Phlebodia - instructions for use. Phlebodia is an effective angioprotective drug based on diosmin Common negative reactions

Excipients: talc - 10.24 mg, colloidal silicon dioxide - 3.5 mg, stearic acid - 50.05 mg, microcrystalline cellulose - up to 910 mg.

The composition of the film shell: Sepifilm 002 (hypromellose (E 464) - 9.832 mg, microcrystalline cellulose - 7.866 mg, macrogol 8 stearate type 1 - 1.967 mg); Sepispers AP 5523 pink (propylene glycol - traces, hypromellose (E 464) - 0.458 mg, titanium dioxide (E 171) - 4.026 mg, crimson dye [Ponso 4R] (E 124) - 0.401 mg, iron oxide black (E 172) - 0.13 mg, iron oxide red (E 172) - 0.02 mg); Opagloss 6000 (carnauba wax (E 903) - 0.075 mg, beeswax (E 901) - 0.075 mg, shellac (E 904) - 0.15 mg, ethanol 95 ° - traces).

15 pcs. - PVC/aluminum blisters (1) - cardboard packs.
15 pcs. - PVC/aluminum blisters (2) - cardboard packs.
15 pcs. - PVC/aluminum blisters (3) - cardboard packs.

pharmachologic effect

Angioprotective agent, bioflavonoid. It has a venotonic effect, improves lymphatic drainage, improves microcirculation, reduces the adhesion of leukocytes to the venous wall and their migration into paravenous tissue, improves oxygen diffusion and perfusion in the skin tissue, and has an anti-inflammatory effect. Blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.

Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract, found in 2 hours after ingestion. Cmax in blood plasma is achieved 5 hours after ingestion. Evenly distributed and accumulated in all layers of the wall of the vena cava and saphenous veins lower extremities, to a lesser extent - in the veins of the kidneys, liver, lungs and other tissues. Selective accumulation of diosmin and/or its metabolites in venous vessels reaches a maximum 9 hours after administration and persists for 96 hours. Excreted in urine - 79%, in feces - 11%, in bile - 2.4%.

Indications

Lower extremities, chronic lymphovenous insufficiency of the lower extremities, hemorrhoids, microcirculation disorders.

Contraindications

Children and adolescents up to 18 years of age, first trimester of pregnancy (limited use experience), lactation (breastfeeding), hypersensitivity to diosmin.

Dosage

Taken inside. Depending on indications daily dose is 600-1800 mg. The duration of use depends on the indications and treatment regimen.

Side effects

From the side digestive system: often - dyspeptic disorders, incl. nausea, vomiting, diarrhea, heartburn, constipation; infrequently - colitis.

From the side of the central nervous system: rarely - malaise, dizziness.

Allergic reactions: rarely - urticaria; frequency unknown - isolated swelling of the face, lips, eyelids; in exceptional cases - angioedema (Quincke's edema).

special instructions

Pregnancy and lactation

Use is contraindicated in the first trimester of pregnancy (experience of use is limited). Use in the second and third trimesters is possible only as prescribed by a doctor and in cases where the expected benefit of therapy for the mother outweighs the potential risk for the fetus. Not recommended for use during breastfeeding, because There are no data on the excretion of diosmin in breast milk.

IN experimental studies no teratogenic effect on the fetus was detected.

Phlebodia 600, international name"Diosmin" - angioprotective drug.

Produced in France in the INNOTHERA CHOUZY laboratory.

Pharmacological group of drugs - angioprotectors.

Release form and composition of the drug

The drug is available in round, convex tablets with a pink film coating. The tablets are packaged in blisters of 15 pieces and placed in cardboard packages along with instructions for use.

A pack may contain 1 or 2 blisters, that is, 15 or 30 tablets.

Active ingredient Phlebodia 600 is "Diosmin" - 600 mg, to auxiliary agents relate:

• microcrystalline cellulose - 910 mg;
• stearic acid - 50.05 mg;
• colloidal silicon dioxide - 3.5 mg;
• talc - 10.24 mg.

Compound shells:

• shellac - 150 mcg;
• beeswax - 75 mcg;
• carnauba wax - 75 mcg;
• red oxide - 20 mcg;
• black oxide - 130 mcg;
• crimson dye - 401 mcg;
• titanium dioxide - 4.026 mg;
• hypromellose, propylene glycol - 458 mcg;
• macrogol stearate - 1.967 mg;
• microcrystalline cellulose - 7, 866 mg;
• hypromellose - 9, 832 mg.

