Diabetes group. Antihyperglycemic agent Diabeton MV: instructions for use and interaction with other drugs

Diabeton MV is a unique drug of its kind. Its auxiliary components contain a special substance – hypromellose. It forms the basis of a hydrophilic matrix, which, when interacting with gastric juice, turns into a gel. Due to this, a smooth release of the main active substance, gliclazide, occurs throughout the day. Diabeton has high bioavailability and can be taken only once a day. There is no effect on fat metabolism, safe for the elderly and people with impaired kidney function.

Diabeton MV is produced in the form of tablets with a notch and the inscription “DIA” “60” on both sides. Active ingredient: gliclazide 60 mg. Auxiliary components: magnesium stearate - 1.6 mg, anhydrous colloidal silicon dioxide - 5.04 mg, maltodextrin - 22 mg, hypromelose 100 cP - 160 mg.

The letters “MV” in the name Diabeton stand for modified release, i.e. gradual.

Manufacturer: Les Laboratoires Servier, France

How does Diabeton MV work?

Diabeton belongs to the 2nd generation sulfonylurea preparations. It activates the pancreas and b-cells responsible for the production of insulin. Effective if the cells somehow function. The drug is prescribed after analysis for c-peptide, if the result is less than 0.26 mmol / l.

The release of insulin when taking gliclazide is as close as possible to physiological: the peak of secretion is restored in response to dextrose penetrating into the blood from carbohydrates, and the production of the hormone in phase 2 is enhanced.

Pharmacokinetics

After oral administration, Diabeton is completely absorbed. Increased concentration active substance in the blood continues for 6 hours and can be maintained at the achieved level for up to 12 hours.

The connection with plasma proteins reaches 95%, the volume of distribution is 30 l. To maintain a constant concentration in plasma for 24 hours, it is enough to take the medicine 1 tablet 1 time per day.

The substance is broken down in the liver. Excreted by the kidneys: metabolites are excreted,<1% выходит в первозданном виде. Диабетон МВ выводится из организма наполовину через 12−20 часов.

Indications for use

• Diabeton MV (60 mg) is prescribed by a doctor when specially designed diets and physical activity are ineffective.
• It is also used to prevent diabetic complications: reducing the risk of macrovascular (stroke, myocardial infarction) and microvascular (retinopathy, nephropathy) complications in patients with type 2 diabetes.

Contraindications

• Diabetes mellitus type I;
• intolerance to gliclazide, sulfonylurea and sulfonamide derivatives, lactose;
• galactosemia, glucose-galactose malabsorption;
• increased levels of glucose and ketone bodies in the blood;
• in severe forms of renal and liver failure, diabetes is contraindicated;
• childhood and adolescence
• pregnancy period;
• breast-feeding;
• states of diabetic precoma and coma.

Pregnancy and breastfeeding

No studies have been conducted on pregnant women, and there is no data on the effects of gliclazide on the unborn child. During experiments on experimental animals, no disruption of embryonic development was noted.

If pregnancy occurs while taking Diabeton MB, then it is discontinued and switched to insulin. The same goes for planning. This is necessary to reduce the chances of the baby developing congenital defects.

Use during breastfeeding

There is no relevant verified information about the release of Diabeton into milk and the possible risk of developing a hypoglycemic state in a newborn; consumption during lactation is prohibited. When for some reason there is no alternative, they switch to artificial feeding.

Instructions for use

Diabeton MV can only be taken by adults. The dose is taken once a day in the morning during meals. The daily dosage is determined by the doctor, its maximum can reach 120 mg. Take a tablet or half of it with a glass of clean water. Do not chew or crush.

If you miss 1 dose, do not take a double dose.

Initial dosage

At the beginning of treatment, it is equal to half a tablet, i.e. 30 mg. If necessary, the dose of Diabeton MV is gradually increased to 60, 90 or 120 mg.

A new dosage of the drug is prescribed no earlier than 1 month after the previous one was prescribed. The exception is people whose blood glucose concentration does not change after 2 weeks from the first dose. In such patients, the dosage is increased after 14 days. For patients over 65 years of age, no adjustment is required.

Taking after other antidiabetic drugs

The doses of previous medications and the duration of their elimination are taken into account. Initially, the dosage is 30 mg, it is adjusted in accordance with blood glucose levels.

If Diabeton MV has become a replacement for a drug with a long elimination period, the latter should be stopped within 2-3 days. The initial dose is also 30 mg. People with known kidney disease do not need dosage adjustment.

Risk group:

1. Hypoglycemic state due to poor nutrition.
2. Pituitary and adrenal insufficiency, long-term lack of thyroid hormones.
3. Discontinuation of corticosteroids after prolonged treatment.
4. Severe form of coronary artery disease, deposition of cholesterol plaques on the walls of the carotid arteries.

Side effects

When taking Diabeton in combination with disordered eating, hypoglycemia may occur.

Its signs:

• headaches, dizziness, impaired perception;
• constant feeling of hunger;
• nausea, vomiting;
• general weakness, hand tremors, convulsions;
• causeless irritability, nervous overexcitation;
• insomnia or severe drowsiness;
• loss of consciousness with possible coma.

The following reactions may also be detected and disappear after eating sweets:

• Excessive sweating, skin becomes clammy to the touch.
• Hypertension, rapid heartbeat, arrhythmia.
• Sharp pain in the chest due to lack of blood supply.

Other unwanted effects:

• dyspepsia (abdominal pain, nausea, vomiting, diarrhea or constipation);
• allergic reactions while taking Diabeton;
• decrease in the number of leukocytes, platelets, number of granulocytes, hemoglobin concentration (changes are reversible);
• an increase in the activity of liver enzymes (AST, ALT, alkaline phosphatase), isolated cases of hepatitis have been recorded;
• At the beginning of Diabetes therapy, a disorder of the visual system is possible.

Overdose

In case of an overdose of Diabeton, a hypoglycemic state may develop. If consciousness is not impaired and there are no serious symptoms, then you should drink sweet juice or tea with sugar. To prevent hypoglycemia from recurring, you need to increase the amount of carbohydrates in the diet or reduce the dosage of the drug.

Hospitalization is required when a severe hypoglycemic condition has developed. The patient is injected intravenously with a stream of 50 ml of a 40% glucose solution. Then, to maintain the glucose concentration above 1 g/l, 10% dextrose is infused.

Interaction with other drugs

Drugs that increase the effect of gliclazide

The antifungal agent Miconazole is contraindicated. Increases the risk of developing a hypoglycemic state up to coma.

You should carefully combine the use of Diabeton with the non-steroidal anti-inflammatory drug Phenylbutazone. When used systemically, it slows down the elimination of the drug from the body. If taking Diabeton is necessary and nothing can replace it, the dosage of gliclazide is adjusted.

Ethyl alcohol aggravates the hypoglycemic state and inhibits compensation, which contributes to the development of a coma. For this reason, it is advisable to exclude alcohol and medications containing ethanol.

Also, the development of a hypoglycemic state with uncontrolled use with Diabeton is promoted by:

• Bisoprolol;
• Fluconazole;
• Captopril;
• Ranitidine;
• Moclobemide;
• Sulfadimethoxine;
• Phenylbutazone;
• Metformin.

The list contains only specific examples; other drugs included in the same group as those listed have the same effect.

Drugs that reduce the effect of diabetes

You can't take Danazol because... it has a diabetogenic effect. If the dose cannot be stopped, adjustments to gliclazide are necessary during and after therapy.

Combination with antipsychotics in large dosages requires careful monitoring, because they help reduce hormone secretion and increase glucose levels. Selection of the dose of Diabeton MV is carried out both during therapy and after its discontinuation.

