Antipyretics for children are prescribed by a pediatrician. But there are emergency situations with fever when the child needs to be given medicine immediately. Then the parents take responsibility and use antipyretic drugs. What is allowed to be given to infants? How can you lower the temperature in older children? What medications are the safest?
GCS for injection
Active substance
Release form, composition and packaging
Injection transparent, colorless or slightly yellowish or greenish-yellowish.
Excipients: nicotinamide, sodium metabisulfite, disodium edetate, sodium hydroxide, water for injection.
1 ml - ampoules (3) - plastic trays (1) - cardboard boxes.
pharmachologic effect
Synthetic glucocorticoid drug, dehydrogenated analogue. It has anti-inflammatory, antiallergic, immunosuppressive effects, increases the sensitivity of beta-adrenergic receptors to endogenous catecholamines.
Interacts with specific cytoplasmic receptors (receptors for GCS are present in all tissues, especially in the liver) to form a complex that induces the formation of proteins (including enzymes that regulate vital processes in cells.)
Protein metabolism: reduces the amount of globulins in, increases the synthesis of albumins in the liver and kidneys (with an increase in the albumin/globulin ratio), reduces the synthesis and increases protein catabolism in muscle tissue.
Lipid metabolism: increases the synthesis of higher fatty acids and triglycerides, redistributes fat (fat accumulation occurs mainly in the shoulder girdle, face, abdomen), leads to the development of hypercholesterolemia.
Carbohydrate metabolism: increases the absorption of carbohydrates from the gastrointestinal tract; increases the activity of glucose-6-phosphatase (increased flow from the liver into the blood); increases the activity of phosphoenolpyruvate carboxylase and the synthesis of aminotransferases (activation of gluconeogenesis); promotes the development of hyperglycemia.
Water-electrolyte metabolism: retains Na + and water in the body, stimulates the excretion of K + (mineralocorticoid activity), reduces the absorption of Ca 2+ from the gastrointestinal tract, reduces bone mineralization.
The anti-inflammatory effect is associated with inhibition of the release of inflammatory mediators by eosinophils and mast cells; inducing the formation of lipocortins and reducing the number of mast cells producing hyaluronic acid; with a decrease in capillary permeability; stabilization of cell membranes (especially lysosomal) and organelle membranes. Acts on all stages of the inflammatory process: inhibits the synthesis of prostaglandins at the level of arachidonic acid (lipocortin inhibits phospholipase A2, suppresses the liberation of arachidonic acid and inhibits the biosynthesis of endoperoxides, leukotrienes, which contribute to inflammation, allergies, etc.), the synthesis of “pro-inflammatory cytokines” (interleukin 1, tumor necrosis factor alpha, etc.); increases the resistance of the cell membrane to the action of various damaging factors.
The immunosuppressive effect is caused by the involution of lymphoid tissue, inhibition of the proliferation of lymphocytes (especially T-lymphocytes), suppression of the migration of B cells and the interaction of T and B lymphocytes, inhibition of the release of cytokines (interleukin-1, 2; interferon gamma) from lymphocytes and macrophages and decreased antibody formation.
Prednisolone is metabolized in the liver, partially in the kidneys and other tissues, mainly by conjugation with glucuronic and sulfuric acids. Metabolites are inactive.
It is excreted in bile and urine by glomerular filtration and is 80-90% reabsorbed by the tubules. 20% of the dose is excreted unchanged by the kidneys. T1/2 from plasma after intravenous administration 2-3 hours.
Indications
Prednisolone is used for emergency treatment in conditions requiring rapid promotion concentrations of GCS in the body:
— shock conditions (burn, traumatic, surgical, toxic, cardiogenic) - in case of ineffectiveness of vasoconstrictors, plasma-substituting drugs and other symptomatic therapy;
- allergic reactions (acute severe forms), blood transfusion shock, anaphylactic shock, anaphylactoid reactions;
- cerebral edema (including due to a brain tumor or associated with surgery, radiation therapy or head injury);
- bronchial asthma (severe form), status asthmaticus;
— systemic diseases connective tissue(systemic lupus erythematosus, rheumatoid arthritis);
- acute adrenal insufficiency;
- thyrotoxic crisis;
- acute hepatitis, hepatic coma;
- reduction of inflammatory phenomena and prevention of cicatricial contractions (in case of poisoning with cauterizing liquids).
Contraindications
For short-term use for health reasons, the only contraindication is hypersensitivity to prednisolone or the components of the drug.
In children during the growth period, GCS should be used only according to absolute indications and under the particularly careful supervision of the attending physician.
WITH caution the drug should be prescribed for the following diseases and conditions:
- gastrointestinal diseases - gastric ulcer and duodenum, esophagitis, gastritis, acute or latent peptic ulcer, recently created intestinal anastomosis, ulcerative colitis with threat of perforation or abscess formation, diverticulitis;
- pre- and post-vaccination period (8 weeks before and 2 weeks after vaccination), lymphadenitis after BCG vaccination;
— immunodeficiency conditions (including AIDS or HIV infection);
- diseases of cardio-vascular system(including recent myocardial infarction - in patients with acute and subacute myocardial infarction, the necrosis focus may spread, the formation of scar tissue may slow down and, as a result, rupture of the heart muscle), severe chronic heart failure, arterial hypertension, hyperlipidemia);
— endocrine diseases- diabetes mellitus (including impaired carbohydrate tolerance), thyrotoxicosis, hypothyroidism, Itsenko-Cushing's disease, obesity (III - IV stage);
- severe chronic renal and/or liver failure, nephrourolithiasis;
— hypoalbuminemia and conditions predisposing to its occurrence;
- systemic osteoporosis, myasthenia gravis, acute psychosis, poliomyelitis (except for the form of bulbar encephalitis), open- and closed-angle glaucoma;
- pregnancy.
Dosage
The dose of Prednisolone and the duration of treatment are determined by the doctor individually depending on the indications and severity of the disease.
Prednisolone is administered intravenously (drip or stream) or intramuscularly. The intravenous drug is usually administered first as a stream, then as a drip.
At acute adrenal insufficiency single dose 100-200 mg for 3-16 days.
At bronchial asthma the drug is administered depending on the severity of the disease and the effectiveness of complex treatment from 75 to 675 mg per course of treatment from 3 to 16 days; in severe cases, the dose can be increased to 1400 mg per course of treatment or more with a gradual dose reduction.
At status asthmaticus Prednisolone is administered at a dose of 500-1200 mg/day, followed by a decrease to 300 mg/day and transition to maintenance doses.
At thyrotoxic crisis 100 mg of the drug is administered in a daily dose of 200-300 mg; if necessary, the daily dose can be increased to 1000 mg. The duration of administration depends on therapeutic effect, usually up to 6 days.
At shock resistant to standard therapy , At the beginning of therapy, Prednisolone is usually administered as a bolus, after which it is switched to drip administration. If blood pressure does not increase within 10-20 minutes, repeat the injection of the drug. After recovery from the shock state, drip administration is continued until blood pressure stabilizes. A single dose is 50-150 mg (in severe cases - up to 400 mg). The drug is re-administered after 3-4 hours. The daily dose can be 300-1200 mg (with subsequent dose reduction).
At acute hepatic-renal failure(in acute poisoning, postoperative and postpartum periods etc.), Prednisolone is administered at 25-75 mg/day; if indicated, the daily dose can be increased to 300-1500 mg/day and higher.
At rheumatoid arthritis and systemic lupus erythematosus Prednisolone is administered in addition to systemic administration of the drug at a dose of 75-125 mg/day for no more than 7-10 days.
At acute hepatitis Prednisolone is administered at 75-100 mg/day for 7-10 days.
At poisoning with cauterizing liquids with burns of the digestive tract and upper respiratory tract Prednisolone is prescribed at a dose of 75-400 mg/day for 3-18 days.
If intravenous administration is not possible, Prednisolone is administered intramuscularly in the same doses. After relief of the acute condition, Prednisolone tablets are prescribed orally, followed by a gradual reduction in the dose.
With long-term use of the drug daily dose should be reduced gradually. Long-term therapy should not be stopped suddenly!
Side effects
Frequency of development and severity side effects depends on the duration of use, the size of the dose used and the ability to comply with the circadian rhythm of prescribing Prednisolone.
When using Prednisolone, the following may occur:
From the endocrine system: decreased glucose tolerance, steroid diabetes mellitus or manifestation of latent diabetes mellitus, suppression of adrenal function, Itsenko-Cushing syndrome (moon face, pituitary type obesity, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, muscle weakness, stretch marks), delayed sexual development in children.
From the outside digestive system: nausea, vomiting, pancreatitis, steroid ulcer of the stomach and duodenum, erosive esophagitis, gastrointestinal bleeding and wall perforation gastrointestinal tract, increased or decreased appetite, indigestion, flatulence, hiccups. In rare cases, increased activity of liver transaminases and alkaline phosphatase.
From the cardiovascular system: arrhythmias, bradycardia (up to cardiac arrest); development (in predisposed patients) or increased severity of heart failure, changes in the electrocardiogram characteristic of hypokalemia, increased blood pressure, hypercoagulation, thrombosis. In patients with acute and subacute myocardial infarction - the spread of necrosis, slowing down the formation of scar tissue, which can lead to rupture of the heart muscle.
From the nervous system: delirium, disorientation, euphoria, hallucinations, manic-depressive psychosis, depression, paranoia, increased intracranial pressure, nervousness or anxiety, insomnia, dizziness, vertigo, pseudotumor of the cerebellum, headache, convulsions.
