Chondroxide indications for use. Means for active nutrition and restoration of the state of cartilage - Chondroxide tablets: instructions for use, result in the treatment of osteoarthritis and osteochondrosis

With degenerative-dystrophic processes in the spine and joints, cartilage tissue suffers. Violation of the shock-absorbing function of the elastic pad reduces the mobility of the spine, causes increased friction of adjacent elements, and provokes pain.

Chondroxide tablets - effective remedy for active nutrition and restoration of cartilage. Despite the presence of one active component, the drug shows good results in the complex treatment of osteoarthritis, osteoporosis, osteochondrosis, spondylarthrosis, and other diseases of the spine.

Composition and action on the body

Chondroitin sulfate is an important component, without which the proper functioning of the elements of the spine and joints is impossible. Chondroxide tablets contain 0.25 g of the active substance. To enhance the effect, the drug contains povidone, magnesium carbonate, calcium stearate.

The combination of chondroitin sulfate with additional ingredients has a complex effect on the spine and joints:

• activates the production of synovial fluid;
• reduces the rate of natural and pathological destruction of cartilage;
• reduces the risk of calcium leaching from bones;
• reduces pain in the affected area, improves mobility against the background of osteochondrosis and other pathologies of the spine;
• positively affects the structure of chondrocytes, activates the functioning of cells cartilage tissue;
• enhances the synthesis of important components - proteoglycans;
• activates cartilage regeneration;
• normalizes metabolism in case of damage to the elastic lining in the vertebral structures;
• exhibits anti-inflammatory action;
• reduces pain with osteoarthritis, and.

Taking the average therapeutic dose leads to the maximum accumulation of the active substance in the blood three to four hours after taking the medication. In the synovial fluid, the maximum concentration of chondroitin sulfate was recorded after four to five hours. After 2 days, the largest amount of the active substance accumulates in articular cartilage. The positive point is that the active ingredient easily penetrates the synovial membrane. During the day, chondroitin sulfate is excreted in the urine.

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Cost and storage conditions

The drug Chondroxide group belongs to the category of drugs with an above-average cost. Approximate price of Chondroxide tablets in package No. 60 is 630 rubles. An ointment for treating problem areas costs 370 and 420 rubles (30 and 40 g, respectively).

The packaging with chondroprotector tablets should be stored in a dry room with a temperature of no more than 20 degrees. The drug can be purchased in pharmacy chains by prescription. The shelf life of Chondroxide tablets is 24 months. You can not take an expired medicine with chondroitin sulfate. It is necessary to protect the tablets for the restoration of cartilage from children: up to 12 years, the drug is not used in pediatric practice.

Chondroxide tablets: analogues

The list of chondroprotectors includes many items based on chondroitin sulfate. More effective doctors consider the use of combined products containing not only the specified component, but also hyaluronic acid, vitamins, methylsulfonylmethane. The optimal type of drug for cartilage regeneration is determined by a vertebrologist or rheumatologist.

Popular analogues:

• Chondro Strength.
• Artra.
• Gel Chondroitin with bodyaga.
• Triactive.
• Chondrovit.
• Structum.
• Formula - C.
• Chondrolon.
• Mukosat.
• Artron Complex.

New packaging! Chondroxide ® 250 mg, 60 tablets

Identification and classification

Registration number

international generic name

chondroitin sulfate

Dosage form

pills

Compound

1 tablet contains:

active substance: chondroitin sulfate sodium - 250 mg;

Excipients: calcium stearate, crospovidone, povidone K30, microcrystalline cellulose, magnesium hydroxycarbonate (magnesium carbonate heavy).

Description

Round flat-cylindrical tablets from white to white with a yellowish or creamy tint, scored on one side and chamfered on both sides, blotches are allowed.

Pharmacotherapeutic group

tissue repair stimulant of natural origin

Pharmacological properties

Pharmacodynamics

It has a chondrostimulating, regenerating, anti-inflammatory effect.

Chondroxide ® is involved in the construction of the basic substance of cartilage and bone tissue; affects metabolic processes in hyaline and fibrous cartilage, inhibits enzymes that cause damage to cartilage. The drug inhibits the destruction of cartilage tissue and stimulates the regenerative processes in the articular cartilage.

Chondroxide ® stimulates the biosynthesis of proteoglycans, promotes the regeneration of the articular bag and cartilaginous surfaces of the joints, and has an anti-inflammatory effect. It slows down the resorption of bone tissue and reduces the loss of calcium, accelerates the processes of bone tissue restoration.

