescent tablets 200 mg:

• lack of lactase, lactose intolerance;
• malabsorption glucose-galactose;
• the patient's age is up to 2 years;

Additional contraindications for granules:

• fructose intolerance;
• lack of sucrase / isomaltase;
• glucose-galactose deficiency;
• the patient's age is up to 6 years.

Side effects

During treatment, the following side effects may occur:

• allergic manifestations: rash, , exanthema, skin, lowering , , ; in rare cases - anaphylactic reactions, toxic epidermal necrolysis, Stevens-Johnson syndrome;
• digestive system: stomach ache, vomit , nausea , dyspepsia;
• respiratory system: bronchospasm, (mainly manifested in people with bronchial asthma);
• sense organs: sensation of tinnitus;
• other manifestations: , bleeding (isolated cases).

Instructions for use ACC (Method and dosage)

The drug in effervescent tablets or granules in sachets must be taken orally and at the same time adhere to the dosage indicated in the instructions. You need to drink after eating.

ACC powder, instructions for use

The instruction for ACC powder 100 mg provides that the agent must be dissolved in half a glass of water, and then immediately drunk. Children from two to six years old receive 200-300 mg of the drug per day in 2-3 doses. ACC for children, patients aged 6 to 14 years receive 300-400 mg per day in 2-3 doses. Patients after 14 years of age receive 400-600 mg of the drug per day in 2-3 doses. People who have cystic fibrosis and weigh more than 30 kg can receive up to 800 mg of medication per day. In this case, all contraindications must be taken into account.

If we are talking about an acute illness without complications, then the patient can receive the drug without medical supervision for no longer than five days. In chronic diseases, the duration of therapy should be determined by the doctor.

Instructions for use ACC for children

200 mg tablets or powder for children are rarely used. This drug is prescribed for children from 6 years of age. ACC powder 100 mg for children is used from 2 years old, the dosage should be prescribed by a doctor.

Effervescent tablets are dissolved in 1 tbsp. water, you can also use tea or juice for this purpose.

Before taking 200 mg powder, it should be taken into account that additional heavy drinking can enhance the mucolytic effect of the drug. The method of application of powder 200 mg depends on the recommendations of the doctor.

ACC for coughing with a cold can be taken for 5-7 days. If the cough medicine does not help during this period, you need to consult a doctor who will give recommendations on how to take ACC in sachets.

It is important to consider how to drink 200 mg powder for cystic fibrosis and chronic bronchitis: in this case, the treatment is longer.

Overdose

If acetylcysteine ​​was taken by a patient in a dose that exceeds 500 mg per day, he may show signs of an overdose, which is why the prescribed treatment regimen should be strictly adhered to. In this case, the patient may develop vomiting, diarrhea, , stomach ache. In case of overdose, symptomatic therapy is carried out.

Interaction

In the case of simultaneous administration of acetylcysteine ​​​​and cough suppressants with a dry cough, the cough reflex can be suppressed and, as a result, sputum stagnation is noted.

In case of simultaneous treatment (tetracyclines, penicillins, cephalosporins), their interaction with the thiol group of acetylcysteine ​​may be noted. As a result, the antibacterial activity of such drugs is reduced. It is important to avoid such an effect, for which you need to adhere to an interval of at least 2 hours between taking antibiotics and acetylcysteine.

When used concomitantly with vasodilator drugs and the vasodilating effect of the latter may be enhanced.

Terms of sale

The drug is sold in pharmacies by prescription.

Storage conditions

It is necessary to store granules and tablets at t not higher than 25 ° C, keep away from children.

Best before date

The storage period is 3 years.

special instructions

When using acetylcysteine, cases of the development of severe allergic manifestations were very rarely recorded. If, after using the medicine, the patient develops changes in the skin or mucous membranes, you should immediately consult a doctor. The medication is then stopped.

Before starting treatment, you should know how to prepare a solution, in what water to dissolve granules and tablets. How to dilute 200 mg ACC depends on the prescribed treatment regimen. As a rule, the granules are dissolved by gradually stirring them in one tbsp. hot water. The solution should also be drunk hot. It is recommended to dilute the medicine in glassware.