From the senses: posterior subcapsular cataract, increased intraocular pressure with possible damage optic nerve, tendency to develop secondary bacterial, fungal or viral eye infections, trophic changes in the cornea, exophthalmos, sudden loss vision (with parenteral administration in the head, neck, nasal turbinates, scalp, deposition of drug crystals in the vessels of the eye is possible).
From the side of metabolism: increased calcium excretion, hypocalcemia, weight gain, negative nitrogen balance (increased protein breakdown), increased sweating.
Caused by mineralocorticoid activity: fluid and sodium retention (peripheral edema), hypernatremia, hypokalemic syndrome (hypokalemia, arrhythmia, myalgia or muscle spasm, unusual weakness and fatigue).
From the musculoskeletal system: slower growth and ossification processes in children (premature closure of epiphyseal growth zones), osteoporosis (very rarely - pathological bone fractures, aseptic necrosis of the head of the humerus and femur), rupture of muscle tendons, steroid myopathy, decreased muscle mass (atrophy).
From the skin and mucous membranes: delayed wound healing, petechiae, ecchymosis, skin thinning, hyper- or hypopigmentation, steroid acne, stretch marks, tendency to develop pyoderma and candidiasis.
Allergic reactions: skin rash, itching, anaphylactic shock, local allergic reactions.
Local for parenteral administration: burning, numbness, pain, tingling at the injection site, infection at the injection site, rarely - necrosis of surrounding tissues, scarring at the injection site; atrophy of the skin and subcutaneous tissue with intramuscular injection (injection into the deltoid muscle is especially dangerous).
Others: development or exacerbation of infections (the appearance of this side effect is facilitated by jointly used immunosuppressants and vaccination), leukocyturia, withdrawal syndrome.
Overdose
It is possible to enhance the above side effects.
It is necessary to reduce the dose of Prednisolone. Treatment is symptomatic.
Drug interactions
Pharmaceutical incompatibility of Prednisolone with other intravenously administered drugs is possible - it is recommended to administer it separately from other drugs (iv bolus, or through another dropper, as a second solution). When mixing a solution of prednisolone with heparin, a precipitate forms.
Simultaneous administration of prednisolone with:
inducers of liver microsomal enzymes(phenobarbital, rifampicin, phenytoin, theophylline, ephedrine) leads to a decrease in its concentration;
diuretics(especially “thiazide” and carbonic anhydrase inhibitors) and amphotericin B - may lead to increased removal of K+ from the body and an increased risk of heart failure;
with sodium-containing drugs- to the development of edema and increased blood pressure;
cardiac glycosides- their tolerability worsens and the likelihood of developing ventricular extrasytolia increases (due to caused hypokalemia);
indirect anticoagulants- weakens (less often strengthens) their effect (dosage adjustment required);
anticoagulants and thrombolytics- the risk of bleeding from ulcers in the gastrointestinal tract increases;
ethanol and NSAIDs- the risk of erosive and ulcerative lesions in the gastrointestinal tract and the development of bleeding increases (in combination with NSAIDs in the treatment of arthritis, it is possible to reduce the dose of GCS due to the summation of the therapeutic effect);
paracetamol - the risk of developing hepatotoxicity increases (induction of liver enzymes and the formation of a toxic metabolite of paracetamol);
- accelerates its elimination and reduces its concentration in the blood (when prednisolone is discontinued, the level of salicylates in the blood increases and the risk of side effects increases);
insulin and oral hypoglycemic drugs, antihypertensive drugs - their effectiveness decreases;
vitamin D - its effect on the absorption of Ca 2+ in the intestine decreases;
somatotropic hormone - reduces the effectiveness of the latter, and with praziquantel - its concentration;
M-anticholinergics(including antihistamines and tricyclic antidepressants) and nitrates- helps to increase intraocular pressure;
isoniazid and mexiletine- increases their metabolism (especially in “slow” acetylators), which leads to a decrease in their plasma concentrations.
Carbonic anhydrase inhibitors and loop diuretics may increase the risk of osteoporosis.
Indomethacin, displacing prednisolone from its connection with albumin, increases the risk of developing its side effects.
ACTH enhances the effect of prednisolone.
Ergocalciferol and parathyroid hormone prevent the development of osteopathy caused by prednisolone.
Cyclosporine and ketoconazole, by slowing down the metabolism of prednisolone, can in some cases increase its toxicity.
The simultaneous administration of androgens and steroidal anabolic drugs with prednisolone promotes the development of peripheral edema and hirsutism, and the appearance of acne.
Estrogens and oral estrogen-containing contraceptives reduce the clearance of prednisolone, which may be accompanied by an increase in the severity of its action.
Mitotane and other inhibitors of adrenal function may necessitate an increase in the dose of prednisolone.
When used simultaneously with live antiviral vaccines and against the background of other types of immunization, it increases the risk of viral activation and the development of infections.
Antipsychotics (neuroleptics) and azathioprine increase the risk of developing cataracts when prednisolone is prescribed.
When used simultaneously with antithyroid drugs, the clearance of prednisolone decreases and with thyroid hormones increases.
special instructions
During treatment with Prednisolone (especially long-term), observation by an ophthalmologist, monitoring of blood pressure, water and electrolyte balance, as well as peripheral blood patterns and blood glucose levels are necessary.
In order to reduce side effects, antacids can be prescribed, as well as increasing the intake of K + into the body (diet, potassium supplements). Food should be rich in proteins, vitamins, and limit the content of fats, carbohydrates and table salt.
The effect of the drug is enhanced in patients with hypothyroidism and liver cirrhosis. The drug may worsen existing emotional instability or psychotic disorders. If a history of psychosis is indicated, Prednisolone in high doses is prescribed under the strict supervision of a physician.
It should be used with caution in acute and subacute myocardial infarction - the necrosis may spread, the formation of scar tissue may slow down, and the heart muscle may rupture.
In stressful situations during maintenance treatment (for example, surgery, trauma or infectious diseases), the dose of the drug should be adjusted due to an increased need for GCS.
With sudden withdrawal, especially in the case of previous use of high doses, withdrawal syndrome may develop (anorexia, nausea, lethargy, generalized musculoskeletal pain, general weakness), as well as an exacerbation of the disease for which Prednisolone was prescribed.
During treatment with Prednisolone, vaccination should not be carried out due to a decrease in its effectiveness (immune response).
When prescribing Prednisolone for intercurrent infections, septic conditions and tuberculosis, it is necessary to simultaneously treat with bactericidal antibiotics.
In children during long-term treatment with Prednisolone, careful monitoring of the dynamics of growth and development is necessary. Children who during the treatment period were in contact with patients with measles or chickenpox are prescribed specific immunoglobulins prophylactically.
Due to the weak mineralocorticoid effect, Prekisolone is used in combination with mineralocorticoids for replacement therapy for adrenal insufficiency.
In patients with diabetes mellitus, blood glucose levels should be monitored and therapy adjusted if necessary.
X-ray monitoring of the osteoarticular system (images of the spine, hand) is indicated.
Prednisolone in patients with latent infectious diseases kidneys and urinary tract can cause leukocyturia, which may have diagnostic value.
Prednisolone increases the content of 11- and 17-hydroxyketocorticosteroid metabolites.
Pregnancy and lactation
During pregnancy (especially in the first trimester) it is used only for health reasons. With long-term therapy during pregnancy, the possibility of impaired fetal growth cannot be excluded. If used in the third trimester of pregnancy, there is a risk of atrophy of the adrenal cortex in the fetus, which may require replacement therapy in the newborn.
Conditions for dispensing from pharmacies
The drug is available with a prescription.
Storage conditions and periods
List B. The drug should be stored at a temperature not exceeding 25°C out of the reach of children. Shelf life - 3 years. Do not use after the expiration date stated on the package.
Prednisolone injections are a drug with enhanced biological activity, which is used in emergency situations. Injections of the drug can have antiallergic, anti-inflammatory and immunosuppressive effects.
The form of the drug used determines the speed of its effect and the likelihood adverse reactions. Prednisolone tablets are prescribed for long-term therapy, and the drug in ampoules is used when delay is dangerous. When administered intramuscularly, the medicine begins to act after a quarter of an hour, when administered intravenously - after 3 minutes.
Prednisolone injections, according to the instructions for use, are prescribed under the following clinical circumstances:
- Acute allergic manifestations;
- A complication of diffuse toxic goiter that threatens the patient’s life;
- Intractable attack of bronchial asthma;
- Shock condition that is not amenable to prescribed treatment;
- Renal and liver failure in an aggravated form;
- Rheumatic ailments;
- Hepatitis;
- Pathology of the adrenal cortex;
- Prevention of scar formation when damaged by cauterizing substances.
Apart from emergency assistance, injections of the drug are included in the complex treatment of malignant neoplasms, chronic pulmonary, autoimmune and skin diseases, and cardiac pathologies. Prednisolone injections are used in hematology and ophthalmological practice.
The dosage and duration of therapy should be determined by the doctor. It takes into account the severity of the disease, the patient’s health status, concomitant ailments and possible contraindications.
The average dose is 10-30 mg of the drug intramuscularly. From 30 to 200 mg is administered through an IV in emergency situations.
For children, the amount of medication is prescribed at the rate of 1-3 mg per 1 kg of body weight.
The drug is administered intravenously through a dropper or intramuscularly. After relief of the emergency condition, Prednisolone is taken in tablet form.
Contraindications
Prednisolone, according to the instructions for using intramuscular injections, is very effective, but has a whole list of contraindications and unwanted side effects. Injections are not prescribed if you are intolerant or hypersensitive to the ingredients of the medication. It is used with extreme caution:
- In immunodeficiency conditions;
- During the period of therapy and recovery from viral infectious diseases;
- In patients with diseases of the digestive tract;
- After administration of the vaccine;
- Patients with pathologies of the cardiovascular and endocrine systems;
- In case of renal failure.
