Antipyretics for children are prescribed by a pediatrician. But there are emergency situations for fever when the child needs to be given medicine immediately. Then the parents take responsibility and use antipyretic drugs. What is allowed to give to infants? How can you bring down the temperature in older children? What medicines are the safest?
Ofloxacin - an antibacterial drug second generation from the group of fluoroquinolones. Pharmacological agents This group is an alternative to broad-spectrum antibiotics.
Due to the structure and mechanism of action, the drug has a high bactericidal activity against gram-negative and gram-positive microorganisms.
The main advantage of Ofloxacin is that it is effective in deactivating microflora, resistant to other antibiotics.
The use of Ofloxacin
The antibiotic has been successfully used to treat various diseases. The drug is used to treat infectious diseases of the respiratory tract(including pneumonia, bronchitis). The drug is widely used in otorhinolaryngology for the treatment of sinusitis, pharyngitis, otitis, laryngitis, tracheitis.
Photo 1. Packing of the drug Ofloxacin in the form of tablets with a dosage of 200 mg. Producer "Darnitsa".
At infectious diseases of the skin(for example, with furunculosis, carbunculosis, phlegmon), the drug shows high efficiency. Ofloxacin copes with the treatment of infections of the osteoarticular apparatus, gastrointestinal tract, small pelvis (for example, salpingitis, oophoritis).
Antibiotic used in nephrology and urology for the treatment of pyelonephritis, cystitis, urethritis. Among the pathologies of the venereological profile, the drug is used to treat gonorrhea, chlamydia. An antibacterial drug is prescribed to prevent the development of infectious pathologies. with immunodeficiencies(including HIV).
In ophthalmic practice the drug shows high efficiency in the fight against conjunctivitis, keratitis, blepharitis, iritis, complications after traumatization of the organ of vision.
Reference. An antibacterial drug is used to treat tuberculosis in combination with other drugs.
Contraindications
Ofloxacin has some contraindications for use:
- epileptic status;
- function pathologies nervous system(meningitis, encephalitis in history);
- state of pregnancy;
- fermentopathy of glucose-6-phosphate dehydrogenase.
The drug is contraindicated in children under 18 years old, since the growth of the skeleton has not yet been completed by this point. Patients diagnosed with atherosclerosis of the cerebral arteries, circulatory disorders of the brain, chronic illness kidneys should limit the prescription of the antibiotic to the minimum dosage.
Side effects
From the gastrointestinal tract, the following adverse reactions may occur:
- state anorexia;
- feeling nausea;
- defecation disorders(usually in the form of diarrhea);
- bloating;
- pain in the abdominal region;
- hyperactivity of liver enzymes;
- excess bilirubin;
- development jaundice due to cholestasis.
From the side of the central nervous system, the following adverse reactions may occur:
- cephalgia;
- convulsive jitter;
- dizziness;
- difficulty in movement;
- feeling numbness in the limbs;
- increased anxiety;
- depressive disorders;
- feeling double vision;
- changes taste perception.
On the part of the musculoskeletal system, the following adverse reactions may occur:
- muscle pain;
- joint pain;
- inflammation synovial sheaths and tendons.
From the side of the cardiovascular system, the following adverse reactions may occur:
- inflammation vessels;
- increase the frequency of myocardial contractions;
- significant depressurization up to collapse.
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From the side of the skin, the following adverse reactions may occur:
- petechial hemorrhages;
- dermatitis;
- rash in the form of papules;
- inflammation vessels.
From the side of the hematopoietic system, the following adverse reactions may occur:
- decrease in leukocytes;
- development agranulocytosis;
- development anemia;
- decrease in platelets;
- decrease in the work of all hematopoietic sprouts.
From the urinary system, the following adverse reactions may occur:
- sharp jade;
- violation kidney activity;
- increased creatinine in blood;
- excess content urea.
Possible manifestation of allergic diseases in the form of:
- urticaria;
- angioedema;
- skin rash;
- allergic pneumonitis;
- allergic jade;
- anaphylaxis(rarely).
Compound
One tablet of an antibacterial agent consists of 400 mg ofloxacin as an active ingredient, corn starch, cellulose, talc, povidone, calcium stearate, aerosil.
Levofloxacin
Levofloxacin - synthetic antibiotic fluoroquinolone. The active substance of the drug is isomeric analogue ofloxacin.
Compound
One Levofloxacin tablet contains 250 mg levofloxacin hemihydrate.
Photo 2. Packages of Levofloxacin in the form of tablets with a dosage of 250 and 500 mg. Producer "Dalhimfarm".
Indications
Indications for the use of Levofloxacin are infectious diseases caused by sensitive microflora:
- acute sinusitis;
- chronic bronchitis in the acute stage;
- pneumonia;
- urinary tract infections;
- prostatitis;
- infectious lesions skin;
- infections of the gastrointestinal tract.
Contraindications
Among the contraindications are: hypersensitivity to fluoroquinolones, status epilepticus, renal insufficiency, pregnancy and lactation.
A drug contraindicated children and adolescents.
Side effects
From the gastrointestinal tract there may be such adverse reactions as changes in the act of defecation (in the form of diarrhea), flatulence, pain of an abdominal nature. These effects are rare and appear in 1% cases.
From the side of the central nervous system may be side effects, as cephalgic pains, patients sometimes feel dizzy, the cycle of sleep and wakefulness is disturbed.
Fatigue appears, work capacity and stress resistance decrease.
From the musculoskeletal system pain of muscular and articular origin may be noted. Pain syndrome of this nature is subjectively felt by a person as an ache in the body.
Negative Effects from the side of cardio-vascular system manifest themselves infrequently and are expressed in inflammation of the vessels, an increase in the frequency of myocardial contractions, a significant decrease in pressure up to collapse.
From the side of the skin the appearance of petechial hemorrhages, dermatitis, rash in the form of papules, inflammation of the vessels is possible.
Rarely occur allergic diseases in the form of urticaria and skin rash. Very rarely seen anaphylaxis And angioedema.
Important! Levofloxacin is widely used in phthisiology for the treatment of tuberculosis. It is a reserve medicine, it is used only if the strain of Koch's bacillus is highly resistant to other drugs.
Levofloxacin or Ofloxacin: which is better
The activity of Levofloxacin against microorganisms twice as much than ofloxacin. The half-life of a substance from the body lasts about 6 hours, and Ofloxacin - around 5.
The drugs differ in dosages. In order to treat infectious pathologies of the respiratory tract, it is prescribed. For the treatment of a similar pathology, 500 mg Levofloxacin once a day. This creates a concentration of Levofloxacin 2.5 times more than ofloxacin.
Ciprofloxacin
Ciprofloxacin is an antimicrobial drug with a wide spectrum of effects, also belongs to fluoroquinols. Medication has a bactericidal effect.
Compound
One antibiotic tablet contains 250 mg ciprofloxacin as active ingredient. The list of excipients consists of cellulose, hypromellose, croscarmellose, polysorbate, stearate.
Photo 3. Packing Ciprofloxacin in the form of tablets with a dosage of 500 mg. Produced by Actavis.
Indications
The indications for prescribing the drug are infectious pathologies various systems:
- respiratory tract;
- ENT organs;
- urinary system;
- reproductive system;
- gastrointestinal tract;
- skin;
- musculoskeletal system.
The drug is used to prevent infections with immunodeficiencies.
Contraindications
Contraindications include high sensitization to drugs of the fluoroquinolone group. The drug should not be used to treat patients in status epilepticus. Insufficiency of kidney and liver function makes taking Ciprofloxacin unacceptable.
Attention! During gestation and lactation It is strictly forbidden to take any drugs from the group of fluoroquinolones.
The drug is contraindicated in children and adolescents. For older people, there is a high risk of kidney disease while taking an antibiotic.
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Side effects
Patients Ciprofloxacin is most often tolerated without adverse effects. Allergic manifestations (sensation of itching, rashes) are rarely noted, it rarely develops angioedema.
Photo 4. Quincke's edema in a woman. In some cases, it can cause suffocation.
Appetite may disappear, pain in the epigastrium, diarrhea, and malaise may be felt. Sometimes sleep is disturbed, cephalgic syndrome develops. The perception of taste and smell properties may be disturbed.
Important! Ciprofloxacin is successfully used by phthisiatricians for the treatment of tuberculosis. Being a remedy from the reserve group, the antibiotic shows a high effect against resistant colonies of tuberculosis bacteria.
Differences between Ciprofloxacin and Ofloxacin
Ciprofloxacin is a first-generation fluoroquinolone drug. Unlike Ofloxacin, its spectrum of action more narrow, because more bacteria are resistant to it. Ciprofloxacin and Ofloxacin are similar in mechanism of action and structure, but have a number of differences. The activity of Ciprofloxacin against microorganisms exceeds that of Ofloxacin.
The drugs differ from each other in effective doses. For the purpose of treatment infectious diseases respiratory system appointed 200 mg ofloxacin twice a day. For the treatment of a similar pathology, 400 mg ciprofloxacin once a day. Ciprofloxacin has fewer side effects than ofloxacin.
Ofloxin and Ofloxacin: is it the same or is there any difference?
In order to find out if there is a difference in the drugs Ofloxin and Ofloxacin, it is necessary to analyze their composition, compare contraindications and side effects of antibiotics.
Compound
Ofloxin is an analogue of Ofloxacin. The composition as an active substance includes 200 mg ofloxacin. Excipients: corn starch, cellulose, talc, povidone, calcium stearate, aerosil.
Photo 5. Packing of Ofloxin in the form of tablets with a dosage of 400 mg. Produced by Zentiva.
Application
Medicine used in the treatment of:
- respiratory tract infections (including pneumonia, bronchitis);
- otorhinolaryngological diseases (sinusitis, pharyngitis, otitis media, laryngitis, tracheitis);
- infections of the skin (for example, with furunculosis, carbunculosis, phlegmon);
- diseases of the osteoarticular apparatus;
- ailments of the gastrointestinal tract;
- pelvic infections (eg, salpingitis, oophoritis);
- urological pathologies (pyelonephritis, cystitis, urethritis);
- venereal infections (gonorrhea, chlamydia).
Contraindications
Epilepsy and high sensitization to quinolones - contraindications for use Ofloksina.
It is forbidden to prescribe an antibiotic to pregnant women, as well as women in the lactation period.
In case of impaired renal function, the usual dosages are prescribed at the beginning of therapy, and later they are reduced, taking into account creatinine clearance values.
Side effects
Adverse reactions appear in the form dyspeptic disorders, appetite disappears, epigastric pains, diarrhea are noted. The concentration of bilirubin in the blood plasma increases. Anemia may develop with increased fatigue, the appearance of apathy.
The reaction rate slows down during complex work. Sleep is disturbed, dizzy, extremely rarely there can be hallucinations.
Ofloxin and Ofloxacin - complete structural analogues, and there are no differences between them.
Drug Comparison: Rational Choice of Fluoroquinolone Antibiotics
Ofloxacin and Ofloxin are the same medicine. Levofloxacin is an isomer of Ofloxacin and differs from the latter in a number of properties. To achieve the effect, a lower dose of the drug is needed, so the choice of Levofloxacin preferred.
Ciprofloxacin is a first generation fluoroquinolone less efficient to use than Ofloxacin and Levofloxacin, since a greater number of microorganisms managed to form resistance to it. For tuberculosis and severe infectious pathologies Odnoklassniki shows the highest effect
Thank you
The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!
medicinal product Levofloxacin represents antibiotic wide spectrum of action. This means that the drug has a detrimental effect on a wide range of pathogenic and opportunistic microorganisms that are the causative agents of infectious and inflammatory processes. Since each infectious and inflammatory pathology is caused by certain types of microbes and is localized in specific organs or systems, antibiotics that are detrimental to this group of microorganisms are most effective in treating the diseases they cause in the same organs.Thus, the antibiotic Levofloxacin is effective for the treatment of infectious diseases. inflammatory diseases ENT organs (for example, sinusitis, otitis), respiratory tract(eg bronchitis or pneumonia), urinary organs (eg pyelonephritis), genital organs (eg prostatitis, chlamydia) or soft tissues (eg abscesses, boils).
