Lorista h instructions for use. How to properly use Lorista N for diabetes

The drug "Lorista" is an angiotensin receptor blocker. Localization of blockade - heart vessels, adrenal glands, kidneys. The process leads to a decrease in blood pressure. Let's take a closer look at what Lorista tablets are - instructions for use, indications, contraindications and patient reviews.

The active ingredient of Lorista tablets is potassium losartan. Excipients:

Film shell composition:

• talc;
• titanium dioxide;
• hypromellose;
• quinoline yellow dye;
• propylene glycol.

"Lorista" is available in the form of oval tablets. Color depends on dosage:

• 12.5 mg and 25 mg. Yellow color;
• 50 mg and 100 mg. White color.

The drug "Lorista N" also contains 12.5 mg of hydrochlorothiazide, and "Lorista ND" - 25 mg of hydrochlorothiazide.

pharmachologic effect

Losartan is an angiotensin II type AT1 receptor antagonist. It is non-protein in nature. With the help of losartan and its metabolite, the effects of angiotensin are blocked, regardless of its synthesis. Plasma renin activity increases, plasma aldosterone concentration decreases.

Due to the indirect effect of losartan, AT2 receptors are activated (due to an increase in angiotensin levels). At the same time, the activity of the ACE enzyme, which takes part in the metabolism of bradykinin, is not suppressed.

OPSS, afterload, pressure in the pulmonary circulation decrease, and a diuretic effect is observed. The risk of developing myocardial hypertrophy is reduced, and tolerance to physical stress increases in patients with CHF.

When losartan is taken once a day, both upper and lower blood pressure levels are significantly reduced. Blood pressure control occurs evenly throughout the day. The antihypertensive effect is in accordance with the natural circadian rhythm. At the end of the dosage, the levels decrease by 70-80 percent from the levels at the peak of the drug’s effect, 5-6 hours after use. There is no withdrawal syndrome and no significant effect on heart rate. The effectiveness of the drug is the same for males and females, older and younger people.

Pharmacokinetics

The drug is well absorbed from gastrointestinal tract. When taken with food, there is no significant effect on serum concentrations.

Bioavailability – approximately 33%. The maximum concentration of losartan in plasma occurs an hour after internal use, its metabolite - after 3-4 hours.

Almost 99% of losartan and its metabolite bind to blood proteins, mainly albumin. Distribution volume – 34 l. Passage through the blood-brain barrier is very weak.

Metabolism is significant during the initial passage through the liver. An active metabolite and several inactive ones are formed, including two main metabolites resulting from hydroxylation of the butyl group of the chain. N-2-tetrazole glucuronide is also formed. It is less significant.

Plasma clearance of losartan and metabolite is approximately 10 and 0.83 ml/sec, renal clearance is 1.23 and 0.43 ml/sec. The half-life of losartan is 2 hours, the metabolite is 6-9 hours. Approximately 58% of the drug is excreted through the bile, 35% through the kidneys.

Indications for use

Let's look at the cases in which Lorista tablets are prescribed.

They are helping:

• reducing the likelihood of associated cardiovascular disease and death in patients with left ventricular hypertrophy and hypertension, which is manifested by a decrease in the incidence of heart attack, stroke and cardiovascular mortality;
• kidney protection in patients diabetes mellitus the second type with proteinuria in order to reduce proteinuria, progression of organ damage, transition to the thermal stage and death;
• CHF in the absence of results from therapy with ACE inhibitors or with contraindications to their use.

Contraindications

Contraindications are:

• excessive sensitivity to the components of the drug;
• severe liver dysfunction and lack of experience in taking it;
• taking aliskiren or drugs containing it for diabetes mellitus or renal failure in severe or moderate form;
• hereditary lactose intolerance, glucose-galactose malabsorption syndrome and lactase deficiency;
• pregnancy and lactation;
• age category up to 18 years due to the lack of data on the safety and effectiveness of administration.

Should be used with caution in patients with pathologies such as:

• condition after kidney transplant (in the absence of experience);
• coronary heart disease;
• severe heart failure;
• cerebrovascular disease;
• angioedema;
• unilateral or bilateral stenosis renal arteries;
• hypertrophic obstructive cardiomyopathy;
• primary hyperaldosteronism;
• heart failure with life-threatening arrhythmias;
• hyperkalemia;

Important: In patients with reduced blood volume (for example, when treated with diuretics in large dosages), symptomatic arterial hypotension often develops.