Prednisolone injections for pregnant women and young children are prescribed solely based on vital signs under direct medical supervision. During the period of treatment with this medication breast-feeding must be interrupted. The drug is not prescribed to children under 3 months and elderly people over 70 years of age.
The following side effects were observed during Prednisolone therapy:
- Muscular atrophy;
- Weight gain;
- Decreased ability of the body to process glucose;
- Adrenal gland dysfunction;
- Insulin-dependent diabetes mellitus;
- Increase in intracranial and blood pressure;
- Stomach or duodenal ulcer;
- Sinus rhythm disturbance;
- Inhibition of sexual development in adolescents,
- Corneal pathologies;
- Increased sweating;
- Convulsions;
- Migraine;
- Sleep disorders;
- Depression, confusion.
At the injection site, rashes, itching and other local allergic manifestations are possible.
pharmachologic effect
GKS. Suppresses the functions of leukocytes and tissue macrophages. Limits the migration of leukocytes to the area of inflammation. It disrupts the ability of macrophages to phagocytose, as well as to form interleukin-1. Helps stabilize lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the area of inflammation. Reduces capillary permeability due to the release of histamine. Suppresses fibroblast activity and collagen formation.
Inhibits the activity of phospholipase A 2, which leads to suppression of the synthesis of prostaglandins and leukotrienes. Suppresses the release of COX (mainly COX-2), which also helps to reduce the production of prostaglandins.
Reduces the number of circulating lymphocytes (T- and B-cells), monocytes, eosinophils and basophils due to their movement from the vascular bed into the lymphoid tissue; suppresses the formation of antibodies.
Prednisolone suppresses the release of ACTH and b-lipotropin by the pituitary gland, but does not reduce the level of circulating b-endorphin. Inhibits the secretion of TSH and FSH.
When directly applied to blood vessels, it has a vasoconstrictor effect.
Prednisolone has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats. Stimulates gluconeogenesis, promotes the uptake of amino acids by the liver and kidneys, and increases the activity of gluconeogenesis enzymes. In the liver, prednisolone enhances the deposition of glycogen, stimulating the activity of glycogen synthetase and the synthesis of glucose from protein metabolism products. An increase in blood glucose levels activates the release of insulin.
Prednisolone inhibits the uptake of glucose by fat cells, which leads to the activation of lipolysis. However, due to an increase in insulin secretion, lipogenesis is stimulated, which contributes to the accumulation of fat.
It has a catabolic effect in lymphoid and connective tissue, muscles, adipose tissue, skin, bone tissue. To a lesser extent than hydrocortisone, it affects the processes of water-electrolyte metabolism: it promotes the excretion of potassium and calcium ions, the retention of sodium and water ions in the body. Osteoporosis and Itsenko-Cushing syndrome are the main factors limiting long-term GCS therapy. As a result of the catabolic action, growth suppression in children is possible.
In high doses, prednisolone can increase the excitability of brain tissue and help lower the seizure threshold. Stimulates excess production of hydrochloric acid and pepsin in the stomach, which leads to the development of peptic ulcers.
When used systemically, the therapeutic activity of prednisolone is due to its anti-inflammatory, antiallergic, immunosuppressive and antiproliferative effects.
When applied externally and locally, the therapeutic activity of prednisolone is due to its anti-inflammatory, antiallergic and antiexudative (due to the vasoconstrictor effect) effect.
Compared with hydrocortisone, the anti-inflammatory activity of prednisolone is 4 times greater, mineralocorticoid activity is 0.6 times less.
Pharmacokinetics
When taken orally, it is well absorbed from the gastrointestinal tract. The maximum plasma concentration is observed after 90 minutes. In plasma, most of the prednisolone is bound to transcortin (cortisol-binding globulin). Metabolized primarily in the liver.
The half-life is approximately 200 minutes. Excreted unchanged by the kidneys - 20%.
Indications
For oral and intramuscular use: rheumatism; rheumatoid arthritis; dermatomyositis; periarteritis nodosa; scleroderma; Bekhterev's disease; bronchial asthma, status asthmaticus; acute and chronic allergic diseases; Addison's disease, acute adrenal insufficiency, adrenogenital syndrome; hepatitis, hepatic coma, hypoglycemic conditions, lipoid nephrosis; agranulocytosis, various forms of leukemia, lymphogranulomatosis, thrombocytopenic purpura, hemolytic anemia; chorea; pemphigus, eczema, itching, exfoliative dermatitis, psoriasis, prurigo, eczema, seborrheic dermatitis, lupus erythematosus, erythroderma, psoriasis, alopecia.
For use in ophthalmology: allergic, chronic and atypical conjunctivitis and blepharitis; inflammation of the cornea with intact mucosa; acute and chronic inflammation of the anterior segment of the choroid, sclera and episclera; sympathetic inflammation of the eyeball; after injuries and operations with prolonged irritation eyeballs.
For intra-articular administration: chronic polyarthritis, post-traumatic arthritis, osteoarthritis of large joints, rheumatic lesions of individual joints, arthrosis.
For infiltration administration into tissues: epicondylitis, tendovaginitis, bursitis, humeroscapular periarthritis, keloids, sciatica, Dupuytren's contracture, rheumatic and similar lesions of joints and various tissues.
Dosage regimen
When taken orally for replacement therapy in adults, the initial dose is 20-30 mg/day, the maintenance dose is 5-10 mg/day. If necessary, the initial dose can be 15-100 mg/day, maintenance - 5-15 mg/day. The daily dose should be reduced gradually. For children, the initial dose is 1-2 mg/kg/day in 4-6 divided doses, maintenance dose is 300-600 mcg/kg/day.
When administered intramuscularly, the dose, frequency and duration of use are determined individually. When administered intra-articularly, a dose of 25-50 mg is used in large joints, for medium-sized joints - 10-25 mg, for small joints - 5-10 mg. For infiltration into tissue, depending on the severity of the disease and the size of the affected area, doses from 5 to 50 mg are used.
Used locally in ophthalmology 3 times a day, the course of treatment is no more than 14 days; in dermatology - 1-3 times/day.
Side effect
From the endocrine system: Itsenko-Cushing syndrome, weight gain. Hyperglycemia up to the development of steroid diabetes, depletion (up to atrophy) of the function of the adrenal cortex.
From the digestive system: increased acidity of gastric juice, ulcerogenic effect on the gastrointestinal tract.
Metabolism: increased excretion of potassium, sodium retention in the body with the formation of edema, negative nitrogen balance.
From the cardiovascular system: arterial hypertension.
From the blood coagulation system: increased blood clotting.
From the musculoskeletal system: osteoporosis, aseptic bone necrosis.
From the organ of vision: steroid cataract, provoking latent glaucoma.
From the central nervous system: mental disorders.
Effects due to immunosuppressive effects: decreased resistance to infections, delayed wound healing.
When used externally: possible appearance of steroid acne, purpura, telangiectasia, as well as burning, itching, irritation, dry skin; with prolonged use and/or when applied to large surfaces of the skin, a resorptive effect may develop.
When applied topically: a slight burning sensation is possible.
Contraindications
Peptic ulcer of the stomach and duodenum, osteoporosis, Itsenko-Cushing syndrome, tendency to thromboembolism, renal failure, severe arterial hypertension, systemic mycoses, viral infections, vaccination period, active form of tuberculosis, glaucoma, productive symptoms during mental illness. Hypersensitivity to prednisolone.
Infiltration injection into lesions of the skin and tissues during chicken pox, specific infections, mycoses, with a local reaction to vaccination.
In ophthalmology - viral and bacterial eye diseases, primary glaucoma, diseases of the cornea with damage to the epithelium. In dermatology - bacterial, viral, fungal skin lesions, tuberculosis, syphilis, skin tumors.
Pregnancy and lactation
During pregnancy (especially in the first trimester) it is used only for health reasons. If it is necessary to use it during lactation, the expected benefits of treatment for the mother and the risk for the child should be carefully weighed.
Not intended for intravenous administration. During the day, it is recommended to use it taking into account the circadian rhythm of endogenous secretion of GCS in the interval from 6 to 8 am.
Use with caution in patients with a history of psychosis; nonspecific infections subject to simultaneous chemotherapy or antibiotic therapy. At diabetes mellitus application is possible only with absolute readings or to prevent suspected insulin resistance. For latent forms of tuberculosis, prednisolone can only be used in combination with anti-tuberculosis drugs.
During treatment (especially long-term), observation by an ophthalmologist, monitoring of blood pressure and water-electrolyte balance, as well as peripheral blood patterns and blood sugar levels are necessary; In order to reduce side effects, you can prescribe anabolic steroids, antibiotics, and also increase the intake of potassium in the body (diet, potassium supplements). It is recommended to clarify the need for ACTH administration after a course of treatment with prednisone (after performing a skin test!). In Addison's disease, concomitant use with barbiturates should be avoided.
After stopping treatment, withdrawal syndrome, adrenal insufficiency, and exacerbation of the disease for which prednisolone was prescribed may occur.
It should not be used externally for more than 14 days. If used for acne vulgaris or rosacea, an exacerbation of the disease is possible.
Prednisolone in the form of tablets, injection solution, dry substance for injection, eye drops, ointments are included in the List of Vital and Essential Drugs.
