Xymelin analogues are cheaper. What is better nazivin or xylene

Antipyretics for children are prescribed by a pediatrician. But there are emergency situations for fever when the child needs to be given medicine immediately. Then the parents take responsibility and use antipyretic drugs. What is allowed to give to infants? How can you bring down the temperature in older children? What medicines are the safest?

Nazivin, Otrivin, Vibrocil, Xymelin, Tizin belong to the group of anticongestants - medicines, contributing to the elimination of swelling of the mucosa. They are prescribed for a cold that accompanies allergic diseases, infectious respiratory processes. United in the group of adrenomimetics - vasoconstrictor drugs. They are very similar to each other in terms of the mechanism of action, with slight differences. How are these medicines different?

Contains oxymetazoline in an aqueous solution as an active ingredient.

Produced in the form of drops with a pipette dispenser for young children in spray bottles. Concentration:

  • 0.01% for children under 1 year old.
  • 0.025% for children over 1 year old.
  • 0.05% - for patients older than 6 years and adults.

Pharmacodynamic properties

The main effect is realized through the effect on alpha2,1-adrenergic receptors, which contributes to:

  • Narrowing of the vessels of the mucosa at the site of application.
  • Resolution of edema.
  • Improves nasal breathing.

It does not have a pronounced systemic effect on the body, it is mainly characterized by a local reaction of the effect realization.

Indications

The main reason for the appointment of Nazivin is respiratory infections, manifested by nasal congestion, edema, or, conversely, abundant mucus secretion. The drug is prescribed for:

  • Acute runny nose, which arose against the background of a cold of any etiology.
  • Allergic, vasomotor rhinitis, hay fever.
  • Acute or exacerbation of chronic inflammatory processes in the sinuses (frontal, maxillary, main).
  • Acute inflammatory diseases middle ear, eustachian tubes.
  • Performing diagnostic manipulations that require narrowing of the nasal vessels, reducing mucosal edema.

The drug has a mild and long-lasting (up to 12 hours) effect.

Nazivin is not assigned if:

  • Available allergic reaction on the main substance of the drug.
  • We are talking about the treatment of atrophic rhinitis.
  • The patient suffers from angle-closure glaucoma.

Important! During pregnancy and lactation, it is possible to prescribe Nazivin after assessing all possible risks for the woman and child.

Side effects are more often caused by a violation of the duration, frequency of administration. Appear:

  • Burning, dryness of the nasal cavity.
  • A paradoxical reaction - increased edema while taking the drug.
  • Redness of the mucous membrane.
  • Headache, sleep disturbance, anxiety.
  • Palpitations, rhythm disturbances, hypertension.
  • Dyspeptic manifestations in the form of nausea and vomiting, respiratory failure.

The effectiveness of the drug decreases with prolonged use. If the use is exceeded for more than 7 days, atrophic changes in the nasal mucosa may develop, signs of an overdose may appear.

Otrivin

The main active ingredient is xylometazoline.

The line of products is represented by drops, nasal spray of various dosages suitable for use in children from infancy and adult patients.

Pharmacodynamic properties

Like Nazivin, it refers to vasoconstrictor drugs that act in a stimulating way on adrenoreceptors. According to the mechanism of action, it has similar characteristics with Nazivin. A distinctive feature of Otrivin is the content of menthol, essential oil eucalyptus, which have an additional effect of cooling the mucous membranes.

It is not absorbed into the general circulation, the systemic effect on the body is minimal.

Indications

The use of Otrivin is indicated for:

  • Acute respiratory infections accompanied by rhinitis.
  • Vasomotor rhinitis and rhinitis with an allergic component.
  • Inflammatory diseases of the middle ear.
  • Planning of diagnostic manipulations on ENT organs.

The therapeutic effect develops within a few minutes after instillation of the nasal cavity and lasts up to 12 hours.

Contraindications, special instructions

The development of side effects, the use of Otrivin during pregnancy, lactation are the same as for other drugs of the adrenergic agonist group. The list of contraindications is identical to Nazivin.