Release form
To date, the antibiotic Levofloxacin is available in the following dosage forms Oh:1. Tablets 250 mg and 500 mg.
2. Eye drops 0.5%.
3. Solution for infusion 0.5%.
Levofloxacin tablets, depending on the content of the antibiotic, are often referred to as "Levofloxacin 250" and "Levofloxacin 500", where the numbers 250 and 500 show the amount of their own antibacterial component. They are yellow in color and have a round biconvex shape. On the section of the tablet, two layers can be clearly distinguished. Tablets of 250 mg and 500 mg are available in packs of 5 or 10 pieces.
Eye drops are a homogeneous solution, transparent, practically uncolored. Produced in bottles of 5 ml or 10 ml, equipped with a cap of a special design in the form of a dropper.
The solution for infusion is available in 100 ml bottles. One milliliter of the solution contains 5 mg of the antibiotic. A full bottle of solution for infusion (100 ml) contains 500 mg of an antibiotic intended for intravenous administration.
Levofloxacin - group
According to the type of action, Levofloxacin belongs to bactericidal drugs. This means that the antibiotic kills pathogens by acting on them at any stage. But bacteriostatic antibiotics can only stop the reproduction of bacteria, that is, they can only affect dividing cells. It is precisely because of the bactericidal type of action that Levofloxacin is a very powerful antibiotic that destroys both growing, resting, and dividing cells.According to the mechanism of action, Levofloxacin belongs to the group systemic quinolones, or fluoroquinolones. Group antibacterial agents, belonging to systemic quinolones, is used very widely, because it has high efficiency and a wide spectrum of action. Systemic quinolones, in addition to Levofloxacin, include such well-known drugs as Ciprofloxacin, Lomefloxacin, etc. All fluoroquinolones disrupt the process of synthesis of the genetic material of microorganisms, preventing them from multiplying, and thereby leading to their death.
Levofloxacin - manufacturer
Levofloxacin is produced by various pharmaceutical concerns, both domestic and foreign. In the domestic pharmaceutical market, Levofloxacin preparations from the following manufacturers are most often sold:- CJSC "Vertex";
- RUE "Belmedpreparaty";
- CJSC "Tavanik";
- Concern Teva;
- JSC "Nizhpharm", etc.
Doses and composition
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Eye drops and solution for infusion as auxiliary components contain the following substances:
- sodium chloride;
- disodium edetate dihydrate;
- deionized water.
- microcrystalline cellulose;
- hypromellose;
- primellose;
- calcium stearate;
- macrogol;
- titanium dioxide;
- iron oxide yellow.
Spectrum of action and therapeutic effects
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Levofloxacin destroys pathogenic bacteria that cause inflammation in various organs. As a result, the cause of inflammation is eliminated, and as a result of the use of an antibiotic, recovery occurs. Levofloxacin is able to cure inflammation in any organ caused by susceptible microorganisms. That is, if cystitis, pyelonephritis or bronchitis is caused by bacteria that Levofloxacin has a detrimental effect on, then all these inflammations in different bodies can be treated with antibiotics.
Levofloxacin has a detrimental effect on a wide range of gram-positive, gram-negative and anaerobic microbes, a list of which is presented in the table:
Gram-positive bacteria | Gram-negative bacteria | anaerobic bacteria | Protozoa |
Corynebacterium diphtheriae | Actinobacillus actinomycetemcomitans | Bacteroides fragilis | Mycobacterium spp. |
Enterococcus faecalis | Acinetobacter spp. | Bifidobacterium spp. | Bartonella spp. |
Staphylococcus spp. | Bordetella pertussis | Clostridium perfringens | Legionella spp. |
Streptococci pyogenic, agalactose and pneumonia, groups C, G | Enterobacter spp. | Fusobacterium spp. | Chlamydia pneumoniae, psittaci, trachomatis |
Virids from the group of streptococci | Citrobacter freundii, diversus | Peptostreptococcus | Mycoplasma pneumoniae |
Eikenella corrodens | Propionibacterium spp. | Rickettsia spp. | |
Escherichia coli | Veillonella spp. | Ureaplasma urealyticum | |
Gardnerella vaginalis | |||
Haemophilus ducreyi, influenzae, parainfluenzae | |||
Helicobacter pylori | |||
Klebsiella spp. | |||
Moraxella catarrhalis | |||
Morganella morganii | |||
Neisseria meningitidis | |||
Pasteurella spp. | |||
Proteus mirabilis, vulgaris | |||
Providence spp. | |||
Pseudomonas spp. | |||
Salmonella spp. |
Indications for use
Eye drops are used for a narrow range of inflammatory diseases that are associated with the visual analyzer. And tablets and solution for infusions are used for a wide range of infectious and inflammatory diseases. various bodies and systems. Levofloxacin can be used to treat any infection caused by microorganisms that the antibiotic has a detrimental effect on. Indications for the use of drops, solution and tablets for convenience are shown in the table:Indications for use eye drops | Indications for the use of tablets | Indications for use of solution for infusion |
Superficial eye infections of bacterial origin | Sinusitis | Sepsis (blood poisoning) |
Otitis media | anthrax | |
Exacerbations of chronic bronchitis | Tuberculosis resistant to other antibiotics | |
Pneumonia | Complicated prostatitis | |
Urinary tract infections (pyelonephritis, cystitis, etc.) | Complicated pneumonia with the release of a large number of bacteria into the blood | |
Genital infections, including chlamydia | ||
Acute or chronic prostatitis of bacterial origin | panniculitis | |
Atheroma | Impetigo | |
Abscesses | pyoderma | |
Furuncles | ||
Intra-abdominal infection |
Levofloxacin - instructions for use
Features of the use of tablets, drops and solution are different, so it would be advisable to consider the intricacies of using each dosage form separately.Levofloxacin tablets (500 and 250)
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The duration of the course of treatment with Levofloxacin tablets and dosage depend on the severity of the infection and its nature. So, the following courses and dosages of the drug are recommended for the treatment of various diseases:
- Sinusitis - take 500 mg (1 tablet) 1 time per day for 10-14 days.
- Exacerbation of chronic bronchitis - take 250 mg (1 tablet) or 500 mg (1 tablet) 1 time per day for 7 to 10 days.
- Pneumonia - take 500 mg (1 tablet) 2 times a day for 1 to 2 weeks.
- Infections of the skin and soft tissues (boils, abscesses, pyoderma, etc.) - take 500 mg (1 tablet) 2 times a day for 1-2 weeks.
- Complicated urinary tract infections (pyelonephritis, urethritis, cystitis, etc.) - take 500 mg (1 tablet) 2 times a day for 3 days.
- Uncomplicated urinary tract infections - take 250 mg (1 tablet) 1 time per day for 7 to 10 days.
- Prostatitis - take 500 mg (1 tablet) 1 time per day for 4 weeks.
- Intra-abdominal infection - take 500 mg (1 tablet) 1 time per day for 10-14 days.
- Sepsis - take 500 mg (1 tablet) 2 times a day for 10-14 days.
Solution for infusion Levofloxacin
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Levofloxacin can be combined with the following infusion solutions:
1.
saline.
2.
5% dextrose solution.
3.
2.5% Ringer's solution with dextrose.
4.
solutions for parenteral nutrition.
The duration of intravenous antibiotic use should not exceed 2 weeks. It is recommended to administer Levofloxacin all the time while the person is sick, plus two more days after the temperature returns to normal.
Dosages and duration of use of Levofloxacin infusion solution for the treatment of various pathologies are as follows:
- Acute sinusitis- administer 500 mg (1 bottle of 100 ml) 1 time per day for 10-14 days.
- Exacerbation of chronic bronchitis - administer 500 mg (1 bottle of 100 ml) 1 time per day for 7-10 days.
- Pneumonia
- Prostatitis- administer 500 mg (1 bottle of 100 ml) 1 time per day for 2 weeks. Then they switch to taking 500 mg tablets once a day for another 2 weeks.
- Acute pyelonephritis - administer 500 mg (1 bottle of 100 ml) 1 time per day for 3-10 days.
- Biliary tract infections - administer 500 mg (1 bottle of 100 ml) 1 time per day.
- Skin infections- administer 500 mg (1 bottle of 100 ml) 2 times a day for 1 to 2 weeks.
- Anthrax - administer 500 mg (1 bottle of 100 ml) 1 time per day. After stabilization of the person's condition, transfer to taking Levofloxacin tablets. Take 500 mg tablets once a day for 8 weeks.
- Sepsis- administer 500 mg (1 bottle of 100 ml) 1-2 times a day for 1-2 weeks.
- Abdominal infection - administer 500 mg (1 bottle of 100 ml) 1 time per day for 1 to 2 weeks.
- Tuberculosis - administer 500 mg (1 bottle of 100 ml) 1-2 times a day for 3 months.
Tablets and solution
The following features and recommendations for the use of Levofloxacin apply to tablets and solution for infusion.Reception of Levofloxacin should not be stopped in advance, and the next dose of the drug should be skipped. Therefore, if you miss another tablet or infusion, you should immediately take it, and then continue using Levofloxacin in the recommended regimen.
People suffering from severe renal impairment, in which CC is less than 50 ml / min, you need to take the drug according to a certain scheme during the entire course of treatment. Levofloxacin is taken, depending on the QC, according to the following schemes:
1.
CC above 20 ml / min and below 50 ml / min - the first dosage is 250 or 500 mg, then take half of the primary, that is, 125 mg or 250 mg every 24 hours.
2.
CC above 10 ml / min and below 19 ml / min - the first dosage is 250 mg or 500 mg, then take half of the primary, that is, 125 mg or 250 mg once every 48 hours.
In rare cases, Levofloxacin can lead to inflammation of the tendons - tendinitis, which is fraught with ruptures. If tendinitis is suspected, the use of the drug should be discontinued, and therapy of the inflamed tendon should be started urgently.
Levofloxacin can lead to hemolysis of red blood cells in people suffering from hereditary deficiency of glucose-6-phosphate dehydrogenase. Therefore, antibiotics should be used in this category of patients with caution, constantly monitoring bilirubin and hemoglobin.
The antibiotic negatively affects the speed of psychomotor reactions, as well as concentration. Therefore, during treatment with Levofloxacin, all activities that require a good concentration of attention and a high speed of reactions, including driving a car or servicing various mechanisms, should be abandoned.
Overdose
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- confused mind;
- dizziness;
- nausea;
- erosion of the mucous membranes;
- changes on the cardiogram.
Interaction with other drugs
The combined use of Levofloxacin with Fenbufen, non-steroidal anti-inflammatory drugs (for example, Aspirin, Paracetamol, Ibuprofen, Nimesulide, etc.) and theophylline enhances the readiness of the central nervous system for convulsions.The effectiveness of Levofloxacin is reduced when used simultaneously with Sucralfate, antacids (for example, Almagel, Renia, Phosphalugel, etc.) and iron salts. In order to neutralize the effect of the listed drugs on Levofloxacin, their intake should be separated by 2 hours.
The combined use of Levofloxacin and glucocorticoids (for example, hydrocortisone, prednisolone, methylprednisolone, dexamethasone, betamethasone, etc.) leads to an increased risk of tendon ruptures.
Reception alcoholic beverages together with Levofloxacin leads to an increase in side effects developing from the central nervous system (dizziness, drowsiness, visual impairment, loss of concentration and weak reaction).