When treated with glucocorticosteroids, glucose concentrations increase with a possible decrease in carbohydrate tolerance.

β2-adrenergic agonists, when administered intravenously, increase glucose concentrations. If necessary, the patient is transferred to insulin.

Combinations you shouldn't miss

When treated with warfarin, Diabeton may increase its effect. This should be taken into account with this combination and the dose of the anticoagulant should be adjusted. Dose adjustment of the latter may be required.

special instructions

Hypoglycemia

It is advisable to take Diabeton MV only for people who eat a balanced and regular diet without skipping an important meal - breakfast. Carbohydrates in the diet are very important because... The risk of developing a hypoglycemic state increases precisely with their irregular use, as well as with a low-calorie diet.

You should be aware that the use of sweeteners does not eliminate the symptoms of hypoglycemia.

Hypoglycemic symptoms may recur. If the symptoms are severe, even if there is a temporary improvement in the condition after carbohydrate food, specialized care is required, sometimes even including hospitalization.

To prevent this from happening, you should carefully select the dosage of Diabeton.

Cases that increase the risk of hypoglycemic conditions:

1. A person's unwillingness and inability to follow doctor's orders.
2. Poor nutrition, skipping meals, hunger strikes.
3. Minor physical activity with a large amount of carbohydrates consumed.
4. Kidney failure.
5. Gliclazide overdose.
6. Thyroid diseases.
7. Taking certain medications.

Kidney and liver failure

The properties of the substance change due to liver and severe renal failure. The hypoglycemic state can be long-lasting; emergency treatment is necessary.

Patient Information

You should exercise regularly and monitor your glucose levels, stick to a special menu and eat without skipping meals. The patient and his relatives should be aware of hypoglycemia, its signs and methods of relief.

Insufficient glycemic control

When a patient experiences fever, infectious diseases, undergoes major surgery, or is injured, glycemic control is weakened. Sometimes it becomes necessary to switch to insulin with the abolition of Diabeton CF.

Secondary drug resistance can occur, which occurs as the disease progresses or the body's response to the drug decreases. Typically, its development occurs after prolonged treatment with oral hypoglycemic drugs. To confirm secondary resistance, the endocrinologist evaluates the correctness of the selected dosages and the patient’s compliance with the prescribed diet.

Impact on the ability to drive vehicles and operate machinery

When working behind the wheel or any work that requires lightning-fast decision-making, special care should be taken.

Analogues of Diabeton MV

What can be replaced?

Diabeton CF can be replaced with other medications with the same dosage and active ingredient. But there is such a thing as bioavailability - the amount of a substance that reaches the target, i.e. the ability of the drug to be absorbed. For some low-quality analogues it is low, which means that the therapy will be ineffective, because As a result, the dosage may be incorrect. This is due to the poor quality of raw materials and auxiliary components, which do not allow the active substance to be fully released.

To avoid troubles, it is better to make all replacements only after consulting your doctor.

Maninil, Metformin or Diabeton - which is better?

To compare which is better, it is worth considering the negative aspects of the drugs, because They are all prescribed for the same disease. Above is information about the drug Diabeton MV, so Maninil and Metformin will be discussed further.

Maninil and Metformin belong to different pharmacological groups, so their principle of action is different. And each has its own advantages that will be necessary for certain groups of patients.

Positive sides:

By frequency of administration: Diabeton MV is taken once a day, Metformin - 2-3 times, Maninil - 2-4 times.

Diabeton MV 60 mg instructions for use indicate that the drug is included in the group of second-generation sulfonylurea derivatives.

The drug is actively used in the treatment of diabetes mellitus that develops in an insulin-independent form.

The effect of this group of medications on the human body is associated with the process of activation of pancreatic beta cells, which are stimulated and intensively produce endogenous insulin.

The use of sulfonylurea derivatives occurs when there are functional and full-fledged beta cells in the organ.

The mechanism of action of this group of drugs is the manifestation of the following effects:

• stimulation of pancreatic beta cells and increasing their sensitivity at the cellular level;
• increasing the action of insulin and suppressing the performance of the hormone that breaks it down (insulinase);
• weakening of the relationship between insulin and proteins, reducing the degree of binding of insulin to antibodies;
• help increase the sensitivity of muscle and lipid tissue receptors to insulin;
• increase the number of insulin receptors on tissue membranes;
• help improve glucose utilization in the liver and muscles;
• neutralize the process of gluconeogenesis in the liver;
• in lipid tissues they suppress lipolysis and also increase the level of absorption and oxidation of glucose.

Today, there are several types of sulfonylurea derivative medications:

1. First generation drugs that are practically not used in modern medicine - Tolazamide, Carbutamide.
2. The second generation, representatives of which are Glibenclamide, Gliclazide and Glipizide.
3. Third generation - Glimepiride.

The choice of the drug used should be made by the attending physician.

What is a hypoglycemic agent?

The drug Diabeton is a hypoglycemic agent used to treat type 2 diabetes mellitus.

The medicine can be produced in various dosages, depending on the amount of active ingredient in the composition - 60 and 80 milligrams.

The main active ingredient is gliclazide, one of the second generation sulfonylurea derivatives. The release form of the medicine is film-coated tablets.

It should be noted that Diabeton MB with a dosage of 60 mg is presented in the form of a modified-release drug.

Diabeton tablets are used in the following cases:

• in the therapeutic treatment of patients diagnosed with non-insulin-dependent diabetes mellitus;
• to prevent the development of pathological complications, including reducing the risk of nephropathy and retinopathy, stroke and myocardial infarction.

The active component, which is part of the drug, helps to reduce platelet adhesion and aggregation, inhibits the development of a parietal thrombus and has a beneficial effect on increasing vascular fibrinolytic activity.

In addition, during therapy, normalization of vascular permeability is observed.

The benefits of Diabeton MV 60 also include:

1. It has antiatherogenic characteristics, which manifests itself in the normalization of cholesterol levels and a reduction in the number of free radicals.
2. Prevents the appearance and development of microthrombosis and atherosclerosis.
3. Reduces the level of sensitivity of blood vessels to adrenaline.

After using the drug, its concentration in the blood plasma gradually increases over six hours, after which it remains there for another six to twelve hours.

Instructions for use of the drug

Sugar level

The medicine Diabeton mr 60 is used in the therapeutic treatment of pathology only in adults.

For each patient, the attending physician draws up a regimen for taking the drug during therapy.

The general requirements for the use of the medicinal product are described in detail in the instructions for use of the medicinal product.

According to the instructions for use of the medication, the medicine should be taken in accordance with the following regimen:

1. Once a day, regardless of meals. It is recommended to use the tablet drug in the morning, during breakfast.
2. Take the tablets orally with a sufficient amount of liquid.
3. The daily dosage can range from 30 to 120 mg of the active ingredient, which is 0.5-2 tablets at a time.
4. The required dose of the drug is determined by the attending physician individually for each patient, taking into account the characteristic features of the course of the disease.
5. If under any circumstances the next dose of medication is missed, there is no need to increase the next dosage
6. It is better to start therapeutic treatment with the minimum possible dose, which is half a Diabeton MB 60 mg tablet. In addition, this dosage can be used to maintain the desired effect as maintenance treatment.
7. Doses should be increased gradually from thirty milligrams of the active ingredient. After certain periods of time, the medical specialist decides to increase it, first to 60 mg, then to 90 and 120 mg of the active substance. It should be noted that after the start of therapeutic treatment, the first increase in dosage is possible no earlier than a month later.
8. The maximum possible dosage of the drug per day should be 120 mg.

In some cases, combination therapy takes place. The tableted drug Diabeton MB 60 can be used in conjunction with drugs from the biguanide group, alpha-glucosidase inhibitors or insulin therapy.

