Mildronate (solution for injection): instructions for use. Mildronate: description, indications for use, general properties and effect Mildronate injection instructions for use

Due to its mechanism, it is used in the treatment of diseases of the heart and blood vessels, to increase the endurance of the body. In the reviews of patients who took the drug, it is said that it improves the physical, mental state at the time of overload and the rehabilitation period.

A drug that can improve and enhance metabolic processes in the tissues of the body. This new generation metabolic drug is used primarily as a cure for ischemia.

It has been observed that long-term treatment with the drug weakens the development of angina pectoris. The active substance of the drug, meldonium, also affects the central nervous system, improving cognitive functions and mental activity.

For what disorders is the drug prescribed:

1.Cardiology:

• cardiac ischemia;
• stable angina pectoris;
• heart failure;
• menopausal cardiomyopathy;
• prevention of myocardial infarction.

2.Neurology:

• cerebral and cardiac ischemia;
• consequences of cerebrovascular accidents.

3. Ophthalmology:

• pathological changes in the fundus;
• retinopathy;
• impaired blood circulation in the retinal area.

4. Pulmonology:

• obstructive changes in the lungs.

5. Narcology:

• removal of symptoms of the consequences of chronic alcoholism.

6. General practice:

• nervous fatigue;
• low performance;
• asthenia not related to exercise;
• overload in athletes.

The drug is not used as the main medicine for diseases, but as an adjunct to treatment.

Compound

Mildronate (reviews of patients who took the drug indicate an improvement in well-being) contains the active substance meldonium, which is an analogue of y-butyrobetaine, a precursor of levocarnitine, which is part of every cell of the human body.

One capsule of the drug contains:

• Meldonium digidratum as an active ingredient, 250 mg;
• dried starch, extracted from potatoes, as a leavening agent;
• silicon oxide (absorbent);
• salt of calcium and stearic acid, as an auxiliary component.

Capsule composition:

• titanium dioxide as a filler;
• gelatin as a source of collagen.

In what form is it issued

The drug is available in two dosage forms- gelatin shell and ampoules. The white capsule contains a crystalline hygroscopic powder with a slight odor. Packed capsules of 10 pcs. in blisters, blister. There are 4 cells in a cardboard pack, there is an attached instruction for use. Cost - from 300 rubles.

The liquid form is available in ampoules, each containing 5 ml of the drug, intended for intravenous injection. One ml of the drug contains 100 mg active substance, meldonium. The cost of a package of 10 ampoules is from 300 rubles.

Pharmacodynamics

The main effect of the drug is the restoration of foci of impaired blood circulation in certain areas of the tissue, where the accumulation of an undesirable amino acid, carnitine, occurs. Mildronate, while maintaining the rate of metabolic processes, reduces the level of carnitine, inhibiting its biosynthesis and absorption in the kidneys.

Levocarnitine is involved in the oxidation of fatty acids, reducing their rate, which are the main source of myocardial energy. Carnitine is also involved in the transport of acids across the mitochondrial membrane.

Due to a decrease in the oxidizability of fatty acids in mitochondria, cells switch to a glycolytic source, which causes the heart muscle to use oxygen in an enhanced mode. In addition, meldonium enhances the ability of red blood cells to release oxygen.

Meldonium reduces the concentration of glucose in the blood, has a cardioprotective effect, and reduces the development of atherosclerosis. The drug continuously trains the heart, thereby preparing cellular metabolism and membrane structures for survival in conditions of ischemic stress, if any.

The drug has a vasodilating effect due to the production of nitric oxide in the endothelium (cell inner surface) of the vessels.

The active substance, meldonium dihydrate, has an effect on the body:

In heart failure Meldonium digidratum increases myocardial contractility, affects the reduction in the frequency of angina attacks.

Pharmacokinetics

After taking the drug, Meldonium digidratum is rapidly absorbed, its bioavailability is 78%. Bioavailability in the systemic circulation, or the maximum concentration is reached 1-2 hours after ingestion.