The drug has a number of analogues for the active substance, which differ in the content of excipients.

pharmachologic effect

Thanks to diosmin (active ingredient), the drug has the following properties:

• venotonic effect;
• reduces stagnation in the veins, and also increases their tone;
• improves capillary resistance, increasing lymphatic drainage and microcirculation;
• has an anti-inflammatory effect;
• is a regulator of the blood supply to the skin;
• blocks free radicals, the synthesis of thromboxane and prostaglandins.

The drug also enhances the vasoconstrictive action of norepinephrine (norepinephrine), adrenaline (epinephrine).

Pharmacokinetics of the drug

Phlebodia 600 is well absorbed into the blood plasma from the gastrointestinal tract, where it is observed after 2 hours from the time of administration.

After 5 hours, Cmax in blood plasma is reached.

Distribution process

The drug is evenly distributed, and also accumulates in the walls of the hollow and saphenous veins located in the lower extremities.

To a lesser extent, it is found in the veins of the lungs, liver, kidneys and other tissues. Selective accumulation in the venous vessels is achieved a maximum of 9 hours after administration and persists for 96 hours, after which 79% is excreted in the urine, 11% in the feces and 2.4% in the bile.

Indications, contraindications and warnings for admission

Instructions for use for Phlebodia 600 indicate that the drug shown at:

• violation of microcirculation;
• hemorrhoids;
• chronic lymphovenous insufficiency of the lower extremities;
• varicose veins in the lower extremities.

The drug is contraindicated at:

• increased susceptibility to the components of the drug;
• lactation;
• children, as well as adolescents under the age of 18.

Precautions when taking the drug

Before taking Phlebodia 600 tablets, need to take into account:

1. You should not be afraid of drug treatment for people whose activities are associated with increased concentration of attention (drivers of motor vehicles), since it does not have an effect that inhibits a person's reaction;
2. If necessary, it can be used during pregnancy, but it is prohibited when breastfeeding, although there is no data on the penetration of the drug into milk;
3. Can be used with drugs of other groups.

Doses and methods of application depending on the disease

Dosages vary depending on the disease.

With hemorrhoids

During an exacerbation of hemorrhoids

• reduces the manifestation of venous stasis in the hemorrhoidal veins;
• neutralizes inflammation;
• relieves pain and discomfort.

The drug should be taken during a meal, 2-3 tablets. The course of therapy is 1 week.

Venous insufficiency

Used in combination with other drugs indicated for the treatment of this disease, it is only an addition to them. Purpose of treatment:

• slow down the progression of the disease;
• prevent complications;
• improve the quality of life (relieve pain, reduce swelling).

The drug is applied 1 time in the morning, before eating breakfast. The course of admission depends on the severity diseases:

• in mild cases - 2 months;
• with convulsions and trophic disorders - from 3 to 4 months;
• with trophic ulcers - 6 months.

During pregnancy

The drug is prescribed for the treatment of lymphovenous insufficiency in chronic form in the 2nd or 3rd trimester of pregnancy.

It is prescribed in a dose: 1 tab. /1 p. per day Reception stops 14 days before the expected birth.

Symptoms of overdose have not been observed to date. And reviews from patients who took Phlebodia 600 during pregnancy are mostly positive.

Side effects

What negative consequences can taking the drug:

• manifestation allergic reactions. In this case, treatment must be interrupted;
• headache;
• dyspepsia.

If these manifestations occur, you should consult a doctor to review the prescribed dose.

special instructions

For treatment acute form hemorrhoids, it is necessary to take Phlebodia 600 in combination with other drugs.

If positive results will not be in the near future, it is necessary to be examined again and correct the ongoing therapy.

There is evidence that the drug is effective in preventing bleeding that may occur due to the use of an intrauterine device, as well as during phlebectomy.

How much is Flebodia 600

The price of Phlebodia 600 depends on the number of blisters in the package, as well as on the region of purchase.

They can vary:

• "Flebodia 600" 15 tablets - 395 00 - 695 00 rubles;
• "Flebodia 600" 30 tablets - 685 00 - 1 742 00 rubles.

You can buy Phlebodia 600 in pharmacies or drugstores by prescription.

Its validity period is 3 years after this time, the medicine loses its strength and is prohibited for use.

The temperature during storage should not exceed 30 ° C, and the place where the medicine is kept should provide for the inaccessibility of children.