Consideration should be given not only to which cough to take the medicine, but also to be careful when taking the medicine for patients with obstructive bronchitis And bronchial asthma . It is important to constantly monitor bronchial patency.

Sick with it must be taken into account that the composition of the drug contains sucrose.

During treatment with the drug, the patient may drive vehicles or work with dangerous machinery.

ACC analogues

Analogues of this drug are means Acestine , Acetylcysteine ​​solution for inhalation , Acetylcysteine , , ACC Inject etc. The price of drugs depends on the manufacturer, packaging. A specialist will help you choose the most optimal remedy.

ACC for children

As a rule, children are prescribed ACC powder 100 mg. It can be used from 2 years. In this case, the instructions for the ACC for children must be strictly observed. The dosage of ACC for children is determined by the attending physician, depending on the disease. The drug ACC 200 in granules and effervescent tablets is prescribed for children from 5 years of age.

ACC during pregnancy and lactation

There is currently only limited information on the use of ACC in pregnancy, so it is not prescribed at this time. During lactation, treatment is also not carried out, if there is such a need, lactation is stopped.

Reviews about ACC

Many users speak positively about children's and adult ACC, noting that it helps cough very effectively. Parents write that the children's drug alleviates the child's condition after several doses. Many reviews of ACC for children indicate that the drug facilitates sputum discharge, reduces the severity of cough, and improves the general condition. At the same time, side effects develop very rarely.

ACC price, where to buy

You can buy the drug at any pharmacy, its cost depends on the form and packaging. The price of ACC in powder 100 mg is from 130 rubles for 20 sachets. The price of a powder of 200 mg is from 180 rubles. for 20 pcs. The average price of ACC syrup (granules for cooking) is from 140 rubles. How much syrup for children costs depends on the place where the drug is sold. Effervescent tablets can be purchased at a price of 250 rubles. for 20 pcs.

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ZdravCity

Azz pore. d/prep. r-ra d / vn. intake 200mg №20 (orange) Lindopharm GmbH

Azz pore. d/prep. r-ra d / vn. approx. 600mg (sachet) 3g #6Lindopharm GmbH/Salutas Pharma GmbH

Azz pore. d/prep. r-ra d / vnutr. intake (orange) 100mg №20 Lindopharm GmbH

ACC syrup 20mg/ml 100ml n1Pharma Wernigerode GmbH/Salutas Pharma GmbH

Acc long tab. thorn. 600mg n10Hermes Artsnaimittel GmbH/Salutas Pharma, GmbH

Pharmacy Dialog

ACC long (tab.ship.600mg №20)

ACC syrup 20mg/ml 200ml

ACC 200 200mg №20 Orange

ACC long (tab.ship.600mg №20)

ACC 100 (pack. granules No. 20 (orange))

Europharm * 4% discount with promo code medical11

ACC effervescent tablets 100 mg n20Hermes Pharma Ges. M.b.H./Salyutas

ACC syrup 20 mg/ml 100 mlPharma Wernigerode GmbH/Salutas F

To get rid of single and chronic cases of diseases of the bronchopulmonary system, accompanied by the release of difficult-to-separate sputum, drugs are used.

One of the most effective and widely used is, produced in the following forms for ingestion:

The composition of the drug contains sucrose, which is important to know for people with diabetes.

Mechanism of action

ACC powder is prescribed for a wet cough. The main causes of this type of cough is accumulated in the lungs and bronchi.

Due to the coughing mechanism, the body tries to get rid of mucus, which is often very thick. Liquefaction of sputum contributes to its rapid discharge and getting rid of cough.

Medicinal action occurs due to the main component of acetylcysteine. Acetylcysteine ​​molecules break down bonds between mucopolysaccharide chains, making mucus less viscous and easier to expectorate. Instructions for use of ACC powder emphasizes the fact that the drug has a positive effect in cases where purulent inclusions are present in the separated mucus.

ACC powder is beneficial for patients suffering from chronic diseases of the lungs and bronchi. Acetylcysteine ​​activates the synthesis of substances that are components of the body's antioxidant system, which protect cells from damage during inflammatory processes. Due to this property, ACC is recommended to be taken for preventive purposes.