Important: Nazivin and Otrivin are two drugs similar in mechanism of action, presented in the pharmacy network with a wide variety of dosages that have general indications, side effects. They differ in the active substance belonging to the same group of compounds, the composition of excipients. When choosing medicinal product: Nazivin or Otrivin, you should be guided by the doctor's recommendations.

Xymelin

Another representative of the group of drugs with adrenomimetic action. The main component is xylometazoline.

Xymelin is similar in pharmacodynamics, indications, side effects to other drugs in its pharmaceutical group.

Distinctive features

The main distinguishing features of Xymelin are:

  • The line of funds is represented by various forms of release: drops, sprays, including Xymelin Eco, containing menthol, Extra, which is combination drug containing an anticholinergic component that suppresses mucus production.
  • Not intended for children under two years of age.
  • It is not recommended for use during pregnancy, lactation, especially the Eco and Forte forms.
  • In addition to the already known adverse reactions Prolonged use may cause nosebleeds.

Before using Xymelin, you should consult your doctor.

Tizin

It's a drug similar action, which is the same as the others discussed above. A distinctive feature is the active substance - tetrahydrozoline salt. The same indications are established for it, it has the same therapeutic and side effects, as other drugs from the group of vasoconstrictor drugs.

Tizin's features are:

  • It has a more pronounced vasoconstrictor effect than Otrivin or Nazivin.
  • It acts quickly enough, the effect appears within 1-2 minutes after application, but lasts a shorter period - no more than 6 hours.
  • It is not recommended to prescribe during pregnancy, lactation.
  • Not intended for children under two years of age.

When choosing a drug: Tizin or Nazivin, one should be guided by the recommendations of the attending physician, taking into account the indications, clinical picture diseases.

Vibrocil

A drug that is fundamentally different from the others described above.

The main forms of release are:

  • Drops.
  • Gel for lubrication of the nasal mucosa.
  • Spray.

This is a combination drug consisting of the phenylephrine sympathomimetic, which acts selectively on the receptors of the venous vessels of the nasal mucosa and an antihistamine component.

Mechanism of action

Unlike other vasoconstrictor drugs, Vibrocil in the treatment of the common cold:

  • Quite quickly and effectively eliminates swelling of the mucous membrane.
  • Contributes to a significant reduction in the amount of secretion produced.
  • Restores the work of ciliated epithelium.
  • It has a pronounced anti-allergic effect.
  • Works well when used the day before surgical interventions on ENT organs, in the postoperative period.

Has a local effect.

Indications

In addition to a runny nose that occurs against the background colds, the appointment of Vibrocil is indicated for allergic rhinitis, sinusitis, hay fever.

Contraindications, application features

The drug is contraindicated in the presence of intolerance to one of the components that make up its composition, heart rhythm disturbances, rhinitis with atrophic changes in the mucosa.

Important. Vibrocil is not prescribed in the following cases:

  • Children under 1 year old.
  • Pregnant and lactating mothers.

In children, elderly, debilitated patients, signs of systemic influence may appear in the form of cardiac arrhythmias, hypertension, changes in neurological status, agitation, and sleep disturbances.

When comparing various drugs prescribed for the treatment of rhinitis, the question often arises as to which is better than Nazivin or Otrivin, or another drug. It should be understood that for each drug there are clearly defined indications, features of use. Only the attending physician, assessing clinical symptoms can prescribe the "right and best" remedy.


Vasoconstrictor drug for local use in ENT practice

Active ingredients

Release form, composition and packaging

Spray nasal dosed as a clear, colorless or slightly colored liquid.

Excipients: disodium edetate dihydrate - 70 µg, glycerol 85% - 3.91 mg, concentrated hydrochloric acid - up to pH 4.5, sodium hydroxide - up to pH 4.5, purified water - up to 140 µl.

10 ml - plastic bottles with a pump dispenser (1) - packs of cardboard.

pharmachologic effect

Combined preparation for local use in ENT practice.