With the simultaneous use of prednisolone with anticoagulants, the anticoagulant effect of the latter may be enhanced; with salicylates - the likelihood of bleeding increases; with diuretics - possible aggravation of electrolyte metabolism disorders; with antidiabetic drugs - the rate of decrease in blood sugar decreases; with cardiac glycosides - the risk of developing glycoside intoxication increases; with rifampicin - weakening of the therapeutic effect of rifampicin.
Below are analogues of PREDNISOONE tablets, medications similar in indications for use and their pharmacological action, as well as prices and availability of analogues in pharmacies. To compare with analogues, carefully study the active ingredients of the drug; as a rule, the price of more expensive drugs contains its advertising budget and additives that increase the effect of the main substance. PREDNISOONE tablets instructions for use
We kindly ask you not to make a decision to replace PREDNISOONE tablets on your own, only as directed and with the permission of your doctor.
ADVANTAN
- Instructions for use
LOCOID
Indications for use of the drug Lokoid:
Superficial processes in the epidermis without signs of infection, sensitive to the action of corticosteroids:
- dermatitis;
- eczema;
- psoriasis.- Instructions for use
ELOCOM
A drug Elokom used for skin diseases requiring glucocorticosteroid therapy, including:
— symptomatic treatment inflammation and itching in skin and allergic diseases;
— treatment of psoriasis, atopic and seborrheic dermatitis;
- lichen planus, radiation dermatitis.- Instructions for use
SODERM
Soderm intended for the treatment of inflammatory, allergic or itchy diseases of the scalp, for which the symptomatic use of potent corticoids is prescribed (eczema, psoriasis, dermatitis).
- Instructions for use
PREDNITOP
corticosteroids.
Prednitop cream is used in the treatment acute diseases skin conditions such as ulcers and redness.
Prednitop ointment is used to treat dry or weeping skin diseases.
Fatty ointment Prednitop is used for chronic diseases skin, which is accompanied by roughening of skin folds and peeling
It should be taken into account that local treatment The use of Prednitop for fungal and bacterial skin infections is allowed only in combination with antifungal and antibacterial drugs.- Instructions for use
CARIZON
Carizon are: psoriasis (with the exception of common plaque psoriasis), persistent eczema, lichen planus, discoid lupus erythematosus and other skin diseases that are not treatable with less active corticosteroids.
- Instructions for use
AFLODERM
Dermatoses and inflammatory skin diseases that respond to topical therapy with glucocorticosteroid drugs (including: eczema, atopic dermatitis, allergic and contact dermatitis, incl. phytodermatitis, psoriasis, photodermatitis and sunburn, allergic reactions to insect bites).
Afloderm cream used for the treatment of acute and subacute stages inflammatory diseases skin, including those accompanied by exudation.
Afloderm cream recommended for the treatment of inflammatory skin diseases on delicate and sensitive areas of the body (face, neck, chest, genital area) and when there is a need for additional hydration of the affected skin, which is provided by the components of the drug base.- Instructions for use
DERMOVATE
A drug Dermovate used for the treatment of psoriasis (except for the form of widespread plaque psoriasis), lichen planus, discoid lupus erythematosus, persistent eczema (refractory forms).
- Instructions for use
GISTAN-N
Cream Gistan-N used for inflammation and itching of the skin in dermatoses (including psoriasis, atopic dermatitis, seborrheic dermatitis), for which GCS therapy is indicated.
- Instructions for use
SYNTICORT CREAM
Synthicort cream intended to reduce or eliminate inflammatory symptoms in dermatological diseases amenable to therapy with glucocorticosteroids:
- eczema;
— dermatitis (atopic, contact, seborrheic, exfoliative, intertriginous, radiation, solar);
— limited neurodermatitis;
- lichen planus;
- psoriasis;
- Hyde's nodular prurigo;
- Instructions for use
SYNTICORT OINTMENT
Synticort ointment intended to weaken or eliminate inflammatory symptoms in dermatological diseases amenable to therapy with glucocorticosteroids:
- eczema;
— dermatitis (atopic, contact, seborrheic, exfoliative; intertriginous, radiation, solar);
— limited neurodermatitis;
- lichen planus;
- psoriasis;
- Hyde's nodular prurigo;
- skin or anogenital itching;
- discoid lupus erythematosus;
— generalized erythroderma (as part of complex therapy).- Instructions for use
MOLESKINE C
- Instructions for use
MOMETASONE
Or cream Mometasone are: itching and inflammation in dermatoses that are amenable to GCS therapy; conditions with symptoms of hyperkeratosis (chronic eczema, psoriasis, seborrheic and atopic dermatitis) in adults and children over two years of age.
- Instructions for use
KUTIVATE
Cutivate intended for the treatment of patients suffering from dermatoses that require the use of topical glucocorticosteroids, including atopic, infantile and discoid eczema, psoriasis (excluding the plaque form), nodular itching; those suffering from lichen planus, lichen simplex, neurodermatosis, discoid lupus erythematosus, seborrheic dermatitis, prickly heat, as well as hyperemia, swelling and itching caused by insect bites; with generalized erythroderma.
Cutivate cream and ointment can be used to reduce the risk of relapses in patients with chronic atopic eczema (if fluticasone is effective in the acute phase of the disease).- Instructions for use
MESODERM
CreamMesoderm used for treatment:
- eczema of various forms and localization;
- psoriasis;
— neurodermatitis;
— dermatitis (contact, seborrheic, solar, exfoliative, radiation, intertriginous);
- anogenital itching;
- senile itching.
Mesoderm also used as an addition to systemic glucocorticoid therapy for generalized erythroderma.- Instructions for use
BELODERM
Beloderm intended for the treatment of skin diseases that respond to therapy with topical corticosteroids, including:
– atopic dermatitis/neurodermatitis
- allergic contact dermatitis
- eczema (various forms)
— contact dermatitis (including professional) and other non- allergic dermatitis(including solar and radiation dermatitis)
- reactions to insect bites
— psoriasis
- bullous dermatoses
- discoid lupus erythematosus
- lichen planus
- exudative erythema multiforme
— pruritus of various etiologies.- Instructions for use
PSORIDERM
Indications for use of the drug Psoriderm are:
- psoriasis (except for the common plaque form);
— chronic eczema (refractory forms);
- lichen planus;
- discoid lupus erythematosus;
- other skin diseases, when less active corticosteroids are ineffective.- Instructions for use
KLOBESKIN
Indications for use of the drug Klobeskin are: psoriasis (with the exception of widespread plaque psoriasis), persistent eczema, lichen planus, discoid lupus erythematosus and other skin diseases that cannot be treated with less active corticosteroids.
- Instructions for use
METIZOLONE
Metizolone are: atopic dermatitis (endogenous eczema, neurodermatitis), contact eczema, degenerative, dyshidrotic, nummular eczema, nonspecific eczema, eczema in children.
- Instructions for use
LOCOID KRELO
Indications for use of the drug Lokoid Krelo are: superficial, non-infected, sensitive to local corticosteroids skin diseases: eczema; dermatitis (including atopic, contact, seborrheic); psoriasis.
- Instructions for use
ELOZON
Indications for use of the cream Elozon are: inflammatory phenomena and itching in dermatoses amenable to corticosteroid therapy, including psoriasis (except for widespread plaque psoriasis) and atopic dermatitis, in adults and children over 2 years of age.
- Instructions for use
SINAFLAN
Indications for use of the drug Sinaflan are: eczema, atopic dermatitis, simple chronic lichen (limited neurodermatitis), toxicerma, simple allergic dermatitis, seborrheic dermatitis, itching, urticaria, prurigo, diaper rash, exudative erythema multiforme, psoriasis (exudative form); lichen planus, discoid lupus erythematosus, hand dyshidrosis, otitis externa, first degree burns, insect bites.
- Instructions for use
CELESTODERM-V
Celestoderm-B used to reduce the inflammatory manifestations of dermatoses sensitive to GCS therapy, such as: eczema (atopic, coin-shaped), contact dermatitis, seborrheic dermatitis, neurodermatitis, solar dermatitis, exfoliative dermatitis, stasis dermatitis, radiation dermatitis, intertriginous dermatitis, psoriasis, anogenital and senile itch.
- Instructions for use
UNIDERM
Cream Uniderm used for the treatment of inflammatory symptoms and itching in dermatoses amenable to GCS therapy.
- Instructions for use
AKRIDERM
Indications for use of the cream Akriderm are: atopic dermatitis; allergic contact dermatitis; eczema (various forms); contact dermatitis (including occupational) and other non-allergic dermatitis (including solar and radiation dermatitis); reactions to insect bites; psoriasis; bullous dermatoses; discoid lupus erythematosus; lichen planus; exudative multimorphic erythema; skin itching of various etiologies.
- Instructions for use
TRIACORT
Indications for use of ointment Triacort are: simple and allergic dermatitis, eczema, atopic dermatitis, diffuse neurodermatitis, psoriasis, granuloma annulare, lichen planus, simple chronic lichen (limited neurodermatitis), toxicerma, keloid scars, alopecia areata, complete alopecia, insect bites.
- Instructions for use
ELOCOM CREAM
- Instructions for use
SINAFLANA OINTMENT
Indications for use Sinaflan ointment are: allergic and inflammatory skin diseases of non-microbial etiology, accompanied by severe itching: seborrheic dermatitis, atopic dermatitis, eczema, neurodermatitis, erythema multiforme, systemic lupus erythematosus, lichen planus, psoriasis, prurigo, urticaria, insect bites.
- Instructions for use
FLUCINAR
A drug Flucinar intended for short-course use for acute dermatitis of a non-infectious nature, including severe forms accompanied by itching and hyperkeratosis: atopic and seborrheic dermatitis; flat and pityriasis rosea; contact eczema; psoriasis.