Absorption of the active substance occurs instantly. For a period of one to three hours, the maximum indicators of the presence of ACC components in the blood vessels are reached. Instructions for use of the powder states that inactive metabolites are excreted by the kidneys.

It is worth noting: the substances of the drug cross the placenta, which is especially important for pregnant women to know.

Method of use for cough

The drug is recommended for use in all cases of diseases associated with the appearance of viscous sputum in the lungs and bronchi. These diseases include the following:

• any degree of severity;
• congenital diseases associated with dysfunction of the respiratory system (cystic fibrosis);
• inflammatory processes in the sinuses.

In any form of these diseases, a positive effect is observed from the drug ACC (powder). How to take the medicine in each case, the doctor prescribes, indicates the size of the doses and the frequency of administration.

In any case, the instruction for the use of ACC granules states that it is necessary to dissolve the contents in a glass of hot water and drink. Depending on the disease and age of the patient, the number of doses per day and the duration of the use of the medicine are set. Usually, one sachet of medicine is consumed at one time.

It is important that abundant fluid intake during treatment improves the effect of the drug and speeds up recovery.

Instructions for use

For any course of the disease of the bronchopulmonary system, ACC powder is used. How to take the drug, explains the instructions attached to the drug. The choice of dose is based on the body weight and age of the patient, the severity of the disease, the presence of other physiological disorders in the body.

The doctor will always prescribe the exact dose of ACC to the patient. Instructions for use in sachets have special instructions and may differ from other forms of release.

How to breed?

The paramount question of the person taking the medicine is how to breed ACC? The powder must be used strictly according to the instructions, improper use of the substance can lead to unexpected consequences.

In this case, you should not be afraid of any unforeseen situations, but you need to follow some recommendations.

The contents of the sachet must be dissolved in liquid before taking and immediately drunk. Thus, the best effect of the ACC preparation will be achieved. The powder, the composition of which contains ascorbic acid, has a pleasant taste.

In some cases, the medicine can be taken 2 hours after dilution of the powder in water.

Do not take the liquid in which the drug was diluted after two hours.

It is important to take the right amount of water to dissolve the powder. The recommended dose is a whole glass, that is, approximately 200 ml. This volume is suitable for both children and adults. As is traditionally noted in the instructions for use for mucolytics, additional liquid will only have a positive effect on the body, it will thin the sputum faster and accelerate the release of mucus.

What water to dissolve?

Competently following the instructions helps with ACC powder. In what water to dissolve - hot or cold - one of the important points in the treatment process.

Adults and children are prescribed ACC powder. Instructions for use says that it is best to dilute it in hot water. Children cannot always drink a drink, so in such cases it is acceptable to use warm water.

In what water to dissolve the ACC powder also depends on the conditions of admission. If you are on the road, and there is no hot water at hand, then you should not skip taking the drug - you can dissolve it in a liquid at room temperature.

How to use?

A convenient form of release is ACC in sachets. How to take the medicine indicates its instructions. Drink a diluted drink should be immediately after a meal.

The duration of admission in standard cases of colds is from five to seven days. If the patient suffers from chronic forms of bronchopulmonary diseases, then ACC sachets are prescribed for a longer period.

Although not indicated in the instructions for use, the effectiveness of acetylcysteine ​​decreases with prolonged treatment. For this reason, long-term monotherapy with ACC powder is not used.

How many times a day to drink?

The result of treatment and recovery time depend on how often the patient takes ACC. The powder, the method of application of which is determined by the age and body weight of the patient, contributes to the rapid disposal of sputum.

Typically, the following age groups of patients are distinguished:

• children from two years to six;
• children aged six to fourteen;
• children over 14 and adults.

The answer to the question also depends on the type and complexity of the disease - how many times a day to drink ACC? Powder in packages can have a different dosage - 100, 200 and 600 mg. This also depends on how often you take it.