Phlebodia 600 is one that has a venotonic effect: it increases the tone of the veins, reduces their extensibility and reduces venous congestion. The drug improves lymphatic drainage, that is, increases the frequency of capillary contractions and their functional density, reduces lymphatic pressure.

Phlebodia 600 is also excellent for improving microcirculation, its systematic use can lead to a decrease in vascular permeability and an increase in their resistance. Phlebodia 600 has an anti-inflammatory effect and can block the production of free radicals.

Phlebodia refers to venotonics, which include. Excipients in the composition of the drug: colloidal silicon dioxide, talc, microcrystalline cellulose, stearic acid, a protective film such as Sepifilm 002, a mixture of dyes such as Sepisperse AP 5523 (these include hypromellose, propylene glycol, titanium dioxide, cochineal red (Ponso 4R), iron oxide red, iron oxide black), Opagloss 6000.

Indications for use

The properties of the drug allow you to use it:

• for the treatment and prevention, as well as chronic lymphovenous insufficiency of the lower extremities;
• for the treatment of microcirculation disorders and edematous syndrome during pregnancy.

Mode of application

If Phlebodia 600 is used to treat lymphovenous and if there are no complications, then the drug is taken 1 tablet once a day for 2 months. This course is recommended for mild varicose veins.

With moderate severity of the disease, the drug is taken 1 tablet daily, for 3 months. With a severe degree of varicose veins, including if they are formed, the drug is taken 1 tablet every day for six months.

The drug is also used for the treatment in pregnant women, which arose against the background of lymphovenous insufficiency. According to the instructions for use, in this case, appoint 1 tablet daily. Phlebodia must be canceled 2 to 3 weeks before the birth.

Pharmacokinetics

Phlebodia is rapidly absorbed from the gastrointestinal tract. In plasma, it is detected 2 hours after direct administration. The maximum concentration is reached 5 hours after ingestion. Phlebodia is evenly distributed and accumulates in all layers of the walls of the vena cava. The smallest amount of the drug accumulates in the liver, kidneys, lungs and other tissues. The main part of the drug - 79% - is excreted in the urine, of the remaining: 11% - with feces, and with bile - 2.4%.

Contraindications and side effects

Phlebodia is not used for hypersensitivity or individual intolerance to the components. The medicine cannot be used by persons under the age of 18.

Side effects:

• headache;
• dyspepsia;
• allergic reactions associated with the presence of hypersensitivity to the components of the drug.

Phlebodia and pregnancy

It is noted that in clinical practice no side effects have been identified from the use of the drug in. Moreover, experimental studies have shown that the drug does not have a teratogenic effect on the fetus.

When breastfeeding, the drug, like a number of other venotonics, is not recommended, since it has not been studied whether it penetrates into breast milk and how it affects its composition.

Overdose of Phlebodia 600 and special instructions

Signs indicating an overdose are not described in clinical practice.

There are some special instructions. In the treatment of an acute attack of hemorrhoids, phlebodia is used in combination with other drugs. If a positive effect does not occur quickly, then an additional examination should be carried out and, based on its results, the prescribed treatment should be adjusted.

Despite the fact that the list of indications for the use of the drug was indicated above, in medical practice Phlebodia is also used for the treatment of fetoplacental insufficiency, during the period and for the prevention of bleeding resulting from the use of an intrauterine device.

Reviews about Flebodia 600

Advantages of the drug:

• no side effects with long-term use;
• the ability to use the drug as a prophylactic agent. Many women with a predisposition to varicose veins noted that after taking the drug they felt light in their legs, leg fatigue disappeared;
• the disappearance of small ones;
• reasonable price - 30 tablets cost an average of $20. Since only one tablet needs to be taken per day during treatment, a monthly course is inexpensive;
• thanks to the use of Phlebodia in the complex treatment of hemorrhoids, it was possible to avoid surgery.

Disadvantages of the drug:

• large tablet size. This disadvantage can be easily overcome by dividing the tablet into two parts;
• the presence of dyes in the preparation. It should be noted that this statement is true.