Xylometazoline is an alpha-adrenergic agonist. Causes constriction blood vessels nasal mucosa, thus eliminating swelling and hyperemia of the nasopharyngeal mucosa. Facilitates nasal breathing in rhinitis.

Ipratropium bromide has an anticholinergic effect. When administered intranasally, it reduces the secretion of the glands of the nasal mucosa.

In therapeutic doses, Xymelin Extra does not irritate the mucous membrane, does not cause hyperemia. The action of the drug occurs after 5-10 minutes and lasts for 6-8 hours.

Pharmacokinetics

With intranasal use of xylometazoline hydrochloride and ipratropium bromide, both are poorly absorbed and are present in the blood in small quantities.

Indications

symptomatic treatment swelling and hyperemia of the nasal cavity;

- sharp respiratory diseases with the phenomena of rhinitis (runny nose);

- spicy allergic rhinitis;

- pollinosis;

- sinusitis.

Contraindications

- hypersensitivity to the components of the drug;

- hypersensitivity to or similar compounds (hyoscyamine, scopolamine);

arterial hypertension;

- tachycardia;

- severe atherosclerosis;

- glaucoma;

atrophic rhinitis;

- hyperthyroidism;

- condition after transsphenoidal hypophysectomy;

- condition after surgical interventions on the meninges (in history);

- pregnancy;

- age up to 18 years;

- therapy with MAO inhibitors or tricyclic antidepressants, including a period of 14 days after their cancellation.

Carefully: diabetes; pheochromocytoma; diseases of cardio-vascular system, incl. IHD, angina pectoris III-IV functional class; cervical obstruction Bladder, stenosis of the interureteral fold, prostatic hyperplasia; porphyria.

Caution is advised in the treatment of patients predisposed to nosebleeds; with sensitivity to adrenergic drugs, which can lead to symptoms such as sleep disturbance, dizziness, skeletal muscle tremor, arrhythmia, increased blood pressure; in patients with paralytic ileus; patients with cystic fibrosis.

Caution is advised when using the drug in patients with a history of hypersensitivity reactions. immediate type including urticaria, angioedema, rash, bronchospasm, laryngeal edema, and anaphylactic reactions.

Dosage

The drug is used intranasally.

One injection of Extra contains about 70 micrograms of xylometazoline hydrochloride and 84 micrograms of ipratropium bromide.

Adults over 18- 1 injection in each nasal passage 3 times / day. There must be at least 6 hours between two injections.

The drug is used for no more than 7 days without consulting a doctor. It is recommended to stop treatment immediately after relief of symptoms, even if this happened earlier than after 7 days (maximum duration of therapy), in order to minimize the risk of adverse events. Prolonged use of xylometazoline can cause swelling of the nasal mucosa and increased secretion, which is due to the development of increased sensitivity of cells to active ingredients drug, the so-called "rebound" effect.

Experience with elderly patients (over 70 years old) limited.

Mode of application

Before the first use of the spray, press the pump dispenser several times until the full dose is released. With further use, additional activation of the dosing device is not required. If there is an uneven dosing of the spray or a break in the use of the drug was more than 9 days, you must repeatedly press the pump device several times to activate it until the full dose is released.

Side effects

Classification of the frequency of occurrence of adverse reactions: very often (≥1 / 10); often (≥1/100,<1/10); нечасто (≥1/1000, <1/100); редко (≥1/10 000, <1/1000); очень редко (<1/10 000), включая отдельные сообщения и реакции с неизвестной частотой (не может быть рассчитана на основании доступных данных).

From the immune system: the frequency is unknown - hypersensitivity reactions (anaphylactic reaction, angioedema, rash, itching, laryngospasm).

From the nervous system: often - a violation of taste,; infrequently - impaired sense of smell, dizziness, tremor; very rarely - insomnia, convulsions, hallucinations.

From the side of the organ of vision: infrequently - eye irritation, dry eyes; frequency unknown - increased intraocular pressure, mydriasis, eye pain, photopsia, deterioration in angle-closure glaucoma, impaired visual clarity, pupil dilation, halo effect (presence of rainbow circles around the light source in the field of view).