The synthesis and breakdown of the substance occurs in the liver, with the formation of two metabolites. It is excreted through the kidneys, the half-life depends on the dose, but not more than 6 hours. Trace concentrations remain in the body for a long time.

Application

Mildronate (reviews from patients who took the drug are mostly positive) improves metabolism in muscle cells heart, supports the energy supply of all organs. Like any drug, meldonium should be taken on the recommendation of a doctor, taking into account the existing symptoms, age, and characteristics of the patient's body.

For children under 18

Since no studies have been conducted in medicine on the use of the drug in childhood, then it is forbidden to appoint him under 18 years of age.

For adults

Mildronate for adults is recommended in the following doses - 500 mg or 2 capsules. It is taken in one dose, in the morning, or divided into two doses of 250 mg, in the morning and at night. daytime. Since the drug has a tonic effect, it is not recommended to take it in the evenings. The course of treatment is no more than 14 days. If necessary, you can continue taking after a 2-3 week break.

In case of circulatory disorders in the brain, the dose can be increased to 1 g, which is taken in one or two doses. Treatment is carried out from 4 to 6 weeks. People involved in energy-intensive mental activity are prescribed 4 tab. per day (500 mg) for 2 weeks.

IN complex therapy to relieve withdrawal symptoms, a 10-day treatment is carried out, 4 capsules per day.

Mildronate in ampoules is used intramuscularly, intravenously and for ophthalmic injections. The drug does not require additional dilution with saline. More often, intravenous infusions are carried out, and intramuscular injections are made in the absence of acute conditions of the disease.

For pregnant

Clinical trials of the drug for the effect female body during pregnancy and breastfeeding was not carried out, which makes its use impossible during these periods.

For the elderly

Elderly people should use the drug with caution. Since many people aged 60+ have chronic diseases, renal and hepatic, the use of the drug should be coordinated with the attending physician.

Contraindications

Mildronate is contraindicated in people who have hypersensitivity to one of the components of the drug. Patient reviews indicate that some people who took the drug had skin redness, which quickly passed.

The drug is contraindicated in people with increased hypertension due to:

• disturbed venous outflow;
• intracranial hematoma.

People with reduced kidney and liver function should use the medicine with caution, you should first consult with your doctor. Does meldonium affect the ability to drive vehicle whether the speed of psychomotor reactions increases - these aspects have not been studied and data are not available. It is undesirable to combine the drug with alcohol.

Overdose

Cases of overdose are not reported, because the drug is of low toxicity, does not cause severe reactions.

After injections, in case of an increased volume of the drug, symptoms may occur:

• lowering blood pressure;
• headache;
• increased heart rate;
• general weakness.

In such cases, the symptomatic treatment. Doctors advise at the same time to monitor the work of the kidneys and liver, but hemodialysis is ineffective, because the medicine has high level binding to blood proteins.

Side effects

Mildronate (reviews of patients taking the drug contain information about side effects) is generally well tolerated. However, in susceptible individuals and those who have exceeded doses, secondary reactions may occur.

When taking the drug, it should be remembered that it can affect the results of some laboratory and instrumental studies:

• increase the concentration of c-reactive protein in the blood;
• increase eosinophils in the blood;
• increase triglyceride and cholesterol levels;
• accelerate sinus rhythm at the time of the ECG.

In the case of doping control, the drug gives positive result that should be taken into account by people participating in competitions.

drug interaction

Mildronate (reviews of patients who took the drug can be found on the pages of medical sites) is used with drugs:

• prolonged action (having a long therapeutic effect);
• antianginal drugs (increasing blood flow to the heart);
• diuretic;
• glycosides (herbal preparations used to treat heart failure).

The drug can be combined with drugs that affect blood microcirculation:

• reducing the activity of blood coagulation;
• influencing cardiac arrhythmias;
• preventing thrombosis.