- Instructions for use
BETAMETHASONE
Ointment Betamethasone used to reduce the inflammatory manifestations of dermatoses sensitive to glucocorticoid therapy, such as: eczema and dermatitis of any type, including atopic eczema, photodermatitis, lichen planus, neurodermatitis, nodular prurigo, discoid lupus erythematosus, necrobiosis lipoidica, pretibial myxedema and erythroderma. In addition, it is also effective in the treatment of psoriasis of the scalp and other forms of psoriasis, with the exception of extensive plaque.
- Instructions for use
BETLIBEN
Indications for use of ointment Betlieben are: allergic skin diseases (including acute, subacute and chronic contact dermatitis, occupational dermatitis, seborrheic dermatitis, atopic dermatitis, solar dermatitis, neurodermatitis, pruritus, dyshidrotic dermatitis, eczema), acute and chronic forms of non-allergic dermatitis, psoriasis.
- Instructions for use
FLUOROCORT
Ointment Fluorocort intended for the treatment of skin diseases sensitive to corticosteroids (eczema, psoriasis vulgaris, allergic dermatitis).
- Instructions for use
STEROCORT
Indications for use of the drug Sterocort are: atopic dermatitis (neurodermatitis, endogenous eczema) real (true) eczema simple contact dermatitis and allergic contact dermatitis dyshidrotic eczema, childhood eczema, seborrheic dermatitis (and eczema), including on the scalp; nummular eczema, dermatoses of the scalp of an inflammatory nature, accompanied by itching.
- Instructions for use
ALERGODERM
Ointment Alergoderm intended for short-term treatment of acute and severe non-infectious inflammatory skin diseases (without exudation), which are accompanied by persistent itching or hyperkeratosis: seborrheic dermatitis, atopic dermatitis, nodular urticaria (papular urticaria), allergic contact dermatitis, erythema multiforme, tuberculous lupus, psoriasis, red flat lichen.
- Instructions for use
www.medcentre.com.ua
pharmachologic effect
GKS. Suppresses the functions of leukocytes and tissue macrophages. Limits the migration of leukocytes to the area of inflammation. It disrupts the ability of macrophages to phagocytose, as well as to form interleukin-1. Helps stabilize lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the area of inflammation. Reduces capillary permeability due to the release of histamine. Suppresses fibroblast activity and collagen formation.
Inhibits the activity of phospholipase A 2, which leads to suppression of the synthesis of prostaglandins and leukotrienes. Suppresses the release of COX (mainly COX-2), which also helps to reduce the production of prostaglandins.
Reduces the number of circulating lymphocytes (T- and B-cells), monocytes, eosinophils and basophils due to their movement from the vascular bed into the lymphoid tissue; suppresses the formation of antibodies.
Prednisolone suppresses the release of ACTH and b-lipotropin by the pituitary gland, but does not reduce the level of circulating b-endorphin. Inhibits the secretion of TSH and FSH.
When directly applied to blood vessels, it has a vasoconstrictor effect.
Prednisolone has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats. Stimulates gluconeogenesis, promotes the uptake of amino acids by the liver and kidneys, and increases the activity of gluconeogenesis enzymes. In the liver, prednisolone enhances the deposition of glycogen, stimulating the activity of glycogen synthetase and the synthesis of glucose from protein metabolism products. An increase in blood glucose levels activates the release of insulin.
Prednisolone inhibits the uptake of glucose by fat cells, which leads to the activation of lipolysis. However, due to an increase in insulin secretion, lipogenesis is stimulated, which contributes to the accumulation of fat.
It has a catabolic effect in lymphoid and connective tissue, muscles, adipose tissue, skin, bone tissue. To a lesser extent than hydrocortisone, it affects the processes of water-electrolyte metabolism: it promotes the excretion of potassium and calcium ions, the retention of sodium and water ions in the body. Osteoporosis and Itsenko-Cushing syndrome are the main factors limiting long-term GCS therapy. As a result of the catabolic action, growth suppression in children is possible.
In high doses, prednisolone can increase the excitability of brain tissue and help lower the seizure threshold. Stimulates excess production of hydrochloric acid and pepsin in the stomach, which leads to the development of peptic ulcers.
When used systemically, the therapeutic activity of prednisolone is due to its anti-inflammatory, antiallergic, immunosuppressive and antiproliferative effects.
When applied externally and locally, the therapeutic activity of prednisolone is due to its anti-inflammatory, antiallergic and antiexudative (due to the vasoconstrictor effect) effect.
Compared with hydrocortisone, the anti-inflammatory activity of prednisolone is 4 times greater, mineralocorticoid activity is 0.6 times less.Pharmacokinetics
When taken orally, it is well absorbed from the gastrointestinal tract. The maximum plasma concentration is observed after 90 minutes. In plasma, most of the prednisolone is bound to transcortin (cortisol-binding globulin). Metabolized primarily in the liver.
The half-life is approximately 200 minutes. Excreted unchanged by the kidneys - 20%.Indications
For oral and intramuscular use: rheumatism; rheumatoid arthritis; dermatomyositis; periarteritis nodosa; scleroderma; Bekhterev's disease; bronchial asthma, status asthmaticus; acute and chronic allergic diseases; Addison's disease, acute adrenal insufficiency, adrenogenital syndrome; hepatitis, hepatic coma, hypoglycemic conditions, lipoid nephrosis; agranulocytosis, various forms of leukemia, lymphogranulomatosis, thrombocytopenic purpura, hemolytic anemia; chorea; pemphigus, eczema, itching, exfoliative dermatitis, psoriasis, prurigo, eczema, seborrheic dermatitis, lupus erythematosus, erythroderma, psoriasis, alopecia.
For use in ophthalmology: allergic, chronic and atypical conjunctivitis and blepharitis; inflammation of the cornea with intact mucosa; acute and chronic inflammation of the anterior segment of the choroid, sclera and episclera; sympathetic inflammation of the eyeball; after injuries and operations with prolonged irritation of the eyeballs.
For intra-articular administration: chronic polyarthritis, post-traumatic arthritis, osteoarthritis of large joints, rheumatic lesions of individual joints, arthrosis.
For infiltration administration into tissues: epicondylitis, tendovaginitis, bursitis, humeroscapular periarthritis, keloids, sciatica, Dupuytren's contracture, rheumatic and similar lesions of joints and various tissues.Dosage regimen
When taken orally for replacement therapy in adults, the initial dose is 20-30 mg/day, the maintenance dose is 5-10 mg/day. If necessary, the initial dose can be 15-100 mg/day, maintenance - 5-15 mg/day. The daily dose should be reduced gradually. For children, the initial dose is 1-2 mg/kg/day in 4-6 doses, maintenance - 300-600 mcg/kg/day.
When administered intramuscularly, the dose, frequency and duration of use are determined individually. When administered intra-articularly, a dose of 25-50 mg is used in large joints, for medium-sized joints - 10-25 mg, for small joints - 5-10 mg. For infiltration into tissue, depending on the severity of the disease and the size of the affected area, doses from 5 to 50 mg are used.
Used locally in ophthalmology 3 times a day, the course of treatment is no more than 14 days; in dermatology - 1-3 times/day.Side effect
From the endocrine system: Itsenko-Cushing syndrome, weight gain. Hyperglycemia up to the development of steroid diabetes, depletion (up to atrophy) of the function of the adrenal cortex.
From the digestive system: increased acidity of gastric juice, ulcerogenic effect on the gastrointestinal tract.
Metabolism: increased excretion of potassium, sodium retention in the body with the formation of edema, negative nitrogen balance.
From the cardiovascular system: arterial hypertension.
From the blood coagulation system: increased blood clotting.
From the musculoskeletal system: osteoporosis, aseptic bone necrosis.
From the organ of vision: steroid cataract, provoking latent glaucoma.
From the central nervous system: mental disorders.
Effects due to immunosuppressive effects: decreased resistance to infections, delayed wound healing.
When used externally: possible appearance of steroid acne, purpura, telangiectasia, as well as burning, itching, irritation, dry skin; with prolonged use and/or when applied to large surfaces of the skin, a resorptive effect may develop.
When applied topically: a slight burning sensation is possible.Contraindications
Peptic ulcer of the stomach and duodenum, osteoporosis, Itsenko-Cushing syndrome, tendency to thromboembolism, renal failure, severe arterial hypertension, systemic mycoses, viral infections, vaccination period, active form of tuberculosis, glaucoma, productive symptoms in mental illness. Hypersensitivity to prednisolone.
Infiltration injection into lesions of the skin and tissues during chickenpox, specific infections, mycoses, and local reactions to vaccination.
In ophthalmology - viral and bacterial eye diseases, primary glaucoma, diseases of the cornea with damage to the epithelium. In dermatology - bacterial, viral, fungal skin lesions, tuberculosis, syphilis, skin tumors.Pregnancy and lactation
During pregnancy (especially in the first trimester) it is used only for health reasons. If it is necessary to use it during lactation, the expected benefits of treatment for the mother and the risk for the child should be carefully weighed.
special instructions
Not intended for intravenous administration. During the day, it is recommended to use it taking into account the circadian rhythm of endogenous secretion of GCS in the interval from 6 to 8 am.
Use with caution in patients with a history of psychosis; nonspecific infections subject to simultaneous chemotherapy or antibiotic therapy. In diabetes mellitus, use is possible only for absolute indications or to prevent suspected insulin resistance. For latent forms of tuberculosis, prednisolone can only be used in combination with anti-tuberculosis drugs.