1. The first age group of children (from 2 to 6 years old) is prescribed 1 sachet of ACC in granules at a dosage of 100 mg 2 or 3 times a day. This corresponds to a daily dose of 200–300 mg of acetylcysteine.
2. Children from six to fourteen years old, in accordance with the instructions for use, should take 300–400 mg of the active substance per day. To do this, drink three times a day, 1 sachet of medication with a dosage of 100 mg or twice a day, a sachet of 200 mg.
3. Adults and children over 14 years of age are recommended to consume 400 to 600 mg of acetylcysteine ​​per day for cure. The number of doses of the drug depends on the chosen dosage - 100 mg, 200 mg or 600 mg.

If you have a bag of ACC with a dosage of 600 mg, then it is enough to take the medicine once a day. A dosage of 200 mg is taken 2 or 3 times. Packets labeled 100 mg are taken two at a time, twice or thrice a day.

Important information for patients

Here is some important information that people who take ACC need to know. In what water to dissolve (hot or cold) - described above. But it is also worth considering the type of drinking utensils. Do not use metal or rubber, only glass or ceramic mugs, glasses.

1. If the patient suffers from irritation of the gastric mucosa, then it is better to take not effervescent tablets, but granular ACC. Powder, how to drink and dilute is described above.
2. Be sure to read the accompanying papers of the ACC preparation. Instructions for use of the powder has prescribed contraindications. For example, the drug should not be used by people with allergic reactions to acetylcysteine.
3. People with stomach and duodenal ulcers should not be used to treat ACC.
4. Instructions for use of granules do not recommend taking the substance to women during pregnancy and lactation.
5. You can not combine taking the drug and antitussives.

Acetylcysteine ​​is incompatible with antibiotics of the tetracycline and penicillin series, reduces their absorption. Therefore, if patients are prescribed taking antibacterial drugs, then it is worth distinguishing between taking ACC powder and an antibiotic with a break of at least two hours.

People suffering from chronic diseases of the bronchopulmonary system, pulmonary or heart failure, may be prescribed ACC. The powder, the use of which in prescribed doses, guarantees easier breathing, as well as a reduction in the risk of infectious inflammation in the bronchi and lungs.

What reviews does the drug receive?

Patients with various diseases of the bronchopulmonary system are increasingly being prescribed ACC by doctors. Reviews powder in most cases receives only positive.

The timely start of taking the powder guarantees the speedy disposal of the disease.

A large number of patients note the fact that almost from the first day of admission, a positive effect is observed. The drug is well tolerated. Consumers also write that the substance has the following advantages:

• liquefaction of sputum in 3-4 days, even with a severe course of the disease;
• the ability to accept children and adults;
• pleasant taste sensations, which is important for children.

Patients testify that the drug allows you to get rid of an annoying cough in a matter of days, the cause of which is viscous sputum. Especially in demand is the granular form, which allows you to prepare a healing drink in a matter of moments.

Granules are convenient to use on the road, at work, on a business trip. At one time, only one sachet of ACC is needed. Sachets, instructions for use are in a cardboard box, which is convenient to take with you.

There are various forms of ACC release. Instructions for use of the powder describe the dosage of 100 mg, 200 mg and 600 mg. But the greatest demand for adults is in sachets labeled 200 mg ACC. It is convenient to take a cough powder in this dose at a time three times a day, since usually 600 mg of acetylcysteine ​​per day are prescribed for adult patients.

ACC powder in granules 100 mg for children is ideal for children, corresponds to a single dose. The main thing is to strictly follow the doctor's recommendations - how many times a day to drink ACC. The powder dissolves quickly and is very pleasant to the taste, which is important for babies.

Useful video

Useful information about the treatment of bronchitis, see this video:

Conclusion

1. ACC powder helps to quickly get rid of cough and other diseases of the bronchi and lungs.
2. Proper use will allow you to get rid of sputum in the lungs in a short time, dilute it and remove it from the body.
3. To properly take the drug, you need to understand how to dissolve ACC. This is indicated in the instructions for use: just pour the contents of the package into hot water, stir and drink immediately.
4. Usually, one package is enough for a single dose, the main thing is to choose the right dosage - 100, 200 or 600 mg.
5. In most cases, a positive effect is observed after a few days of use.