Instructions for use

Let's take a closer look at Lorista tablets, how and at what pressure this drug is taken, and its instructions for use. The medicine is intended for internal use, once a day. Accepted at high blood pressure as prescribed by a doctor.

For hypertension, the average daily dosage is 50 mg. The maximum effect occurs after 3-6 weeks of treatment. Sometimes they resort to increasing the dosage in order to achieve a more significant effect (up to 100 mg per day in one or two doses).

For larger dosages, treatment should begin with 25 mg per day. There is no need to adjust the initial dosage in old age or with pathologies of the kidneys. In case of liver dysfunction, a lower dosage should be prescribed.

For CHF, the initial dosage is 12.5 mg per day. The increase should occur gradually at weekly intervals (12.5; 25; 50 mg per day). The drug "Lorista" is often prescribed together with diuretics and cardiac glycosides.

To reduce the risk of stroke with arterial hypertension and left ventricular hypertrophy, the required initial dosage is 50 mg. Then small doses of hydrochlorothiazide are added or the dosage of Lorista is doubled.

To ensure kidney protection in type 2 diabetes mellitus with proteinuria, the initial dosage is 50 mg. The increase can be doubled, taking into account the decrease in pressure.

Side effects

Central and peripheral nervous system:

The cardiovascular system:

• angina pectoris;
• dose-dependent orthostatic hypotension;
• heartbeat;
• vasculitis;
• arrhythmia;
• bradycardia;
• tachycardia.

Respiratory system:

• dyspnea;
• swelling of the nasal mucosa;
• nasal congestion;
• bronchitis;
• pharyngitis;
• infectious process in the upper sections respiratory tract;
• cough.

Digestive system:

• dyspeptic symptoms;
• flatulence;
• tooth pain;
• pathologies of the liver;
• vomit;
• nausea;
• anorexia;
• hyperbilirubinemia;
• constipation;
• dry mouth;
• hyperbilirubinemia;
• hepatitis;
• gastritis;
• increased activity of liver enzymes.

Urinary system:

• pathologies of kidney function;
• frequent urge to urinate;
• increase in creatinine and urea in the blood (moderate);
• infectious processes in the urinary tract.

Reproductive system:

• impotence;
• decreased libido.

Musculoskeletal system:

Sense organs:

• vision pathologies;
• tinnitus;
• conjunctivitis;
• pathologies of taste sensations.

Hematopoietic system:

• Henoch-Schönlein purpura;
• anemia.

Dermatological reactions:

• baldness;
• dry skin;
• excessive sweating;
• photosensitivity;
• erythema.

Metabolism:

• gout;
• hyperkalemia.

Allergies:

• skin rashes;
• angioedema;
• hives.

Lorista is usually well tolerated, side effects weak. Their appearance does not require discontinuation of the drug.

Overdose

Symptoms of overdose:

• tachycardia;
• bradycardia;
• pronounced decrease in pressure.

Interaction with other drugs

There is no clinically significant interaction with cimetidine, erythromycin, indirect anticoagulants, hydrochlorothiazide, phenobarbital, digoxin, ketoconazole. When used simultaneously with fluconazole and rifampicin, the level of losartan potassium metabolite decreased.

When taking potassium-sparing diuretics and potassium supplements, the likelihood of hyperkalemia increases. When using non-steroidal anti-inflammatory drugs, the effectiveness of diuretics and other drugs to lower blood pressure decreases.

When taking thiazide diuretics, the decrease in blood pressure will be additive. The effectiveness of other drugs for lowering blood pressure is growing.

Interaction with alcohol

Admission up to 18 years old

The use of the medicine is contraindicated under the age of 18 years. The reason is the lack of information about effectiveness and safety.

Use during pregnancy

Taking the drug "Lorista" during pregnancy is not recommended, since renal perfusion of the fetus begins to work in the third trimester, and depends on the development of the renin-angiotensin system. In this regard, there is a danger for the child when using the medicine in the second and third trimester.

