Furazolidone for what instructions for use. Good pills for worms and parasites in adults: how much do they cost? Below are approximate prices for the drug

Antibacterial drug, nitrofuran derivative

Active substance

Furazolidone

Release form, composition and packaging

◊ Pills yellow or greenish-yellow, flat-cylindrical, chamfered.

Excipients: potato starch - 20 mg, calcium stearate (calcium stearate) - 1 mg, sugar (sucrose) - 10 mg, Tween-80 (polysorbate) - 0.2 mg, lactose (milk sugar) - 18.8 mg.

10 pieces. - cellless contour packages.
10 pieces. - contour cellular packaging (2) - cardboard packs.
10 pieces. - contour cellular packaging (3) - cardboard packs.
10 pieces. - contour cellular packaging (4) - cardboard packs.
10 pieces. - contour cellular packaging (5) - cardboard packs.
50 pcs. - polymer jars (1) - cardboard packs.

pharmachologic effect

A product derived from nitrofurans. Active against gram-positive and gram-negative microbes, Trichomonas spp., Giardia lamblia. The most sensitive to furazolidone are Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Salmonella typhi, Salmonella paratyphi.

Has little effect on pathogens of purulent and anaerobic infections. Microbial resistance develops slowly. Blocks monoamine oxidase. Nitrofurans disrupt the processes of cellular respiration of microorganisms, suppress the tricarboxylic acid cycle (Krebs cycle), and also inhibit the biosynthesis of nucleic acids of microorganisms, resulting in the destruction of their membrane or cytoplasmic membrane. As a result of the action of nitrofurans, microorganisms produce fewer toxins, and therefore improvement general condition patient is possible even before pronounced suppression of microflora growth. Unlike many other antimicrobial medicines they not only do not depress, but even activate immune system body (increase complement titer and the ability of leukocytes to phagocytose microorganisms).

Pharmacokinetics

Well absorbed when administered orally. Against the background of inflammation of the meninges, concentrations are created in the cerebrospinal fluid equal to those in. It is quickly and intensively metabolized mainly in the liver with the formation of a pharmacologically inactive metabolite (amino derivative). It is excreted mainly by the kidneys (65%), small amounts are found in feces, where therapeutic concentrations are achieved against pathogens of intestinal infections.

Indications

- dysentery;

- paratyphoid fever;

- giardiasis;

— food toxic infections.

Contraindications

- pregnancy, lactation;

- increased individual sensitivity to the group of nitrofurans;

— end-stage chronic renal failure;

- deficiency of glucose-6-phosphate dehydrogenase;

— childhood up to 3 years (for this dosage form).

Carefully

Chronic renal failure, glucose-6-phosphate dehydrogenase deficiency, liver disease and nervous system.

Dosage

Inside, after eating.

At dysentery, paratyphoid fever and food toxic infections- 100-150 mg 4 times a day (but not more than 800 mg), for 5-10 days.

For giardiasis: adults- 100 mg 4 times/day, children- 10 mg/kg/day, distributed daily dose for 3-4 doses.

The highest single dose for adults is 200 mg; daily - 800 mg.

Side effects

Decreased appetite, up to anorexia; nausea, vomiting; allergic reactions(skin rash, hyperemia and itching of the skin, angioedema).

With long-term use - neuritis.

Overdose

Symptoms: acute toxic hepatitis, hematotoxicity, neurotoxicity (polyneuritis).

Treatment: drug withdrawal, taking large amounts of fluid, symptomatic therapy, antihistamine drugs, group B.

Drug interactions

Furazolidone in combination with ethanol can lead to the development of disulfiram-like reactions, and therefore their simultaneous use is not recommended. Antidepressants, monoamine oxidase inhibitors, amphetamine, phenylephrine, tyramine can cause a sharp increase in blood pressure.

special instructions

Increases sensitivity to the action of ethanol.

Medicines that alkalize urine reduce the effect, while those that acidify urine increase it.

Aminoglycosides enhance antimicrobial properties.

Who doesn’t remember small yellow tablets, packaged the old fashioned way in simple paper currency? They may be unfamiliar to the younger generation, but to our mothers and grandmothers this is a colossal medicinal properties I know him very well. What is the drug Furazolidone for?