From the side of the cardiovascular system: rarely - palpitations, supraventricular tachycardia, arterial hypertension; very rarely - arrhythmic pulse; frequency unknown - atrial fibrillation.

From the respiratory system: very often - epistaxis, irritation and / or dryness of the nasal mucosa; often - a burning sensation, tingling, nasal hypersecretion, sneezing, nasal congestion (with frequent and / or prolonged use of the drug), dry throat, sore throat, rinalgia, rhinorrhea; infrequently - an ulcer of the nasal mucosa, sneezing, sore throat, cough, dysphonia; frequency unknown - discomfort in the paranasal sinuses, spasm of the larynx, swelling of the pharynx.

From the digestive system: often - dry mouth; infrequently - dyspepsia, nausea; frequency unknown - difficulty swallowing.

From the skin and subcutaneous tissues: frequency unknown - itching, skin rash, urticaria.

From the urinary system: frequency unknown - difficulty urinating.

General disorders and disorders at the injection site: infrequently - discomfort, fatigue; frequency unknown - chest discomfort, thirst.

If any of the side effects indicated in the instructions are aggravated or other side effects are noted that are not indicated in the instructions, the patient should inform the doctor about this.

Overdose

Symptoms: after intranasal use of the drug, acute overdose is unlikely, because. absorption of the drug is very small. In case of an overdose of xylometazoline, the clinical picture is characterized by: dizziness, nausea, sweating, a decrease in body temperature, headache, bradycardia, disturbance of accommodation, arterial hypertension, respiratory depression, coma, convulsions. Arterial hypertension may be replaced by arterial hypotension.

Treatment: symptomatic therapy should be carried out under medical supervision. With excessive use of ipratropium bromide, an overdose is unlikely due to the extremely low absorption of the substance into the blood, but dry mouth, accommodation disorders, and tachycardia may develop. Treatment is symptomatic. A significant overdose can cause symptoms associated with the anticholinergic effect of the drug on the part of the central nervous system, including hallucinations, for which cholinesterase inhibitors are prescribed. Appropriate supportive measures should be taken in case of any suspicion of overdose. If necessary, immediate symptomatic treatment is indicated under medical supervision. These measures should include monitoring the patient for 6 hours. In case of severe poisoning with cardiac arrest, resuscitation should continue for at least 1 hour.

drug interaction

The simultaneous use of the drug with MAO inhibitors, tri- and tetracyclic antidepressants, as well as in the case of taking these drugs within the previous 2 weeks, is contraindicated. Simultaneous use or use within the previous 2 weeks of tri- and tetracyclic antidepressants and sympathomimetic drugs may enhance the sympathomimetic effect of xylometazoline, therefore it is not recommended.

Sympathomimetic drugs cause the release of catecholamines, incl. , which has a vasoconstrictor effect, resulting in increased blood pressure. With a significant increase in blood pressure, treatment with Xymelin Extra should be discontinued and symptomatic treatment should be carried out.

With the concomitant administration of other drugs with anticholinergic activity, it is possible to enhance the anticholinergic effect of ipratropium bromide.

The above interaction was studied individually for both active substances that are part of the drug Xymelin Extra. In combination for both active substances, the above interaction has not been studied.

special instructions

Before using the drug, it is necessary to clear the nasal passages.

Do not use the drug for a long time, for example, with chronic rhinitis.

Patients should be warned not to spray Xymelin Extra into or around the eyes. If the drug gets into the eyes, rinse them with cold water.

If the symptoms of the disease worsen or the patient's condition does not improve within 3 days of taking Xymelin Extra, you should consult your doctor.

Influence on the ability to drive vehicles and control mechanisms

The use of the drug in therapeutic doses does not affect the ability to drive vehicles and work with mechanisms. Overdose or contact with the drug in the eyes may affect the ability to drive vehicles and other potentially hazardous activities.