Important: If pregnancy is diagnosed, treatment should be stopped. Lactation must also be stopped due to the lack of information about the excretion of losartan in milk.

special instructions

With a reduced volume of circulating blood, symptomatic arterial hypotension may occur. In this case, the pathology should be eliminated or treatment should be started with small dosages. With mild or moderate liver cirrhosis, losartan is concentrated in the blood more. A lower dosage of the drug is recommended.

When kidney function is impaired, hyperkalemia often develops. It is important to periodically monitor the concentration of potassium in the blood, especially in old age. With renal artery stenosis, creatinine and urea in the blood sometimes increase. It is necessary to monitor these indicators.

Among them are antagonists of angiotensin enzyme receptors.

Type of drug

The drug "Lorista" is available in several varieties: in the form of a single-component drug "Lorista", combined forms "Lorista N" and "Lorista ND", which differ in dosage active ingredients. Two-component forms of the drug have an antihypertensive effect and have a diuretic effect.

Compound

Lorista tablets, a one-component drug, are available in three dosages containing the active ingredient losartan potassium, 12.5 mg, 25 mg, 50 mg. Corn and pregelatinized starch, a mixture of milk sugar and cellulose, aerosil, and magnesium stearate are used as auxiliary components. The film coating of dosages of 25 mg or 50 mg of losartan potassium consists of hypromellose, talc, propylene glycol, titanium dioxide, and for a dose of 12.5 mg a yellow quinoline dye is also used.

Tablets of the drugs “Lorista N” and “Lorista ND” consist of a core and a shell. The core includes two active components: losartan potassium 50 mg (for the N form) and 100 mg (for the ND form) and hydrochlorothiazide 12.5 mg (for the “N” form) and 25 mg (for the “ND” form). To form the core, additional components are used in the form of pregelatinized starch, microcrystalline cellulose, milk sugar, and magnesium stearate.

Lorista N and Lorista ND tablets are film-coated consisting of hypromellose, macrogol 4000, quinoline yellow dye, titanium dioxide and talc.

How the drug works

The combined antihypertensive drug (Lorista drug) is described in the instructions according to pharmacological action each active component.

One of the active ingredients is losartan, which acts as a selective antagonist of the enzyme angiotensin type 2 on non-protein receptors.

Test tube and animal studies have established that the action of losartan and its carboxyl metabolite is aimed at blocking the effects of angiotensin on angiotensin type 1 receptors. This activates renin in the blood plasma and causes a decrease in the concentration of aldosterone in the blood serum.

By causing an increase in the content of type 2 angiotensin, losartan activates the receptors of this enzyme, while at the same time does not change the functioning of the type 2 kininase enzyme involved in the metabolism of bradykinin.

The action of the active component of the drug "Lorista" is aimed at reducing the total peripheral resistance of the vascular bed, pressure in the vessels of the pulmonary circulation, afterload, and providing a diuretic effect.

Losartan prevents the development of pathological enlargement of the heart muscle and increases the resistance to physical work of the human body who has chronic heart failure.

Daily use of one dose of losartan causes a sustained decrease in upper (systolic) and lower (diastolic) blood pressure. Throughout the day, under the influence of this substance, blood pressure is uniformly controlled, and the antihypertensive effect coincides with the natural circadian rhythm. The decrease in pressure at the end of the losartan dosage occurs by 80% compared to the peak activity of the active component. When treated with the drug, there is no effect on the heart rate, and when you stop taking it, signs of drug withdrawal do not develop. The effectiveness of losartan extends to male and female female body of all ages.

As part of combined drugs, the effect of hydrochlorothiazide as a thiazide diuretic is associated with impaired absorption of chlorine, sodium, magnesium, potassium and water ions found in primary urine back into the blood plasma distal section kidney nephron. The substance enhances the retention of calcium ion and uric acid. Hydrochlorothiazide exhibits antihypertensive properties due to the dilation of arterioles. The diuretic effect begins after 60-120 minutes, and the maximum diuretic effect lasts from 6 to 12 hours. The optimal antihypertensive effect from treatment with the drug occurs after 1 month.

What is it used for?