In contact with

Latin name: ACC
ATX code: R05C B01
Active substance: acetylcysteine
Manufacturer: Sandoz (Slovenia),
Hexal, Salutas Fahlberg-List Ph. (Germany),
Pharmacy leave condition: Over the counter

ACC is a series of drugs for dry cough based on acetylcysteine. They are used in various forms to liquefy and remove bronchial secretions.

Indications for use

The action of all drugs is aimed at diluting mucus, facilitating passage through the respiratory tract and withdrawal from them. ACC is prescribed for dry cough that occurs with many diseases of the respiratory system:

• Bronchitis
• pneumonia
• Laryngotracheitis
• Bronchial asthma
• sinusitis
• cystic fibrosis
• Inflammation of the middle ear, etc.

Medicinal properties

Mucolytics are among the most popular cough suppressants. This efficiency is explained by the properties of the main component of the drugs - acetylcysteine. The substance is a derivative of the amino acid cysteine.

After entering the body, it is absorbed almost instantly, the highest concentration in the blood is formed after 1-3 hours. The substance destroys the process of formation of viscous mucus. As a result, the sputum liquefies, becomes mobile and is easily expectorated. Mucolytics also effectively affect purulent bronchial secretions.

Features of the composition, form and reception

Effervescent tablets or powder are dissolved in 200 ml of water and drunk immediately (recommended after meals). The treatment solution should not be diluted in advance; in case of emergency, the interval between preparation and administration can be no more than two hours.

All forms of the ACC mucolytic contain acetylcysteine ​​as an active ingredient. The composition and concentration of excipients are different.

ACC 100

Price: 200 rubles

Produced in the form of effervescent tablets for dissolution. Pills are round, flat-cylindrical, white. Packed in 20 pieces in plastic tubes. In a pack of cardboard - one tube, insert-description.

One ACC 100 pill contains 100 mg of the active ingredient. Additional components: anhydrides of citric acid and lactose, mannitol, vitamin C, saccharin, nutritional supplement with blackberry flavor and smell.

• Children (2-5 years old): 1 pc. x 2-3 p. during the day.
• (6-14 years old) - 1 pc. x 3 p. (or 2 tons x 2 rubles).
• Teenagers (14+) and adults: 2 tons x 2-3 rubles.

In the treatment of cystic fibrosis, the daily dose of the drug is increased to 800 mg (for people whose weight exceeds 30 kg). Appointment of ACC 100 for children from 6 years of age: drink 2 tab. x 3 p. during the day.

ACC 200

Average price from 160 to 200 rubles

One pill contains 200 mg of the active substance, the auxiliary components are given in the same composition as in ACC 100.

In one sachet: acetylcysteine ​​- 200 mg, including sucrose, ascorbic acid, saccharin, flavorings.

• Powder for solutions (in a sachet of 3 g) - granular white mixture. The reconstituted drink has a honey-lemon flavor or orange. In a carton box - 20 sachets, annotation.
• Effervescent tablets are flat-cylindrical pills. Packaged in tubes of 20 pieces. The carton pack contains one tube, a manual.

If there is no medical prescription, ACC 200 is taken according to the instructions:

• (2-5 years) 1/2 tab. x 2 p. during the day.
• (6-12 years old) - 1/2 x tab. 3 p. (or 1 sachet x 2 p.).
• For adults and adolescents 14+: 1 tab. x 2-3 p. (1 sachet x 2-3 rubles).

Treatment of mucovidosis with ACC 200 pills is carried out similarly to mucolytic therapy with 100 mg of the active substance, that is, the daily rate increases to 800 mg. Accordingly, the number of effervescent tablets or sachets ACC 200 is calculated.

ACC Long

Average price: 400 rubles

Produced in tablets for dissolution. White pills have a flat-cylindrical shape, bevelled edges and a separating risk on the upper surface. They may have an unexpressed sulfuric odor. The solution is colorless, smells like blackberries. Pills are packaged in 10, 20 pieces in tubes with a lid.

One tablet contains 600 mg of the active substance. Additional ingredients: citric and ascorbic acids, sodium compounds, mannitol, Blackberry food supplement, lactose.

ACC Long, according to the instructions for use, can be used for therapy only after reaching the age of 14. If there is no medical prescription - drink one pill per day.