Eye drops Levofloxacin
Drops are used exclusively locally for the treatment of inflammation of the outer membranes of the eye. In this case, adhere to the following scheme for the use of antibiotics:1. During the first two days, apply 1-2 drops into the eye every two hours, during the entire period of wakefulness. You can bury your eyes up to 8 times a day.
2. From the third to the fifth day, apply 1-2 drops to the eyes 4 times a day.
Levofloxacin drops are used for 5 days.
Levofloxacin for children
Levofloxacin should not be used to treat various pathological conditions in children and adolescents under 18 years of age, since the antibiotic adversely affects cartilage tissue. During the period of active growth of children, the use of Levofloxacin can provoke a lesion articular cartilage, which is fraught with violations of the normal functioning of the joints.Application for the treatment of ureaplasma
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So, for the treatment of ureaplasmosis, uncomplicated by other pathologies, it is enough to take Levofloxacin in tablets of 250 mg 1 time per day for 3 days. If the infectious process is delayed, then the antibiotic is taken at 250 mg (1 tablet) 1 time per day, for 7 to 10 days.
Treatment of prostatitis
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In severe prostatitis, it is better to start therapy with an antibiotic infusion of 500 mg (1 bottle of 100 ml) 1 time per day. Intravenous administration of Levofloxacin is continued for 7-10 days. After that, it is necessary to switch to taking an antibiotic in tablets, which they drink 500 mg (1 piece) 1 time per day. Tablets should be taken for another 18 to 21 days. The total course of treatment with Levofloxacin should be 28 days. Therefore, after several days of intravenous administration of the antibiotic, the rest of the time up to 28 days, you need to drink tablets.
Prostatitis can only be treated with Levofloxacin tablets. In this case, the man should take the drug 500 mg (1 tablet) 1 time per day for 4 weeks.
Levofloxacin and alcohol
Alcohol and Levofloxacin are incompatible with each other. During the treatment period, you should stop drinking alcoholic beverages. If a person needs to drink a certain amount of alcohol, then it should be borne in mind that Levofloxacin will increase the effect of drinks on the central nervous system, that is, intoxication will be stronger than usual. The antibiotic aggravates the dizziness, nausea, confusion, reaction rate and concentration impairment caused by alcohol.Contraindications
Tablets and solutions for infusion Levofloxacin- hypersensitivity, allergy or intolerance to the components of the drug, including levofloxacin or other quinolones;
- renal failure with CC less than 20 ml / min;
- the presence of inflammation of the tendon in the past in the treatment of any drugs from the group of quinolones;
- age under 18;
- pregnancy;
- breast-feeding.
Relative contraindications to the use of Levofloxacin tablets and solution are severe renal dysfunction and deficiency of glucose-6-phosphate dehydrogenase. in such cases, the drug should be taken under close medical supervision of the person's condition.
Eye drops Levofloxacin contraindicated for use in the following cases:
- sensitivity or allergy to any drugs from the quinolone group;
- age less than 1 year.
Side effects
Side effects of Levofloxacin are quite numerous, and they develop from various organs and systems. All side effects of the antibiotic are divided according to the frequency of development:1. Often - observed in 1 - 10 people out of 100.
2. Sometimes - observed in less than 1 person out of 100.
3. Rare - occurs in less than 1 in 1,000 people.
4. Very rare - occurs in less than 1 in 1,000 people.
All side effects of tablets and solution for infusion, depending on the frequency of occurrence, are shown in the table:
often | Side effects encountered Sometimes | Side effects encountered rarely | Side effects encountered very rarely | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Diarrhea | Itching | Anaphylactic reactions | Edema on the face and throat | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Nausea | Skin redness | Hives | Shock | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Increased activity of liver enzymes (AST, ALT) | Loss of appetite | Bronchospasm, up to severe suffocation | A sharp drop in blood pressure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Digestive disorders (belching, heartburn, etc.) | Diarrhea with some blood | Increased sensitivity to sunlight and ultraviolet light | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Vomit | Exacerbation of porphyria | Pneumonitis | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Stomach ache | Anxiety | Vasculitis | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Headache | body shaking | blisters on the skin | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
dizziness | Paresthesias on the hands (sensation of "goosebumps") | Toxic epidermal necrolysis | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
torpor | hallucinations | Exudative erythema multiforme | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Drowsiness | Depression | Decrease in blood glucose concentration | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sleep disorders | Excitation | visual impairment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
An increase in the number of blood eosinophils | convulsions | taste disorder | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Decrease in the total number of blood leukocytes | Confused mind | Decreased ability to distinguish odors | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
General weakness | heartbeat | Decreased tactile sensitivity (sensation of touch) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
pressure drop | Vascular collapse | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Tendinitis | tendon rupture | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Pain in the muscles | muscle weakness | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
, as well as increased reproduction headache ; Levofloxacin - synonyms![]() Levofloxacin eye drops have the following synonymous drugs:
Levofloxacin tablets and solution for infusions have the following synonyms in the domestic pharmaceutical market:
AnaloguesAnalogues of Levofloxacin are drugs that contain as an active ingredient another antibiotic with a similar spectrum of antibacterial activity. For convenience, analogues of eye drops, tablets and infusion solution are shown in the table:
According to the latest medical statistics, the spread of prostatitis and its forms has recently begun to increase. The reasons for this situation can be called a lot of factors, among which, the main place is occupied by the unsatisfactory attitude of a man to his health, poor ecology, poor-quality food, etc. Therefore, it is not surprising how seriously pharmacologists have to work to offer patients the latest and most effective drugs for the treatment of prostatitis. Among them, there is also Levofloxacin - an antibiotic of the latest generation, with a wide spectrum of action. This type of drug, like Amoxiclav, belongs to antibiotics with a wide spectrum of action and is ideal for the systemic treatment of various diseases, including prostatitis (acute, chronic, bacterial). The release form of the drug is tablets or solutions for injection. Any form of the drug is quickly absorbed into the blood, affects the body on cellular level, and the directed action of the agent allows you to effectively kill entire colonies of harmful microorganisms. For people suffering from infectious and bacterial diseases, it will be much cheaper to purchase such a medication than to buy other synonyms and an antibiotic substitute, which also have side effects and contraindications. Levofloxacin analogues have the following properties:
It is important to know Before taking the medicine, you should read all the information that the instructions for taking the drug offer you. Like any other antibiotic, domestic or imported, Levofloxacin can cause side effects and individual intolerance. Today you can choose not only Levofloxacin, analogues of this drug, similar in composition, action and form of release, are presented on the market in large quantities. Tavanik- the same effective antibiotic that is prescribed for a variety of diseases. It is characterized by a high degree medicinal activity and impact on groups of harmful microorganisms, its use allows you to get positive results of treatment in the shortest possible time of therapy. The price of the product depends on the form of release: tablets can be bought from 600 rubles, an injection solution will cost you 1620 rubles. Ciprofloxacin refers to active antibiotics with a wide spectrum of action. Used to treat infectious diseases internal organs and tissues, in particular, the genitourinary system. The drug is produced in various forms, for example, these are eye drops, suspensions and solutions for injections, tablets and capsules. The cost of an antibiotic is low, from 18 rubles, and any pharmacy can offer you this drug. Along with the above Russian counterparts, there are also foreign analogues of Levofloxacin on the market that can defeat any infectious disease. Elefloks, produced by an Indian pharmaceutical company, is actively used to treat various forms of prostatitis, inhibits the activity of harmful microorganisms. Applied in systemic treatment, in which the disease is quickly treatable. Glevo- a product of Indian pharmacology, with a wide spectrum of action, excellent for the treatment of all forms of prostatitis. Levofloxacin belongs to the group of fluoroquinols. To the same group with the active substance levofloxacin belong:
All antibiotics of this group are very effective in the treatment of prostatitis. Therefore, your choice of a drug can only be influenced by your individual intolerance to the components of one of them, the severity of the disease, in which it is necessary to use complex treatment, in which not all antibiotics may be compatible with other drugs. All drugs have detailed instructions, after reading which, you will find out what side effect can be expected, what contraindication in your case, may affect the choice of remedy. Tavanic or Levofloxacin which is better?
The drug Levofloxacin has an active effect on various areas of tissues affected by harmful microorganisms, and it acts directly at the cellular level, which speeds up treatment and gives positive results. With prostatitis, different groups of bacteria can be present in the body that affect the organ and disease-causing: anaerobic gram-positive and gram-negative, simple microorganisms and chlamydia. With all these "pests" the drug fights very effectively. Tavanic is an antibiotic of the latest generation with high rates of effectiveness in the treatment of diseases of various internal organs, bone tissue. The active substance in the drug is levofloxacin, the auxiliary ones are crospovidone, cellulose, titanium dioxide, macrogol 8000, iron oxide red and yellow. When taking the drug, its concentration in the blood lasts for a rather long period. The antibacterial drug gives the fastest and most positive results in the treatment of various forms of prostatitis, ranging from mild to chronic, as it affects tissue cells, their membranes and walls. It is especially effective in complex treatment, because. its active and active component, levofloxacin, interacts well with other drugs. note If we compare Tavanic or Levofloxacin, which is better, then the first drug has fewer side effects and has a faster action and the spectrum of its effects is much wider. Comparing the cost of drugs, it can be noted that you can buy Levofloxacin at a price of 77 rubles, and Tavanic - from 590 rubles. Most often, when the doctor has prescribed a course of treatment with this drug, the patient is prescribed 2 doses. The average daily dose of the drug at each dose is from 500 ml to 1 g, depending on the form of the disease, the prostate gland is in. If injections are prescribed, then the daily dose of liquid is from 250 to 500 ml, depending on the severity of the disease. The medicine is taken regardless of the meal, because. mucosa quickly absorbs the substances of the drug. It is important to know With mild forms of prostatitis, as well as with diseases that affect the bronchi, the course of treatment can be from 14 to 28 days. In this case, the daily dose is from 500 ml to 1 g. To decide whether Tavanic or Levofloxacin is better, the attending physician will help you, who will select the optimal antimicrobial drug for effective therapy. Levofloxacin or Ciprofloxacin: a comparative evaluation of drugsThe drug has a wide spectrum of action, inhibits the vital activity of various microorganisms, quickly penetrates into the bloodstream, is distributed throughout the tissues of the body, and any infection is amenable to such therapy. The doctor prescribes the drug, which calculates the daily dose of the drug. The course of treatment can be from 1 to 4 weeks, depending on the degree of the disease. If we consider Levofloxacin and Ciprofloxacin, the difference lies in the fact that the first is more effective, it can interact with other drugs, while Ciprofloxacin, under the influence of other drugs, can reduce its concentration and activity, which delays the course of treatment. Both medicines, Levofloxacin and Ciprofloxacin, are antibiotics that should only be taken on the advice of a doctor, who considers each clinical case on an individual basis. The main difference between the two antibiotics is the active substance: in the first preparation it is levofloxacin, and in the second it is ofloxacin. Under the action of Ofloxacin, not all groups of bacteria can be destroyed, since microorganisms have a different degree of sensitivity to ofloxacin, so the treatment of prostatitis may be different due to the causes of the disease and the effectiveness of treatment may also differ. Levofloxacin Astrapharm: description of the drug and its distinctive featuresDistinctive features from Levofloxacin Levofloxacin Astrapharm is able to inhibit the activity of gram-positive and gram-negative microbes, while Levofloxacin acts on all groups of bacteria. Most often, Levofloxacin Astrapharm is used for effective treatment bacterial chronic prostatitis. In therapy with Levofloxacin, a positive trend is observed already in the middle of treatment, and this occurs regardless of the form of the disease. If we talk about Levofloxacin Astrapharm blister, then it is more effective in the treatment of mild and moderate forms of prostatitis. Regardless of what choice you make in the treatment of prostatitis, you must remember that only a systemic, well-chosen treatment can give positive dynamics and results. Treatment of inflammation of the prostate gland is carried out in a complex manner. One way is antibiotic therapy. Ciprofloxacin helps in the shortest possible time to destroy the infection that caused prostatitis. Reviews of people who took the drug indicate that the drug is tolerated normally, in many cases there are no side effects if the dosage and duration of administration were not violated. But no matter how effective the drug is, we must not forget that only a doctor can prescribe it! Why the drug is popularProstatitis ranks first among male diseases. Every second representative of the stronger sex is diagnosed with inflammation of the prostate or adenoma. Moreover, the disease is insidious in that it can be asymptomatic. It is imperative to carry out prevention for men who are at risk, namely, with:
Particular attention to their health should be paid to men who have crossed the threshold of the 45th anniversary. Ciprofloxacin is a broad spectrum antibiotic. It is prescribed for the treatment of not only inflammation of the prostate gland, but also multiple pathologies of the genitourinary system caused by bacteria. Most often, an antibacterial agent is used to treat advanced stages of prostate inflammation. Treatment with pills helps to destroy such an infection:
Produced in the form of tablets, solution for injection. The drug contains the main component - ciprofloxacin hydrochloride and additional trace elements. Effective treatment in the complex, for example, tablets, physiotherapy, rectal suppositories, prostate massage. Advantages of Ciprofloxacin:
The action of the drug is based on the cessation of DNA synthesis in the cells that cause prostatitis. Begins to act immediately after taking the first tablet. Another advantage of the active substance of the drug is the suppression of not only active harmful microorganisms, but those in a dormant state. This is especially true during the treatment of inflammation, which may be asymptomatic. Ciprofloxacin has analogues that treat inflammation:
Are there any contraindicationsLike any drug, Ciprofloxacin has contraindications. Being an antibacterial agent, it can cause an allergic reaction. Antibiotic treatment is not prescribed for:
The medicine is prescribed only by a doctor.