We are talking about Furazolidone, a drug with a wide spectrum of action for any inflammatory disease within the body. What does furazolidone not cure? The annotation for the drug states that Furazolidone has an antimicrobial effect.

It was prescribed for giardiasis and pyelonephritis, acute intestinal poisoning and suppuration of superficial wounds, as well as for cystitis, colpitis, pyelitis, vaginitis various etiologies, including paratyphoid fever, the development of various coccal infections and dysentery in the body.

Appointments

Being a powerful antimicrobial and antibacterial drug, Furazolidone is capable of exhibiting the properties of an immunomodulator, since its action is directed against fungal and monadic forms, as well as gram-negative aerobic microorganisms. Gram-positive bacteria react to the drug to a much lesser extent, and purulent and anaerobic infections are not at all susceptible to the action of the drug.

The therapeutic effect of Furazolidone directly depends on the dosage of the drug. Large doses achieve a bactericidal effect, and small doses achieve a bacteriostatic effect. Therefore, only the attending physician can prescribe treatment with Furazolidone and the optimal dose to the patient. The drug is excreted from the body by the kidneys.

Diseases gastrointestinal tract for which Furazolidone is prescribed, for what and for what diseases it is prescribed:

• , or bacillary dysentery;
• enteritis, or inflammation of the small intestinal mucosa;
• giardiasis;
• paratyphoid;

For diseases of the ureters and reproductive system:

• for infectious and inflammatory diseases Bladder– cystitis;
• with inflammation of the mucous membranes of the renal pelvis - pyelitis;
• with inflammation of the urethra - urethritis;
• for diseases caused by inflammation against the background of Trichomonas infection - Trichomonas colpitis;
• with an inflammatory process of the vaginal mucosa - vaginitis.

Not so widely, but in cases of urgent need, Furazolidone can be used as an external agent. The crushed preparation is used to cover burn wounds with clear signs infectious infection. Furazolidone is an indispensable assistant for all kinds of problems, acting quickly and effectively.

Dosage and administration of the drug

Furazolidone tablets are taken orally after meals with plenty of water. The dosage and duration of taking the drug is determined by the attending physician, individually for each patient, depending on his weight and age. The drug is not addictive, but the duration of use is no more than 10 days.

For paratyphoid fever or in the treatment of food or toxic poisoning, the dose of the drug for an adult patient does not exceed 0.15 g. per day. The drug is taken 3 or 4 times, at equal intervals. The daily dose for children in the treatment of giardiasis is calculated based on 10 mg for each full kilogram of the child’s weight.

To take Furazolidone, use the following regimen:

• The course of taking the drug lasts from 3 to 6 days, followed by a three-day break, and treatment continues according to the established scheme. Depending on the severity of the disease, there may be two, or maximum three, such courses.
• When treating giardiasis in adults, Furazolidone is taken 4 times a day with a daily dose of 0.1 g of the drug. The duration of the course is 3 days.
  For gynecological infections, a complex consisting of oral administration of the drug in an amount of 0.1 g is prescribed. per day and vaginal or rectal suppositories containing Furazolidone in their composition.
• The maximum single dose of Furazolidone for various severe diseases should not exceed 0.2 g, and per day - no more than 0.8 g.

Side effects

Side effects when taking Furazolidone appear extremely individually and only in rare cases. The body's reaction to taking the drug may include a rash, itching or hives on the skin. The stomach can also respond in rare cases with a peculiar reaction, as accompanied by a gag reflex or a severe decrease in appetite, even to the point of aversion to food.

As a rule, B vitamins are prescribed in combination with Furazolidone: B1, B6 and B12 in injections or tablets.

The main point when taking Furazolidone is the need to take the tablets with plenty of liquid. The product dries out the oral mucosa quite strongly, which can also be attributed to side effects on the body.

Contraindications

Intolerance to the drug is possible only on an individual basis. Contraindications include severe chronic renal failure in the terminal stage. And, of course, the recommendations indicate that the drug should be taken with extreme caution during pregnancy and breastfeeding.

Only in extreme cases, when there is a direct threat to the health of the expectant mother, Furazolidone can be prescribed by a doctor in one of the trimesters of pregnancy. But doctors are extremely reluctant to take such measures, because modern medicine has remedies that are not similar, but also effective enough to prevent the inflammatory process inside the body caused by microbial flora.

Furazolidone is also not prescribed to children under one year of age.