Meldonium enhances the effect of antihypertensive drugs and vasodilators:

• nitroglycerin;
• beta-blockers;
• nifedipine;
• nitrates;
• calcium channel antagonists.

It is undesirable to use meldonium simultaneously with these drugs, since tachycardia and hypotension may develop. It is also able to enhance the effects of drugs that expand the lumen of peripheral and coronary vessels that lower blood pressure.

Terms and conditions of storage

It is necessary to store the drug in a dry place, protected from children. The temperature should not exceed +25°C. Shelf life - no more than 4 years.

Terms of dispensing from pharmacies

The drug is over-the-counter, available for free sale.

Analogues

For the treatment of diseases in which Mildronate is used, the following drugs can be used:

The table shows the approximate doses of drugs. They vary depending on the disease, the condition of the patient. Medicines and analogues are selected according to the doctor's prescription, since many side effects are possible.

Mildronate has a large amount good reviews. Patients who took the drug correctly indicate a pronounced positive effect in the prevention of coronary diseases.

Video about the drug Mildronate

The mechanism of action of the drug Mildronate:

An antiarrhythmic agent of the IB class, which improves metabolism - metabolic processes in the human body, is Meldonium. Instructions for use suggest taking capsules or tablets of 250 mg and 500 mg, injections in ampoules for injections for the treatment of cerebrovascular disorders, recuperation in athletes, coronary artery disease.

Important! Meldonium is recognized as doping. Its use in professional sports is prohibited!

Composition and form of release

Meldonium comes to pharmacies in the form of:

• capsules 500 mg and 250 mg;
• solution for injections (injections).

The active substance is meldonium dihydrate. Its volume in tablets or capsules is 250 mg or 500 mg. 1 ml of solution contains 100 mg.

Pharmacological properties

Means that improves metabolism, an analogue of gamma-butyrobetaine. Suppresses gamma-butyrobetaine hydroxynase, inhibits the synthesis of carnitine and the transport of long-chain fatty acids through cell membranes, prevents the accumulation in cells of activated forms of unoxidized fatty acids - derivatives of acylcarnitine and acylcoenzyme A.

Under conditions of ischemia, it restores the balance of the processes of oxygen delivery and its consumption in cells, prevents the violation of ATP transport; at the same time, it activates glycolysis, which proceeds without additional oxygen consumption.

As a result of a decrease in the concentration of carnitine, gamma-butyrobetaine, which has vasodilating properties, is intensively synthesized. The mechanism of action determines the diversity of its pharmacological effects: increased efficiency, reduced symptoms of mental and physical overstrain, activation of tissue and humoral immunity, cardioprotective effect.

Efficiency

In the case of acute ischemic myocardial damage, it slows down the formation of a necrotic zone, shortens the rehabilitation period. In heart failure, it increases myocardial contractility, increases tolerance to physical activity reduces the frequency of angina attacks.

In acute and chronic ischemic disorders of cerebral circulation, it improves blood circulation in the focus of ischemia, promotes the redistribution of blood in favor of the ischemic area. Effective in vascular and dystrophic pathology of the fundus.

It has a tonic effect on the central nervous system, eliminates functional disorders from the side nervous system in patients with chronic alcoholism with withdrawal syndrome.

What is Meldonium for?

Indications for use include complex therapy:

• physical overvoltage;
• withdrawal syndrome in chronic alcoholism;
• reduced performance;
• disorders of cerebral circulation;
• dishormonal cardiomyopathy;
• postoperative rehabilitation.

What helps parabulbar introduction:

• retinal vein thrombosis;
• retinopathy (diabetic and hypertensive);
• retinal hemorrhage;
• violation of blood circulation in the retina.

Instructions for use

When taken orally, a single dose is 0.25-1 g, the frequency of administration and the duration of treatment depend on the indications.

Parabulbarno enter 0.5 ml of injection with a concentration of 500 mg / 5 ml for 10 days.

At intravenous administration the dose is 0.5-1 g 1 time per day, the duration of treatment depends on the indications.