The drug "Lorista", tablets, instructions for use recommends using:

• for the treatment of arterial hypertension, in which combination treatment is indicated;
• to reduce the likelihood of heart disease vascular system and the number of deaths from and pathological changes in the left ventricle.

Mode of application

This medicine is for oral use. Eating food does not affect the effect of the medication. Lorista blood pressure tablets can be combined with antihypertensive drugs. Eating food does not affect the effect of the medication.

For the drug "Lorista" (tablets), the instructions for use include dosage recommendations for the single-component form, "N" and "ND" combinations. For all types of medication, the initial and maintenance dose for high blood pressure is 1 tablet once a day. The maximum effect on reducing blood pressure is observed 3 weeks after the start of treatment. To achieve a significant effect, it is allowed to increase the daily dose of Lorista N to 2 tablets at a time. The maximum permissible number of 50/12.5 mg tablets per day is 2 pieces.

If there is no adequate therapeutic effect from taking the drug “Lorista N”, then the drug “Lorista ND”, tablets, is prescribed. The instructions for this product include information about the maximum amount of a higher dosage (100/25 mg) per day, which is no more than 1 tablet.

When the volume of blood circulating through the vessels decreases during treatment with high doses of diuretics, the initial daily dose of losartan is 25 mg at a time. Therefore, therapy with such an antihypertensive drug is possible only after eliminating diuretics and normalizing blood volume.

For the drug "Lorista" (tablets), the instructions do not contain information about the need to adjust the dose for elderly patients and for people undergoing hemodialysis, or for those with renal failure with a creatinine clearance of 30 to 50 ml per minute.

To reduce the likelihood of cardiovascular diseases and the number of deaths due to arterial hypertension and pathological changes in the left ventricle, the standard initial dose of losartan per day is prescribed 50 mg at a time. If results in lowering blood pressure have not been achieved at the initial dosage, an increase to 100 mg of losartan is necessary, which is possible when using 2 tablets of Lorista N or 1 tablet of Lorista ND per day at a time.

Side effects

Some patients may experience undesirable effects from treatment with this antihypertensive drug. When using the drug "Lorista" (tablets), the instructions for use include a list side effects related to various systems body.

The effect on the central nervous system is manifested by headache, systemic and unsystematic dizziness, insomnia, fatigue, migraine.

When affecting the cardiovascular system, the drug causes orthostatic dose-dependent hypotension, palpitations, tachycardia, and vascular inflammation.

The effect on the respiratory system is manifested by cough, infection in the upper respiratory tract, pharyngitis, swelling of the nasopharyngeal mucosa.

The digestive system malfunctions in the form of diarrhea, dyspepsia, nausea, vomiting, pain in abdominal cavity, hepatitis, liver dysfunction, when the activity of liver enzymes and bilirubin is changed.

The effect on the musculoskeletal system is manifested by myalgia, back pain, and arthralgia.

The effect on the hematopoietic organs is manifested by anemia and purpura.

Laboratory parameters also change, characterized by hyperkalemia, increased levels of hemoglobin, creatinine, hematocrit, and urea in the blood plasma.

The action may be accompanied by allergic reactions, manifested by urticaria, skin itching, angioedema of the neck, upper torso and peripheral organs.

Contraindications

Not everyone can be treated with Lorista. The instructions for use do not recommend using this remedy for anuria, severe renal impairment, when the dose is less than 30 ml per minute.

Contraindicated in case of hyperkalemia, refractory hypokalemia, impaired water balance in the body during therapy with high doses of diuretics, severe liver dysfunction, high blood pressure, lactase enzyme deficiency, glucose and galactose intolerance, pregnancy, breastfeeding, children and adolescents under 18 years of age .

The instructions prohibit treatment with Lorista (tablets) in case of hypersensitivity to sulfonamide compounds, losartan, hydrochlorothiazide or auxiliary components of the medication.

Caution is required when used in patients with impaired water-electrolyte balance in the blood when there are signs of hypochloremic alkalosis, low levels of sodium, potassium, magnesium ions and high concentrations of calcium ions in the human body.