The drug is prescribed with great caution to persons with acute mental and nervous disorders, as well as diseases of the nervous system. In some cases, Furazolidone is capable of disrupting concentration, which can lead to unexpected or inappropriate actions on the part of people with a weakened psyche. For the same reason, the drug is not prescribed to those patients who manage vehicles or work with mechanical devices that are dangerous to others.

In conclusion, it should be noted that when taking the drug, you must strictly adhere to the prescriptions of your doctor. Violation of recommendations, exceeding doses of the drug and the length of the treatment process can lead to such undesirable consequences, as liver damage of a toxic nature, leading to polyneuritis or If an overdose of the drug is suspected, urgent measures should be taken to lavage the stomach and intestines. To do this, enterosorbents and saline laxatives are taken in large quantities, a cleansing enema is given, and vomiting is artificially induced.

Furazolidone is a modern, high efficiency antibacterial agent. It belongs to the nitrofuran family and, accordingly, is not an antibiotic, and this opens up additional opportunities for the use of the drug during pregnancy. Furazolidone, the instructions for use of which should be carefully studied, is also rightly considered a relatively safe medicine.

Today, this drug is actively used to treat infections that were caused by the activity of pathogenic microorganisms, in particular bacteria. The drug is not antiviral; therefore, it is not included in therapy viral diseases. Furazolidone has proven its effectiveness against such common and dangerous ailments as:

• various food infections;
• dysentery;
• cystitis;
• lambiasis;
• paraphyte;
• diseases caused by Escherichia coli, streptococci and staphylococci.

Furazolidone is effective against various foodborne infections

The instructions for Furazolidone state that this drug is recommended for the treatment of acute inflammatory processes caused by the activity of anaerobic gram-negative bacteria.

The drug is a derivative of nitrofurforol. Accordingly, his pharmacological properties largely depend on the dose taken. A small dosage is an excellent way to stop the growth of bacteria, stabilizing the patient’s condition, making it possible to resort to other methods of treatment. Increasing the dose taken allows you to provoke a pronounced bactericidal effect. That is, the drug will begin to kill pathogenic microorganisms, which gradually leads to the patient’s complete recovery.

What is Furazolidone used for? It has good antimicrobial effects based on the ability of nitro groups to be reduced to amino groups, which occurs under the influence of certain enzymes of the human body. Amino groups are very poisonous to various types of bacteria. The more poison, the faster the pathogen dies.

Furazolidone has good antimicrobial effects

An important advantage of this drug is considered to be its stimulating effect, which is very important for increasing the effectiveness of therapy. It is also necessary to note the phagocytic effect on leukocytes. As is known, this significantly increases the body’s sensitivity to ethyl alcohol. Accordingly, taking pills simultaneously with alcohol can lead to poisoning, nausea and vomiting. If you took Furazolidone for poisoning, you will have to start all over again.

The drug is available in tablet form. One box contains two contour packs of 10 tablets each. One tablet consists of 0.05 g of active substance and excipients, including lactose.

At the moment, Furazolidone is on the market, so purchasing it will not be difficult. Each package contains detailed instructions that clearly describe how to take Furazolidone, what it is for, what is the dosage, what possible side effects and existing contraindications. It is strictly not recommended to ignore the instructions. The more thoroughly you familiarize yourself with it, the better for your health.

• indications for the use of Furazolidone – therapy of bacteriological lesions and inflammatory processes provoked by them;
• Directions for use: The tablet should be swallowed whole with plenty of water, at least one glass;
• You need to drink after eating.

The type of disease, its development, severity, and characteristics of the patient’s body are also of great importance. This is why self-medication is not recommended.

Be sure to first consult with your doctor, who will select the required dosage based on your illness.

Before using the tablet, you should consult your doctor.