In addition, to prescribe the drug, it is necessary to undergo an examination and find out which bacteria caused the inflammation. Self-treatment can lead to complications. The set duration must be respected. Many men, after taking pills for several days and feeling relieved, reducing symptoms, stop taking them. In this case, the infection may still not be completely suppressed, the treatment will be incomplete. Tablets have a prolonged action. Another common mistake is taking twice the dose of medication. Many believe that this will make recovery faster. But this is an absolute fallacy. Nothing but side effects, a person will not get. It is forbidden to take alcohol while taking an antibacterial agent. Ethanol molecules completely stop the action of the components of Ciprofloxacin. The full effect will not come, the infection will not be suppressed. In case of an overdose, the following conditions may occur:
During treatment, in parallel, you need to take drugs that restore the intestinal microflora. The only drawback of an antibiotic is the ability to destroy, along with a pathogenic infection, beneficial bacteria in the body. It is also useful to take fermented milk products to restore the intestinal flora. Take with caution if non-steroidal anti-inflammatory drugs (except acetylsalicylic acid) are prescribed in parallel. In this case, convulsive conditions may develop. Opinion about the drugVladimir, 58 years old, Moscow Recently got sick with prostatitis. I am taking ciprofloxacin. The tablets are well tolerated, without any side effects. Already on the third day, urination was restored, the need to get up at night to go to the toilet disappeared. Alexander 39 years old, St. Petersburg One of the advantages is the inexpensive cost of the drug, but at the same time it is very effective. There is no unpleasant aftertaste. The doctor prescribed during the treatment to take another drug Vitaprost. Natalia, 41 years old, Moscow My husband took these pills for prostatitis. I won't say anything bad. There were no side effects. I recently got sick with cystitis. I was surprised when the doctor also prescribed Ciprofloxacin for me. Symptoms of cystitis disappeared after 2 days. Nikolay, 37 children, Moscow In addition to the fact that the instructions for use can only be read under a magnifying glass, I can’t say anything bad about the drug. Prescription tablets are released. Andrey Ivanovich, 48 years old, urologist, Moscow Oksana, 39 years old, St. Petersburg These tablets are prescribed for diseases of the genitourinary system. My husband was appointed in 2014. I drank, there were no side effects. Eugene, 45 years old, Moscow Before starting the treatment of prostatitis with these pills, I read the reviews and decided to take an allergy test, an antibiotic. There are no allergies, as well as side effects. Dmitry, 41 years old, Moscow Good antibiotic. Helped me with prostatitis. Alexander, 44, Moscow Tell me, can I take these pills with chronic prostatitis? Evgeny Alexandrovich, urologist, Moscow If inflammation occurs against the background of an infection, then the doctor may prescribe Ciprofloxacin, if the etiology is non-infectious, then there is no point in drinking an antibiotic. Prostatitis is a common prostate disease that affects many men around the world. Inflammation of the organ is caused by a number of reasons, which is important to consider when determining the tactics of treatment for each individual patient. The scheme is drawn up on an individual basis and very often do without antibacterial drugs fails.
When is antibiotic treatment indicated? Prostatitis can be caused by bacteria, or it can be non-infectious in nature. In the latter case, the appointment of antibiotics, as a rule, is not required. They should be taken if the prostatitis has an acute or chronic course against the background of bacterial damage to the prostate gland. In this case, the severity of the symptoms does not matter. Often, chronic bacterial prostatitis generally occurs without any signs indicating the presence of inflammation. In addition, the appointment of antibacterial agents may be due to test therapy, even against the background of abacterial inflammation. It is very important to follow all the points of diagnosing prostatitis in order to find out the cause of inflammation, identify the pathogenic agent and determine its individual sensitivity to a particular drug: First stage diagnostic studies. The first stage includes: Blood sampling for clinical analysis. Urine sampling for bacterial culture, for a three-glass sample. Sampling of the urethral epithelium for the detection of STIs by PCR, including chlamydia, mycoplasmosis, gonorrhea, etc. Collection of prostate secretion for a comprehensive study. Ultrasound examination of the prostate. Blood sampling to determine the level of PSA in it, which makes it possible to exclude prostate cancer. The second stage of diagnostic studies: When the content of leukocytes in the prostatic secret does not exceed 25, then testing with the drug Omnic (tamsulosin) is indicated. It is taken for a week, after which the secret is taken for analysis again. The results of the examination determine the type of prostatitis Abacterial prostatitis. When even against the background of taking the drug Omnik, there is no leukocyte jump, and no bacteria are found in the crops, then the inflammation of the prostate gland is defined as non-bacterial. This condition is called pelvic pain syndrome, which requires symptomatic therapy. At the same time, the patient is waiting for the result of tests for tuberculosis, which will be ready in at least 10 weeks. If they are positive, then the patient is placed in an anti-tuberculosis dispensary (in the urological department). Tuberculous prostatitis. You can determine the disease by performing a biopsy of the prostate. The infection most often affects not only the prostate gland, but also the epididymis, urinary system, seminal vesicles. Despite the fact that in Russian Federation tuberculosis acquires an epidemic character, and not only the lungs, but also other organs are affected, the diagnosis of this disease presents certain difficulties. There is also a danger in the fact that special forms of the disease caused by therapy-resistant bacteria are becoming more common. Tuberculosis of the genitourinary system of men often develops latently, without giving acute symptoms. Laboratory research may give a false negative result, especially if a man takes antibiotics for prostatitis from the fluoroquinlone group. Symptoms that may indicate prostate tuberculosis are low-grade fever, aching or burning pains in the perineal region, in the lumbosacral region, and increased fatigue. The age of patients in whom tuberculous prostatitis is most often detected is in the range between 20-40 years. Bacterial infectious prostatitis. In the event that the analysis of the secret of the prostate indicates leukocytosis with an increase in the number of leukocytes of more than 25, and taking Omnik makes this figure higher, then it makes sense to talk about bacterial or latent infectious prostatitis. Antibacterial therapy in this case is carried out without fail. The PCR method allows a day later to identify the existing pathogens of a sexual infection, so the doctor will be able to recommend taking this or that drug at the next visit. The drug of choice remains the agent for which the established flora has maximum sensitivity, or an antibiotic is prescribed that is active against most pathogenic agents. If there is no effect from the ongoing treatment, then it is necessary to wait for the result of bacteriological seeding, which makes it possible to more accurately determine the choice of remedy. What antibiotics are most effective for prostatitis? It is impossible to determine any specific antibiotic for bacterial prostatitis that would help all men without exception in the treatment. It all depends on the sensitivity of the microbes that caused the disease in each case.
If specific bacteria are not detected, then medication is recommended based on culture of prostate secretion. There, nonspecific streptococci and staphylococci are most often detected. Treatment involves an integrated approach and does not last for 30-60 days: An antibiotic is prescribed. NSAIDs are indicated. You should take funds aimed at normalizing blood circulation. Immunostimulating therapy is carried out. Vitamin complexes or monovitamins are prescribed. In some cases, phytotherapy is prescribed. Thermal microwave therapy, prostate massage can be performed only when tuberculosis is excluded. Otherwise, the disease may worsen, which will worsen the patient's condition. Sedative drugs, antidepressants are recommended for men with chronic prostatitis against the background of the development of depressive moods, with a deterioration in the quality of life. In this case, psychotropic drugs are auxiliary. Depending on which pathogen is identified, one or another antibiotic for prostatitis is selected. The sensitivity of pathogenic microorganisms to antibacterial drugs is presented in the table:
It should not be excluded that the cause of the development of inflammation of the prostate gland are mycotic microorganisms. Therefore, in complex therapy possible appointment the following drugs: Safocid, Fluconazole, Azithromycin and Secnidazole.