Bilateral narrowing of the arteries of the kidneys or narrowing of the lumen of the artery to the only kidney, diabetes mellitus, increased levels of uric acid in the blood plasma, deposition of urate in the joints, presence in the past allergic reactions for drugs that inhibit angiotensin-converting enzymes, bronchial asthma, systemic diseases blood levels warrant caution in the use of antihypertensive medications.

Features of application

During treatment with Lorista (tablets), the instructions for use allow you to additionally take other antihypertensive drugs. For older people, no special selection of the initial dosage is required.

The actions of the drug may lead to an increase in the concentration of creatinine and urea in the blood serum of patients who have bilateral renal artery stenosis or stenosis of the artery of one kidney.

Under the influence of hydrochlorothiazide, arterial hypotension increases, electrolyte balance is disturbed, which is characterized by a decrease in circulating blood volume, hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia. The effect of a diuretic is aimed at increasing the concentration of cholesterol and triglycerides, changing the body’s tolerance to glucose molecules, reducing the excretion of calcium ions in the urine, which leads to their increase in the blood serum. Hydrochlorothiazide can cause hyperuricemia and gout.

Included combination drug contains milk sugar, which is contraindicated in patients suffering from a deficiency of the lactase enzyme, galactosemia or glucose-galactose intolerance syndrome.

At the initial stages of treatment with an antihypertensive drug, a decrease in blood pressure and attacks of dizziness are possible, which disrupts the psychophysical activity of the body. Therefore, patients whose work involves increased attention when driving or complex mechanisms, must determine their condition before beginning their duties.

Analogs

JSC "KRKA, d.d., Novo Mesto" is a manufacturer of the antihypertensive drug "Lorista" (tablets). Analogs this tool contain the active ingredient losartan potassium. For combined forms, similar medications contain two active ingredients: losartan potassium and hydrochlorothiazide.

For the drug "Lorista", the analogue will have the same antihypertensive effect and similar side effects. One of these remedies is the drug “Cozaar”, tablets of 50 or 100 mg of potassium losertan. The manufacturer is Merck Sharp and Dome B.V., the Netherlands.

For combined forms, the analogue is “Gizaar” and “Gizaar forte”. The manufacturer is Merck Sharp and Dome B.V., the Netherlands. Tablets of the medication of a lower dosage are covered with a yellow film coating, oval in shape, with the symbol “717” on one of the surfaces and a score line on the other side, and oval tablets of a higher dosage are coated with a white film coating with the designation “745” on one of the sides.

The composition of the drug "Gizaar Forte" includes losartan potassium in the amount of 100 mg and hydrochlorothiazide, which contains 12.5 mg. The composition of the drug "Gizaar" includes losartan potassium in the amount of 50 mg and hydrochlorothiazide, which contains 12.5 mg.

Unlike the drug "Lorista ND", the drug "Gizaar Forte" contains half as much hydrochlorothiazide, and the content of potassium losertan is the same. Both drugs have antihypertensive effects with a slight diuretic effect.

Another combined analogue is the drug “Lozap plus” produced by “Zentiva a.s.”, Czech Republic. Available in the form of oblong tablets with a score on both surfaces, coated with a light yellow film. The medication contains losartan potassium in an amount of 50 mg and hydrochlorothiazide, which contains 12.5 mg.

A similar drug for Lorista N is medicine Vasotens N, produced by Actavis Group JSC, Iceland. Available in two dosages. The lower dose tablets contain 50 mg losartan potassium and 12.5 mg hydrochlorothiazide, and the higher dose tablets contain 100 mg losartan potassium and 25 mg hydrochlorothiazide.