Chondroxide ® slows down the progression of osteoarthritis and osteochondrosis. When using the drug Chondroxide ®, pain decreases and the mobility of the affected joints improves, while the therapeutic effect persists for a long time after the end of the course of therapy.

Having a structural similarity with heparin, it can potentially prevent the formation of fibrin clots in the synovial and subchondral microvasculature.

Pharmacokinetics

Suction

With a single oral dose of the average therapeutic dose, the maximum plasma concentration is reached after 3-4 hours, in the synovial fluid - after 4-5 hours. The bioavailability of the drug is 13%.

Distribution

Accumulates mainly in cartilage (maximum concentration in articular cartilage is reached after 48 hours); the synovium is not an obstacle to its penetration into the joint cavity.

breeding

Excreted by the kidneys within 24 hours.

Indications for use

Degenerative-dystrophic diseases of the joints and spine: treatment and prevention of osteoarthritis, osteochondrosis of the spine.

Contraindications

Hypersensitivity to the components of the drug, childhood(efficacy and safety of use in children have not been established), pregnancy, breastfeeding period.

Carefully

Bleeding, tendency to bleed.

Dosage and administration

Inside, 0.5 g (2 tablets) 2 times a day.

Tablets are taken with a small amount of water.

The therapeutic effect of the drug persists for 3-5 months after its withdrawal, depending on the location and stage of the disease. If necessary, it is possible to conduct repeated courses of treatment, the duration of which is determined individually.

Side effect

Frequency estimate: rarely - from >= 0.01% to< 0,1%.

Violations by gastrointestinal tract: rarely - nausea, vomiting, diarrhea.

Violations by immune system: rarely - allergic reactions.

Overdose

Symptoms: rarely - nausea, vomiting, diarrhea, with prolonged use in excessively high doses (more than 3 g / day), hemorrhagic rashes are possible.

Treatment: conducting symptomatic therapy.

Interaction with other drugs

It is possible to enhance the action of indirect anticoagulants, antiplatelet agents, fibrinolytics.

special instructions

When the drug is used together with indirect anticoagulants, antiplatelet agents, fibrinolytics, more frequent monitoring of blood coagulation parameters is required.

Influence on the ability to drive vehicles and work with mechanisms

Does not affect the ability to drive a car and other mechanisms.

Release form

Tablets 250 mg. 10 tablets in a blister pack made of printed lacquered aluminum foil and polyvinyl chloride / polyvinylidene chloride film or aluminum foil, laminated with polyvinyl chloride and polyamide film.

3, 5, 6, 9 or 10 blister packs together with instructions for use of the medicinal product in a carton pack.

Storage conditions

In a place protected from light at a temperature not exceeding 25 ºС.

Registration number LS-002295

Trade name of the drug Chondroxide®

INN Chondroitin sulfate

Dosage form pills

Compound

One tablet contains as an active substance: chondroitin sulfate - 0.25 g (dry and 100% substance) and excipients: calcium stearate, crospovidone, polyvinylpyrrolidone (povidone), microcrystalline cellulose, magnesium carbonate basic water (magnesium carbonate) - a sufficient amount to obtain a tablet weighing 0.48

Description

Tablets from white with a yellowish tint to white with a creamy tint, interspersed, scored and chamfered.

Pharmacotherapeutic group

Tissue regeneration stimulator.

Code ATX: M01AX25.

Pharmacological properties
It has a chondrostimulating, regenerating, anti-inflammatory effect.

Chondroxide® is involved in the construction of the basic substance of cartilage and bone tissue; affects metabolic processes in hyaline and fibrous cartilage. Inhibits the processes of degeneration (destruction) of cartilage and connective tissue; inhibits enzymes that cause cartilage damage.

Chondroxide® stimulates the biosynthesis of proteoglycans, promotes the regeneration of the articular bag and cartilaginous surfaces of the joints, increases the production of intra-articular fluid, and reduces inflammation.

Potentially may prevent the formation of fibrin clots in the synovial and subchondral bloodstream.

Chondroxide® slows down the progression of osteoarthritis and osteochondrosis, normalizes metabolism in hyaline tissue, stimulates regeneration (recovery) processes in articular cartilage. When using the drug Chondroxide®, pain decreases and the mobility of the affected joints improves, while the therapeutic effect persists for a long time after the end of the course of therapy.

Pharmacokinetics

With a single oral dose of the average therapeutic dose, the maximum plasma concentration is reached after 3-4 hours, in the synovial fluid after 4-5 hours.