ACC powder

Produced in packaged form for the preparation of medicinal drinks. The content of the sachet is a fine granular white dry mixture. The solution is clear, smells like honey or lemon.

One sachet contains 100 (or 200) mg of the active substance. Additional components - sucrose, ascorbic acid, saccharin, food additives.

ACC cough powder, according to the instructions, must be diluted in water immediately before taking. As a last resort, delayed use should be carried out within two hours after preparation.

ACC Inject

Average price: 140 rubles

In 1 ml - 300 mg of the active substance, as well as disodium, ascorbic acid, water, etc. It is intended for intravenous and intramuscular injections. Packed in 5 ampoules in a pack with instructions for use. The dosage and duration of the course is determined by the doctor. For young children (up to 6 years old), therapy is carried out only for health reasons in a hospital setting.

ACC syrup for children

Average price: 300 rubles

It is produced in the form of a transparent viscous liquid with a cherry flavor. The solution is packaged in glass light-protective bottles of 100, 200 ml. In a pack of cardboard - a bottle, a measuring cap. Average cost: (100 ml) - 233 rubles, (200 ml) - 342 rubles.

1 ml contains 20 mg of the active substance and auxiliary components: sodium compounds, disodium edetate, sweetener, water, food additive "Cherry".

The dosage and how to take ACC children's syrup is determined by the pediatrician. This takes into account age, weight and characteristics of the course of the disease. If there is no appointment, then follow the instructions:

• From 2 to 5 years: 5 ml x 2-3 r.
• 6-14: 5 ml x 3 p. (or 10 ml x 2 p.)
• 14+: 10 ml x 2-3 p.

During pregnancy and HB

If necessary, therapy with mucolytics during lactation should be abandoned.

Contraindications

It is forbidden to drink ACC preparations for children and adults with:

• Hypersensitivity
• Exacerbations of peptic ulcer
• bloody sputum
• Children's age (up to 6 years: ACC 200, ACC 600 mg), (up to 14: ACC 600 mg).

Precautionary measures

It is undesirable to take ACC if there are disorders in the functioning of the kidneys, liver, adrenal glands, as well as varicose veins, bronchial asthma. In case of urgent need, therapy should be carried out under medical supervision.

Cross-drug interactions

When taking mucolytics, it should be borne in mind that the components may react with other drugs:

• Can not be combined with drugs that affect the cough region of the brain
• Antibiotics should be drunk 2-3 hours after taking ACC, since when taken together, the medicinal properties are mutually weakened.
• Combination with bronchodilators enhances the effect of drugs.
• Activated charcoal inhibits the action of ACC.
• A mucolytic cannot be combined with nitroglycerin, as this leads to an increase in the action of the latter.

Side effects

Mucolytics of ACC from cough are usually normally perceived by the body if the conditions of admission and contraindications have been met. The negative consequences are:

• Headaches
• Nausea with bouts of vomiting
• Disorders of the gastrointestinal tract
• Low blood pressure
• palpitations
• Bleeding in the lungs (very rare)
• skin allergies
• Bronchospasm.

In the case of the development of such signs, the mucolytic should be canceled and consult a physician.

Overdose

After the use of high doses, nausea, vomiting, diarrhea, and stomach pain develop. To neutralize the symptoms, drugs are canceled, symptomatic treatment is carried out. According to manufacturers, clinical observations have not recorded life-threatening conditions from overdose.

Terms and conditions of storage

Mucolytics are used for 3 years from the date of issue. To avoid deterioration, they should be kept in a place protected from light and heat at room temperature 15-25 °C.

Analogues

To replace the antitussive, you should consult your doctor.

Fluimucil

Zambon (Italy)

Price:

• amp. No. 5 - 216 rubles.
• gran. No. 20 (60) - 171 (189) rubles.
• table: No. 10 - 138 rubles, No. 30 - 402 rubles.

The cough medicine is included in the list of vital and essential drugs, contains acetylcysteine. Promotes rarefaction of bronchial mucus, activation of its output. Produced in powder and effervescent tablets, solution, syrup, injections.

Advantages:

• Efficiency
• Several dosage forms
• Acceptable price.

Flaws:

• Taste for an amateur
• It is difficult to open the tablet package.