During treatment (especially long-term), observation by an ophthalmologist, monitoring of blood pressure and water-electrolyte balance, as well as peripheral blood patterns and blood sugar levels are necessary; In order to reduce side effects, you can prescribe anabolic steroids, antibiotics, and also increase the intake of potassium in the body (diet, potassium supplements). It is recommended to clarify the need for ACTH administration after a course of treatment with prednisone (after performing a skin test!). In Addison's disease, concomitant use with barbiturates should be avoided.
After stopping treatment, withdrawal syndrome, adrenal insufficiency, and exacerbation of the disease for which prednisolone was prescribed may occur.
It should not be used externally for more than 14 days. If used for acne vulgaris or rosacea, an exacerbation of the disease is possible.Prednisolone in the form of tablets, solution for injection, dry substance for injection, eye drops, ointments is included in the List of Vital and Essential Drugs.
Drug interactions
With the simultaneous use of prednisolone with anticoagulants, the anticoagulant effect of the latter may be enhanced; with salicylates - the likelihood of bleeding increases; with diuretics - possible aggravation of electrolyte metabolism disorders; with antidiabetic drugs - the rate of decrease in blood sugar decreases; with cardiac glycosides - the risk of developing glycoside intoxication increases; with rifampicin - weakening of the therapeutic effect of rifampicin.
www.poisklekarstv.com
Instructions for use
Prednisolone is characterized by anti-inflammatory, antihistamine, anti-shock, anti-exudative and anti-toxic effects.
Indications for use
Prednisolone has a very wide range of uses. It is prescribed for the treatment of diseases of the endocrine system such as:
- Primary and secondary, as well as acute, insufficiency of the adrenal cortex.
- Adrenogenital syndrome.
- Subacute thyroiditis.
This drug is also used in preparation for surgical intervention in patients who suffer from adrenal insufficiency, as well as in complex diseases and injuries in such patients.
Prednisolone is prescribed to get rid of serious ailments of an allergic nature that do not go away when treated with other drugs. Such ailments include:
- Serum sickness.
- Atopic and contact forms of dermatitis.
- Regular or seasonal runny nose caused by allergies.
- Manifestations of excessive sensitivity to drugs
- Angioedema.
- Anaphylaxis.
With the help of Prednisolone, rheumatic diseases such as:
- ordinary and juvenile rheumatoid arthritis;
- psoriatic and acute gouty arthritis;
- spondylitis of ankylosing type;
- myocarditis;
- rheumatic fever in the process of exacerbation;
- nodular type of periarteritis;
- systemic scleroderma.
- polymyalgia rheumatica, called Horton's disease;
- polychondritis in the relapse stage;
- systemic vasculitis.
This drug is used to treat liver diseases such as active hepatitis B chronic form and alcoholic type hepatitis with encephalopathy.
Prednisolone is also prescribed to persons with an excess of calcium in the body due to sarcoidosis or malignant formations.
Prednisolone can also be prescribed in the treatment of dermatological diseases such as:
- pemphigus;
- exfoliative type dermatitis;
- seborrheic and bullous dermatitis of herpetic form;
- pemphigoid;
- complex forms of eczema;
- complex erythema multiforme or Stevens-Johnson syndrome;
- mycosis fungoides type.
This medicine is also used to get rid of the following inflammatory processes in the joints:
- Bursitis in acute and subacute stages.
- Osteoarthritis after injury.
- Epicondylitis.
- Tenosynovitis.
Prednisolone is also used to treat hematological diseases such as:
- hemolysis;
- aplastic anemia of congenital type;
- Wergolf's disease or idiopathic thrombocytopenic purpura;
- sudden onset of autoimmune hemolytic anemia.
The above-described medication is also used in the treatment of the following oncological diseases:
- Lymphoma.
- Tumor of the mammary glands.
- Leukemia - both acute and chronic.
- Prostate cancer.
- Advanced myeloma.
In the practice of ophthalmologists, Prednisolone can be used to get rid of complex inflammatory and allergic manifestations in acute and chronic forms, which include:
- Inflammation of the optic nerve.
- Ophthalmia of a sympathetic type.
- Complex, indolent posterior or anterior uveitis.
In neurology, the above-mentioned drug is used for therapy during such ailments:
- multiple sclerosis at the acute stage;
- myasthenia gravis;
- tuberculous type meningitis with subarachnoid block;
Prednisolone has a beneficial effect on patients with such problems respiratory organs, such as bronchial asthma, Loeffler's syndrome, berylliosis, symptomatic sarcoidosis, chronic pulmonary emphysema and pulmonary tuberculosis.
It is also used to get rid of pericarditis. This medication is also recommended when performing transplantation of tissue areas or organs in order to prevent a reaction of non-acceptance of the transplant.
Release form, composition
You can find the above medicine on sale in different forms:
- Tablets containing 0.001, 0.005, 0.02 or 0.05 grams of prednisolone, as well as gelatin, lactose, magnesium stearate and potato starch. They have a white or whitish color, a round shape without convexity, a chamfer and an inscription on one of the sides. They are sold in boxes of 100 pieces and in glass bottles of 30 pieces.
- Ampoules with 1 milliliter of suspension for injections, which contain 25 or 50 milligrams of prednisolone. They can be placed in 5, 10, 50, 100 and 1000 pieces per box.
- Ampoules of 25 and 30 milligrams per 1 milliliter in a pack of 3 pieces.
- 0.5% suspension for eyes in packs of 10 milliliters.
- 0.5% ointment in tubes of 10 grams.
Mode of application
The dosage of Prednisolone should be determined by doctors individually for each specific case. Taking into account the daily pattern of secretion of endogenous glucocorticoids, this medication is usually prescribed in a single dose in the morning.
The desired dose for adult patients varies from 5 to 60 milligrams of the drug per day, and the maximum dose should be 200 milligrams.
For children, the dosage is determined at the rate of 0.14 milligrams per kilogram of body weight per day. The dose is divided into three or four doses.
The eye suspension is injected into the conjunctival sac, one or two drops three times a day. The course of therapy should be no more than two weeks.
Prednisolone in the form of a solution or suspension for injections is usually used for infiltration, application, as well as injection into muscles and joints, with the obligatory observance of sterility.
Interaction with other drugs
If the patient is taking medications for diabetes or blood clotting medications, then when prescribing Prednisolone, the doses of these drugs should be adjusted by the doctor.
Extreme care must be taken when using Prednisolone and barbiturates in parallel in patients suffering from Addison's disease.
Side effects
With prolonged use, the above medical drug may provoke the following adverse reactions in the body:
- Obesity.
- Disruptions in the menstrual cycle.
- Hirsutism.
- Complex of Itsenko-Cushing symptoms.
- The appearance of acne and striae.
- Slowing down the excretion of fluid and sodium.
- Insufficient potassium levels.
- Jumps in intraocular, arterial and intracranial pressure.
- Alkalosis due to potassium deficiency.
- Inadequate blood circulation.
- Loss of muscle mass and muscle weakness.
- Osteoporosis.
- Steroid type myopathy.
- Pathological damage to long tubular bones.
- Aseptic tissue death of the heads of the humerus and femur bones.
- Spinal fracture of compression type.
- Inflammation of the pancreas.
- Increased release of gases.
- Steroid ulcer with probable rupture and bleeding.
- Malfunctions of the food digestion system.
- Ulcerative type esophagitis.
- Increased cravings for food.
- Atrophic changes in the skin.
- Taking too long to heal skin lesions.
- Internal bruising and petechiae.
- Increased sweating.
- Thinning and redness of the skin.
- Urticaria and allergic dermatitis.
- Swelling of the angioedema type.
- Sleep problems.
- Convulsive manifestations.
- Head pain and dizziness.
- Adrenal and hypothalamic-pituitary insufficiency of the secondary type.
- Decreased growth in pediatric patients.
- Glaucoma.
- Exophthalmos.
- Posterior cataract of subcapsular type.
- Delirious syndrome.
Contraindications
Prednisolone cannot be prescribed in the following cases:
- Increased sensitivity to the components of this medicine.
- Infectious diseases of fungal nature.
- Hypertension.
- Psychosis.
- Acute endocarditis.
- Complex form of diabetes and Itsenko-Cushing's disease.
- Syphilis.
- Elderly age.
- Pregnancy period.
- Kidney inflammation.
- Osteoporosis.
- Ulcer of the stomach and duodenum.
- Tuberculosis in the active stage.
- History of operations.
During pregnancy
The teratogenic effect of prednisolone has not been documented in medical practice, but there is evidence that its use during the gestational period increases the likelihood of placental insufficiency, oxygen starvation in the fetus and its death during childbirth.
Therefore, this drug can be prescribed to pregnant women only in cases of extreme need under strict medical supervision.
Storage conditions and periods
Prednisolone should be kept in a place protected from the sun and access of small children at a temperature not exceeding 25 degrees Celsius. Its shelf life is 3 years.
Price
Analogs
Prednisolone analogues include the following drugs:
- Medopred;
- Decortin;
- Cordex;
- Prednisole;
- Paracortol;
- Mecortolone;
- Sgerolon.
Compound Prednisolone in ampoules: active substance at a concentration of 30 mg/ml, as well as sodium pyrosulfate (additive E223), disodium edetate, nicotinamide, sodium hydroxide, water for injection.
Compound Prednisolone tablets: 1 or 5 mg of active substance, colloidal silicon dioxide, magnesium stearate, stearic acid, starch (potato and corn), talc, lactose monohydrate.
Prednisolone ointment contains 0.05 g of active substance, soft white paraffin, glycerin, stearic acid, methyl and propyl parahydroxybenzoate, Cremophor A25 and A6, purified water.