For certain groups of patients, it may be necessary to adjust the dosages indicated in the annotation. These include:

• people with severe kidney disease;
• those at risk of developing hypoglycemia.

The category of people at risk of developing hypoglycemia includes patients with an unbalanced diet, adherence to strict diets or fasting, endocrine diseases, and atherosclerosis of the carotid arteries.

The tableted drug can be used as complex therapy to achieve a more lasting hypoglycemic effect or for prophylactic purposes to prevent the development of complications of the pathology. A healthcare professional may prescribe therapy with metformin hydrochloride, alpha-glucisidase inhibitors, or thiazolindione derivatives.

When using a medication, it is necessary to regularly monitor the concentration of glucose in the blood to avoid the development of hypoglycemia.

In what cases is it forbidden to use a hypoglycemic agent?

Like any medication, Diabeton MB 60 has a certain list of contraindications for use.

Despite the fairly large list of positive properties of the drug, it is necessary to take into account all sorts of negative aspects that may appear after its use.

First of all, it is necessary to pay attention to the list of prohibitions under which treatment using this medical product cannot be carried out.

The main contraindications include the following aspects:

• treatment of type 1 diabetes;
• in case of observation of diabetic ketoacitosis or diabetic precoma condition in the patient;
• manifestation of hypoglycemia in a patient;
• in the presence of pathologies of an infectious nature;
• there is a development of severe liver or kidney disease;
• there is intolerance or hypersensitivity to one or more components of the drug;
• leukopenia;
• in the condition after resection of the pancreas;
• while taking Miconazole;
• if you have lactose intolerance or lactase deficiency.

To date, there is not enough information on how this medication works in the treatment of diabetes mellitus in children. That is why therapy is not prescribed to such patients (under eighteen years of age). In addition, contraindications include taking the drug by pregnant girls and women during breastfeeding.

Also, the drug is prescribed with extreme caution in the following cases:

1. If there is an increased risk of hypoglycemia.
2. If there are factors that require mandatory transfer of the patient to insulin injections.
3. After surgical interventions.

In addition, the drug should be used with great caution if the patient has diseases of the digestive system.

Possible negative impacts

Reviews from patients who have used the drug are most often positive.

Reviews from doctors indicate that improper use of a medication can lead to the development of various negative manifestations, which are side effects.

Disturbances in the normal functioning of various organs and systems can occur with varying frequency and severity.

The main negative reactions include:

• disorders of the digestive tract manifest themselves in the form of a feeling of heaviness in the stomach, pain in the abdomen, a metallic taste in the mouth, belching, nausea, vomiting or diarrhea;
• the immune system may react negatively to the start of therapeutic treatment in the form of purpura, itching of the skin or urticaria, an increase in the level of photosensitivity, erythema, Quincke's edema;
• adverse reactions from the circulatory system have the following symptoms - thrombocytopenia, hemolytic, leukopenia, erythropenia;
• problems may arise with the normal functioning of the liver and diseases such as hepatitis or cholestatic jaundice may develop;
• the occurrence of transient visual disorders;
• incorrect selection of the dosage of the medication leads to the development of hypoglycemia, its main symptoms are the appearance of fever, fatigue, hand tremors, a general feeling of fatigue with an increased level of drowsiness;
• a sharp increase in body weight.

An overdose of a drug is accompanied by the following symptoms:

1. Increased level of sweating.
2. Constant feeling of hunger.
3. Impaired speech and consciousness.
4. The appearance of problems with sleep.

In case of overdose, the appearance and progression of signs of hypoglycemia is also possible.

What medications can replace a hypoglycemic drug?

The price of the drug Diabeton MV can vary from 280 rubles in different city pharmacies.

The main manufacturer of medicinal antihyperglycemic agents is France.

Due to the imported origin of the drug, patients are often interested in whether there are domestic analogue drugs and what their cost is?

The main substitutes for the drug are the following domestic tablets:

• Diabepharm MV;
• Glidiab and a modified form of Glidiab MB;
• Gliclazide-akos MV;
• Glucostabil.

Each of the above medicines has the active ingredient Gliclazide.

Packing (60 tablets) Glidiab with a dosage of 80 mg costs about 120 rubles. The manufacturer of the medicinal product is the Russian Federation. It is a complete analogue of the medical drug Diabeton 80.

The tableted drug MB is a modified-release hypoglycemic agent. The medicine is developed on the basis of gliclazide and can have different dosages of the active component (30 or 60 mg). Its main function is to normalize blood glucose levels as a result of ineffective diet and exercise. The price of the drug is lower than the cost of Diabeton MV and ranges from 128 rubles.

The Russian analogue Diabepharm MV can be bought in city pharmacies for about 130 rubles (60 tablets). The tableted product is practically no different in composition (the same active component, but the difference in excipients), indications, contraindications and the possibility of side effects from the drug Diabeton MV.

In some cases, the attending physician may replace the intake of Diabeton MV tablets with other medications:

1. From the sulfonylurea group, but with a different active ingredientꓼ
2. A medicine from a different group, but with similar pharmacological properties (glinides)ꓼ

Also, taking Diabeton MV can be replaced with drugs with a similar principle of action (DPP-4 inhibitors).

An expert will tell you how the sugar-lowering drug Diabeton MV works in the video in this article.

Instructions for use

Additional Information

Diabeton MB is a medicine for type 2 diabetes. The active substance is gliclazide. It stimulates the beta cells of the pancreas to produce more insulin, which lowers blood sugar. Refers to sulfonylurea derivatives. MV is a modified release tablet. Gliclazide is not released from them immediately, but evenly over 24 hours. This provides benefits in the treatment of diabetes. However, Diabeton is not considered the first choice drug for type 2 diabetes. It is recommended to prescribe it only after metformin. Read the article for detailed indications for use, contraindications, dosages, advantages and disadvantages of Diabeton MV. Find out what you can replace this medicine with to avoid harm from its side effects

Drug card

Use of the drug Diabeton

The medicine Diabeton in regular tablets and modified release (MR) is prescribed to patients with type 2 diabetes whose disease is not well controlled by diet and exercise. The active substance of the drug is gliclazide. It belongs to the group of sulfonylurea derivatives. Gliclazide stimulates the beta cells of the pancreas to produce and release more insulin into the blood, a hormone that lowers sugar.

It is recommended first of all to prescribe to patients with type 2 diabetes not Diabeton, but the drug metformin - the drugs Siofor, Glucophage or Gliformin. The dosage of metformin is gradually increased from 500-850 to 2000-3000 mg per day. And only if this remedy does not lower sugar enough, sulfonylurea derivatives are added to it.

Many doctors prescribe Diabeton MB to their patients instead of metformin. However, this is incorrect and does not comply with official recommendations. Gliclazide and metformin can be combined. Taking these tablets together usually allows a diabetic patient to maintain normal sugar levels for several years.

Gliclazide sustained-release tablets act uniformly over 24 hours. Today, diabetes treatment standards recommend that doctors prescribe Diabeton MB to their patients with type 2 diabetes instead of the previous generation of sulfonylurea derivatives. See, for example, the article “Results of the study “DYNASTY” (“Diabeton CF: observational program among patients with type 2 diabetes mellitus in routine practice”)” in the journal “Problems of Endocrinology” No. 5/2012, authors M. V. Shestakova, O K. Vikulova and others.

Diabetes CF significantly lowers blood sugar. Patients like that it is convenient to take once a day. It works safer than the older sulfonylurea drugs. However, it has harmful effects that make it better for diabetics not to take it at all. Read below about the harm of Diabeton, which outweighs all its benefits. The site promotes effective methods of treating type 2 diabetes without harmful pills.