Flebodia 600 analogues

P N016081/01

Tradename:

PHLEBODIA 600

INN: diosmin (diosmine)

Dosage form: film-coated tablets

Composition per 1 tablet

Active substance:

Diosmin in terms of dry matter .............. 600 mg

Excipients:

talc................................................. ..10.24 mg
colloidal silicon dioxide .....................3.5 mg
stearic acid..............................50.05 mg
microcrystalline cellulose............up to 910 mg

The composition of the film shell:

Sepifilm® 002 (hypromellose (E 464) - 9.832 mg, microcrystalline cellulose - 7.866 mg, macrogol 8 stearate type 1 - 1.967 mg). Sepisprs® AP 5523 pink (propylene glycol - traces, hypromellose (E 464) - 0.458 mg, titanium dioxide (E 171) - 4.026 mg, crimson dye [Ponso 4R] (E 124) - 0.401 mg, iron oxide black (E 172) - 0.130 mg, iron oxide red (E 172) - 0.020 mg).

Opagloss® 6000 (carnauba wax (E 903) - 0.075 mg, beeswax (E 901) - 0.075 mg, shellac (E 904) - 0.150 mg, ethanol 95 ° - traces).

Description

Pink, round biconvex film-coated tablets.

Pharmacotherapeutic group

Angioprotective agent.

ATX Qty: C05CA03

Pharmacological properties

The drug has a phlebotonizing effect (reduces vein extensibility, increases vein tone (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of contraction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases the resistance of capillaries (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration to paravenous tissues, improves oxygen diffusion and perfusion in the skin tissue, and has an anti-inflammatory effect. Enhances the vasoconstrictive action of adrenaline, norepinephrine, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.

Pharmacokinetics

Rapidly absorbed from gastrointestinal tract, is detected in plasma 2 hours after administration. The maximum plasma concentration is reached 5 hours after ingestion. It is evenly distributed and accumulated in all layers of the wall of the vena cava and saphenous veins of the lower extremities, to a lesser extent - in the kidneys, liver and lungs and other tissues. Selective accumulation of diosmin and/or its metabolites in venous vessels reaches a maximum by 9 hours after ingestion and persists for 96 hours. 79% is excreted by the kidneys, 11% by the intestines, and 2.4% by the bile.

Indications for use

As part of complex therapy:

To eliminate the symptoms of lymphovenous insufficiency of the lower extremities: a feeling of heaviness or fatigue in the legs, pain;
- additional treatment in case of microcirculation disturbance:
- symptomatic treatment of acute hemorrhoids.

Contraindications

Hypersensitivity to the components of the drug, the period of breastfeeding, childhood up to 18 years of age, pregnancy (first trimester) (experience of use is limited).

Pregnancy and breastfeeding

So far, in clinical practice, there have been no reports of any side effects when using the drug in pregnant women. Use during pregnancy in II and III

trimesters is possible only on prescription in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

In experimental studies, no teratogenic effects on the fetus have been identified. It is not recommended to take the drug during breastfeeding, because there is no data on the penetration of the drug into breast milk.

Method of administration and dosage

Before using the drug, you should consult your doctor.

The drug is intended for oral administration.

With varicose veins of the lower extremities and chronic lymphovenous insufficiency (edema, pain, convulsions), one tablet is prescribed per day in the morning on an empty stomach. The duration of therapy is usually 2 months. With exacerbation of hemorrhoids, the drug is prescribed 2-3 tablets per day with meals for 7 days. If one or more doses of the drug are missed, it is necessary to continue using the drug as usual and at the usual dose.

Side effect

In rare cases, hypersensitivity to the components of the drug, requiring a break in treatment: on the part of the gastrointestinal tract - dyspeptic disorders (heartburn, nausea, abdominal pain), on the part of the central nervous system- headache.

If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Overdose symptoms are not described.

Interaction with other drugs

Clinically significant interaction effects with other drugs have not been described.

special instructions

Treatment of an acute attack of hemorrhoids is carried out in combination with other drugs, in the absence of a rapid clinical effect, it is necessary to conduct an additional examination and adjust the ongoing therapy.
Impact on ability to drive vehicles

There is no evidence of a negative effect of the drug on the ability to drive vehicles and other mechanisms.

Release form

Film-coated tablets.

15 tablets in PVC / aluminum blister.

I or 2 blisters with instructions for use in a cardboard box.

Best before date

3 years. Do not use after the expiration date.

Storage conditions

Store at a temperature not exceeding 30 °C.

Keep out of the reach of children.

Terms of dispensing from pharmacies

Over the counter.

Innotera Laboratories

22 avenue Aristide Briand, 94110 Arcay, France Produced by: Innotera Chouzy

Rue Rene Chantero, L "Isle Ver, 41150 Chouzy-sur-Cies, France

Russian representative office

JSC "Laboratory Innotec International" (France):

127051, Moscow, st. Petrovka, d.20/1,

Phlebodia 600 is a French drug for the treatment of varicose veins of the lower extremities and hemorrhoids. The active substance is diosmin. It is present in the dosage that gave the drug part of its name - 600 mg. Regular intake of Phlebodia 600 allows a person to reduce the symptoms of chronic venous insufficiency.