Take orally, regardless of food intake, frequency of administration is 1 time per day. Arterial hypertension: the average daily dose is 50 mg. The maximum antihypertensive effect is achieved within 3-6 weeks of therapy. In some patients, a more pronounced effect can be achieved by increasing the dose of the drug to 100 mg per day in two doses or in one dose. When taking large doses of diuretics, it is recommended to start therapy with 25 mg per day in one dose. In elderly patients, as well as in patients with impaired renal function, including patients on hemodialysis, no adjustment of the initial dose is required. No dose adjustment is required for elderly patients or patients with impaired renal function, including patients on hemodialysis. Patients with impaired liver function should be prescribed lower doses of the drug. Chronic heart failure: the initial dose is 12.5 mg per day in one dose. In order to achieve the usual maintenance dose of 50 mg per day, the dose of the drug must be increased gradually, at intervals of one week (for example, 12.5 mg, 25 mg, 50 mg once daily). The drug is usually prescribed in combination with diuretics and cardiac glycosides. The dose of the drug should be increased according to the following scheme: 1 week: from days 1 to 7 - 1 tablet of 12.5 mg once a day. Week 2: from 8 to 14 days - 1 tablet 25 mg once a day. Week 3: from 15 to 21 days - 1 tablet 50 mg once a day. Week 4: from 22 to 28 days - 1 tablet 50 mg once a day. Reducing the risk of stroke in patients with arterial hypertension and left ventricular hypertrophy: the standard initial dose of the drug is 50 mg per day in one dose. Subsequently, hydrochlorothiazide may be added to low doses and/or the dose of the drug is increased to 100 mg per day. Kidney protection in patients with type 2 diabetes mellitus with proteinuria: the standard initial dose of the drug is 50 mg per day in one dose. The dose of the drug can be increased to 100 mg per day, taking into account the reduction in blood pressure. Application in pediatrics. The safety and effectiveness of the drug in children have not been established.

Lorista N is a combination antihypertensive drug used for heart failure and high blood pressure. The active ingredients are losartan potassium and hydrochlorothiazide.

Losartan is a selective antagonist of angiotensin II type AT1 receptors of non-protein nature. Indirectly causes activation of AT2 receptors by increasing the level of angiotensin II. Losartan does not inhibit the activity of kininase II, an enzyme that is involved in the metabolism of bradykinin.

As a result of taking losartan once a day, systolic and diastolic blood pressure (blood pressure) is statistically significantly reduced. Throughout the day, losartan normalizes blood pressure, while the antihypertensive effect is consistent with the natural circadian rhythm. At the end of the action of a single dose of the drug, the decrease in blood pressure was ~70–80% of its maximum effect, which occurs 5–6 hours after administration.

Hydrochlorothiazide is a thiazide diuretic with antihypertensive properties. The hypotensive effect develops due to the expansion of arterioles, and at the same time has virtually no effect on normal blood pressure. The diuretic effect occurs after 1-2 hours, reaches a maximum after 4 hours and lasts 6-12 hours.

Effects of Lorista N - reduces pressure in the pulmonary circulation and general peripheral vascular resistance, reduces afterload, and has a diuretic effect. Prevents the development of myocardial hypertrophy, increases tolerance to physical activity in patients with chronic heart failure.

The antihypertensive effect of treatment with the drug can be noticed after a few days. However, it should be noted that it may take about a month to achieve the desired therapeutic result.

Lorista N 12.5 mg +50 mg is produced in the form of film-coated tablets. Active ingredients: losartan (in the form of losartan potassium) – 50 mg, hydrochlorothiazide – 12.5 mg.

Lorista ND tablets contain the same combination of active ingredients, only twice as much - 100 mg of losartan and 25 mg of hydrochlorothiazide.

Indications for use

What does Lorista N help with? The drug is prescribed in the following cases:

• Arterial hypertension (combination therapy).
• Reducing the risk of cardiovascular morbidity and mortality in patients with arterial hypertension and left ventricular hypertrophy.

Instructions for use of Lorista N, dosage

The drug is taken orally, regardless of food intake. Loristu N 12.5 mg+50 mg. can be combined with other drugs to reduce blood pressure.

Arterial hypertension

Initial and maintenance dosage - 1 tablet \ 1 time per day. In elderly patients and patients with moderate renal impairment, including those on dialysis, no adjustment of the initial dose is required.

To achieve a more pronounced effect, it is possible to increase the dose of the drug to 2 tablets of Lorista N (50/12.5 mg) once a day.

The maximum daily dose is 2 tablets of the drug.

Arterial hypertension and left ventricular hypertrophy

In order to reduce the risk of cardiovascular pathologies and mortality, losartan is prescribed at an initial dose of 50 mg once a day. If the target blood pressure value cannot be achieved while taking losartan at a daily dose of 50 mg, it is necessary to select the dose by combining it with small doses of hydrochlorothiazide (12.5 mg per day).