What does Furazolidone help with:

• food intoxication and dysentery - the daily dose of the drug is 100-150 mg. The duration of the course is approximately a week. The doctor will determine this;
• urethritis - you need to take 2 tablets four times a day. The duration of the therapeutic course is only three days. This is the so-called shock therapy - fast and intense;
• lambiasis - the treatment principle is similar here, the patient will have to take 8 tablets per day. The reception should be divided into four times. The main difference is a longer course, which is determined by the doctor. Children with this disease are prescribed 10 mg per kilogram of weight;
• trichomoniasis - with such an infection, they look at its type. Why is Furazolidone used in this case? The drug helps remove acute symptoms– pain in the vaginal or prostate area (depending on the gender of the patient), fever, etc., that is, everything that indicates an inflammatory process;
• Cystitis is a common disease that requires timely treatment. In this case, the drug is prescribed four times a day, two tablets. The course of treatment varies, but on average it lasts 3-7 days;
• wounds and burns in which a bacterial infection develops. There is no need to drink anything here. The patient will need to apply medicinal dressings made on the basis of this medicine. You can buy powder or crush tablets. All compresses must be wet.

Furazolidone helps with wounds and burns in which a bacterial infection develops

The indications of Furazolidone are known. What about contraindications? Despite the fact that this drug is considered relatively safe, since it does not have a significant effect on the human body, some warnings still exist.

The main negative is that the product is toxic, although low. However, you need to be careful and follow the recommendations of doctors and the manufacturer directly. Thanks to this, you can avoid a number of problems, such as:

• nausea;
• persistent loss of appetite;
• vomit;
• sharp or dull pain in the abdominal area;
• rash on the skin;
• hives;
• Quincke's edema;
• severe itching.

Recommendations to help avoid such side effects, are very simple. First of all, always take your tablets with plenty of water. Also, do not take them on an empty stomach - only after meals. At the same time, take antihistamines - they will help reduce the risk of allergic reactions.

The tablet should be taken with plenty of water

Furazolidone - what are these tablets for? We found that they help with infectious diseases caused by various bacteria. This is one side of the coin. The second is contraindications. Not all patients will be able to take this drug, as they may have serious contraindications.

To be fair, it should be noted that there are not so many of them, which sets this drug apart from many competitors. It is strictly forbidden to take Furazolidone if the patient has severe hypersensitivity to the main or any auxiliary substance present in the composition, since this is a direct path to allergies.

Patients who suffer should be treated very carefully various diseases nervous system, kidney and liver failure. The same applies to cases where a person has lactose deficiency (glucose-phosphate dehydrogenase). The drug should not be prescribed to patients under three years of age.

It is also not recommended to be treated with it during breastfeeding. Many doctors do not risk prescribing it during pregnancy. But in this case, it should be noted that there is no categorical prohibition (or any prohibition in general). And this should be discussed in more detail.

Clinical trials on the effect of this drug on the child or mother, of course, were carried out. However, there is currently no clear answer as to whether such an impact is present and whether it can be negative. This is due to the fact that the tests were not completed completely.

There is currently no clear answer as to whether the drug has a negative effect on the fetus.

It is reliably known that the active component of the drug does not have a negative effect on the fetus in the first trimester of pregnancy. There are also no prerequisites to believe that this is possible with the further development of the child.

It has been found that a fetus that has a congenital lactose deficiency may develop this after taking Furazolidone. dangerous disease as hemolytic anemia. Accordingly, this possibility must be excluded.

Based on all of the above, we can conclude that the reception this tool allowed during pregnancy. But with some caveats:

• treatment with the drug is prescribed only if there is really an urgent need for it;
• the mother does not suffer;
• the fetus is first examined for lactose deficiency;
• the appointment must be carried out under the constant supervision of the attending physician;
• preliminary consultation with a specialist is also mandatory;
• at the slightest sign of the drug's effect on the mother or fetus, it should be stopped immediately and consult a doctor for further instructions.

Now you know why Furazolidone tablets are taken. This drug has proven its effectiveness. Its popularity is largely due not only to this or its reasonable cost, but also to its low impact on the body.

The drug Furazolidone has proven effectiveness in the treatment of infectious diseases. Compliance with the dosages indicated in the instructions for a particular disease will help reduce the risk of side effects. Before taking it, it is important to check the list of contraindications.

Composition of the drug and release form

The drug is presented for sale in the form of flat-cylindrical yellow tablets, which are packaged in contour packages of 10 pieces (2-3 in a cardboard pack) or in plastic jars of 50 pieces. The composition of Furazolidone is given in the table:

Pharmacotherapeutic action of Furazolidone

The antimicrobial agent Furazolidone belongs to nitrofuran derivatives, a synthetic substance from the 5-nitrofurforol group. Gram-negative, gram-positive, aerobic bacteria (giardia, salmonella, shigella, trichomonas, campylobacter, vibrio cholerae) are highly sensitive to it. Depending on the concentration, the drug exhibits a bacteriostatic or bactericidal effect.