Instructions for use

The drug acts by increasing the tone venous wall and reduce its permeability. Phlebodia 600 also has an antiplatelet effect, therefore, it significantly reduces the risk of blood clots forming in blood vessels.

With varicose veins, the agent improves oxygen saturation of tissues, and therefore reduces the risk of trophic.

Phlebodia 600 contains micronized diosmin. It is ground to microparticles in order to increase bioavailability. The active substance enters the blood within 2 hours after ingestion, and the maximum plasma concentration is observed after 5 hours.

The drug is taken according to different schemes, depending on the indications:

• - 1 tablet per day, in the morning, on an empty stomach, a course of 2 months;
• , which is accompanied by severe symptoms of lympho-venous insufficiency - a course of 4 months;
• with varicose veins complicated by trophic ulcers - a course of 6 months;
• with exacerbation of hemorrhoids - 3 tablets per day, with meals, a course of 7 days, and then 1 tablet in the morning on an empty stomach, for 2 months;
• with varicose veins or for - 1 tablet per day, starting from the 2nd trimester, and ending the course 3 weeks before delivery.

Diseases for which Phlebodia 600 is used are chronic. They are never completely cured, even if it is possible to achieve sustainable clinical improvement, including with the use of surgical methods treatment. Therefore, courses of drug therapy should be regular. However, after each of them should take a break for 2 months.

Phlebodia 600 may cause side effects. They mainly develop from the gastrointestinal tract:

• nausea;
• heartburn;
• belching;
• abdominal pain;
• flatulence;
• diarrhea.

If side effects occur, start taking the drug not on an empty stomach, but during or after a meal. This usually improves portability. medicines based on diosmin.

Flebodia 600 has practically no contraindications. Exceptions - children's age, the first trimester of pregnancy, individual intolerance to the components. In the 2-3 trimester of pregnancy, the drug is used only at the discretion of the doctor.

Price

Phlebodia 600 is sold in packs of 15, 30 and 60 tablets. As in the case of any other drugs, it is more profitable for the price to buy large packages. Moreover, it is expedient from the point of view of compliance medical advice. It is better to immediately buy pills for the entire course, so as not to interrupt it and not reduce the effectiveness of treatment.

The prices for a package and for a monthly course of treatment are shown in the table below. When calculating the results, we are guided by the fact that you will take Phlebodia 600 1 tablet per day. Prices are taken from one pharmacy to avoid calculation errors. They are current as of September 2016.

In the case of an increase in the dose (for example, with an exacerbation of hemorrhoids), prices will change. For obvious reasons, the cost of the course will increase.

Reviews

About Phlebodia 600 are found mainly positive reviews. People talk about reducing the symptoms of varicose veins or hemorrhoids while taking the drug. Usually the effect is felt already in the first week - the legs are not so strong, they decrease, fatigue, night cramps.

There are far fewer negative reviews. They were left mainly by those who expected from Phlebodia 600 a complete cure for varicose veins, which, of course, is impossible. The drug only slows down the development of the disease. Also part negative feedback associated with poor tolerance of Phlebodia 600 against the background of a long course. Mostly it is heaviness in the abdomen or diarrhea. Such reviews are quite rare.

Analogues

At drug Phlebodia 600 has many competitors. Quite a number operating funds contains diosmin. Analogues can be divided into:

• full– diosmin is the only active substance and is present in a similar dose;
• incomplete– diosmin in a different dose, and the composition contains additional components.

Flebodia 600 has only one complete analogue - it is called. This is a domestically produced drug, which is slightly more affordable. However, the difference is insignificant – about 5%.

Incomplete analogues of Phlebodia 600:

• Venolek.

They contain 450 mg of diosmin and 50 mg of hesperidin. Comparison of prices in this case is difficult, because the treatment with these Phlebodia 600 analogues involves their use at a dose of not 600 mg, but 900 mg of diosmin per day.

If we consider the price of a course of treatment, Flebodia 600 will probably be cheaper, because it is used in 1 tablet. The listed incomplete analogues are prescribed 2 tablets per day, however, the effect of their administration will certainly be more pronounced due to the increased dosage and the presence of other flavonoids in the composition.