Advantages and disadvantages

Treatment of type 2 diabetes with the drug Diabeton MV gives good results in the short term:

• in patients, blood sugar decreases significantly;
• the risk of hypoglycemia is no more than 7%, which is much lower than for other sulfonylurea derivatives;
• The medicine is convenient to take once a day, so patients do not abandon treatment;
• When taking gliclazide in sustained-release tablets, patients gain insignificantly.

Diabeto CF has become a popular treatment for type 2 diabetes because it has benefits for doctors and is convenient for patients. It is many times easier for endocrinologists to prescribe pills than to motivate diabetics to diet and exercise. The drug quickly lowers sugar and is well tolerated. No more than 1% of patients complain about side effects, and all the rest are satisfied.

Disadvantages of the drug Diabeton MV:

1. It accelerates the death of beta cells in the pancreas, causing the disease to develop into severe type 1 diabetes. This usually occurs between 2 and 8 years.
2. In slender and thin people causes severe insulin-dependent diabetes especially quickly - no later than after 2-3 years.
3. Does not eliminate the cause of type 2 diabetes - decreased sensitivity of cells to insulin. This metabolic disorder is called insulin resistance. Taking Diabeton may intensify it.
4. Lowers blood sugar, but does not reduce mortality. This was confirmed by the results of a large international study, ADVANCE.
5. This medicine may cause hypoglycemia. True, its likelihood is less than if you take other sulfonylurea derivatives. However, type 2 diabetes can be easily controlled without any risk of hypoglycemia.

Experts have known since the 1970s that sulfonylureas cause the transition from type 2 diabetes to severe insulin-dependent type 1 diabetes. However, these drugs continue to be prescribed. The reason is that they take the burden off doctors. If there were no sugar-lowering pills, doctors would have to prescribe a diet, exercise, and insulin therapy regimen for each diabetic. This is hard and thankless work. Patients behave like Pushkin’s hero: “It’s not difficult to deceive me, I’m happy to be deceived myself.” They willingly take medications, but they do not like to diet, exercise, or even inject insulin.

Diabeton CF - harmful pills. However, the previous generation of sulfonylureas is even worse. The disadvantages listed above are more pronounced in them. Diabetes CF at least does not affect mortality, but other drugs increase it. If you are not ready to switch, then at least take modified-release (MR) tablets.

The destructive effect of Diabeton on the beta cells of the pancreas practically does not concern endocrinologists and their patients. There are no publications about this problem in medical journals. The reason is that most people with type 2 diabetes do not live long enough to develop insulin-dependent diabetes. Their cardiovascular system turns out to be a weaker link than the pancreas. Therefore, they die from a heart attack or stroke. Treatment of type 2 diabetes based on a low-carbohydrate diet simultaneously normalizes sugar, blood pressure, blood test results for cholesterol and other cardiovascular risk factors.

Clinical trial results

The main clinical trial of the drug Diabeton MB was the ADVANCE: Action in Diabetes and VAscular disease study.
preterax and Diamicron MR Controlled Evaluation. It was started in 2001 and the results were published in 2007-2008. Diamicron MR - this is the name under which gliclazide is sold in modified-release tablets in English-speaking countries. This is the same as the drug Diabeton MV. Preterax is a combination medicine for hypertension, the active ingredients of which are indapamide and perindopril. In Russian-speaking countries it is sold under the name Noliprel. The study involved 11,140 patients with type 2 diabetes and hypertension. They were observed by doctors in 215 medical centers in 20 countries.

Diabetes CF lowers blood sugar but does not reduce mortality in patients with type 2 diabetes.

According to the results of the study, it turned out that blood pressure pills in patients with type 2 diabetes reduce the incidence of cardiovascular complications by 14%, kidney problems by 21%, and mortality by 14%. At the same time, Diabeton MB lowers blood sugar, reduces the incidence of diabetic nephropathy by 21%, but does not affect mortality. Russian-language source - article “Managed treatment of patients with type 2 diabetes mellitus: results of the ADVANCE study” in the journal “System Hypertension” No. 3/2008, author Yu. Karpov. Original source: The ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes" in The New England Journal of Medicine, 2008, No. 358, 2560–2572.

Patients with type 2 diabetes are prescribed sugar-lowering pills and insulin injections if diet and exercise do not produce good results. In fact, patients simply do not want to follow a low-calorie diet and exercise. They prefer to take medications. It is officially believed that there are no other effective treatment methods other than medications and injections of large doses of insulin. Therefore, doctors continue to use sugar-lowering pills, which do not reduce mortality. On the website you can learn how to easily control type 2 diabetes without a “starvation” diet and insulin injections. There is no need to take harmful medications because alternative treatments work well.

Modified release tablets

Diabeton MV - modified release tablets. The active substance - gliclazide - is released from them gradually, and not immediately. Due to this, a uniform concentration of gliclazide in the blood is maintained for 24 hours. It is enough to take this drug once a day. As a rule, it is prescribed in the morning. Regular Diabeton (without CF) is an older medicine. Its tablet completely dissolves in the gastrointestinal tract after 2-3 hours. All the gliclazide it contains immediately enters the bloodstream. Diabeton MB lowers sugar smoothly, and ordinary tablets - sharply, and their action ends quickly.

Modern modified release tablets have significant advantages over older drugs. The main thing is that they are safer. Diabeton MB causes hypoglycemia (low sugar) several times less frequently than regular Diabeton and other sulfonylurea derivatives. According to studies, the risk of hypoglycemia is no more than 7%, and it usually goes away without symptoms. Against the background of taking a new generation of drugs, severe hypoglycemia with impaired consciousness rarely occurs. This drug is well tolerated. No more than 1% of patients experience side effects.

Comparison of Diabeton MB and immediate release tablets

In articles in medical journals, it is noted that the Diabeton MB molecule, due to its unique structure, is an antioxidant. But this has no practical significance; it does not affect the effectiveness of diabetes treatment. Diabeton MB is known to reduce the formation of blood clots. This may reduce the risk of stroke. But nowhere has it been proven that the drug actually gives such an effect. The disadvantages of the diabetes medicine - sulfonylurea derivatives - were listed above. In Diabeton MV, these disadvantages are less pronounced than in older drugs. It has a more gentle effect on pancreatic beta cells. Insulin-dependent type 1 diabetes does not develop as quickly.

How to take this drug

Diabeton MV is taken once a day, usually with breakfast. The 60 mg scored tablet can be split into two to give a 30 mg dose. However, it should not be chewed or crushed. When taking the medicine, take it with water. The site promotes effective methods of treating type 2 diabetes. They allow you to refuse Diabeton so as not to be exposed to its harmful effects. However, if you do take pills, then do it every day without skipping. Otherwise the sugar will rise too high.

While taking Diabeton, alcohol tolerance may worsen. Possible symptoms include headache, difficulty breathing, rapid heartbeat, abdominal pain, nausea and vomiting.

Diabetes can cause hypoglycemia, and alcohol will mask its symptoms. Is it dangerous! Fainting due to low sugar looks similar to severe alcohol intoxication. High risk of death! Reduce your consumption of hard liquor or don't drink at all. At least figure it out.

Sulfonylurea derivatives, including Diabeton MV, are not first-choice medications for type 2 diabetes. It is officially recommended to prescribe to patients first). Gradually their dose is increased to the maximum - 2000-3000 mg per day. And only if this is not enough, Diabeton MV is added. Doctors who prescribe Diabeton instead of metformin are doing the wrong thing. Both drugs can be combined, and this gives good results. Even better is to switch to a type 2 diabetes treatment program, giving up harmful pills.