Xymelin Extra: instructions for use and reviews

Latin name: Xymelin Extra

ATX code: R01AB06

Active substance: ipratropium bromide + xylometazoline (xylometazoline)

Manufacturer: Takeda GmbH (Germany), Nycomed Pharma (Norway)

Description and photo update: 21.11.2018

Xymelin Extra is a local combination drug with a vasoconstrictor effect used in ENT practice.

Release form and composition

The dosage form of Xymelin Extra is a nasal spray: transparent, colorless or somewhat colored (in a cardboard box - 1 plastic bottle with a pump dispenser of 10 ml).

Active substances in 1 spray dose:

  • xylometazoline hydrochloride - 0.07 mg;
  • ipratropium bromide monohydrate - 0.084 mg.

Auxiliary components: disodium edetate dihydrate - 0.07 mg; 85% glycerol - 3.91 mg; concentrated hydrochloric acid - up to pH 4.5; sodium hydroxide - up to pH; purified water - up to 0.14 ml.

Pharmacological properties

Pharmacodynamics

Xymelin Extra is one of the local combination drugs used in ENT practice.

The main properties of the components:

  • xylometazoline: is an alpha-agonist. It leads to narrowing of the blood vessels of the nasal mucosa, which helps to eliminate edema and hyperemia of the nasopharyngeal mucosa. With rhinitis, it facilitates nasal breathing;
  • ipratropium bromide: has anticholinergic properties. When administered intranasally, it helps to reduce the secretion of the glands of the nasal mucosa.

When using the drug in therapeutic doses, the mucous membrane is not irritated and hyperemia does not occur.

The action of Xymelin Extra develops in 5-10 minutes, its duration is 6-8 hours.

Pharmacokinetics

With intranasal use, the active components of Xymelin Extra are little absorbed, their plasma concentration is negligible.

Indications for use

  • swelling and hyperemia of the nasal cavity (symptomatic therapy);
  • acute respiratory diseases occurring with rhinitis;
  • sinusitis;
  • hay fever;
  • acute allergic rhinitis.

Contraindications

Absolute:

  • atrophic rhinitis;
  • arterial hypertension;
  • burdened history of surgical interventions on the meninges;
  • thyrotoxicosis;
  • tachycardia;
  • glaucoma;
  • severe atherosclerosis;
  • age up to 18 years;
  • I trimester of pregnancy;
  • individual intolerance to the components of the drug.

Relative (Xymelin Extra is prescribed under medical supervision):

  • cystic fibrosis;
  • prostatic hyperplasia;
  • diabetes;
  • bladder neck obstruction;
  • angina pectoris III-IV functional class;
  • the presence of a predisposition to the development of the following diseases / conditions: nosebleeds, paralytic ileus, dizziness, skeletal muscle tremor, sleep disturbances, arrhythmias, increased blood pressure;
  • II-III trimesters of pregnancy and lactation.

Instructions for use Xymelin Extra: method and dosage

Xymelin Extra is applied intranasally.

Side effects

Possible adverse reactions with frequent / prolonged use: dryness / irritation of the nasopharyngeal mucosa, nosebleeds, sneezing, burning and tingling in the throat and nose, headache, swelling of the nasal mucosa, hypersecretion of glands of the nasal mucosa.

In rare cases, the development of the following disorders is noted: insomnia, headache, systemic allergic reactions, dizziness, blurred vision, tachycardia, palpitations, arrhythmia, increased blood pressure.

Overdose

The appearance of an acute overdose after intranasal use of Xymelin Extra is unlikely, since the absorption of its active substances is extremely small.

The main symptoms are manifested in the form of xerostomia, accommodation disorders, tachycardia, headache, arterial hypertension.

Therapy: symptomatic. Discontinuation of the drug is indicated.

special instructions

Before using Xymelin Extra, the nasal passages must be cleared.

Long-term therapy, for example in chronic rhinitis, is not recommended.

The spray should not be sprayed into or around the eyes. If Xymelin Extra gets into the eyes, rinse them with cold water.

If after three days of drug therapy the condition has not improved or worsened, you should consult your doctor.