The mechanism of action of Furazolidone is the blockade of microbial enzyme systems. The drug disrupts cellular respiration, suppresses the Krebs cycle, and blocks the biosynthesis of nucleic acids. This leads to the destruction of the bacterial membrane, the cytoplasmic membrane. Destroyed microbial cells release fewer toxins and activate the immune system.

The drug has no effect on anaerobic microorganisms, Pseudomonas aeruginosa, stimulates the immune system, and resistance to it rarely and slowly develops. The drug increases the phagocytic activity of leukocytes and the compliment titer, and increases the body's sensitivity to alcohol. The medicine is used to create high concentrations in the intestine to treat intestinal bacterial and protozoal infections.

The tablets are poorly absorbed, but are well distributed throughout tissues and fluids (cerebrospinal fluid, plasma, intestinal lumen). The maximum concentration of the active component remains in the blood for 5.5 hours. The drug is intensively metabolized to form an inactive metabolite and is excreted by the kidneys and feces.

Indications and contraindications

The instructions for use indicate the following indications for the use of Furazolidone:

• cholera;
• dysentery;
• paratyphoid;
• giardiasis;
• salmonellosis;
• trichomonas colpitis;
• food poisoning;
• pyelitis;
• urethritis;
• cystitis;
• infected wounds, burns.

The drug is prescribed with caution for glucose-6-phosphate dehydrogenase deficiency and diseases of the nervous system. Contraindications to the use of the product:

• intolerance to the components of the composition;
• lactation, pregnancy;
• end-stage renal failure;
• age up to 3 years for tablets and up to a month for suspension;
• severe liver failure.

Possible side effects when taking medication:

• itching, skin rash, Quincke's edema;
• pulmonary edema, bronchospasm;
• loss of appetite, vomiting, nausea;
• neuritis;
• hepatotoxicity;
• peripheral neuropathy (risk is higher with anemia, diabetes mellitus, hypovitaminosis of B vitamins).

An overdose of Furazolidone is manifested by toxic hepatitis, blood changes, and polyneuritis. Treatment consists of discontinuing the drug, taking antihistamines, B vitamins, and drinking plenty of fluids.

Instructions for use of Furazolidone

The drug is taken orally after meals to prevent dyspeptic disorders, washed down with water. With long-term use to prevent nephritis, it is combined with B vitamins. Use of the drug for adults:

Dosage and method of administration for children

In children, a granular form of the drug is used, from which a suspension is prepared. It is allowed from a month of age, tablets - from 3 years. A single dose is 0.0025 g per kg of weight, a daily dose is 0.01 g per kg of weight, divided into 3-4 doses over a course of 5-7 days.

In infants, the drug is used to treat infected wounds and burns in the form of a sterile bandage soaked in a solution. To prepare the suspension, take 100 ml of warm water, pour it into a bottle, shake and measure. When treating with Furazolidone, the pediatrician must take into account the type and severity of the disease and the presence of chronic ailments. General rules treatment of children:

• The course lasts no longer than 10 days.
• The product is taken 4 times a day after meals, washed down with water.
• In the child’s diet, the amount of thiamine-containing products (canned meat and fish, smoked meats, legumes, chocolate, cheese, yogurt, kefir) is reduced - otherwise the baby will develop dizziness and high blood pressure.

Furazolidone for diarrhea

The use of Furazolidone for diarrhea helps stop diarrhea caused by pathogenic microorganisms (Shigella, amoebas, salmonella). Adults are supposed to take 2-3 tablets 4 times a day, children over 5 years old - ½ -1 tablet the same number of times. The daily dose for children older than one year is divided into 3-4 doses and is 10 mg per kg of weight. The effect is visible after 2-5 days of treatment; if there is no improvement after a week, the medicine is changed. Therapy lasts no longer than 10 days.

It is advisable to begin treatment of diarrhea with probiotics and enterosorbents; only in severe cases of the disease or no effect after 2-3 days of therapy can you start taking Furazolidone. If there is no result, the patient is transferred to the antibiotics Azithromycin, Imipenem, Amikacin.