If necessary, the daily dose of losartan should be increased to 100 mg in combination with hydrochlorothiazide at a dose of 12.5 mg, and then the daily dose of Lorista N should be increased to 2 tablets.

According to reviews from cardiologists, it is advisable to take Lorista N if there is a risk of cardiovascular diseases if monotherapy with losartan does not help achieve the target blood pressure level.

Side effects

According to the instructions for use, the appointment of Lorist N may be accompanied by the following side effects:

• dose-dependent hypotension, tachycardia, bradycardia, palpitations, arrhythmia, angina pectoris, vasculitis;
• headache, fatigue, insomnia, dizziness, memory loss, asthenia, migraine, tremor, depression;
• cough, bronchitis, pharyngitis, shortness of breath, swelling and nasal congestion;
• urinary tract infections, kidney dysfunction, increased levels of creatinine and urea in the blood serum, uncontrollable urge to urinate;
• abdominal pain, nausea, diarrhea, dry mouth, gastritis, anorexia, flatulence, vomiting, constipation, toothache, hepatitis and impaired liver function;
• impotence and decreased libido;
• back pain and chest, cramps, leg and muscle pain, arthralgia and arthritis; blurred vision, conjunctivitis, ringing in the ears, impaired taste;
• erythema (redness of the skin caused by dilation of capillaries), dry skin, increased sweating, excessive hair loss, photosensitivity (high sensitivity to ultraviolet radiation);
• skin rash, angioedema, urticaria, itching; anemia, gout, hyperkalemia.

Contraindications

It is contraindicated to prescribe Lorista N in the following cases:

• severe renal failure with creatinine clearance (CC)< 30 мл/мин;
• anuria;
• dehydration (including during therapy with diuretics in high doses);
• hyperkalemia;
• severe liver failure;
• arterial hypotension;
• refractory hypokalemia;
• lactase deficiency, glucose-galactose malabsorption syndrome, galactosemia;
• period of pregnancy and lactation (breastfeeding);
• children and adolescents under 18 years of age;
• hypersensitivity to sulfonamide derivatives, losartan and/or any other ingredients of the drug.

Overdose

Cases of drug overdose have not been registered. Symptoms of overdose include a decrease in blood pressure, a reflex increase in heart rate and bradycardia.

Therapy – forced diuresis, elimination of symptoms.

Analogues of Lorista N, price in pharmacies

If necessary, you can replace Lorista N with an analogue of the active substance - these are the following drugs:

1. Hydrochlorothiazide + Losartan TAD,
2. Losarel Plus,
3. Losartan-N,
4. Losartan/Hydrochlorothiazide-Teva,
5. Simartan-N,
6. Presartan N.

When choosing analogues, it is important to understand that the instructions for use of Lorist N, the price and reviews do not apply to drugs with similar effects. It is important to consult a doctor and not change the drug yourself.

Price in Russian pharmacies: Lorista N tablets 50 mg + 12.5 mgyu, 30 pcs - from 240 to 275 rubles, 60 pcs. – from 430 to 507 rubles.

Store at temperatures up to 30 °C. Keep away from children. Shelf life – 3 years. Prescription available in pharmacies.

Lorista is medicinal product, a pill that effectively fights high blood pressure blood pressure, eliminates heart failure.

The positive effect of the product is due to its main component – ​​Losartan. This substance inhibits angiotensin II receptors in the blood vessels, heart, kidneys and adrenal cortex, which reduces vasoconstriction.

In this article we will look at why doctors prescribe Lorist, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS People who have already used Lorista can be read in the comments.

Composition and release form

Available in yellow hard-shell tablets. The dosage of the drug depends on the mass of the active substance - Losartan. In pharmacies the drug is presented in the following dosages: 12.5/ 25/ 50/ 100 mg.

• The active ingredient of the drug is losartan potassium. 1 tablet contains 12.5 mg, 25 mg, 50 mg or 100 mg.

Clinical and pharmacological group: angiotensin II receptor antagonist.

What does Lorista help with?