Diabeton MB can be combined with other diabetes tablets, except sulfonylurea derivatives and glinides (meglitinides). Read also ““. If Diabeton does not lower blood sugar, then you need to transfer the patient to insulin injections. In such a situation, no other pills will help. Start injecting insulin, do not waste time, otherwise severe complications of diabetes will appear.

Sulfonylureas make the skin more sensitive to ultraviolet radiation. The risk of sunburn increases. It is recommended to use sunscreen and it is better not to sunbathe. Consider the risk of hypoglycemia that can be caused by taking Diabeton. When driving or performing hazardous work, check your blood sugar with a glucose meter every 30 to 60 minutes.

Who is it not suitable for?

Diabeton CF should not be taken by anyone at all, because alternative treatments for type 2 diabetes work well and do not cause side effects. The official contraindications are listed below. Also find out which categories of patients should use this medicine with caution.

During pregnancy and breastfeeding, any pills that lower sugar are contraindicated. Diabeton CF is not prescribed to children and adolescents, because its effectiveness and safety for this category of patients have not been established. Do not take this drug if you have a history of allergies to it or other sulfonylureas. This medicine should not be taken by people with type 1 diabetes, or if you have unstable type 2 diabetes or frequent episodes of hypoglycemia.

If you follow a low-carbohydrate diet, there is an increased risk that Diabeton tablets will cause hypoglycemia. You need to reduce the dosage, or better yet, stop taking them altogether. Alternative treatments for type 2 diabetes based on a low-carb diet are good at lowering sugar, so there is no need to take harmful medications.

Sulfonylureas should not be taken by people with severe liver or kidney disease. If you have diabetic nephropathy, discuss with your doctor. Most likely, he will advise replacing the pills with insulin injections. For older people, Diabeton CF is officially suitable if their liver and kidneys are functioning normally. Unofficially, it stimulates the transition of type 2 diabetes to severe insulin-dependent type 1 diabetes. Therefore, diabetics who want to live a long time without complications should not take it.

In what situations is Diabeton MV prescribed with caution:

• hypothyroidism - a weakened function of the thyroid gland and a lack of its hormones in the blood;
• deficiency of hormones produced by the adrenal glands and pituitary gland;
• irregular meals;
• alcoholism.

Analogues of Diabeton

The original drug Diabeton MB is produced by the pharmaceutical company Servier Laboratories (France). Since October 2005, it has stopped supplying Russia with the previous generation of medicines - Diabeton 80 mg rapid-acting tablets. Now you can buy only the original Diabeton MB - modified release tablets. This dosage form has significant advantages, and the manufacturer decided to concentrate on it. However, gliclazide is still available in immediate-release tablets. These are analogues of Diabeton, which are produced by other manufacturers.

Analogues of the drug Diabeton MV

Analogues of tablets Diabeton rapid release

Drugs whose active ingredient is gliclazide in immediate-release tablets are now considered obsolete. It is advisable to use Diabeton MV or its analogues instead. Even better is a method of treating type 2 diabetes based on. You will be able to keep your blood sugar consistently normal and will not need to take harmful medications.

Diabeton or Maninil - which is better?

The source for this section was the article “Risks of general and cardiovascular mortality, as well as myocardial infarction and acute cerebrovascular accident in patients with type 2 diabetes mellitus, depending on the type of initial glucose-lowering therapy” in the journal “Diabetes Mellitus” No. 4/2009. Authors: I.V. Misnikova, A.V. Dreval, Yu.A. Kovaleva.

Different treatments for type 2 diabetes have different effects on the risk of heart attack, stroke and overall mortality in patients. The authors of the article analyzed the information contained in the Moscow Region Diabetes Register, which is part of the State Diabetes Register of the Russian Federation. They looked at data from people who were diagnosed with type 2 diabetes in 2004. We compared the effect of sulfonylurea derivatives and metformin if treated with them for 5 years.

It turned out that drugs - sulfonylurea derivatives - are more likely to harm than help. How they worked in comparison with metformin:

• the risk of general and cardiovascular mortality doubled;
• the risk of heart attack increased by 4.6 times;
• the risk of stroke increased threefold.

At the same time, glibenclamide (Maninil) turned out to be even more harmful than gliclazide (Diabeton). True, the article did not indicate which forms of Manilil and Diabeton were used—slow-release tablets or regular ones. It would be interesting to compare the data with patients with type 2 diabetes who were immediately prescribed insulin treatment instead of pills. However, this was not done because there were not enough such patients. The vast majority of patients categorically refused to inject themselves with insulin, so they were prescribed pills.

Frequently asked questions and their answers

Diabeton controlled my type 2 diabetes well for 6 years and now it has stopped helping. I increased his dose to 120 mg per day, but blood sugar is still high, 10-12 mmol/l. Why did the medicine lose its effectiveness? How to treat now?

Diabeton is a sulfonylurea derivative. These pills lower blood sugar, but also have harmful effects. They gradually destroy the beta cells of the pancreas. After 2-9 years of taking them, the patient in the body begins to really lack insulin. The medicine has lost its effectiveness because your beta cells have burned out. This could have happened earlier. How to treat now? You need to inject insulin, no options. Because your type 2 diabetes has turned into severe type 1 diabetes. Cancel Diabeton, switch to and still inject insulin to keep normal sugar.

An elderly man has had type 2 diabetes for 8 years. Blood sugar is 15-17 mmol/l, complications have developed. I took Maninil, now they switched to Diabeton - to no avail. Should I start taking Amaryl?

The same situation as the author of the previous question. Due to years of improper treatment, type 2 diabetes progressed to severe type 1 diabetes. No pills will give any results. Do it, start injecting insulin. In practice, it is usually impossible to provide proper treatment to elderly diabetics. If the patient shows forgetfulness and stubbornness, leave everything as it is and wait calmly.

For type 2 diabetes, the doctor prescribed me Siofor 850 mg per day. After 1.5 months I switched to Diabeton because my sugar didn’t drop at all. But the new drug is also of little use. Shouldn't you switch to Glibomet?

If Diabeton does not lower sugar, then Glibomet will not be of any use. If you want to lower your sugar, start taking insulin. For the situation of advanced diabetes, no other effective remedy has yet been invented. First of all, go on a low-carb diet and stop taking harmful medications. However, if you have had type 2 diabetes for a long time and you have been treated incorrectly over the past years, then you also need to inject insulin. Because the pancreas is exhausted and cannot cope without support. A low-carb diet will lower your sugar, but not to normal. To prevent complications from developing, sugar should not be higher than 5.5-6.0 mmol/l 1-2 hours after meals and in the morning on an empty stomach. Inject insulin carefully, little by little, to achieve this goal. Glibomet is a combination drug. It contains glibenclamide, which has the same harmful effects as Diabeton. Do not use this medicine. You can take “pure” metformin - Siofor or Glucophage. But no pills can replace insulin injections.

Is it possible to take Diabeton and Reduxin simultaneously for weight loss if you have type 2 diabetes?

There is no data on how Diabeton and reduxin interact with each other. However, Diabeton stimulates the production of insulin by the pancreas. Insulin, in turn, converts glucose into fat and inhibits the breakdown of adipose tissue. The more insulin in the blood, the more difficult it is to lose weight. Thus, Diabeton and reduxin have the opposite effect. Reduxin causes significant side effects and addiction quickly develops. Read the article ““. Stop taking Diabeton and Reduxin. Go on a low-carb diet. It normalizes sugar, blood pressure, cholesterol in the blood, and extra pounds also go away.

I have been taking Diabeton MB for 2 years now, fasting sugar is about 5.5-6.0 mmol / l. However, a burning sensation in the feet has recently begun and vision is falling. Why do complications of diabetes develop despite the fact that sugar is normal?