Athletes are prescribed for rehabilitation therapy according to special schemes in combination with other means. Officially recognized as doping.

How to take in diseases?

1. In case of impaired cerebral circulation, Meldonium is recommended during the period of exacerbation, 0.5 g once a day for 10 days, then in encapsulated form, 0.5 g daily for 14–21 days.
2. At chronic form circulatory disorders of the brain prescribe a course of treatment lasting 14-21 days. The solution for injection is administered intramuscularly at 0.5 g 1 time per day or administered orally at 0.25 g (the frequency of administration depends on the severity of the patient's condition).
3. Withdrawal syndrome requires a course of Meldonium therapy for 7-10 days. Then the patient is shown a four-time intake of the drug during the day, 0.5 g orally or twice - intravenously.
4. With stable angina pectoris, the first 3-4 days are prescribed 0.25 g 3 times. Then it is taken orally twice a week at a daily dosage of 0.25 g 3 times. The duration of therapy is from 4 to 6 weeks.
5. In case of cardialgia associated with dyshormonal myocardial dystrophy, the drug is administered intravenously by jet method 1 time per day, 0.5-1 g or intramuscularly up to 2 times a day, 0.5 g each. After 10-14 days, the encapsulated form is prescribed 0.25 mg in the morning and evening, treatment is continued for another 12 days.
6. With an unstable form of angina pectoris and myocardial infarction, Meldonium is used intravenously by a jet method of 0.5 g or 1 g once a day. In the future, it is prescribed orally: 3-4 days - 0.25 g 2 times, then 2 days a week, 0.25 g 3 times a day.
7. In case of vascular diseases of the fundus, retinal dystrophy, Meldonium is prescribed retrobulbar and subconjunctival in a dose of 0.05 g for 10 days.
8. In chronic heart failure, the drug is administered intravenously in a jet method once a day at a dose of 0.5-1 g or replaced by an intramuscular injection of 0.5 g up to 2 times a day. After 10–14 days of treatment, the patient is transferred to 0.5 g capsules, which he takes 1 time in the morning. The course of treatment is from 4 to 6 weeks.

Contraindications

Side effects

• pruritus;
• redness;
• rash;
• edema;
• tachycardia;
• changes in blood pressure (arterial hypotension);
• psychomotor agitation;
• dyspeptic symptoms.

Children, pregnancy and lactation

Meldonium is not prescribed to pregnant women, since it has not been possible to prove its safety to mother and child. If you need to prescribe a medicine to a nursing woman, then for the duration of therapy breast-feeding stop: it is not known whether the substance passes into milk.

In children and adolescents under the age of 18, the efficacy and safety of meldonium has not been established. Meldonium in the form of capsules is contraindicated for use in children and adolescents under the age of 18; in the form of syrup - in children under the age of 12 years.

special instructions

Use with caution in diseases of the liver and / or kidneys, especially for a long time.

Many years of experience in the treatment of acute myocardial infarction and unstable angina in cardiology departments shows that meldonium is not a first-line drug in acute coronary syndrome.

Interaction

With simultaneous use with Nitroglycerin, alpha-blockers, Nifedipine, peripheral vasodilators, there is a possibility of tachycardia and arterial hypotension. Enhances the action of antihypertensive, antianginal drugs, cardiac glycosides.

Perhaps a combination with antianginal drugs, anticoagulants, antiarrhythmic drugs and diuretics.

Important! Do not use simultaneously with other preparations containing meldonium.

Meldonium's analogs

According to the structure, analogues are determined:

1. Vasomag.
2. Meldonium dihydrate.
3. Idrinol.
4. Meldonium Organica (Binergia, Escom).
5. Angiocardil.
6. 3-(2,2,2-Trimethylhydrazinium) propionate dihydrate.
7. Cardionate.
8. Midolat.
9. Meditern.
10. Melfor.