List of antibiotics for prostatitis: pros and cons Preparations from the group of fluoroquinolones are prescribed by modern practicing urologists more often than others. They show high efficiency in the treatment of chronic bacterial prostatitis, however, they can have a negative impact on the functioning of the brain, cause mental disorders, and reduce the resistance of skin cells to ultraviolet radiation. Before starting treatment with fluoroquinolones, it is necessary to make sure that the Koch stick is absent in the body. Medicines of this group are used to treat tuberculosis, but it should be complex with the inclusion of anti-tuberculosis drugs in the therapeutic regimen. Therapy with only fluoroquinolones will lead to the fact that tuberculosis bacteria will develop drug resistance and it will be very difficult to get rid of them in the future. A situation is considered dangerous when a man underwent a course of treatment with fluoroquinolones, his condition returned to normal, and after 30-60 days it worsened again. In this case, repeated tuberculin sampling is necessary. The following antibiotics of this group are used: Based on Levofloxacin (Elefloks, Tavanic); Based on Ciprofloxacin (Cifran, Tsiprobay, Tsiprinol); Based on Ofloxacin (Zanocin, Ofloxin). Preparations of the tetracycline group. IN last years they are used less and less, as they have a large number of side effects. The exception is Doxycycline (Unidox Solutab), which is somewhat easier for patients to tolerate. Drugs from the group of Cephalosporins are administered intramuscularly - these are Suprax, Cefotaxime, Ceftriaxone, Kefadim, Klaforan, Cefspan and others. From drugs penicillin series prescribe Amoxiclav, Flemoklav solutab, Augmentin, Flemoxin solutab. As for macrolides, no studies have been conducted to confirm their effectiveness against bacterial prostatitis. However, logically speaking, macrolides are agents of low toxicity, have high activity against certain bacteria, especially against mycoplasma and chlamydia. Therefore, theoretically, their use in inflammation of the prostate is possible. These are such means as: Fromilid with the active ingredient Clarithromycin and Sumamed, or Zitrolide with the active ingredient Azithromycin. In the treatment of prostatitis, it is very important that the drug can penetrate into the tissues of the prostate and accumulate there in the organ. Such opportunities are possessed by drugs of the group of fluoroquinolones, macrolides and aminoglycosides (Gentamicin). If the patient comes with an acute stage of inflammation, then for its speedy elimination it is possible to use several antibiotics at once for prostatitis. Elefloks Eleflox is an antibacterial drug from the group of fluoroquinolones with the main active ingredient Levofloxacin. The drug is available in tablets and in solution for infusion. Eleflox is the drug of choice in the treatment of prostatitis. The main advantage of Eleflox is its high activity against gram-positive and gram-negative bacteria, which most often provoke the development of prostatitis. Among such microorganisms: E. coli, Klebsiella, Proteus mirabilis, fecal enterococcus, Pseudomonas aeruginosa, ureaplasma, chlamydia and mycoplasma. Thanks to taking the drug Elefloks, the improvement occurs after a few days. Another advantage of the drug is its proven microbiological and clinical efficacy. It has a high pharmacokinetic profile and penetrates well into the tissues of the prostate gland, which is essential for the successful treatment of prostatitis. Eleflox based on Levofloxacin is a second-generation fluoroquinolone drug, it is twice as well tolerated by patients than first-generation fluoroquinolones, and also shows high efficiency against penicillin-resistant bacterial strains. This is a significant plus of the drug. It has been established that after taking the drug, its concentration in the prostate gland is 4 times higher than the concentration in the blood plasma. As a result, the bacteria inhabiting the tissues of the prostate quickly die, since Eleflox causes profound changes in the cytoplasm, membranes and cell wall of pathogenic microorganisms. The next advantage of the drug Elefloks is that it is available both in the form of tablets and in the form of a solution for infusion. Therefore, you can choose the method of taking the drug, which will be optimal for a particular patient. The main disadvantage of the drug is the presence of contraindications to its use. It is strictly forbidden to take it for the treatment of prostatitis in the event that a person has a suspicion of tuberculosis. The fact is that fluoroquinolones are included in the treatment regimen for tuberculosis, but effective therapy will require the simultaneous administration of several antibiotics at once. If a person infected with Koch's bacillus takes Eleflox to treat prostatitis, then further anti-tuberculosis therapy may not work. Other contraindications include epilepsy, hypersensitivity to fluoroquinolones in general, and age under 18 years of age. One of the disadvantages of the drug is its high cost, which starts from 700 rubles and more for tablets, and from 420 rubles for a solution. It is worth noting such a minus of the drug Elefloks as side effects that may develop against the background of its use. Among them are various allergic reactions, nausea, diarrhea, headaches, dizziness, increased heart rate, etc. When treating with Eleflox, it should be remembered that it is able to interact with other drugs, which can also be attributed to its disadvantages. For example, when taken simultaneously with glucocorticosteroids, the risk of tendon rupture increases. Therefore, it is necessary to start treatment with this antibacterial drug only after a medical examination. Tavanic is an antibacterial drug for the treatment of prostatitis with the main active ingredient Levofloxacin. Tavanic belongs to the fluoroquinolones. The main advantage of Tavanic is its wide spectrum of antibacterial activity. Moreover, it is effective against most bacteria that are the causative agents of infectious prostatitis. These are not only gram-positive and gram-negative microorganisms, ureaplasmas, mycoplasmas, gonococci, but also anaerobes. Sensitivity to the drug Tavanic has Escherichia coli, which very often causes inflammation of the prostate. Tavanic belongs to the second generation fluoroquinolone antibiotics, that is, it shows a higher activity in terms of getting rid of various bacteria and is better tolerated by patients. The drug is produced by the well-known group of companies Sanofi Aventis, which is one of the global leaders in the field of healthcare. This means that the drug meets all international safety requirements and has passed all the necessary clinical trials. Another advantage of Tavanic is its high ability to penetrate and accumulate in prostate tissues. Moreover, the intracellular concentration of the main active substance is 8-9 times higher than its extracellular concentration. This allows you to effectively use the drug Tavanic for the treatment of intracellular pathogens of prostatitis - chlamydia, ureaplasma and mycoplasma. It is worth noting such a plus of the Tavanic drug as the presence of several dosage forms: it is available in tablets with various dosages and in the form of a solution for infusion. The main disadvantage of Tavanic is the presence of contraindications to its use. These include: epilepsy, hypersensitivity to fluoroquinolones, age under 18 years, the presence of tendon damage during treatment with quinolones. Do not prescribe a drug for the treatment of prostatitis to people with suspected tuberculosis. Therefore, if there is any doubt, it is necessary to take appropriate tests. The disadvantages of the drug include side effects. Most common: diarrhea, nausea, headache, drowsiness, sleep disturbance, asthenia, possibly increased hepatic transaminases. Other side effects are observed with less frequency - these are fever, hepatic reactions, tendon ruptures, etc. With caution, the drug should be taken against the background of treatment with other drugs. For example, with NSAIDs, glucocorticosteroids, vitamin K antagonists, Cimetidine, etc. The last disadvantage of the drug Tavanic can be considered its high cost. So, the price for 5 tablets with a dosage of 500 mg starts from 590 rubles. A bottle with a solution for infusion costs from 1250 rubles. Cifran is an antibacterial drug from the group of fluoroquinolones, with the main active ingredient Ciprofloxacin. Cifran is the drug of choice in the treatment of prostatitis. The main advantage of Cifran is its high activity against bacteria that cause inflammation of the prostate gland. It is prescribed for prostatitis caused by microbes of the intestinal group (E. coli, Klebsiella, Proteus, Enterobacter, etc.). Trichomonas, ureaplasma, Staphylococcus aureus, chlamydia trachomatis, anaerobic bacteria and other pathogenic flora that can provoke the development of inflammation of the prostate gland. The advantage of the drug Tsifran is that it begins to act very quickly. This is possible due to the high bioavailability of the drug, which accumulates in high concentrations in the tissues of the prostate. Under such conditions, the bacteria lose their viability, and recovery occurs. Due to the clinically proven effectiveness of the drug Cifran in the treatment of prostatitis, it is prescribed not only to get rid of acute, but also from chronic form diseases. And Tsifran more effectively fights Pseudomonas aeruginosa, compared with drugs based on Levofloxacin. The advantages of the drug include its relatively low cost, which is about 300 rubles. Cifran, with the main active ingredient Ciprofloxacin, belongs to the first generation fluoroquinolones, while there are already 2nd generation drugs. Therefore, when treating prostatitis with Cifran, there is a higher risk that the bacteria will become resistant to it. In addition, first-generation fluoroquinolones are worse tolerated by patients than second-generation drugs. This can be attributed to the disadvantages of the drug. Cifran has moderate activity against atypical pathogens of inflammation in the prostate gland, which somewhat limits its scope. The disadvantages of the drug Cifran include the presence of side effects, including: nausea, diarrhea, skin rash, candidiasis of the mucous membranes, hepatitis, eosinophilia, arthralgia, headaches, sweating, urticaria, taste disturbances, etc. The drug should not be used to treat children under 18 years of age, to treat patients with pseudomembranous colitis. It is not prescribed for people with a history of hypersensitivity to fluoroquinolones. Tsiprobay Tsiprobay is the antibacterial drug of choice in the treatment of prostatitis. It belongs to the group of fluoroquinolones, the main active ingredient in it is Levofloxacin. Cyprobay is an antibacterial drug that has a detrimental effect on gram-positive and, to a greater extent, gram-negative bacteria, which are common causative agents of prostatitis. Proved it high efficiency against chlamydia, mycoplasma, ureaplasma, gram-negative bacteria of the intestinal group, anaerobes. The drug, when taken orally, is rapidly absorbed and well distributed throughout the tissues, accumulating in high concentrations in the prostate gland. This leads to the death of the pathogenic flora and the rapid elimination of the disease. Another advantage of the drug is two forms of release: a solution for infusion and tablets, which allows for the treatment of prostatitis more effectively, starting with intravenous administration of the drug, and then switching to oral administration. The drug is produced by the well-known pharmaceutical company Bayer, which has been creating and selling medicines since 1863. Therefore, you can be sure that Tsiprobay is a high-quality antibiotic that has passed all the necessary clinical trials. The price of the drug is relatively low; for a package of tablets in a dosage of 500 mg, you will have to pay about 370 rubles. Cyprobay is a first generation fluoroquinolone. Therefore, the risk of developing resistance in bacteria to the drug is higher than to second-generation fluoroquinolones. This can be considered the main disadvantage of the drug. The second disadvantage of the drug Tsiprobay is the presence of contraindications to its use, including: age under 18 years, epilepsy, organic lesions brain, mental illness. With caution, the drug is prescribed to the elderly. The third disadvantage of the drug can be called the presence of side effects - these are fungal lesions of the mucous membranes, eosinophilia, loss of appetite, diarrhea and nausea, headache, taste distortion, sleep disturbance, etc. Before starting treatment, you should definitely visit a doctor, as the drug is able to interact with other drugs, which can provoke an increase in side effects. Tsiprinol Tsiprinol is an antibacterial drug with the main active ingredient Ciprofloxacin. Tsiprinol belongs to the group of first-generation fluoroquinolones and is the drug of choice for the treatment of prostatitis. The main advantage of the drug Tsiprinol is its pronounced bacteriostatic activity against most pathogens of prostatitis. The drug has a wide spectrum of action, inhibiting the enzyme DNA gyrase of bacteria, which makes it impossible to start the process of protein synthesis in their cells. As a result, the pathogenic flora dies. The drug has low toxicity to humans, since DNA gyrase is absent in its cells. Another plus of Tsiprinol is its high activity against bacteria that are resistant to aminoglycosides, penicillins, cephalosporins and tetracyclines. Prostatitis caused by gram-negative bacteria (enterobacteria, E. coli, shigella, pseudomonas, moxarella, legionella, listeria, etc.) responds well to treatment with Tsiprinol. Some gram-positive aerobes are sensitive to the drug: staphylococci and streptococci. An important advantage of the drug is that it has a high bioavailability and accumulates in high concentrations in the tissues of the prostate gland. Cyprinol is able to destroy bacteria that multiply and that are at rest. Another advantage of the drug Tsiprinol is its affordable price. So. For 10 tablets of 500 mg, you will have to pay about 120 rubles. The main disadvantage of the drug is that some bacteria may not be sensitive to it. For example, corynebacteria, fragilis bacteroids, some types of Pseudomonas, treponema. Bacteria resistant to methicillin are resistant to Tsiprinol. The drug is a first-generation fluoroquinolone, while