The doctor prescribed diabetes for high sugar, as well as a low-calorie diet without sweets. But he didn’t say how much to limit caloric intake. If I eat 2000 calories a day, is that normal? Or do you need even less?

A fasting diet theoretically helps control blood sugar, but in practice it does not. Because all the sick people break away from it. You don't have to live with the feeling of hunger all the time! Learn and do a. Switch to a low-carb diet - it's filling, tasty and good for lowering sugar. Stop taking harmful pills. If necessary, inject more insulin little by little. If your diabetes is not advanced, then you can maintain normal sugar levels without insulin injections.

I take Diabeton and also metformin to compensate for my T2DM. Blood sugar stays at 8-11 mmol/l. The endocrinologist says that this is a good result, and my health problems are age-related. But I feel that diabetes complications are developing. What more effective treatment can you recommend?

Normal blood sugar is the same as in healthy people, not higher than 5.5 mmol/l 1 and 2 hours after meals. At any higher levels, complications of diabetes develop. To lower your sugar levels and keep them consistently normal, learn and follow a type 2 diabetes management program. The link to it is given in the answer to the previous question.

The doctor prescribed me to take Diabeton MB at night so that my blood sugar would be normal in the morning on an empty stomach. But the instructions say that you need to take these tablets for breakfast. Who to trust - instructions or doctor's opinion?

You need to do something at night so that your sugar levels are normal the next morning. Your doctor is right about this :). But taking Diabeton is a bad idea because it is a harmful pill. What to replace them with is described in detail above. Read also ““. If you need to inject a little extended-release insulin at night, do it, don’t be lazy.

A patient with type 2 diabetes with 9 years of experience, age 73 years. Sugar rises to 15-17 mmol/l, and maninil no longer lowers it. I began to lose weight sharply. Should I switch to Diabeton?

If maninil does not lower sugar, then Diabeton will be of no use. I started to lose weight sharply, which means that no pills will help. You definitely need to inject insulin. Advanced type 2 diabetes has turned into severe type 1 diabetes, so you need to study and follow. If it is not possible to arrange insulin injections for an elderly diabetic, leave everything as it is and calmly wait for the end. The patient will live longer if he stops taking all his diabetes pills.

Diabeton CF is a popular treatment for type 2 diabetes. Its active ingredient is gliclazide. Below you will find instructions for use written in accessible language. Find out the indications, contraindications, dosages and side effects of this medicine, the ratio of benefits and harm to the body. Find out how to take Diabeton along with other pills that lower blood sugar.

Find out on this page about effective treatments for type 2 diabetes that can help you keep blood sugar 3.9-5.5 mmol/l stable 24 hours a day like healthy people. The system, living with impaired glucose metabolism for more than 70 years, allows you to protect yourself from problems with your legs, eyesight and kidneys.

In addition to the instructions, this page provides answers to frequently asked questions from diabetics. Find out how regular Diabeton differs from CF, how quickly this medicine begins to act, and whether it is compatible with alcohol. You will also find a list of Russian analogues useful, which cost 1.5-2 times cheaper.

Instructions for use

When taking Diabeton MV or its analogues, you need to follow a diet.

Read more about healthy eating:

Below are answers to questions patients often ask about tablets containing gliclazide.

How is regular diabetes different from CF?

Diabeton MV does not begin to lower blood sugar immediately, but it lasts longer than regular Diabeton. It is enough to take it once a day, usually before breakfast. The usual drug Diabeton had to be taken 2 times a day. It catastrophically increased the mortality rate among patients. The manufacturer did not officially admit this, but quietly removed the drug from sale. Now only Diabeton MV is sold and advertised. It acts more gently, but still remains a harmful medicine. It is better not to take it, but to use it.

Glidiab MV or Diabeton MV: which is better?

Diabepharm MV is another Russian substitute for Diabeton MV tablets, produced by Pharmacor Production LLC. It costs about 2 times less than the original drug. It should not be taken for the same reasons as any other tablet containing gliclazide. There are practically no reviews from diabetics and doctors about the drug Diabepharm MV. This drug is not popular.

What is the difference between Diabeton and Maninil? Can they be taken at the same time?

Even more harmful pills than gliclazide. Do not take these medicines together or separately. They contain different active ingredients, but belong to the same group of sulfonylurea derivatives. These drugs increase metabolic disorders in the body of diabetics, increase the risk of death from heart attack and other causes. Instead of taking them, study and follow her recommendations. After 2-3 days, your blood sugar will go down and your health will improve.

How to take Diabeton

It is better not to take diabeton at all for the reasons listed above. Patients with type 2 diabetes who do not know how to properly treat usually drink this medicine for a long time, for several years in a row. Then their pancreas is completely depleted, losing the ability to produce insulin. Relatively mild impaired glucose metabolism progresses to severe type 1 diabetes, which is almost impossible to control. Diabeton ceases to help, like any other pill. Insulin injections become vital..

Doctors prescribe to take Diabeton MB once a day at the same time before meals, usually before breakfast. After a diabetic has taken a pill, you must definitely eat so that there is no. If you forget to take your medicine one day, take your regular dose the next day. Don't try to increase it to make up for a missed day. By following the site's recommendations, you can keep your sugar levels stable and avoid the complications of diabetes. There is no need to take gliclazide and other harmful drugs.

Read about products for diabetics:

How quickly does this medicine start to work?

Unfortunately, there is no exact information on how quickly Diabeton MB begins to act. Most likely, sugar begins to drop after 30-60 minutes. Therefore, you need to eat quickly so that it does not drop below normal. The effect of each tablet lasts more than a day. Therefore, it is enough to take gliclazide in slow-release tablets once a day.

Older versions of the same drug in regular tablets begin to lower sugar faster, but their effect also ends faster. Therefore, doctors prescribe taking them 2 times a day. says that Diabeton CF is a harmful medicine . But gliclazide tablets, which you need to take 2 times a day, are even worse.

In pharmacies you can find several analogues of the Russian-made Diabeton MV drug. They cost approximately 1.5-2 times cheaper than the original French medicine.

Russian analogues of the drug Diabeton MV

The original drug Diabeton in fast (standard) action tablets was withdrawn from the pharmaceutical market in the late 2000s. Cheap substitutes followed suit. You may be able to find some unsold stock in pharmacies. But it's better not to do this.

Diabeton MV and its analogues in slow-release tablets are included in the list of drugs that lower blood sugar. The old generation gliclazide is even more dangerous. It is better to stop taking this remedy and switch to. It became obvious to manufacturers that gliclazide in rapid-release tablets significantly increases the mortality rate of diabetics. This was never officially acknowledged, but the drug was quietly removed from sale.

Is it compatible with alcohol?

Instructions for use of the drug Diabeton CF requires complete abstinence from alcohol during the entire course of treatment. Because drinking alcohol increases the risk of hypoglycemia, liver problems and other complications. The incompatibility of the drug and alcohol is a serious problem, because gliclazide is intended for long-term, multi-year, even lifelong use.

Pay attention to the one, which does not require taking gliclazide and other harmful pills. Patients treated with this technique receive many benefits. One of them is the absence of the need to lead a 100% sober lifestyle. You can afford to drink alcohol in moderation without harm to your health. Read the article “” for more details. Find out which alcoholic drinks are allowed and in what quantities.

How to take Diabeton and metformin correctly?

It is correct to leave only metformin in your treatment regimen for type 2 diabetes, and quickly eliminate Diabetes. Gliclazide is harmful, but metformin is a wonderful medicine. It lowers blood sugar and slows down the development of diabetes complications. The website recommends taking the imported drug Glucophage - the original drug of metformin. Glucophage works better than Siofor and other analogues. And the price difference is not very big. Also worthy of attention is Galvus Met, a combination drug containing metformin.