For the treatment of physical and mental overload, recovery of the body, analogues are prescribed for the action:

Holiday conditions and price

The average price of Meldonium (injections 5 ml No. 10) in Moscow is 145 rubles. In Ukraine, you can buy medicine for 195 hryvnia. in Kazakhstan, pharmacies offer an analogue of Mildronate. In Minsk, the drug is sold for 4-6 bel. rubles. You will need a prescription to get the medication.

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A drug with metabolic activity is Mildronate: injections with it are prescribed not only for chronic pathologies, but also to increase physical and mental endurance.

The drug has a pharmacological effect due to the active ingredient, which is meldonium. 5 ml of injection solution in 1 ampoule contains 0.5 g of this substance. Supplements the composition of the drug water for injection.

Pharmacological properties

The active substance of Mildronate is of synthetic origin, but acts similarly to gamma-butyrobetaine, which is a natural component present in the cells of the human body.

Meldonium has the following positive effects:

1. Antianginal. People taking the drug have a reduced risk of developing angina pectoris. The drug prevents seizures characteristic of this disease.
2. Cardioprotective. Thanks to this property, the functioning of the heart muscle improves.
3. Antihypoxic. The medicine prevents the development of oxygen starvation.
4. Angioprotective. The medication helps with vascular diseases, because it strengthens their walls. Meldonium normalizes blood flow.

Indications and contraindications for use

Mildronate is prescribed for a decrease in physical and mental abilities or their overstrain.

The drug is indicated for the following pathological conditions:

• disorders of cerebral circulation occurring in chronic and subacute forms, incl. and with strokes;
• as part of complex therapy for coronary artery disease;
• cardiomyopathy, cardialgia;
• heart failure in a chronic form;
• diseases of the retina: retinal hemorrhage or vitreous body, retinal vein thrombosis;
• retinopathy hemorrhagic, diabetic, etc.;
• bronchitis and bronchial asthma in chronic form - as an immunomodulating agent;
• COPD;
• after surgical intervention for the purpose of speedy rehabilitation;
• withdrawal syndrome in chronic alcoholics.

The drug is prohibited for use by people experiencing hypersensitivity to meldonium. You can not use the medicine with increased intracranial pressure, the presence of intracranial tumors.

Mildronate in injections: instructions for use

Injections are prescribed if it is necessary to improve a person's condition in a short time. But at the same time, the type of pathology and the severity of its course are taken into account.

Mildronate in the form of a solution is administered intramuscularly, intravenously and parabulbarno, i.e., into the lower eyelid. Last form of introduction medicinal product intended for the treatment of eye pathologies.

The drug can cause excitement and lead to insomnia, so it is recommended to give injections in the morning.

How to inject Mildronate intramuscularly

The place of administration of the drug is determined by the doctor. It is often recommended to inject Mildronate intramuscularly into the buttock.

The solution contains a sufficient concentration of the active substance, so it does not require dilution. But sometimes doctors advise diluting the medication with saline. In such cases, the amount of meldonium does not decrease, but only its concentration decreases. This leads to a change in the rate of action of the drug.

It is not recommended to use other means for diluting Mildronate, except for saline. Failure to comply with this requirement may result in undesirable consequences and affect the medicinal properties of the drug.

Intramuscular administration is indicated for chronic and subacute conditions, and for acute conditions, Mildronate is administered intravenously - drip or jet.

Dosage for different pathologies

The volume of doses administered and the duration of therapy are selected by the doctor individually for each patient. The specialist takes into account the type of disease, the state of health of the patient and other factors.

In accordance with the instructions, adult patients Mildronate is prescribed in the following dosages:

Application in sports

Due to the ability of meldonium to return physical activity and increase endurance, Mildronate in solution for injection has found wide application in sports.

The drug has a positive effect on the condition of athletes of any disciplines, but those who are subjected to aerobic exercise feel the greatest effect.

Mildronate, as a means of nourishing muscles, was appreciated by athletes involved in bodybuilding. But do not think that injections contribute to muscle building. Meldonium is recommended to bodybuilders as a prevention of overwork. Strength training leads to fatigue, but the drug increases the physical capabilities of a person.