second-generation antibiotics have been developed that have higher antimicrobial activity and are better tolerated by patients. Another disadvantage of the drug is that it has a number of side effects. Most often, patients complain of nausea and diarrhea, although the development of a fungal infection, pseudomembranous colitis is not excluded, sometimes allergic reactions occur, up to angioedema and anaphylactic shock. Changes are possible on the part of metabolism, on the part of the nervous system, organs of vision, etc. However, the frequency of side effects is not high and most often Tsiprinol is well tolerated by patients. It is worth noting such a minus of the drug as contraindications to its use. It is strictly forbidden to prescribe Tsiprinol for the treatment of prostatitis in people with hypersensitivity to fluoroquinolones, in patients with chronic renal failure, in children and adolescents under 18 years of age. Tsiprinol is able to interact with other drugs. For example, it should not be taken with tizanidine, as this can cause levels to drop. blood pressure. Zanocin is a broad-spectrum antibacterial drug with the main active ingredient - Ofloxacin. Zanocin is a second-generation fluoroquinolone. Zanocin is the drug of choice in the treatment of prostatitis. The main active ingredient perfectly penetrates into the tissues and secretion of the prostate gland and covers a huge range of prostatitis pathogens. An important advantage of the drug Zanocin is its high activity against most gram-negative microbes of the intestinal group (E. coli, Klebsiella, Proteus, Enterobacter), as well as against Pseudomonas, Trichomonas, Ureaplasma, Mycoplasma and other pathogens of prostatitis. Sensitive to Zanocin strains of bacteria that are resistant to antibiotics of other groups. The undoubted advantage of Zanocin is that it can be used during complex antibacterial therapy, that is, it is prescribed with cephalosporins, macrolides, beta-lactam antibiotics. The drug is available in two forms: in tablets and in the form of a solution for infusion. At the same time, it has an equivalent bioavailability for oral and parenteral administration, so there is no need for dose adjustment. This is a significant plus of the drug, for example, compared with drugs based on Ciprofloxacin. The price range of the drug is average. So, Zanocin tablets at a dosage of 400 mg can be purchased at a price of about 314 rubles. Although Zanocin is the drug of choice for treating prostatitis, some bacterial strains may be resistant to it. For example, Escherichia coli gives resistance to Zanocin in 4.3% of cases in Russia as a whole. In some regions, this figure is higher, for example, in St. Petersburg it is 13%. Therefore, it is recommended to use preparations based on Ofloxacin in the treatment of uncomplicated prostatitis. Another disadvantage of the drug is the presence of side effects, including: nausea, vomiting, diarrhea, fatigue, increased intracranial pressure, tachycardia, anemia, leukopenia, impaired kidney function, etc. The next drawback of the drug is its ability to interact with other drugs, which often leads to an increase in their side effects. For example, you can not combine taking Zanocin and Theophylline, as this will lead to a sharp drop in blood pressure. And the simultaneous use of Zanocin with NSAIDs increases its side effects on the central nervous system. Zanocin is not prescribed for the treatment of prostatitis in people with hypersensitivity to fluoroquinolones, it should not be used to treat children and adolescents under the age of 18 years. Ofloksin Ofloxin is a broad-spectrum antibacterial drug related to second-generation fluoroquinolones. The main active ingredient is Ofloxacin. Another advantage of Ofloxin is its high bioavailability, which ranges from 95 to 100%. In addition, it does not differ between oral and parenteral administration, which does not require dose changes when changing the route of administration. This is quite relevant for the treatment of prostatitis, since a stepwise scheme is often used. The next advantage of the drug is that it perfectly hits the target organs. In this case, we are talking about the tissue and the secret of the prostate gland. Another advantage of the drug: Ofloxin does not have a pathogenic effect on bifidus and lactobacilli, and therefore does not contribute to the violation of the intestinal microflora. It should be noted that, unlike most other fluoroquinolones, Ofloxin does not give any clinically significant phototoxic effect and does not interact with Theophylline. The price of Ofloxin is very acceptable, for 10 tablets at a dosage of 200 mg you will need to pay about 180 rubles. The main disadvantage of Ofloxin is the presence of side effects that occur on average in 4-8% of patients. Most often they are associated with disruption of the digestive tract, central nervous system and skin. Among them: nausea, vomiting, gastralgia, headaches, sleep disturbance, increased anxiety, skin rash and itching, urticaria, petechiae, papular rash, etc. Another disadvantage of the drug is that it is not used to treat people with hypersensitivity to fluoroquinolones, to treat children and adolescents under 18 years of age. Some strains of Escherichia coli are resistant to Ofloxin (about 4.3% of cases), which can lead to ineffective use of the drug for the treatment of prostatitis. Moderate resistance to Ofloksin is shown by some strains of gram-positive bacteria. Unidox Solutab Unidox Solutab is a broad-spectrum antibacterial drug from the tetracycline group. The main active ingredient is Doxycycline. Unidox Solutab is practically the only drug from the tetracycline group that modern proctologists use to treat prostatitis, since it is more easily tolerated by patients than others. Unidox Solutab has antibacterial activity against ureaplasma, mycoplasma, chlamydia, Klebsiella, enterobacteria, Pseudomonas and E. coli. Another advantage of the drug is its high bioavailability, which is 100%. Already half an hour after the first dose, the dose of the drug substance that is necessary to provide a therapeutic effect will be concentrated in the prostate gland. Unidox Solutab is available in the form of dispersible tablets, which makes taking the drug very convenient. The price of the drug is not very high and is about 350 rubles for a pack of 10 tablets. The main disadvantage of Unidox Solutab is that such possible pathogens of prostatitis as Proteus, Serrata, some strains of Pseudomonas, Acinetobacter, symbiotic enterococci are resistant to it. In addition, resistance to Unidox Solutab, which occurs in the treatment of prostatitis, will be extended to other drugs from the tetracycline group. Therefore, in some cases, it is required to replace the drug with a radically different antibiotic. Another disadvantage of the drug is that it is not prescribed for the treatment of people with severe disorders of the kidneys and liver, with porphyrin disease, with hypersensitivity to tetracyclines. Another disadvantage of Unidox Solutab is the side effects that may occur after taking it, including: anorexia, nausea, diarrhea, enterocolitis, allergic reactions, liver damage, anemia, eosinophilia, increased ICP, etc. Suprax is a broad-spectrum antibacterial drug from the group of cephalosporins (3rd generation of drugs). The main active ingredient is cefixime. The main advantage of Suprax in the treatment of prostatitis is its high antibacterial activity against gram-negative bacterial strains. Suprax allows you to get rid of prostatitis caused by gonococci, enterobacteria, Proteus, Klebsiella and E. coli. Suprax is a drug for oral administration. It has three forms of release - in capsules, in tablets, in suspension, so it can be used for treatment not only in a hospital, but also at home. The drug is produced by the well-known company Astellas, which is one of the 20 leading pharmaceutical companies in the world. Therefore, the drug has passed all the necessary clinical trials, which is its undoubted advantage. Taking the drug Suprax does not have a pronounced effect on the human immune system, does not reduce the protective functions of the body, which is also its advantage over some other antibiotics. Suprax does not have a high permeability in the prostate tissue, which is a significant disadvantage of the drug in the treatment of prostatitis. Another drawback of the drug is the insensitivity to it of bacteria such as: ureaplasma, mycoplasma, chlamydia, enterococci, pseudomonads, seration, listeria. Therefore, if prostatitis was caused by one of these microorganisms, the therapeutic effect cannot be achieved. Or you will have to use Suprax in combination with other antibiotics. Another disadvantage of the drug is its high cost. So, for a package with 6 capsules at a dosage of 400 mg, you will have to pay about 700-800 rubles. It is worth noting such a drawback of the drug as the presence of side effects. Perhaps the occurrence of allergic reactions, the appearance of dry mouth, the development of diarrhea, nausea, flatulence, vomiting, dizziness and headaches. Cefotaxime Cefotaxime is a broad-spectrum antibiotic from the group of third-generation cephalosporins with the main active ingredient Cefotaxime. The main advantage of Cefotaxime is its extended spectrum of action compared to previous generations of cephalosporins, as it has increased resistance to beta-lactams. Therefore, Cefotaxime may be prescribed for the treatment of complicated prostatitis. The drug is active against most bacteria that provoke prostatitis, including: E. coli, gonococci, enterobacteria, Klebsiella, Proteus, staphylococci. Cefotaxime can help to get rid of the disease, even when there is no effect from treatment with tetracyclines, penicillins and aminoglycosides. Often it is used in the complex therapy of prostatitis. It should also be noted such a plus of the drug as the absence of contraindications to its use, with the exception of hypersensitivity reactions to cephalosporins. The price of the drug is not high, so a bottle with 1 g of the active substance can be purchased for 20-40 rubles. One of the disadvantages of the drug can be called the fact that it is allowed to be used only for parenteral administration. The drug is not available in tablets or capsules, that is, oral administration is not available. Treatment with Cefotaxime is carried out only in a hospital setting. Another disadvantage of Cefotaxime is the presence of side effects, including: local reactions to the administration of the drug, skin rashes, disorders of the digestive tract, pseudomembranous colitis, headaches, etc. Ceftriaxone Ceftriaxone is a broad-spectrum antibiotic from the group of third-generation fluoroquinolones. The main advantage of the drug is that it has a pronounced bactericidal effect. It can be used to treat prostatitis caused by Gram-positive and Gram-negative bacteria. Another plus of Ceftriaxone is its increased resistance to beta-lactamase enzymes produced by most pathogenic microorganisms. This means that the drug will be effective even where other antibacterial agents (penicillins and even cephalosporins of previous generations) fail. When administered parenterally, the drug penetrates well into the tissues and fluids of the prostate. Moreover, the drug has practically no contraindications, with the exception of the possibility of a hypersensitivity reaction to cephalosporins. The price of Ceftriaxone is not high. The average cost of 1 bottle with 1 g of the active substance varies between 22-30 rubles. One of the disadvantages of the drug is that it can only be used for parenteral use. Therefore, treatment with Ceftriaxone is carried out only in a hospital setting. Another disadvantage of the drug is the possibility of side effects after its administration. These include: diarrhea, nausea, vomiting, eosinophilia, allergic dermatitis, urticaria, headaches, congestion in the gallbladder. Claforan Klaforan is a broad-spectrum antibiotic from the group of third-generation cephalosporins. The main active ingredient is Cefotaxime. The main advantage of the drug Klaforan in the treatment of prostatitis is that it has bactericidal properties against gram-negative and gram-positive pathogenic flora. Unlike some other cephalosporins, Klaforan has a detrimental effect on bacteria that synthesize beta-lactamase. Therefore, it can be used to treat patients who have not responded to tetracycline and other antibiotic therapy. The drug is produced by the well-known pharmaceutical company Sanofi Aventis, which means that it has a high degree of purification. The drug has practically no contraindications. It should not be used solely for the treatment of patients with hypersensitivity to cephalosporins in general. One of the main disadvantages of the drug is that it can be used exclusively for parenteral administration. Therefore, Klaforan treatment is carried out only in a hospital setting. It is also worth noting such a drawback of the drug as its relatively high price compared to other 3rd generation cephalosporins. So, 1 bottle with a dosage of 1 g will cost from 155 rubles. The disadvantages of the drug include the possibility of side effects, including: disorders of the digestive system (nausea, diarrhea, loss of appetite), allergic reactions, arrhythmia, encephalopathy, fever, pain at the injection site, etc. Amoxiclav Amoxiclav is a broad-spectrum antibiotic, with the main active ingredient amoxicillin + clavulanic acid. The drug belongs to the group of penicillins. The main advantage of Amoxiclav in the treatment of prostatitis is that it effectively fights bacteria that produce beta-lactamase enzymes. This allows you to have a pronounced bactericidal effect against a wide range of pathogenic microorganisms. To date, Amoxiclav is one of the most effective antibiotics for the treatment of prostatitis among penicillins. It allows you to get rid of such bacteria that cause prostatitis, such as: gonococci, enterobacteria, enterococci, Klebsiella, Proteus, seracia, E. coli and some others. The drug was developed by the famous pharmaceutical company SmithKline Beecham Pharmaceuticals. Therefore, you can not worry about the quality and safety of the drug. Another advantage of Amoxiclav is its selective activity against bacterial cells. That is, it recognizes pathogenic cells and destroys them, while healthy tissues are not damaged. The advantage of the drug is its relatively low price. So, a package of Amoxiclav tablets 20 pieces in a dosage of 500 mg can be purchased for 