Read about tablets containing metformin:

Is it possible to take Diabeton and Glucophage at the same time? Which of these drugs is better?

Glucophage is a good medicine, but Diabeton is harmful.. Read which popular diabetes pills are harmful and why gliclazide is on their list. He will also explain to you how to maintain normal sugar levels without using harmful and expensive drugs. Glucophage is an original imported medicine that is considered the highest quality of all metformin drugs. It is advisable to take it and not try to save a little by switching to Russian analogues.

There are many different nuances in the treatment of type 2 diabetes, and it is not always possible to immediately find a medicine that helps control glycemia 100%. Due to the variety of antidiabetic medications, it's not just diabetics who are confused.

If you have read the drug Diabeton and its instructions for use, but still do not fully understand whether it is right for you and how you can replace it, if the medicine does not help, then this article is worth spending time on.

Diabeton - a drug for type 2 diabetes

For a diabetic, one of the ways to successfully combat the disease is to normalize the so-called “fasting sugar.” But in pursuit of ideal glucometer readings, you can make a lot of mistakes, since the prescription of a medication must be justified, and this applies primarily to Diabeton. The new-fashioned French drug is prescribed to everyone - from athletes to diabetics, but it is not useful for everyone.

To understand who really needs it, you need to figure out what type of medicine Diabeton is and on the basis of what active substance it is created. The medicine is made from sulfonylurea derivatives; they have been used successfully all over the world for a long time.

In the cardboard box, as in the photo, you can see white oval tablets with “60” and “DIA” printed on each side. In addition to the main active component gliclazide, Diabeton also contains fillers: maltodextrin, lactose monohydrate, magnesium stearate, silicon dioxide.

Diabeton is an international trade name; the official manufacturer of the drug is the French pharmacological company Servier.

The non-proprietary chemical name of the product is gliclazide, based on the name of the active component.

Many analogues of various brands are produced with gliclazide, so the pharmacy can dispense, according to a preferential prescription, not the French Diabeton, but another analogue based on gliclazide, at an order of magnitude cheaper.

Analogues of Diabeton

The original medicine was and remains only Diabeton from Servier.

The shelf life of the drug is 2 years, after which it is not suitable for treatment and must be disposed of. Special conditions for its storage are not required.

Instead of the drug Diabeton, the price of which ranges from 260-320 rubles, the pharmacy can offer analogues:

In addition to the usual drug, Servier also produces Diabeton MB. All other medications are generics; manufacturers did not invent them, but simply acquired the right to produce them, and the entire evidence base relates only to the original drug Diabeton.

Generics differ in the quality of the filler, sometimes this seriously affects the effectiveness of the drug. The most budgetary version of the analogue is with Indian and Chinese roots. Among domestic generics that are successfully conquering the market of Diabeton analogues, Glibiab and Gliclazide-Akos enjoy authority.

How to replace Diabeton

If your doctor has prescribed Diabeton, but you can’t take it, you can find a replacement.

When there is no suitable option among the listed analogues, you can choose:

For whatever reason, it would not be necessary to select a replacement, only a specialist can change the treatment regimen. Self-diagnosis and self-appointment to a diabetic can only do harm!

Maninil or Diabeton - which is better?

Different methods of controlling type 2 diabetes affect the risk of fatal complications in different ways. Glibenclamide, the active ingredient in Maninil, is much stronger than gliclazide, the main ingredient in Diabeton. Whether this will be an advantage can be found in the comments of experts who analyzed questions about Diabeton and reviews on the forums.

How to use - instructions

A simple drug from Diabeton MV, created on the basis of a hydrophilic matrix, is distinguished by the speed of release of the active component. For a conventional analogue, the absorption time of glycoside does not exceed 2 - 3 hours.

After consuming Diabeton MV, gliclazide is released maximally during meal hours, and the rest of the time the glycemic norm is maintained due to the release of microdoses into the bloodstream during the day.

A simple analogue is produced with a dosage of 80 mg, with a prolonged effect - 30 and 60 mg. The special formula of Diabeton MV helped to reduce the dose of the medication, thanks to which it can be used only 1 time per day. Today, doctors rarely choose a simple drug, but it is still available in pharmacies.

Doctors recommend a new generation drug with prolonged capabilities, since it acts much more mildly than other sulfonylurea drugs, the risk of hypoglycemia is minimal, and the effect of one tablet lasts throughout the day.

For those who forget to take pills on time, a one-time dose is a big advantage. And the endocrinologist can safely increase the dose, achieving complete control over the patient’s glycemia. Naturally, Diabeton is prescribed in combination with a low-carbohydrate diet and muscle exercises, without which any antidiabetic pill is ineffective.

As a rule, the medication is prescribed in parallel with Metformin, which, unlike Diabeton, actively affects insulin resistance.

The mechanism of action of Diabeton

Diabeton belongs to a class of drugs that stimulate the pancreas and, in particular, the b-cells responsible for the production of insulin. The degree of activity of such stimulation in the drug is average; if we compare Maninil or Diabeton, then Maninil has a more powerful effect.

For type 2 diabetes accompanied by any degree of obesity, the drug is not indicated. It is added to the treatment regimen when all the symptoms of a decline in the functioning of the gland are present and stimulation is necessary to enhance insulin production.

The medication will restore the first phase of hormone production if it is reduced or absent in a diabetic. In addition to its main purpose (lowering glycemic levels), the drug has a positive effect on blood vessels and the circulatory system. By reducing platelet aggregation (sticking), it reduces the likelihood of blood clots in small vessels, strengthens their internal endothelium, creating angioprotective protection.

The algorithm for the effect of the drug can be presented in the following sequence:

1. Stimulation of the pancreas to increase the flow of the hormone into the bloodstream;
2. Imitation and restoration of the first phase of insulin production;
3. Reducing platelet aggregation to prevent the appearance of clots in small vessels;
4. Small antioxidant effect.

A single dose of the drug maintains the required concentration of the active component in the plasma throughout the day. The drug is metabolized in the liver and excreted by the kidneys (up to 1% in its original form). In adulthood, no significant changes in pharmacokinetic characteristics were recorded.

Parallel intake of food does not affect the speed and quality of absorption and distribution of Diabetes.

Advantages and disadvantages of the drug

If we compare Diabeton MV with analogues of the sulfonylurea class, then in terms of efficiency it is ahead of them:

Along with undeniable advantages, the medicine also has a number of disadvantages:

So that the body does not have to choose between complications from the pancreas or cardiovascular pathologies, it is worth paying attention to a low-carbohydrate diet and adequate physical activity.

Lifestyle modification will help to simultaneously normalize all heart risk factors: high sugar, blood pressure, excess weight, and cholesterol metabolism.

Indications for prescribing medication

Diabeton is designed to normalize the glycemic profile, prevent complications of diabetes, reduce the risk of heart attack, stroke, nephropathy, and retinopathy. But it is also used by athletes to increase muscle mass.

Therefore it is shown:

Diabetes is not prescribed to patients as a starting treatment regimen. It is also harmful for diabetics with signs of obesity, since their pancreas already works under increased load, producing 2-3 norms of insulin to neutralize glucose. Prescribing Diabeton to this category of diabetics can provoke death from cardiovascular situations (CVS).

Significant research has been conducted on this issue to determine the relationship between the choice of medications for the initial treatment of type 2 diabetes and the likelihood of mortality. The findings are presented below.

1. In volunteers with type 2 diabetes who received sulfonylurea derivatives, compared with the control group taking metformin, the risk of mortality from CV events was 2 times higher, coronary heart disease (CHD) - 4.6 times higher, and cerebrovascular accidents (CVA). ) - 3 times.
2. The risk of death from ischemic heart disease and cerebrovascular disease was higher in the group receiving gliclazide, gliquidone and glibenclamide than in volunteers taking metformin.
3. In volunteers who received gliclazide, compared with the group taking glibenclamide, the difference in risks was obvious: overall mortality was 20% less, from CVD - by 40%, and cerebrovascular accident - by 40%.