Accumulates mainly in cartilaginous tissue (maximum concentration in articular cartilage is reached after 48 hours); the synovium is not an obstacle to its penetration into the joint cavity. Excreted by the kidneys within 24 hours.

Indications for use

Degenerative-dystrophic diseases of the joints and spine: treatment and prevention of osteoarthritis, osteochondrosis of the spine.

Contraindications

Hypersensitivity to the components of the drug, pregnancy, lactation.

Carefully

For bleeding and tendency to bleed.

Dosage and administration

Inside, 0.5 g (2 tablets) 2 times a day.
Tablets are taken with a small amount of water.

The recommended dosage of the initial course is 6 months. It should be borne in mind that the therapeutic effect of the drug persists for 3-5 months after its withdrawal, depending on the location and stage of the disease. If necessary, it is possible to conduct repeated courses of treatment, the duration of which is determined individually.

Side effect
In some cases: allergic reactions, nausea, diarrhea.

Interaction with other drugs

It is possible to increase the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics, which requires more frequent monitoring of blood coagulation parameters when used together.

Release form

Chondroxide®, tablets of 0.25 g. 10 tablets in a blister pack, 3, 5, 6, 9, 10 blister packs, together with instructions for the medical use of the drug, are placed in a cardboard pack.

Best before date

2 years. Do not use the drug after the expiration date.

Storage conditions

In a place inaccessible to children at a temperature not exceeding 20 ° C.

Terms of dispensing from pharmacies

On prescription.

Manufacturer

OAO "NIZHFARM", Russia

Consumer claims should be sent to:
603950, Nizhny Novgorod
GSP-459, st. Salganskaya, 7

Chondroxide (INN chondroitin sulfate) is a joint cartilage repair stimulator from the Russian pharmaceutical company Nizhpharm LLC, one of the top three domestic drug manufacturers. It is produced in the form of an injection solution, tablets, as well as external forms - ointments and creams, and in the latter case, the manufacturer managed to achieve an unprecedentedly high content of the active ingredient. The systemic use of NSAIDs in osteochondrosis, osteoarthrosis and other degenerative-dystrophic diseases is fraught with serious adverse reactions, which increases the importance of effective local therapy: it is convenient, safe, does not entail the risk of unwanted pharmacological interactions and provides a therapeutic effect directly on the focus pathological process. The oral form of chondroitin sulfate has a low (13%) bioavailability, due to the impressive molecular weight of the active substance. In this regard, other ways of delivering the active component to the affected tissues, in particular, the local dosage form, are becoming increasingly important. The bioavailability of Chondroxide in the form of an ointment or cream is about 30%, which should be considered a very good indicator. The ointment contains dimethyl sulfoxide as an auxiliary component, which ensures effective penetration of chondroitin sulfate through the skin and mucous membranes to the affected joints and spine.

It is important that Chondroxide has a pronounced ability to slow down the destructive processes in cartilage and stimulate its regeneration. As a result, this leads to the removal pain syndrome and increased joint mobility. The drug has an extremely favorable safety profile and, when used in doses recommended by the manufacturer, has virtually no side effects. OTC status of the drug allows the possibility of its use in the framework of responsible and controlled self-medication. Chondroxide not only significantly reduces the severity of pain, but also has a direct effect on the cause of its occurrence - on the main pathogenetic link in the formation of pain syndrome, providing effective regeneration of the cartilage tissue of the damaged joint. An important caveat: this process requires a certain amount of time: the duration of the use of the drug must be at least one month. Domestic doctors have accumulated considerable experience in the clinical use of Chondroxide. One of the studies was carried out in Tatarstan within the walls of the Kazan State Medical Academy. Scientists compared the effectiveness of Chondroxide and Ibuprofen in the treatment of lumboischialgia (lumbar pain syndrome). The results of the clinical trial proved the high analgesic efficacy of Chondroxide: after 14 days of treatment, the intensity of the pain syndrome in patients decreased by half.

Pharmacology

The agent that affects the phosphorus-calcium metabolism in cartilage tissue is a high molecular weight mucopolysaccharide. It slows down the resorption of bone tissue and reduces the loss of calcium, accelerates the processes of restoration of bone tissue, and inhibits the process of degeneration of cartilaginous tissue. It prevents the contraction of the connective tissue and plays the role of a kind of lubrication of the articular surfaces. When applied externally, it slows down the progression of osteoarthritis. Normalizes metabolism in hyaline tissue. Stimulates the regeneration of articular cartilage.