Influence on the ability to drive vehicles and complex mechanisms

According to the instructions, Xymelin Extra may affect the ability to drive vehicles in case of an overdose or if the spray gets into the eyes.

Use during pregnancy and lactation

  • I trimester of pregnancy: therapy is contraindicated;
  • II-III trimesters of pregnancy and lactation: Xymelin Extra can be used after the doctor evaluates the ratio of the expected benefit to the possible risk. Exceed therapeutic doses should not be.

Application in childhood

Xymelin Extra is not prescribed for patients under 18 years of age.

drug interaction

Possible interactions:

  • monoamine oxidase inhibitors: blood pressure rises;
  • tri- and tetracyclic antidepressants: the sympathomimetic effect of xylometazoline is enhanced;
  • other anticholinergic drugs: the anticholinergic effect of ipratropium bromide may be enhanced.

Analogues

The analogue of Xymelin Extra is Otrivin Complex.

Terms and conditions of storage

Store below 25°C. Keep away from children.

Shelf life - 3 years.

One of the most popular vasoconstrictor drugs that helps get rid of nasal congestion is Xymelin. But it is not always possible to purchase it in pharmacies, which is why it becomes necessary to know about its analogues, which have the same effect on the nasal mucosa.

The action of the drug

Drops in the nose "Xymelin" have a vasoconstrictive effect. The main active ingredient in the drug, xylometazoline, causes constriction of blood vessels, which facilitates breathing, and also relieves swelling in the nasopharynx. Moreover, most patients note that the drug does not cause any discomfort even with its frequent use.

Time of action

Almost all otolaryngologists say that if they are chosen correctly, then they should act from the moment of application for at least eight hours. If the medicine is not suitable, then the time is reduced to almost two hours.

Drops in the nose "Xymelin" can relieve nasal congestion for 10 hours.

Pharmacokinetics

It is noted that a minimum of the active substance, which is part of the Xymelin preparation, enters the bloodstream. Analogues, which will be discussed a little later, also have all the above actions.

Indications for use

There are a number of indications when patients choose Xymelin. Analogues of the drug are also prescribed in the following cases:

  • Acute respiratory viral diseases, which are accompanied by a severe runny nose. Moreover, with acute respiratory infections, a runny nose appears immediately on the first day, breathing becomes difficult. And in order to somehow alleviate it, it is necessary to use vasoconstrictor drops.
  • Sinusitis, during which there is also swelling of the nasal mucosa, but the problem lies much deeper. For sinusitis, it is recommended to instill Xymelin, tilting your head up so that the drug enters the sinuses.
  • Otitis, during which, in order to alleviate the condition, it is necessary to remove the swelling in the nasopharyngeal mucosa.
  • Allergies, especially in the spring and summer, when it is necessary to ease breathing.
  • With eustachitis - inflammation of the mucous membrane of the ear canal and eardrum.

The drug is used not only to relieve the symptoms of various diseases. It is also used in preparation for examination with an endoscope.

"Xymelin": composition and form of release

The main active ingredient of the drug is xylometazoline, which has an alpha-adrenomimetic effect.

If we talk about the forms of release, then the drug can be purchased:

"Xymelin Extra"

Separately, it must be said about a stronger drug, such as Xymelin Extra, which has a more pronounced effect. After applying the drug, the effect is visible after three minutes and lasts for 8 hours.

Many people prefer to purchase Xymelin Extra. Its price is not much different.

How to apply

Not everyone, unfortunately, knows how to properly use vasoconstrictor drugs so that their effect is much longer.

First of all, it should be noted that before injection or instillation, it is necessary to rinse the nasal cavity with a saline solution, which will remove excess mucus, and the main active substance will act on the mucous membrane.

Also, if we talk about sprays, then in no case should you tilt your head, as the substance can flow into the throat, and the effect will be less.

Dosage

Xymelin can be used in both children and adults, which is why the dosages differ.

"Xymelin" for children in the form of a spray, which is prescribed at the age of two to six years, can be used once or twice a day, one injection.

The drug for adults is allowed to be used 3 times a day for no more than seven days, otherwise addiction may occur, in which you will need to use drops or spray daily.