Release form
- Solution for intravenous and intramuscular administration 30 mg/ml 1 ml; 15 mg/ml 2 ml.
- Tablets 1 and 5 mg.
- Ointment for external therapy 0.5% (ATC code - D07AA03).
- Eye drops 0.5% (ATC code - S01BA04).
pharmachologic effect
Pharmacological group: Corticosteroids (drug group - I, this means that prednisolone is a weakly active GCS).
Prednisolone - hormonal or not?
Prednisolone is hormonal drug for local and systemic use with medium duration of action.
It is a dehydrogenated analogue of the hormone produced by the adrenal cortex. . Its activity is four times higher than the activity of hydrocortisone.
Prevents development allergic reaction (if the reaction has already begun, stops it), suppresses activity immune system , relieves inflammation, increases the sensitivity of β2-adrenergic receptors to endogenous catecholamines, and has an anti-shock effect.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics. Prednisolone - what is it?
The mechanism of action of Prednisolone is associated with its ability to interact with certain intracellular (cytoplasmic) receptors. These receptors are found in all tissues of the body, but most of them are in the liver.
As a result of this interaction, proteins that induce synthesis are formed (including , which regulate vital intracellular processes) complexes.
Acts at all stages of development of the inflammatory process: suppresses the synthesis of Pg at the level of arachidonic acid, and also prevents the formation of pro-inflammatory cytokines - IFN-β and IFN-γ, IL-1, TNF, neopterin; increases the resistance of plasma membranes to damaging factors.
It affects the metabolism of lipids and proteins, and also, to a slightly lesser extent, the exchange of water and electrolytes.
Immunosuppressive effect is realized due to the ability of the drug to cause involution of lymphoid tissue , oppress proliferation , B cell migration, and interaction B and T lymphocytes , inhibit the release of IFN-γ, IL-1 and IL-2 from macrophages and lymphocytes , reduce education .
Braking allergic reaction carried out by reducing the secretion and synthesis of mediators , reducing the number of circulating basophilic leukocytes , suppression of release histamine from sensitized mast cells and basophilic leukocytes , developmental suppression connective and lymphoid tissue , reducing the number of mast cells, B and T lymphocytes , reducing the sensitivity of T-effectors to mediators allergies , suppression of education antibodies , changes in the immune response.
Inhibits synthesis and secretion corticotropin and - secondarily - endogenous GCS.
When applied externally, it relieves inflammation and inhibits the development of allergic reaction , relieves itching and inflammation, reduces exudation , suppresses activity immune system in relation to type III-IV hypersensitivity reactions.
Pharmacokinetics
After taking the tablet, it is quickly and completely absorbed from the gastrointestinal tract. TSmax - from 60 to 90 minutes. Up to 90% of the administered dose of prednisolone is bound to plasma proteins.
The substance undergoes biotransformation in the liver. From 80 to 90% of metabolic products are excreted in urine and bile, about 20% of the dose is eliminated in its pure form. T1/2 - from 2 to 4 hours.
Indications for use of Prednisolone
What are the tablets and injection solution for?
Systemic use is advisable for:
- allergic diseases (including when or , toxicoderma , serum sickness , /contact dermatitis , , , , Stevens-Johnson syndrome , );
- chorea minor , , rheumatic carditis ;
- acute and chronic diseases that are accompanied by inflammation in the joints and periarticular tissue (, nonspecific tenosynovitis , seronegative spondyloarthritis , epicondylitis , (including post-traumatic), etc.);
- diffuse connective tissue diseases ;
- status asthmaticus and BA;
- lung cancer (the medicine is prescribed in combination with cytostatics);
- interstitial diseases of the lung tissue ( fibrosis , etc.);
- eosinophilic and aspiration pneumonia , tuberculous meningitis , pulmonary tuberculosis (as an addition to specific therapy);
- primary and secondary hypocortisolism (including after adrenalectomy );
- congenital adrenal hyperplasia (CAH) or dysfunction of their cortex ;
- granulomatous thyroiditis ;
- autoimmune diseases ;
- hepatitis ;
- inflammatory diseases of the gastrointestinal tract ;
- hypoglycemic conditions ;
- nephrotic syndrome ;
- diseases of the hematopoietic organs and blood ( , anemia and associated with defeat hemostasis systems diseases);
- cerebral edema (post-radiation, developing with a tumor, after surgery or trauma; the annotation and Vidal's reference book indicate that in case of cerebral edema, treatment begins with parenteral forms of the drug);
- autoimmune and other skin diseases (including Dühring's disease , , , , Lyell's syndrome , exfoliative dermatitis );
- eye diseases (including autoimmune and allergic; including uveitis , allergic ulcerative ,allergic conjunctivitis , sympathetic ophthalmia , choroiditis , iridocyclitis , nonpurulent keratitis etc.);
- developing against the background oncological diseases hypercalcemia .
Indications for the use of injections are emergency conditions, for example, an acute attack food allergies or anaphylactic shock . After several days of parenteral use, the patient is usually transferred to the tablet form of Prednisolone.
Indications for the use of tablets are chronic and severe pathologies (for example, ).
Prednisolone solution and tablets are also used to prevent transplant rejection and relieve nausea/vomiting in those receiving cytostatics patients.
Prednisolone ointment: why and when is external use of the drug indicated?
As an external agent, prednisolone is used for allergies and for the treatment of inflammatory skin diseases of non-microbial etiology. Indications for use of the ointment:
- (contact, allergic and atopic);
- discoid lupus erythematosus ;
- psoriasis ;
- eczema ;
- erythroderma ;
- hives .
Prednisolone: what are eye drops prescribed for?
Eye drops are prescribed to relieve inflammation of a non-infectious nature affecting the anterior segment of the eye, as well as inflammation that develops after an eye injury or ophthalmic surgery.
Local use of Prednisolone is justified for the following eye diseases:
- uveitis ;
- iritis ;
- allergic conjunctivitis ;
- keratitis (in particular, discoid and parenchymal ; in cases where it is not damaged epithelial tissue cornea);
- scleritis ;
- episcleritis ;
- blepharitis ;
- blepharoconjunctivitis ;
- sympathetic ophthalmia.
Contraindications
If systemic use of the drug is necessary for health reasons, the only contraindication may be intolerance to one or more of its constituent components.
Patients with severe infectious diseases Prednisolone tablets and injections are prescribed only against the background of specific therapy.
Contraindications to intra-articular administration of the drug are:
- pathological bleeding (due to the use anticoagulants or endogenous );
- pyogenic arthritis And periarticular infections (including history);
- transarticular bone fracture ;
- systemic infections ;
- “dry” joint (no signs of inflammation in the joint: for example, with osteoarthritis no signs of inflammation synovial membrane );
- severe joint deformity , bone destruction or periarticular osteoporosis ;
- developed against the background joint instability;
- aseptic necrosis of bone epiphyses , which form the joint;
- pregnancy.
On the skin Prednisolone should not be used for:
- mycoses, viral and bacterial skin lesions ;
- skin manifestations ;
- skin tumors ;
- tuberculosis ;
- (in particular, for rosacea and acne vulgaris);
- pregnancy.
Eye drops are not prescribed to patients with fungal And viral eye infections , impaired integrity of the corneal epithelium, with trachoma , acute purulent And viral conjunctivitis ,purulent eyelid infection And mucous membrane , purulent corneal ulcer ,eye tuberculosis , as well as in conditions that developed after removal of a foreign object from the cornea.
Side effects of Prednisolone
The incidence and severity of side effects of Prednisolone are influenced by the dose used, duration, method, as well as the ability to comply with the circadian rhythm of drug use.
Systemic use of the drug may cause:
- fluid and Na+ retention in the body, development of nitrogen deficiency , hypokalemic alkalosis , hypokalemia , glucosuria , hyperglycemia , weight gain;
- secondary hypocortisolism And hypopituitarism (especially if taking GCS coincides with periods of stress - injuries, surgical operations, diseases, etc.), growth suppression in children, Cushing's syndrome , menstrual cycle disorders, manifestations with LADA diabetes mellitus , decreased glucose tolerance, increased need for oral hypoglycemic agents And in diabetics;
- increased blood pressure, CHF (or increased severity), hypercoagulability , characteristic of hypokalemia ECG changes, , distribution necrotic focus and slowing down scar formation with possible rupture of the heart muscle in patients with acute/subacute MI, obliterating endarteritis ;
- steroid myopathy , muscle weakness, aseptic necrosis heads of the humerus and femur, loss of muscle mass, compression fracture of the spine and pathological fractures of long bones, osteoporosis ;
- ulcerative esophagitis , , digestive disorders, vomiting, nausea, increased appetite, development steroid ulcer With possible complications in the form of its perforation and bleeding from the ulcer, ;
- hypo- or hyperpigmentation of the skin, atrophy of the skin and/or subcutaneous tissue , the appearance of acne, atrophic stripes, abscesses , delayed wound healing, ecchymosis , petechiae , thinning skin, increased sweating, erythema ;
- mental disorders (possible hallucinations, delirium , , ), pseudotumor cerebri syndrome (most often develops in children when the dose is reduced too quickly and manifests itself in the form of decreased visual acuity, headaches, diplopia), sleep disturbances, vertigo , dizziness, headache, development with localization of opacity in the posterior part of the lens, ocular hypertension (there is a possibility optic nerve damage ), steroid exophthalmos , , sudden blindness (with the introduction of a d/i solution into the area of the nasal sinuses, head and neck);
- hypersensitivity reactions (both local and generalized);
- general weakness;
- fainting states.
Effects of application on the skin:
- telangiectasia ;
- purpura ;
- steroid acne ;
- burning, irritation, dryness and itching of the skin.