The drug contributes to the speedy recovery after injuries. Injections help to cope with stressful loads, which often appear during important competitions.

Meldonium helps to provide the cells of the body with the necessary energy, since it delivers glucose to them for a short period of time. An important quality of the drug is its ability to remove toxins and other harmful substances formed during the breakdown of products entering the body.

The medicine is good for athletes and in that it improves coordination of movements and increases their speed.

Mildronate contributes to the rational consumption of energy and accumulates it in the body. It helps to reveal the potential of an athlete in conditions of maximum stress, improves his performance.

The medication should be taken in accordance with the doctor's recommendations.

Most often, athletes are advised to inject the drug into the muscle at a dosage calculated depending on weight: 1 mg of the drug per 1 kg, but not more than 2 g per day. Injections should be done 1 time per day before training (about half an hour). The duration of the course is 1.5-3 months. To avoid addiction, a break in reception for 4 weeks is necessary.

Not so long ago, meldonium was recognized as doping. If a doping test is carried out during the competition, then the athlete will be found to have a substance in the blood, followed by disqualification. It should be borne in mind that the half-life of the medicinal composition is approximately 5 hours. But it has not yet been precisely established how long it will take for the substance to leave the tissues of the body after the completion of the therapeutic course.

Athletes need to remember that meldonium has caused a big scandal in the sports world. This substance has ruined the careers of many athletes who have been convicted of doping.

Side effects and overdose

Mildronate injections can cause the following side effects:

• the development of an allergy, manifested by skin rashes, itching, the appearance of edema, including Quincke's edema;
• dyspepsia, which is characterized by paroxysmal nausea, vomiting, belching, heartburn;
• failure of the heart rhythm - tachycardia;
• downgrade blood pressure;
• excitation of the psychomotor type;
• rarely - eosinophilia, weakness of the whole body.

With intramuscular injections, a local reaction is possible - pain and the development of allergies at the injection site of the drug solution. In this case, the doctor may recommend intravenous infusions.

Cases of overdose in medical practice have not been recorded. Meldonium does not belong to toxic substances and is not hazardous to health, but if the doctor's recommendations are not followed, unpleasant consequences are possible, requiring medical care. Overdose symptoms are the same as side effects medicines.

special instructions

Mildronate has special instructions on its use, which should be studied before the first use.

Pregnancy and lactation

The medical preparation Mildronate intramuscularly, intravenously, parabulbarno or orally is contraindicated in pregnant women. Such restrictions are due to the fact that so far there have not been enough studies showing the effect of the drug on the development of the fetus and on the health of the woman herself.

This contraindication also applies to the period of breastfeeding. Studies have shown that meldonium passes into the breast milk of animals. Experts do not exclude the risk of penetration of the substance into the breast milk of a woman, although there is no information about this.

Appointment of Mildronate to children

Mildronate in ampoules and tablets is not prescribed for children. The drug is not used in pediatrics, because it has not been revealed how it can affect the child's body - a sufficient number of necessary studies have not yet been carried out.

drug interaction

Mildronate is combined with many medications. Among them are antianginal, antiarrhythmic, anticoagulant, antiplatelet, diuretic. Simultaneous administration with bronchodilators and glycosides is possible.

The drug potentiates the action of adrenoblockers, drugs that have an antihypertensive effect, and drugs that dilate blood vessels.

When taking several medications at the same time, you need the advice of a doctor, so you need to consult a specialist. If the drugs are prescribed by different doctors, you should talk about this topic with each of them.

Alcohol compatibility

The instructions for the drug do not say that during the period of taking Mildronate, it is necessary to give up alcohol. But drinking alcohol is still not worth it, especially if the medicine is used for diseases of the heart and blood vessels or disorders associated with the brain. Often, the joint use of medication and alcohol leads to undesirable consequences and crosses out all the positive that has been achieved during the period of therapy.