300-400 rubles. The main disadvantage of the drug in the treatment of prostatitis can be considered its low efficiency against bacterial strains such as: ureaplasma, mycoplasma, chlamydia and pseudomonads. Therefore, although Amoxiclav is a clavulanic acid protected semi-synthetic aminopenicillin, it may not be effective in the treatment of prostatitis caused by atypical or resistant flora. Another obvious disadvantage of Amoxiclav is that it can provoke a number of side effects, including: nausea, diarrhea, vomiting, heartburn, liver and kidney disorders, allergic reactions, fungal infection, etc. Flemoclav Solutab Flemoclav Solutab is an antibiotic from the penicillin group with the main active ingredient Amoxicillin + potassium clavulanate. Flemoklav Solutab, like Amoxiclav, is a protected penicillin, which ensures its high antibacterial activity against most bacteria that can provoke the development of prostatitis. An important advantage of the drug Flemoklav solutab is that it is available in the form of dispersible tablets. This makes it convenient to take for some groups of patients. Moreover, this form of release has a gentle effect on the gastric mucosa and is more easily absorbed by the body. It is impossible not to mention such a plus of the drug Flemoklav solutab, as its ability to fight beta-lactamase strains of bacteria that are resistant to a number of other antibiotics. Among the disadvantages of the drug Flemoklav solutab is its high cost compared to other forms of penicillins with clavulanic acid. So, for the packaging of the drug, it will be necessary to pay 400-500 rubles. Also, the disadvantages of the drug include the presence of contraindications to its use, including: hypersensitivity to the components of the drug, jaundice, abnormal liver function, Infectious mononucleosis, lymphocytic leukemia. It is worth noting such a minus of the drug as the presence of side effects that may occur while taking it. Most often, patients suffer from diarrhea and nausea, as well as fungal infections that occur against the background of dysbacteriosis. It is also possible to develop allergic reactions, exanthema, candidiasis, hepatitis and other undesirable reactions. Augmentin Augmentin is a broad-spectrum antibiotic containing Amoxiclav and clavulanic acid. The main advantage of Augmentin is its resistance to bacteria that produce beta-lactamase enzymes, which is possible due to clavulanic acid in its composition. Augmentin acts against many strains of gram-positive and gram-negative bacteria that can provoke the development of prostatitis. The drug is available in tablets, in the form of a powder for the preparation of a suspension, in the form of a powder for intravenous and intramuscular administration. This is also an important advantage of the drug Augmentin, as it makes it possible to use it for different groups of patients. One of the disadvantages of the drug is its high cost, which, depending on the form of release of the drug, can reach 1800 rubles. The disadvantages of Augmentin include its resistance to some atypical pathogens of prostatitis, including strains of mycoplasma, ureaplasma, chlamydia, pseudomonas, as well as some gram-negative anaerobes. Separately, it should be noted the side effects that may occur while taking Augmentin. Most often, patients complain of diarrhea, a feeling of nausea and fungal infections. Although there may be a violation of the work of such organs and systems as: the central nervous system, lymphatic system, the immune system, liver, gallbladder, vessels, urinary tract, skin. Flemoxin Solutab Flemoxin Solutab is a broad-spectrum antibiotic based on Amoxicillin. The drug belongs to the group of penicillins. Flemoxin Solutab has activity against a number of gram-negative and gram-positive bacteria that can cause prostatitis. These are some strains of staphylococci, streptococci. Moderate activity shows the drug against enterococci, Proteus, Salmonella, Shigella. The drug is released in the form of dispersible tablets, which makes it convenient to take it for some categories of patients. In addition, the trihydrate is better absorbed by the gastrointestinal tract and does not irritate the gastric mucosa. The drug is produced by Astellas, which has positively proven itself in pharmacological market. This means that the drug meets all global safety standards. The drug is in the middle price range. It can be purchased at a price of 230 rubles and above, depending on the dosage. The drug is not effective against bacteria producing beta-lactamase enzymes, against Pseudomonas, Enterobacter, Ureaplasma, Mycoplasma, Chlamydia and some other pathogenic microorganisms. Therefore, the treatment of prostatitis with Flemoxin Solutab alone may not be effective. This is the main disadvantage of the drug. It is also worth noting the presence of side effects that may occur when taking it: a change in taste, vomiting, diarrhea, nephritis, agranulocytosis, skin reactions, etc. Gentamicin Gentamicin is a broad-spectrum antibacterial drug from the group of aminoglycosides. The main advantage of the drug is its high antibacterial activity against gram-negative flora, which can provoke the development of prostatitis, for example, against Salmonella, Enterobacter, Klebsiella, Proteus, Pseudomonas, etc. The drug is rapidly absorbed into the blood and already an hour after its administration in plasma, its therapeutic concentration is observed. A significant advantage of the drug is its low price. So, a package of 10 ampoules can be purchased for only 40-50 rubles. One of the significant disadvantages of the drug Gentamicin is its limited spectrum of action, that is, it will be ineffective against some strains of bacteria that cause prostatitis. Therefore, it is most often used in a complex treatment regimen for inflammation of the prostate. The disadvantages of the drug include the fact that it is administered only parenterally. Oral administration of the drug is not available. Also a minus of Gentamicin are its numerous side effects, including: vomiting, nausea, anemia, leukopenia, oliguria, renal failure, headaches, increased drowsiness, hearing impairment, etc. The drug has contraindications for use, for example, neuritis of the auditory nerve, impaired renal function. Fluoroquinolone for chronic bacterial prostatitisGood pharmacokinetics, high concentration in prostate tissue, good bioavailability. Equivalent pharmacokinetics for oral and parenteral administration (for ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin). Ciprofloxacin and ofloxacin have a prolonged release form - OD tablets, which allow the active substance to be released evenly throughout the day and thereby maintain the equilibrium concentration of the drug. Levofloxacin (floracid), ciprofloxacin, sparfloxacin (especially in association with intracellular sexually transmitted infections), and to a lesser extent, norfloxacin should be considered optimal for prostatitis. All fluoroquinolones showed high activity against typical and atypical pathogens, including Pseudomonas aeruginosa. Disadvantages include photo- and neurotoxicity. In general, fluoroquinolones can be considered as first-line drugs in the treatment of patients with chronic prostatitis, but only after exclusion of tuberculosis.
TrimethoprimIt penetrates well into the prostate parenchyma. Along with tablets, there is a form of the drug for intravenous administration. IN modern conditions the advantages include the low cost of trimethoprim. However, although the drug is active against the most significant pathogens, it does not act on Pseudomonas spp., some enterococci and some representatives of the genus Enterobacteriaceae, which limits the use of this drug in patients with chronic prostatitis. Trimethoprim is available in combination with sulfamethoxazole (400 or 800 mg of sulfamethoxazole + 80 or 160 mg of trimethoprim; respectively, the combined drug tablet contains 480 or 960 mg of the active substance).
TetracyclinesAlso available in two forms of administration, highly active against chlamydia and mycoplasmas, so their effectiveness is higher in chronic prostatitis associated with sexually transmitted diseases. Optimal is doxycycline (Unidox Solutab), which has the best pharmacokinetic data and tolerability.
MacrolidesMacrolides (including azalides) should only be used under certain conditions, as there are few scientific studies supporting their effectiveness in prostatitis and this group of antibiotics has little activity against Gram-negative bacteria. But you should not completely abandon the use of macrolides, since they are quite active against gram-positive bacteria and chlamydia; accumulate in the prostate parenchyma in high concentrations and are relatively non-toxic. The optimal drugs in this group are clarithromycin (fromilid) and azithromycin. Recommended doses:
Other drugsCan recommend combination drug safocide. Its uniqueness lies in the fact that it contains a full combined one-day course of treatment in one blister (4 tablets): 1 tab. fluconazole (150 mg), 1 tablet of azithromycin (1.0 g) and 2 tablets of secnidazole A 1.0 g each. This combination, taken simultaneously, allows you to achieve a bactericidal effect against Trichomonas vaginalis, gram-positive and gram-negative anaerobes, including Gardnerella vaginalis (secnidazole), against Chl trachomatis, Mycoplasma genitalium, gram-positive and gram-negative microflora (azithromycin), as well as against fungi of the genus Candida (fluconazole). Thus, safocid meets all WHO requirements for drugs used to treat sexually transmitted infections, including the treatment of chronic prostatitis: efficiency of at least 95%, low toxicity and good tolerance, the possibility of a single dose, oral administration, slow development of resistance to ongoing therapy. Indications for taking safocide: combined uncomplicated sexually transmitted infections of the genitourinary tract, such as gonorrhea, trichomoniasis, chlamydia and fungal infections, accompanying specific cystitis, urethritis, vulvovaginitis and cervicitis. In an acute uncomplicated disease, a single dose of the safocid complex is sufficient; in a chronic process, a full set is required for 5 days. European recommendations for the management of patients with infections of the kidneys, urinary tract and male genital organs, compiled by a team of authors led by Naber K.G., insist that in case of bacterial chronic prostatitis, as well as in chronic prostatitis with signs of inflammation (categories II and III A), antibiotics should be appoint for 2 weeks after the establishment of the primary diagnosis. After that, a re-evaluation of the patient's condition is carried out, and antibiotic therapy is continued only if a positive result culture material taken before treatment, or if the patient shows a marked improvement against the background of antibiotic treatment. The recommended total duration of treatment is 4-6 weeks. Oral therapy is preferred, but antibiotic doses should be high. The effectiveness of antibiotics in the so-called inflammatory syndrome of chronic pelvic pain (what we consider as latent chronic prostatitis) by the authors of the guide, with reference to the studies of Krieger J.N. et al. is also explained by the likely presence of bacterial microflora not detected by conventional diagnostic methods. Here are several options for the basic treatment of patients with acute prostatitis CIP and latent CIP. Treatment regimen for acute prostatitis
Treatment regimen for chronic infectious and latent infectious prostatitisImportant - at the initial appointment, the examination algorithm must be maintained. First, a 3-glass urine sample with its bacteriological examination, then a digital rectal examination, obtaining a prostate secretion for its microscopy and seeding. Sowing is designed to identify nonspecific microflora and Mycobacterium tuberculosis; according to indications - sexually transmitted infections. If less than 25 leukocytes are found in the prostate secretion in the field of view, test therapy with tamsulosin (omnic) should be performed for 5-7 days with repeated massage of the prostate and re-examination of its secretion. If the number of leukocytes does not increase, and the cultures are negative, the disease should be attributed to non-infectious prostatitis (chronic pelvic pain syndrome) and appropriate pathogenetic and symptomatic therapy should be carried out. If more than 25 leukocytes per field of view are visualized during the initial analysis or their number increases after test therapy, the disease should be considered as infectious or latent infectious. In this case, antibiotic therapy becomes the basis of treatment - empirical at the beginning, and corrected after receiving the results of bacteriological examination. Inflammation of the prostate is often caused by sexually transmitted infections. Accordingly, drug therapy is based on the use of antibacterial agents. Basically, the patient is offered anti-inflammatory therapy, which will destroy the root cause of prostate infection. Treatment of acute and chronic prostatitis is fundamentally different. Adaptive and competent treatment can only be prescribed by a qualified urologist who knows the patient's history. What are the antibiotics for the treatment of prostatitis in men, what characterizes the course of the disease in chronic prostatitis, a list effective drugs from prostatitis, you will learn in this article. Antibiotics for prostatitis in men: the role of drugsMost men think that prostatitis is very difficult to treat, and drugs adversely affect the state of the body as a whole. In part, this is true if the disease is not treated in time. Acute prostatitis can be treated for up to two weeks, chronic with untimely treatment 14-28 days. The role of antibiotics in the treatment of inflammation of the prostate gland is huge. According to statistics, in 95% of cases, prostatitis is caused by an infection (virus, bacterium). It is the antibiotic that can destroy the pathogenic microflora. Basically, when diagnosing a disease, antibiotics of a narrow group are prescribed. If the doctor could not establish the root cause of the disease, then for a start, the patient is prescribed a broad-spectrum remedy. The antibiotic helps to inhibit the pathogens that caused inflammation. It should be noted right away that such drugs really affect the functioning of the liver, kidneys, and heart. It is for this reason that it is worth first undergoing a detailed examination of the body, and then prescribing therapy.