Use for cystitis

To treat inflammation of the bladder (cystitis), tablets or granules are used to prepare a suspension. They are taken orally after meals with a glass of water. Treatment of cystitis is combined with taking B vitamins. During therapy, take 0.1 g 4 times a day, take a break after 3-4 days, then repeat the course for the same period. The maximum therapeutic dose will be 16 tablets.

For pyelitis and pyelonephritis - inflammation of the kidneys caused by streptococci or staphylococci, treatment with Furazolidone is accompanied by taking antibiotics from the group of fluoroquinolones, hydroxyquinolines, sulfonamides, and phosphonic acid. Additionally, painkillers and antipyretics are indicated. Nonsteroidal anti-inflammatory drugs are not recommended.

Furazolidone is antibacterial agent, intended for oral administration. Furazolidone belongs to the group of nitrofuran derivatives.

Release form of the drug

Furazolidone is produced only in a single dosage form The tablets are yellow in color, flat, with a chamfer on one side. There are 10 tablets in a blister, a total of 3 medicinal blisters in one pack. In addition to paper packaging, they are sold in a polymer jar of 50 pieces. Inside the pack there is an insert (instructions for use).

Compound

The main component of the drug is furazolidone. One pill contains 0.05 g of this substance. The product also contains auxiliary components: calcium stearate -0.001 g, potato starch - 0.02 g, sugar (sucrose) - 0.01 g, Tween-80 -0.0002 g,

Effect of the drug

The pharmacological action of Furazolidone primarily depends on the daily dose. If the doses are insignificant, the product has only a bacteriostatic property. But with increasing daily doses, the medication has a bactericidal effect.

The antimicrobial properties of the drug work because the nitro groups that are part of the product are destroyed to the state of amino groups. And under the influence of microorganisms’ own enzymes, it leads to their destruction. In addition to its main actions, Furazolidone has immunostimulating properties. This medication can increase the phagocytic activity of leukocytes. The drug can remain in the blood for 6 hours. The drug is excreted through the kidneys.

Indications for use

In most cases, experts prescribe furazolidone orally for the treatment of the following diseases:

1. Diarrhea.
2. Paratyphoid.
3. Giardiasis.
4. Infections digestive system.
5. Dysentery.

Contraindications for use

Be sure to read the instructions before you start taking Furazolidone. The product may cause the following adverse reactions:

• Chronic liver failure.
• Lactation period.
• Age up to three years.
• Pregnancy period.
• Allergic reaction to the components of the drug.
• Individual intolerance.

The product should be used with caution in patients who have: acute and chronic diseases liver, disturbances in the functioning of the central nervous system.

What does it help with?

Almost always, this drug is used for the treatment of infectious diseases of the genitourinary system, digestive system, and skin dermatitis.

Directions for use and doses

The drug Furazolidone is taken orally after meals. The drug should be swallowed immediately, without chewing, and washed down with plenty of water. The dosage and duration of the course are determined only by the doctor individually for each person.

Adults are prescribed 2-3 tablets 4 times a day. The daily dose of the drug should not exceed 800 mg. The duration of the entire course is 5-12 days, depending on the severity of the disease. For the treatment of lambiasis, adults are recommended to take 2 tablets 4 times a day. For children under 12 years of age, the daily dose is calculated individually based on total body weight. The resulting daily dose is divided into equal parts.

Furazolidone and alcohol

Following the instructions, it states that when drinking alcohol and this drug together, the patient experiences increased individual sensitivity to the standard. As a result, the risk of alcohol intoxication increases, vomiting and nausea appear.

Side effects from taking the drug

Furazolidone is a practically safe drug and in isolated cases causes negative reaction body. But still, like many medications, it has a number side effects. It may lead to the following adverse reactions:

1. Vomit.
2. Nausea.
3. Loss of appetite.
4. Manifestations of allergies.
5. Skin itching, urticaria.
6. In more severe cases it leads to Quincke's edema.
7. Skin dermatitis.
8. Pain in the epigastric region.

In order to reduce the risk of side effects, the tablets should be taken with plenty of water. And besides. Taking antihistamines and vitamin complexes with a high content of B vitamins. With prolonged use, especially in children, cough, shortness of breath, and hemolytic anemia may occur.

Analogs

The product does not have any medicines similar in composition. That is why, when manifesting negative reaction The patient is prescribed another medication.