Pharmacokinetics

With a single oral administration of the average therapeutic dose, Cmax in plasma is achieved after 3-4 hours, in synovial fluid - after 4-5 hours. Bioavailability is 13%. Excreted by the kidneys within 24 hours.

Release form

The solution for intramuscular injection is clear, colorless or with a slightly yellowish tint, with the smell of benzyl alcohol.

Excipients: benzyl alcohol - 9 mg, water for injection - up to 1 ml.

1 ml - glass ampoules (5) - blister packs (1) - cardboard packs.
1 ml - glass ampoules (5) - blister packs (2) - cardboard packs.
2 ml - glass ampoules (5) - blister packs (1) - cardboard packs.
2 ml - glass ampoules (5) - blister packs (2) - cardboard packs.

Dosage

Inside adults - 1.5-1 g 2 times / day.

Outwardly - 2 times / day for 2-3 weeks.

Side effects

Rarely: allergic reactions.

Indications

Osteoporosis, periodontal disease, fractures (to accelerate the formation of callus), degenerative-dystrophic diseases of the joints and spine.

Contraindications

Hypersensitivity to chondroitin sulfate, tendency to bleeding, thrombophlebitis, pregnancy, lactation (breastfeeding).

Application features

Use during pregnancy and lactation

Chondroitin sulfate is contraindicated for use during pregnancy and lactation (breastfeeding).

Use in elderly patients

special instructions

With various forms of periodontopathy, the course of treatment should be continued for at least 3 months.

There are clinical data on the use of chondroitin sulfate in elderly patients with atherosclerosis, while there was a slight decrease in the concentration of cholesterol and triglycerides in the blood plasma.

In this medical article, you can read drug Chondroxide. The instructions for use will explain in which cases it is possible to take injections, ointment or tablets, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Chondroxide, from which you can find out whether the medicine helped in the treatment of arthrosis and osteochondrosis of the spine in adults and children, for which it is also prescribed. The instructions list analogues of Chondroxide, drug prices in pharmacies, as well as its use during pregnancy.

Chondroxide is a drug that has a stimulating effect on the process of cartilage tissue regeneration. Instructions for use prescribes taking 250 mg tablets, ointment, gel and Forte cream for external use, injections to restore cartilage tissue.

Release form and composition

Chondroxide is produced in the following dosage forms:

1. tablets: from white with a yellow tint to white with a creamy tint, inclusions are allowed, with a chamfer and a separating risk (10 pcs in blister packs, in a carton pack of 3, 5, 6, 9 or 10 packs);
2. solution for i / m administration: colorless or with a slight yellow tint, a transparent liquid with the smell of benzyl alcohol (1 ml or 2 ml in glass ampoules, 5 ampoules in blisters, in a carton box 1 or 2 packs);
3. gel for external use 5%: a translucent yellowish mass with a fruity odor (20 g, 25 g, 30 g, 35 g or 40 g each in aluminum tubes, 1 tube in a carton box);
4. ointment for external use 5%: light yellow mass with the smell of dimethyl sulfoxide (30 g or 50 g in aluminum tubes, 1 tube in a cardboard box);
5. cream Chondroxide Forte.

Chondroxide tablets contain 1 pc. chondroitin sulfate 250 mg; as well as calcium stearate, crospovidone, microcrystalline cellulose, magnesium hydroxycarbonate - in the form of excipients.

• 1 g of gel for external use contains chondroitin sulfate 50 mg; additional substances (dimethyl sulfoxide, propylene glycol, isopropanol, ethanol, sodium disulfite, nipazole, nipagin, carbomer, orange food flavor), water.
• 1 ml of solution contains: active substance: chondroitin sulfate sodium - 100 mg; auxiliary components: benzyl alcohol, water for injection.
• 1 g of ointment for external use contains chondroitin sulfate 50 mg; in the form of additional substances dimethyl sulfoxide, lanolin, petrolatum, monoglycerides, water.
• Chondroitin sulfate + Meloxicam + excipients (Chondroxide Forte).

pharmachologic effect

Chondroitin sulfate, the main active substance of Chondroxide, is a polysaccharide that takes part in the phosphorus-calcium metabolic process that occurs in cartilage tissue. Chondroitin sulfate is essential for the normal functioning of the joints and intra-articular cartilage.