But with the right course, you can cure prostatitis without loss and not acquire new pathologies. Antibiotic treatment of chronic prostatitis: how to start therapyOf course, the treatment course begins with the diagnosis. Why can't you self-medicate? The nature of inflammation of the prostate can be different. Infections are also different. Inflammation of the prostate can be caused by:
When diagnosing, the patient is invited to undergo a PCR examination. It helps to establish which pathogenic microbe led to inflammation. And only after identifying it, antibiotic therapy of a narrow profile is prescribed, and in particular the drug to which the detected bacteria are most sensitive. The urologist also additionally prescribes a blood test, urine test, the patient should take a bakposev, etc. Only after a well-conducted diagnosis, antibacterial drugs are selected that locally affect the root cause of the causative agent of inflammation. After all, today there are a lot of drugs of the antibacterial group, which we will discuss later. Treatment of prostatitis with antibiotics: how to treatAntibiotics are the most effective means in the fight against prostatitis.
But do not forget about some rules that should not be neglected in the treatment of diseases with antibiotics:
Treatment of chronic prostatitis is not an easy task, because you need to choose the right antibiotic that will most intensively affect the desired pathogenic microorganism. We provide a list of drugs that contribute to the speedy recovery of the patient. His effective composition It has anti-inflammatory, antimicrobial and soothing effects. Thanks to bee venom improves blood circulation and enhances cell regeneration. "Cream Wax Zdorov" is absolutely safe, has no side effects and enhances the effectiveness of drug treatment. Azithromycin for prostatitisThe active substance is azithromycin dihydrate. It is a broad spectrum antibiotic. It is used for ENT infections, bronchitis, cystitis. Azithromycin is also indicated for prostatitis of any form. This medicine, when it enters the body, immediately affects the pathogenic microflora, destroying pathogenic bacteria. But he has contraindications:
In other cases, this effective remedy in the fight against microorganisms that caused inflammation. AmoxiclavThe drug is also often prescribed by a doctor in the treatment of chronic prostatitis. This tool belongs to the group of penicillins. It effectively affects the inflammatory focus, eliminating swelling of the gland, relieving irritation. Amoxiclav with prostatitis is taken 1 tablet twice a day. It is also quite cheap compared to other antibiotics of the penicillin group. AmoxicillinThis drug is also penicillin group and is used everywhere. This is the disadvantage of this drug. Pathogenic bacteria have become more resistant to amoxicillin due to its frequent use. Doctors rarely prescribe the presented drug, since it is an irrational remedy in the fight against such a pathology. DoxycyclineIt belongs to the group of tetracyclines and is used if the patient has an allergic reaction to penicillins. Doxycycline for prostatitis is prescribed when the causative agents are chlamydia or mycoplasma microorganisms. Moreover, this remedy is indicated for those who have been diagnosed with kidney failure during the diagnosis. This drug gently affects the internal microflora of the intestine, destroying pathogenic microbes. Levofloxacin for prostatitisIt is a broad spectrum antibiotic. Levofloxacin for prostatitis is used for any of its forms (acute, chronic). It is prescribed when other means do not bring the desired effect, because this drug increases the chances of destroying microorganisms that have adapted to other antibiotics. Moreover, it effectively affects a wide range of harmful bacteria. After 1.5 hours, the components of the product penetrate into the focus of inflammation, relieving symptoms and killing microbes. Ceftriaxone for prostatitisThis drug effectively fights the bacterial nature of prostatitis. It is he who is the fastest medicine in the treatment of such a pathology. Ceftriaxone for prostatitis has a wide range of actions:
Ceftriaxone for prostatitis is available in ampoule form. The only negative is the pain of injections, but the result of the drug appears after a day. It is worth noting that it has a strong effect on the microflora of the gastrointestinal tract, so active ingredients (yogurts, linex) should be taken to normalize the intestinal tract. Monural with prostatitisMonural with prostatitis is available in powder form. It is used for difficult urination, as well as to eliminate burning in the urethra. The drug is used in combination and is not an independent drug. It helps to relieve the symptoms of inflammation. Tavanic for prostatitisThis is a German antibacterial drug that affects gram-positive microorganisms (staphylococci, enterococci), etc. also effectively destroys gram-negative bacteria (E. coli). It is used quite often, as it quickly affects the focus of inflammation. Tsiprolet with prostatitisThis tool also belongs to the antibacterial group that can cope with E. coli, staphylococci, gonococci, etc. Ciprolet with prostatitis is very effective if the cause of inflammation is the pathogen described above. The drug has bactericidal and anti-inflammatory properties, therefore it is also used for acute and chronic prostatitis. Ciprofloxacin for prostatitisThis drug stops the growth of pathogenic organisms, has a qualitative effect on gram-positive and negative bacteria, and has an excellent therapeutic effect in the prostate. The main feature of the drug is the minimum side effects. Natural remedy for the prevention and disposal of prostatitis This the best remedy from prostatitis, which strikes the disease from two sides at once. Due to the unique formula and concentration of active ingredients, vitamins, inflammation is removed, erection is restored, prostatitis does not return. The male body works like a Swiss watch. One of the most important directions in the treatment of urological pathology of the male gland is the use of antibiotics. A huge breakthrough for doctors and patients was the invention of fluoroquinolones - a special class of antibacterial agents, with the ability to penetrate directly into the tissue of the damaged organ. At the moment, levofloxacin for prostatitis is considered the gold standard in its treatment. A new generation of antimicrobial agents has been driven by the wrong approach to use similar drugs in past. Inadequate dosages, too short courses of therapy, the choice of the wrong group of drugs ensured the emergence of a mass of resistant bacterial strains. It is when the usual antibiotic does not help, you need to choose Levofloxacin. Its main advantages are:
Thanks to these properties, fluoroquinolone becomes the basis of healing from prostatitis. He gained his effectiveness thanks to a special left-handed formula and the ability to block the enzyme DNA-gyrase of a microbial cell. As a result, the bacterium is unable to correctly reproduce the genetic structure, damage to the cytoplasm occurs, the membranes and the microorganism dies. The drug has a very wide range of applications in addition to inflammation of the male organ. It perfectly helps with bacterial diseases of the urinary system, organs abdominal cavity, community-acquired pneumonia, sepsis and other infectious processes. "Salutem Pro" - male strength and health at any age! Development of Israeli scientists from prostatitis! "Salutem pro" - a plant complex from Israel, thanks to its unique composition, will help in the shortest possible time. More... Levofloxacin for prostatitis is most commonly used in tablets with a dosage of 0.25-0.5 g or infusions in 100 mg vials, which contain 0.5 g of the active substance. After therapy with this drug, the following effects are observed:
Treatment of prostatitis with Levofloxacin is most convenient for patients in the form of oral tablets. Daily dose the drug is 500 mg. The medicine is inactive in relation to food, so it practically does not matter when exactly to drink it, but it is recommended to use it between lunch and dinner once or 2 times a day - it all depends on the stage of neglect of the disease that the patient has acquired. Be sure to drink 0.5 or 1 glass of water. The tablets must not be chewed. The course of treatment is 28 days.
Particular attention should be paid to situations where the patient has concomitant renal failure or other diseases of this system. Since 75% medication excreted in the urine, violations of this process can significantly aggravate the course of the underlying disease. For such people, reduce the dose by half while maintaining the antibiotic regimen and observe the occurrence of any negative changes in dynamics. Levofloxacin for chronic prostatitis or any other form of illness is one of the safest remedies. However, in rare cases, such negative reactions may occur:
In addition, there are a number of contraindications for the use of this antibacterial drug:
Levofloxacin is one of the best options for the etiological treatment of bacterial prostatitis. However, self-medication is highly undesirable. Before use, it is imperative to undergo an examination of the whole body and consult a specialist to select an adequate dose and regimen of therapy.
With bacterial prostatitis, it is impossible to get rid of the pathology without eliminating the pathogens that provoked the inflammatory process. Despite the biased attitude of patients towards the use of antibiotics, only well-chosen antibiotic therapy helps to get rid of the male pathology of an infectious nature. The only way to treat bacterial prostatitis is with antibiotics. How to choose the right antibioticAgents provocateurs in prostatitis can be completely different pathogenic, as well as conditionally pathogenic organisms. They are able to multiply rapidly and cause inflammatory reactions in the organ. To suppress the vital activity of such particles, antimicrobial drugs are used. However, the action of medications is designed to destroy certain groups of bacteria. To choose the right effective remedy with prostatitis, it is necessary to determine the type of microbes and their sensitivity to antibacterial drugs. To do this, a bakposev of the secret of the prostate gland is performed. Based on the results obtained, an appropriate antibiotic can be selected.
For the treatment of prostatitis, a course with Levofloxacin is prescribed. Levofloxacin shows good results, as in the treatment acute forms pathology, and in chronic bacterial prostatitis. Levofloxacin, due to its ability to kill pathogenic particles at any stage of development, is an effective bactericidal drug. Unlike bacteriostatic drugs that stop the reproduction of microbes, that is, affecting only cell division, Levofloxacin destroys cells, both dividing and growing, and at rest. Therefore, the drug is considered quite effective, having a wide range of action. The mechanisms of the drug work correspond to the main properties of the group of quinols, fluoroquinols. The drug, penetrating into disease-causing cells, blocks the activity of certain enzymes involved in the formation of DNA. Thanks to pathological changes in the cell, processes develop that are incompatible with the life of microbes. In this case, the bacteria not only lose their ability to reproduce, but also finally die. Thus, the drug is able to have a detrimental effect on most pathogenic particles found in prostatitis. The drug is effective in the fight against bacteria The drug is often prescribed for exacerbations of pathology, the chronic course of the disease, since, penetrating into the places of the greatest accumulation of pathogenic agents, it is able to effectively eliminate them and contribute to a complete cure. The lack of effect can only be observed in the treatment of a disease caused by bacteria that do not belong to the group of sensitive agents to levofloxacin. Levofloxacin is available in the form of a tablet preparation and an injection solution. The medicinal solution contains 0.5% of the active ingredient, supplemented with:
The solution is clear with a yellowish or yellow-green tint. The drug is available in various forms The tablet form of the drug is found with a content of 500 mg of the medicinal substance. You can also find tablets with 250 mg of the main ingredient and additives in the form of:
Tablets are round-shaped with a white upper shell. In the treatment of prostatitis caused by various pathogens, Levofloxacin is often used. It is allowed to use both a tablet preparation and in the form of intravenous administration of solutions. Regardless of the chosen method of using the drug, therapy for prostatitis is carried out for 28 days. For the treatment of severe prostatitis, the drug is used in the form of injections. So, with severe prostatitis, Levofloxacin is administered intravenously for the first week of treatment, or even 10 days. A single dosage is prescribed up to 500 ml daily. Further therapy continues with tablets. It is recommended to take 1 tablet daily containing 500 mg of the therapeutic component. The course should be 4 weeks in total with intravenous administration of the drug. You can treat prostatitis without injections. With this type of therapy, tablets are taken throughout the course. Men with prostatitis are prescribed a daily pill containing 500 mg of the drug.
Renal failure is the reason for refusal of treatment with Levofloxacin There are also relative contraindications. The drug should be administered with caution when:
Such pathologies require careful monitoring of physicians during therapy with levofloxacin for prostatitis. Taking Levofloxacin, you must strictly adhere to the dosages recommended by doctors. With uncontrolled use of the drug in excess of safe doses, the following may occur:
An overdose of the drug may disrupt the heart rhythm In case of overdose, treatment is used to eliminate the corresponding symptoms. Any methods of accelerating the withdrawal of the drug do not bring results.
In the form of negative consequences, symptoms can often be observed in the form of:
A side effect of the drug can manifest itself in the form of diarrhea. Less common signs of complications are:
Quite rarely, reactions in the form of:
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