Contraindications

Separately, it must be said about who is contraindicated in using Xymelin. Its composition prohibits the use of the drug for those people who have an individual intolerance to the main active substance.

Other contraindications include:

  • arterial hypertension;
  • tachycardia;
  • atherosclerosis;
  • atrophic rhinitis;
  • children's age up to two years.

Use during pregnancy

Separately, it must be said about the use of the drug during pregnancy. "Xymelin", analogues of this drug are strictly prohibited for use during pregnancy, since some of them are absorbed into the blood, which can cause narrowing of the arteries and veins through which nutrients and oxygen are supplied to the child.

Drug for children

"Xymelin" for children is allowed to be used only for those children whose age is older than two years. For younger children, there are other, less powerful drugs that are not able to have a negative effect on the body.

"Xymelin" for children has the same effect on the mucous membrane as in adults, namely, it significantly narrows the vessels in the nasal cavity, which eliminates swelling and improves breathing.

Use in children

"Xymelin" for children should be used as follows.

  • drops of 0.05 percent - one or two drops in each nasal passage once or twice a day;
  • drops of 0.1 percent - two or three drops in each nasal passage once or twice a day;
  • spray 0.05 percent - one injection into each nasal passage once or twice a day;
  • spray 0.1 percent - one spray in each nasal passage once or twice a day.

special instructions

The drug does not have any effect on the ability to drive a vehicle, which is why it is allowed to be used by all drivers.

It should be remembered that the drug should be used with caution for those people who suffer from diabetes, angina, prostatic hyperplasia.

In addition, it is forbidden to use Xymelin for more than seven days, as it is addictive, which is very difficult to get rid of.

Medicine price

Many patients are interested in the question of how much Xymelin costs, because today there are many analogues that cost much less.

If we talk about the drug itself, then its cost, depending on the pharmacy where it is purchased, varies from 150 to 200 rubles. Moreover, this price is considered quite high.

"Xymelin": analogues

Separately, it must be said about the analogues of the drug, since they do not differ in any way in terms of the principle of action and have the same vasoconstrictor effect. Their main difference is only in price. As a rule, analogues are cheaper.

Approximately 180 rubles (average price) must be paid for Xymelin. Analogues are much cheaper, from 80 to 140 rubles.

The most famous analogues include "Rinonorm" (the price of which is about 80 rubles), "Tizin" (the price of which is about 100 rubles), "Dlyanos" (the price of which is from 80 rubles).

What can replace "Xymelin"

It has already been said about the analogues of the drug, but most people prefer to buy either Tizin or Dlyanos, since they are most often found in pharmacies, and the price difference is about 70 rubles. In addition, they are available both in the form of drops and in the form of a spray. Moreover, drugs for children and adults differ. What can not be said about the tool "Rinonorm".

Finding good vasoconstrictor drops to help is quite difficult. But here "Xymelin" and its analogues are suitable for many.

The composition of drops and nasal spray includes the main substance: xylometazoline hydrochloride .

Additional components: single and disubstituted sodium phosphate, benzalkonium and sodium chloride, disodium edetate and purified water.

Release form

Xymelin is available in the form of nasal drops and spray. Drops are packaged in 10 ml dropper bottles, and spray in dark glass bottles with a volume of 15 or 10 ml.

pharmachologic effect

The drug has alpha adrenomimetic And vasoconstrictor action.

Pharmacodynamics and pharmacokinetics

The main component of Xymelin is included in the group of local vasoconstrictor agents or decongestants , which have an α-adrenomimetic effect. Its use causes a significant narrowing of the blood vessels in the nasal mucosa, thereby eliminating swelling and hyperemia of the mucous membranes of the nasopharynx. Helps facilitate nasal breathing during treatment. Therapeutic concentrations of the drug do not cause irritation of the mucosa and the development hyperemia . The action appears after a few minutes, remaining on average 10-12 hours.

The drug is applied topically and is almost not absorbed. In the composition of the plasma, a completely insignificant content of the active substance is found.