With impaired liver and kidney function

In chronic liver or kidney failure, the drug may be prescribed, but therapy is carried out with caution and under the supervision of a physician. You may need to adjust the dose provided by the instructions.

Influence on the ability to drive vehicles and complex mechanisms

During the period of therapy, you should avoid driving a car or working with complex mechanisms. If this cannot be done, you must be extremely careful when performing such actions.

Studies that reveal the effect of meldonium on concentration have not been conducted.

Terms of dispensing from pharmacies

The drug Mildronate is included in the list of prescription drugs. But pharmacies, not wanting to lose profits, often sell the drug without a medical prescription, which is against the rules.

Terms and conditions of storage

Storage conditions - a place protected from the penetration of daylight and sunlight; ambient temperature must not exceed +25°C.

The drug retains its medicinal properties within 4 years from the date of issue. But this applies to closed ampoules. After opening, the solution must be used immediately. He doesn't save useful properties even in the fridge. If the medicine has not been used within 20 minutes, it must be destroyed.

1 ampoule contains meldonium 500 mg

Release form

Solution for injection, 5 ml per ampoule - 10 ampoules per pack

pharmachologic effect

Meldonium (Mildronate) is a structural analogue of gamma-butyrobetaine, a substance that is found in every cell of the human body.

Under conditions of increased stress, Mildronate restores the balance between the delivery and demand of cells for oxygen, eliminates the accumulation of toxic metabolic products in cells, protecting them from damage; also has a tonic effect. As a result of its use, the body acquires the ability to withstand the load and quickly restore energy reserves. Due to these properties, Mildronate is used to treat various disorders of activity. of cardio-vascular system, blood supply to the brain, as well as to increase physical and mental performance. As a result of a decrease in the concentration of carnitine, gamma-butyrobetaine, which has vasodilating properties, is intensively synthesized. In the case of acute ischemic myocardial damage, Mildronate slows down the formation of a necrotic zone and shortens the rehabilitation period. In heart failure, it increases myocardial contractility, increases exercise tolerance, and reduces the frequency of angina attacks. In acute and chronic ischemic disorders of cerebral circulation, Mildronate improves blood circulation in the focus of ischemia, promotes the redistribution of blood in favor of the ischemic area.

The drug eliminates functional disorders of the nervous system in patients with chronic alcoholism with withdrawal syndrome.

Indication for use

• in the complex therapy of coronary heart disease (angina pectoris, myocardial infarction);
• chronic heart failure and dishormonal cardiomyopathy;
• in the complex therapy of acute and chronic disorders of the blood supply to the brain (stroke and cerebrovascular insufficiency);
• hemophthalmus and retinal hemorrhage various etiologies, thrombosis of the central retinal vein and its branches, retinopathy of various etiologies (diabetic, hypertensive);
• reduced performance;
• mental and physical overload (including athletes);
• withdrawal syndrome in chronic alcoholism (in combination with specific alcoholism therapy).

Dosage and administration

In view of the possible development of an exciting effect, it is recommended to apply in the morning.

Mildronate is prescribed intramuscularly (in / m), intravenously (in / in) and parabulbarno. The route of administration, doses and duration of the course of treatment are set individually, depending on the indications, the severity of the condition, etc.

Contraindications

• hypersensitivity to meldonium or any other component of the drug;
• increased intracranial pressure (in violation of venous outflow, intracranial tumors);
• pregnancy and breastfeeding period;
• under 18 years of age (safety not confirmed)

Storage conditions

Store in a dry place at a temperature not exceeding 25°C. Do not freeze! Keep out of the reach of children.

Meldonium: instructions for use and reviews

Latin name: Meldonium

ATX Code: C01EB22

Active substance: meldonium (Meldonium)

Manufacturer: Ellara (Russia); Pharmstandard - Ufa Vitamin Plant (Russia); Pharmstandard - Leksredstva (Russia); Biochemist (Russia); Atoll (Russia); Biosynthesis (Russia)

Description and photo update: 27.11.2018