When applied to large surfaces of the skin and/or with prolonged use of the ointment, systemic effects develop, hypertrichosis , also possible atrophic changes And secondary skin infection .
Treatment with eye drops may be accompanied by ocular hypertension , damage to the optic nerve , impaired visual acuity/narrowing of visual fields, increased likelihood perforation of the cornea , development cataracts with localization of opacity in the posterior part of the lens. In rare cases it is possible spread of fungal or viral eye disease .
Signs of withdrawal syndrome
One of the consequences of using GCS may be "withdrawal syndrome" . Its severity depends on the functional state adrenal cortex . In mild cases, after stopping treatment with Prednisolone, malaise, weakness, fatigue, muscle pain, loss of appetite, hyperthermia, and exacerbation of the underlying disease are possible.
In severe cases, the patient may develop hypoadrenal crisis which is accompanied by vomiting, convulsions , collapse . Without the administration of GCS, the onset of death from acute cardiovascular failure .
Instructions for use of Prednisolone (Method and dosage)
Instructions for the use of Prednisolone in injections
The solution is administered intravenously, intramuscularly and intraarticularly.
Method of administration and dosage of Prednisolone ( Prednisolone Nycomed , Prednisolone hemisuccinate ) are selected individually by the attending physician, taking into account the type of pathology, the severity of the patient’s condition, and the location of the affected organ.
In severe and life-threatening conditions, the patient is prescribed pulse therapy using ultra-high doses for a short period of time. For 3-5 days, he is given 1-2 g of prednisolone daily by intravenous drip infusion. The duration of the procedure is from 30 minutes to 1 hour.
During treatment, the dosage is adjusted depending on the patient's response to therapy.
It is considered optimal to administer Prednisolone intravenously. For intra-articular administration, ampoules with Prednisolone are used only in cases where pathological process tissue inside the joint is affected.
Positive dynamics are a reason to transfer the patient to tablets or suppositories with prednisolone. Treatment with tablets is continued until stable remission develops.
If it is not possible to administer Prednisolone intravenously, the medicine should be injected deep into the muscle. However, it should be borne in mind that with this method it is absorbed more slowly.
In the human body, release adrenal hormones into the bloodstream occurs between 6 and 8:00 am, so injections should also be given at this time. The entire daily dose is usually administered at once. If this is not possible, in morning hours at least ⅔ of the prescribed dose is administered, the remaining third should be administered at lunch (at approximately 12:00).
Depending on the pathology, the dose can range from 30-1200 mg/day. (with its subsequent decrease).
Children aged from two months to 1 year are administered from 2 to 3 mg/kg. Dosage for children from one to 14 years of age is 1-2 mg/kg (as a slow, 3-minute intramuscular injection). If necessary, after 20-30 minutes the medicine is re-administered in the same dose.
If a large joint is affected, 25 to 50 mg of prednisolone is injected into it. From 10 to 25 mg is injected into medium-sized joints, and from 5 to 10 mg into small joints.
Prednisolone tablets: instructions for use
The patient is transferred to taking tablets, following the principle of gradual withdrawal of GCS.
If HRT is used, the patient is prescribed 20 to 30 mg of prednisolone per day. Maintenance dose - from 5 to 10 mg/day. In some pathologies - for example, with nephrotic syndrome - It is advisable to prescribe higher doses.
For children, the starting dose is 1-2 mg/kg/day. (it should be divided into 4-6 doses), maintenance - from 0.3 to 0.6 mg/kg/day. When prescribing, take into account the daily secretory rhythm endogenous steroid hormones .
Recommendations regarding the use of drugs from different manufacturers are the same. That is, instructions for Nycomed tablets does not differ from the instructions for tablets produced by Biosintez.
Prednisolone ointment: instructions for use
The ointment is a means of external therapy. It should be applied to the affected areas of the skin in a thin layer from 1 to 3 times a day. An occlusive dressing can be applied to limited pathological lesions to enhance the effect.
When used in children over one year of age, the drug should be used for the shortest possible course. You should also exclude measures that enhance the absorption and resorption of prednisolone (occlusive, fixing, warming dressings).
Eye drops: instructions for use
Instillations of the drug are carried out 3 times a day, instilled into conjunctival cavity of the affected eye 1-2 drops of solution. In the acute phase of the disease, the instillation procedure can be repeated every 2-4 hours.
For patients who have undergone ophthalmic surgery, drops are prescribed 3-5 days after surgery.
How long can you take Prednisolone?
Therapy glucocorticosteroids is aimed at achieving maximum effect with the lowest possible doses.
The duration of treatment depends on the patient's diagnosis and individual response to treatment. In some cases, the course lasts up to 6 days; with HRT it lasts for months. The duration of external therapy using Prednisolone ointment is usually from 6 to 14 days.
Dosage for animals
The dosage for dogs and cats is selected individually depending on the indications.
So, for example, when infectious peritonitis The cat should be given orally 1 r./day. 2-4 mg/kg prednisolone, with chronic panleukopenia — 2 rubles/day. 2.5 mg each.
The standard dosage for a dog is 1 mg/kg 2 times a day. Treatment lasts 14 days. Upon completion of the course, you must take tests and be examined by a doctor. When discontinuing the drug, the dose for dogs should be reduced by 25% every 14 days.
Overdose
Overdose is possible with long-term use of the drug, especially if the patient is prescribed high doses. She appears peripheral edema ,increased blood pressure , increased side effects.
In case of acute overdose, you should immediately rinse the stomach or give the patient an emetic. Prednisolone does not have a specific antidote. If chronic overdose symptoms appear, it is necessary to reduce the dose used.
Interaction
Interaction with other drugs is observed only with systemic use of Prednisolone.
, antiepileptic drugs , barbiturates help accelerate the metabolism of prednisolone and weaken its effect. The effectiveness of the drug is also reduced in combination with antihistamines .
Carbonic anhydrase inhibitors, thiazide diuretics increase the likelihood of developing severe hypokalemia , sodium-containing drugs - increases blood pressure and edema.
In combination with the risk of developing hepatotoxic effects increases in combination with tricyclic antidepressants possible increase in mental disorders associated with taking prednisolone (including severity depression ), in combination with immunosuppressants - increased risk of developing infections And lymphoproliferative processes .
In combination with ASA, NSAIDs and alcohol, the likelihood of developing peptic ulcer and bleeding from ulcerative defects.
Oral contraceptives the drugs change the pharmacodynamic parameters of prednisolone, thereby enhancing its therapeutic and toxic effects.
Prednisolone weakens anticoagulant effect of anticoagulants , as well as action insulin And oral hypoglycemic agents .
The use of prednisolone in immunosuppressive doses in combination with live vaccines can provoke viral replication, decreased antibody production, and development of viral diseases. When used with inactivated vaccines, the risk of decreased antibody production and neurological impairment increases.
With prolonged use, it increases the content folic acid , in combination with diuretics may cause disturbances in electrolyte metabolism.
Terms of sale
To purchase Prednisolone, you must have a prescription for the drug.
Prednisolone recipe in Latin (for intramuscular administration to a child up to one year):
Rp: Sol. Prednisoloni hydrochloride 3% – 1.0
D.t.d. N 3 in amp.
S. IM 0.7 ml (IM – 2 mg/kg/day; IV – 5 mg/kg/day)
Storage conditions
The ointment retains its properties at a temperature of 5-15°C, tablets and solution for systemic use - at temperatures up to 25°C, eye drops - at a temperature of 15-25°C.
The contents of an opened bottle of drops must be used within 28 days.
Best before date
For ointments, tablets and solution for systemic use - two years, for eye drops - three years.
special instructions
Treatment with Prednisolone should be stopped slowly, gradually reducing the dose.
For patients with a history psychoses , high doses are allowed to be prescribed only under the strict supervision of a physician.
How to “get off” Prednisolone?
Treatment with Prednisolone should be discontinued gradually. Dose reduction is carried out by weekly reducing the dose used by ⅛ or taking the last dose every other day and reducing it by ⅕ (this method is faster).
At fast way on a day without Prednisolone, the patient is recommended to stimulate the adrenal glands using UHF or DQV on their projection, take ascorbic acid (500 mg/day), administer insulin in increasing doses (starting - 4 units, then increase it by 2 units for each dose; the highest dose is 16 units).
Insulin The injection should be taken before breakfast; the person should remain under observation for 6 hours after the injection.
If Prednisolone is prescribed for bronchial asthma , it is recommended to switch to inhaled steroids . If the indication for use is autoimmune disease - on mild cytostatics .
Features of the diet when taking Prednisolone
In addition, it is necessary to limit the amount of high-calorie foods high in carbohydrates and fats (their consumption during GCS therapy increases blood glucose levels and rapid weight gain), table salt and liquid.
When preparing food, you need to use products that contain potassium salts, calcium and protein (dietary meats, dairy products, fruits, hard cheeses, baked potatoes, prunes, apricots, nuts, zucchini, etc.).
What can replace Prednisolone?
Analogues in composition for dosage forms for systemic use: Prednisolone Nycomed (in ampoules), Prednisolone Nycomed ,Dexoftan , Prenatsid , Dexamethasonelong , Ozurdex .
Alcohol compatibility
Alcohol and corticosteroids are incompatible.
Prednisolone during pregnancy
Pregnancy and lactation are contraindications to the use of GCS. The use of these drugs is allowed only for health reasons.
Newborns whose mothers received Prednisolone during pregnancy, due to the possibility of developing hypocorticism must be under medical supervision.
In experiments on animals it was established teratogenicity of the drug .