Second active substance The drug is dimethyl sulfoxide, it mostly plays a supporting role. Dimethyl sulfoxide produces anti-inflammatory, analgesic and fibrinolytic effects. Against the background of the use of Chondroxide, there is a stimulating effect on the following processes:

• restoration of intra-articular fluid and the joint itself;
• regeneration of cartilage tissue;
• synthesis of glycosaminoglycans (this useful material are part of the synovial fluid, which fills the cavity of the joints and is the "protective shell" of the joint, as it protects it from excessive friction of the articular surfaces and from premature wear).

Also, when using Chondroxide, the following effects on the joints occur:

• the number of blood clots formed from fibrin protein filaments is reduced;
• the degenerative process in the joints and cartilage slows down;
• pain in the affected joints decreases, and articular mobility is activated;
• the production of enzymes that cause damage to cartilaginous tissues is blocked.

Indications for use

What helps Chondroxide? Tablets and injections are indicated for use in the treatment and prevention of degenerative-dystrophic lesions of the spine and joints (osteochondrosis, osteoarthrosis).

Indications for the use of ointment for joints - local treatment osteoarthritis and osteochondrosis.

Instructions for use

The drug should be taken orally at 500 mg (2 tablets) 2 times a day with a small amount of water. The recommended duration of the initial course of treatment is 6 months. The therapeutic effect of the drug persists for 3-5 months after its withdrawal, depending on the location and stage of the disease. If necessary, it is possible to conduct repeated courses of treatment, the duration of which is determined individually.

Ointment and gel

Ointment or gel Chondroxide are intended for external use. They are applied to areas of the body above the lesion and rubbed until completely absorbed, the gel is applied with light patting movements. The recommended frequency of procedures is 2-3 times a day. The duration of the course of treatment is 14-21 days, the use of the gel can be extended up to 60-90 days. The course of treatment is repeated as needed.

Cream Forte

Outwardly. Lightly rub a strip of cream with a length of 1 to 5 cm, the frequency of application is 2-3 times a day. The required amount of the drug depends on the size of the painful area. After applying the drug, hands should be washed thoroughly. The duration of treatment depends on the indications and the observed effect. After 2 weeks of using the drug, you should consult your doctor.

injections

Chondroxide solution is intended for intramuscular administration. Recommended dosage: initial dose - 100 mg 1 time in 2 days. With good tolerance after three injections, the initial dose is increased to 200 mg. The course of treatment is 25-35 injections. After 180 days, therapy can be repeated.

Contraindications

Tablet form:

• individual intolerance to the drug and its components;
• pregnancy and lactation;
• children.

Be careful with a tendency to bleed.

For gel and ointment:

• childhood;
• damage to the skin at the site of application;
• hypersensitivity to the composition.

Side effects

In general, Chondroxide tablets are well tolerated. Sometimes, against the background of their reception, it is possible to develop allergic reactions(rash on the skin, itching, urticaria), nausea, periodic vomiting, diarrhea. In these cases, the possibility of further application of this medicinal product determined by the doctor individually.

Children, during pregnancy and lactation

The use of the drug Chondroxide in the form of tablets or Forte cream is contraindicated during pregnancy and lactation. Chondroxide should be used with caution and after consulting a doctor. dosage form gel and ointment during pregnancy and lactation (breastfeeding).

Since the efficacy and safety of use in children has not been established, use in pediatrics only after consulting a doctor very carefully.

special instructions

Avoid contact with the drug open wounds and mucous membranes. If this happens, wash the area thoroughly with soap and warm water. In the case of various forms of periodontopathy, therapy lasts at least 3 months.

drug interaction

The drug is able, when taken simultaneously, to enhance the effect of antiplatelet agents, indirect anticoagulants, fibrinolytic drugs.

Chondroxide's analogs

According to the structure, analogues are determined:

1. Chondroitin.
2. Artrin.
3. Mukosat.
4. Sodium chondroitin sulfate.
5. Chondroitin sulfate.
6. Khonsurid.
7. Chondrolon.
8. Structum.
9. Artradol.
10. Chondroxide gel.
11. Kartilag Vitrum.

Holiday conditions and price

The average cost of Chondroxide (ointment 5% 30 g) in Moscow is 330 rubles. The price of tablets is 625 rubles for 60 pcs. Released: ointment and gel - without a prescription, tablets and solution - by prescription.

Store: ointment - at a temperature of 2-20 C in a place protected from light, gel - at a temperature of up to 25 C, tablets - at a temperature of up to 25 C in a place protected from moisture and light, solution - at a temperature of up to 20 C in a place protected from light place. Shelf life: ointment - 3 years, gel, tablets, solution - 2 years.

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