Indications for use

  • in an acute form;
  • acute respiratory diseases accompanied by rhinitis;
  • sinusitis;
  • preparation of patients for diagnostic procedures in the nasal passages.

Contraindications

  • high sensitivity to it;
  • arterial hypertension;
  • severe atherosclerosis;
  • atrophic rhinitis ;
  • hyperthyroidism;
  • children under 2 years of age;
  • surgical operations in the region of the meninges.

Caution is required when treating patients with .

Side effects

Frequent and prolonged use of drops can lead to the development of side effects in the form of:

  • irritation, dryness of mucous membranes;
  • burning and tingling in the nose;
  • increased sneezing;
  • hypersecretion;
  • swelling of the mucosa;
  • heart failure;
  • elevated;
  • vomiting and so on.

Instructions for use Xymelin (Method and dosage)

Spray Xymelin instructions for use advises using intranasally. At the same time, a 0.1% solution can be injected into patients from 6 years of age. The permissible daily dosage is 2-3 injections for 3 times a day.

The drug, the concentration of which is 0.05%, or children's Xymelin is intended for the treatment of young patients aged 2-6 years. Children daily drip 1-2 times in each nostril, 1-2 drops.

The duration of treatment should not exceed a course of 7 days.

Xymelin during pregnancy

Apply with Xymelin in any form is contraindicated.

Treatment of women with this drug during the time requires a careful assessment of the benefits to the mother and the possible harm to the child. Dosage control is especially important.

Xymelin for children

This drug in the form of a nasal spray is contraindicated in children under 2 years of age.

Spray and nose drops with a concentration of 0.05% are intended for the treatment of children aged 2-6 years. Children's Xymelin is recommended to be instilled into each nasal passage in 1-2 drops.

In the treatment of patients older than 6 years, a 0.1% drug is prescribed, which is instilled one drop at a time or one injection is performed 1-2 times daily.

Overdose

In cases of overdose, side effects may increase. In this case, symptomatic therapy is carried out.

Interaction

The combined use of Xymelin and monoamine oxidase inhibitors, as well as tricyclic antidepressants, may cause the development of undesirable effects.

special instructions

The use of the drug in high doses has an undesirable effect on the nervous system of patients, so you need to carefully drive vehicles or perform dangerous work.

Terms of sale

Over the counter.

Storage conditions

To store the medicine, a place inaccessible to children, at room temperature, is suitable.

Best before date

Analogues

Coincidence in the ATX code of the 4th level:

Main analogues: , Influrin, Zvezdochka NOZ, Sanorin-Xylo, Espazolin, Xylen active.

Reviews about Xymelin

It is generally accepted that nasal drops are the easiest auxiliary drug that can be used independently. However, reviews of Xymelin are confirmation of the fact that such drugs can only be used as directed by a doctor.

Many patients talk about the emergence of a real drug addiction. This usually happens during the cold season and when people begin to actively use such drugs and then cannot give them up due to addiction.

Those patients who used this drug in acceptable dosages and for the time determined by the doctor were divided into those for whom the treatment turned out to be quick and effective and those who did not notice much improvement.

The main thing is to use any remedy for rhinitis with elementary caution. Each vasoconstrictor drug should be applied to clean and moist mucous membranes. For this, simple saline solutions or special tools are used, for example, or. It is interesting that sometimes only these washings become enough for recovery and the need for medications simply disappears.

Xymelin price, where to buy

The price of Xymelin spray varies between 120-200 rubles.

You can buy Xymelin for children at a price of 80 rubles.

  • Internet pharmacies in Russia Russia
  • Internet pharmacies of Kazakhstan Kazakhstan

ZdravCity

    Xymelin drops called. 0.05% 10ml n1 Takeda GmbH

    Xymelin eco with menthol spray naz. 140mcg/dose 10ml n1 Takeda GmbH

    Xymelin eco spray 0.05% 35mcg/dose 10ml Takeda GmbH

    Xymelin extra spray 0.6mg/ml+0.5mg/ml 10ml Takeda GmbH



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