Lorista should be used for the following diseases:

1. Nephrology in people with type 2 diabetes;
2. Arterial hypertension;
3. Chronic heart failure (the drug is used as part of a combination treatment);
4. Left ventricular hypertrophy, as well as arterial hypertension to reduce the risk of stroke;
5. To reduce proteinuria (the presence of protein in urine).

According to the instructions, Lorista N can be prescribed for combined treatment of a patient with antihypertensive drugs and diuretics.

pharmachologic effect

The drug has a reverse effect on angiotensin receptors, which leads to a decrease in blood pressure and a pronounced diuretic effect.

The maximum concentration is reached 1 hour after ingestion, then Lorista binds to plasma proteins and is distributed throughout the body in accordance with the blood flow. Penetration through the protective barrier of the brain is insignificant.

Neutralization of Lorist occurs in the liver with the formation of active and inactive breakdown products. The drug is excreted in urine and bile.

Instructions for use

According to the instructions for use, Lorist is taken orally, regardless of food intake, the frequency of administration is 1 time/day.

1. To protect the kidneys in patients with type 2 diabetes mellitus with proteinuria, the standard starting dose of Lorista is 50 mg/day. The dose of the drug can be increased to 100 mg/day, taking into account the reduction in blood pressure.
2. Treatment of chronic heart failure begins with daily dose 12.5 mg in 1 dose. Then, at 1-week intervals, the dose is gradually increased: first to 25 mg, then to the usual maintenance dose of 50 mg. For this disease, Lorista is usually prescribed in combination with cardiac glycosides and diuretics.
3. Arterial hypertension (AH). The initial dose is 50 mg, in most cases this dose is sufficient as a maintenance dose. The maximum permissible dose for daily use is 100 mg of Lorista. The maximum antihypertensive effect is achieved by 3-6 weeks. treatment. In patients with hypovolemia (for example, when taking diuretics in large doses) or liver dysfunction, the initial dose should be reduced to 25 mg. For elderly patients, patients with reduced renal function and/or those on hemodialysis, no dose adjustment is required.
4. To reduce the risk of stroke in patients with arterial hypertension and left ventricular hypertrophy, the standard initial dose is 50 mg/day. In the future, hydrochlorothiazide may be added in low doses and/or the dose of Lorista may be increased to 100 mg/day.

Detailed instructions for Lorista are included in each package and must be read before using the drug.

Contraindications

The drug should not be used in the following cases:

1. Dehydration;
2. Hyperkalemia;
3. Arterial hypotension;
4. Breastfeeding period;
5. Pregnancy;
6. Lactose intolerance, galactosemia or glucose/galactose malabsorption syndrome;
7. Age under 18 years (safety and effectiveness have not been established);
8. Hypersensitivity to any of the components of the drug.

Lorista should be taken with extreme caution in the following conditions:

1. Violations of water and electrolyte balance;
2. Renal and/or liver failure;
3. Bilateral renal artery stenosis or stenosis of the artery of a single kidney (since the content of urea and creatinine in the blood serum may increase);
4. Reduced circulating blood volume (due to the possible development of symptomatic arterial hypotension).

Side effects

Side effects of Lorista tablets reviews and clinical studies include:

1. General disorders: asthenia, edema, weakness, rash.
2. From the outside respiratory system: sinusitis, runny nose, cough, upper respiratory tract infection, pharyngitis.
3. From the heart: angina pectoris, palpitation, tachycardia.
4. From the digestive tract: dyspepsia, abdominal pain, persistent constipation.
5. From the outside nervous system: vertigo, drowsiness, insomnia, headache, muscle cramps.
6. From the vascular system: symptomatic arterial hypotension, orthostatic dose-dependent effect.
7. Laboratory indicators: increased ALT levels, hyperkalemia.

In most cases, tolerability is good, side effects are minor and pass quickly. No discontinuation of the drug is required.

Analogs

Structural analogues of the active substance:

• Blocktran;
• Brozaar;
• Vasotens;
• Vero Losartan;
• Zisakar;
• Cardomin Sanovel;
• Carzartan;
• Kozaar;
• Lakea;
• Lozap;
• Losarel;
• Losartan;
• Losartan potassium;
• Losakor;
• Lotor;
• Presartan;
• Renicard.

Attention: the use of analogues must be agreed with the attending physician.