So, the choice of sulfonylurea derivatives (including Diabeton) as a first-line medicine provokes a 2-fold chance of death after 5 years, a 4.6-fold chance of getting a heart attack, and a 3-fold chance of a stroke.
For newly diagnosed type 2 diabetes, there is no alternative to Metformin as a first-line drug. With long-term (at least 3 years) use of Diabeton, the risk of developing atherosclerosis is significantly reduced. Other drugs in the sulfonylurea class do not have this effect. Most likely, the anti-sclerotic effect of the drug is provided by its antioxidant capabilities, which protect cells from oxidation.

What harm can diabetes cause in type 2 diabetes - on video.

The antidiabetic medication significantly increases the sensitivity of the liver, muscles and fat to insulin. In bodybuilding, it is used as a powerful anabolic steroid, which can be easily purchased at a pharmacy or online. Diabetics use Diabeton to restore the first phase of hormone production and improve the second phase of its production.

The product should be used by bodybuilders with healthy b-cells. The medication affects fat metabolism, blood circulation, thins the blood, and has antioxidant capabilities. Diabetes is transformed into metabolites in the liver, and the medicine is completely eliminated from the body.

In sports, the medication is used to support high anabolism; as a result, the athlete actively increases muscle mass.

In terms of its influence, it can be compared to insulin injections. With this method of weight gain, you need to strictly adhere to the doses, eat nutritiously 6 times a day (proteins, carbohydrates), and monitor your well-being so as not to miss the occurrence of symptoms of hypoglycemia.

Start the course with ½ tablet, gradually doubling the dose. Take the pill in the morning with food. The course of treatment is 1-2 months, depending on how you feel and the results. You can repeat it every other year; if you use Diabeton more often than once every six months, health complications are inevitable.

When repeating the course, the dosage can be doubled (up to 2 tablets/day). You should not take Diabeton while on a starvation diet or taking other means to gain weight. The medication lasts for 10 hours and requires nutritious food during this period. At the first sign of hypoglycemia, the athlete should eat a candy bar or other sweets.

Diabetes is a serious drug that is taken for medical reasons, so bodybuilders need to carefully experiment with their health.

The video shows the use of Diabeton for weight gain - reviews.

Contraindications for use

All medications have contraindications; before using Diabeton, it is important to pay attention to the following warnings:

How does taking two drugs together affect the outcome of treatment? Miconazole enhances the glucose-lowering capabilities of Diabeton. If you do not monitor your glycemic profile in a timely manner, there is a risk of developing hypoglycemia. If there is no alternative to Miconazole, the doctor should reduce the dose of Diabeton.

The medicine should be taken with caution when combined with:

Diabetes can increase alcohol intolerance. This is manifested by shortness of breath, headache, tachycardia, abdominal cramps, and other dyspeptic disorders. If diabetes provoked hypoglycemia, then alcohol will reliably mask its symptoms. Since the signs of intoxication are similar to glycemic ones, the risk of diabetic coma increases if assistance is not timely.

The optimal dose of alcohol for a diabetic is a glass of dry red wine on occasion. And if you have a choice, it is better not to drink alcohol at all.

Side effects

The main adverse event is hypoglycemia - a drop in glucose levels below the target range, accompanied by the following clinical symptoms:

In mild cases of hypoglycemia, the victim is given carbohydrates; in severe cases, urgent hospitalization is required.

In addition to hypoglycemia, there are other side effects:

All consequences are reversible and disappear without drug intervention after discontinuation of Diabeton. If the drug is prescribed instead of an alternative antidiabetic agent, then glycemia should be monitored for 10 days to avoid effects that are dangerous due to hypoglycemia.

When choosing Diabeton, the doctor must inform the diabetic about possible side effects and symptoms of overdose.

Reception and dosage regimen of Diabeton

In the pharmacy network, the drug is represented by two varieties:

• Diabeton with a dosage of 80 mg;
• Diabeton MV weighing 30 and 60 mg.

For ordinary Diabetes, the starting norm is 80 mg/day, over time it is increased to 2-3 pieces per day, distributed over several doses. A maximum of 4 tablets per day can be taken.

For modified Diabeton, the starting dose is 30 mg/day; if necessary, the dose is gradually adjusted. Diabeton MB is consumed 1 r./day, maximum - up to 120 mg. Even if the maximum dose is prescribed, it still needs to be taken at one time in the morning.

Like all medications of the sulfonylurea class, Diabeton should be taken half an hour before meals. By drinking it at the exact time indicated by the instructions, the diabetic allows the medication to be absorbed and show its activity with the first spoon of food.

The effectiveness of the selected dosage can also be evaluated at home, with a glucometer.

Compare its indicators before and after meals (after 2 hours). The appropriate dose is calculated individually: according to the glycemic profile and laboratory tests for glycosylated hemoglobin HbA1C. You can combine the use of Diabeton with antidiabetic drugs with a different mechanism of action.

Overdose

Since treatment with Diabeton is dangerous for the development of hypoglycemia, a deliberately increased dose of the medication increases its symptoms several times.

The exact lethal dose of the drug has not been established, but if the symptoms are not eliminated in time, any dose will be fatal.

If you attempt suicide or accidentally overdose, you must:

Comprehensive treatment of type 2 diabetes

Diabeton is often used not only as a single drug, but also in complex therapy. It is compatible with all antidiabetic drugs, except for medications of the mulfonylurea class (they have a similar mechanism of action), as well as new norm: it also activates the synthesis of the hormone, but in a different way.

Diabeton works great in combination with Metformin. In this regard, Russian manufacturers have even developed a combination medicine, Glimekomb, containing 40 g of gliclazide and 500 mg of metformin.

The use of such a medicine is characterized by a good increase in compliance (compliance by a diabetic with the prescribed medication regimen). Glimecomb is taken in the morning and evening immediately before or after meals. Side effects of the drug are also common to metformin and gliclazide.

Drug interactions

There are many medications that increase the risk of hypoglycemia when used in parallel with Diabeton. The doctor should be especially careful when prescribing acarbose, metformin, thiazolidinediones, DPP-4 inhibitors, GLP-1 agonists, and insulin with Diabeton.

Many medications that are prescribed to hypertensive patients also enhance the potential of diabetes. The doctor should remember beta-blockers, ACE and MAO inhibitors, fluconazole, sulfonamides, histamine H2 receptor blockers, clarithromycin.

A complete list of drugs that enhance or weaken the activity of the main ingredient of the formula can be found in the original instructions. Even before prescribing Diabeton, it is important for a diabetic to inform his doctor about the medications, dietary supplements, and herbal teas that he is taking.

It is worthwhile to understand the intricacies of your illness and its treatment yourself, since conscious motivation in such cases is a great thing.

What do diabetics think about Diabetes?

Reviews from diabetics about Diabeton are mixed: it helps control sugar, but many could not avoid undesirable consequences. Gliclazide modified-release tablets are more easily tolerated. And side effects are more often observed in diabetics who regularly take Diabeton for several years.

Dmitry, 64 years old. I didn’t know that it was necessary to take into account the interaction of the medication with anticoagulants, since they enhance each other’s capabilities. For now I’m taking Diabeton MV half a tablet, and my sugar levels have been within normal limits for three years.

Lisa, 44 years old. Taking Diabeton increased my digestive problems: heartburn, a feeling of a full stomach and a bloated abdomen. I try to control the glycemic index of foods, as I am very afraid of hypoglycemia.