Antipyretics for children are prescribed by a pediatrician. But there are emergency situations for fever when the child needs to be given medicine immediately. Then the parents take responsibility and use antipyretic drugs. What is allowed to give to infants? How can you bring down the temperature in older children? What medicines are the safest?
1. Pharmacological action
medicinal group
A drug that stimulates the processes of immunity (immunostimulating agent)Therapeutic effects of Cytovir:
- Antiviral action;
- The production of interferon proteins that prevent the spread of viruses;
- Cell activation immune system;
- Normalization of the permeability of the walls of blood vessels;
- Reducing the intensity of inflammatory processes.
2. indications for use
- Prevention and complex and acute respiratory viral infections.
3. How to use
Cytovir capsules
- One capsule of the drug three times a day 30 minutes before meals.
Cytovir syrup
- Children from 1 to 3 years old - 2 ml of syrup 3 times a day;
Cytovir powder
- Cooking: add 40 ml of water (boiled, room temperature) to the vial, shake well.
- Children from 1 to 3 years old - 2 ml of solution 3 times a day;
- Children from 3 to 6 years old - 4 ml 3 times a day;
- Children from 6 years to 10 years - 8 ml 3 times a day;
- Children from 10 years old - 12 ml 3 times a day.
Application Features:
- schemes of therapeutic and prophylactic use are identical;
- the duration of the use of Tsitovir for at least four days;
- prophylactic course can be repeated in 3-4 weeks;
- the duration of use and its dosage can be changed by the attending physician according to individual indications.
4. Side effects
- Cardiovascular system: lowering the level of general blood pressure in people suffering from vegetative-vascular dystonia and / or the elderly;
- Hypersensitivity reactions to Tsitovir or its components.
All described violations occur in isolated cases.
5. Contraindications
- Hypersensitivity to Cytovir or its components;
- The use of the drug in pregnant women, as well as in women during lactation;
- The use of the drug in the form of capsules in patients under 6 years of age or syrup / powder in patients under 1 year of age;
- Individual intolerance to Cytovir or its components.
Apply with caution:
The use of the drug in patients suffering from:
- vegetative-vascular dystonia;
- orthostatic hypotension;
- postural hypotension.
6. During pregnancy and lactation
Pregnant women and nursing mothers Tsitovir is contraindicated.7. Interaction with other drugs
Negative interactions of Cytovir with other drugs have not been identified.8. Overdose
An overdose of Tsitovir has not been described.9. Release form
- Capsules - 12, 24 or 48 pcs.
- Syrup (for children) - a bottle of 50 ml.
- Powder for solution for oral administration (for children) - 20 g.
10. Storage conditions
- The humidity level in the room is within the acceptable range;
- Impossibility of access by children and unauthorized persons;
- Complete absence of light sources in the storage area;
- The complete absence of heat sources.
11. Composition
1 capsule:
- thymogen sodium - 500 mcg;
- bendazol - 20 mg;
- ascorbic acid - 50 mg;
- Excipients: milk sugar, calcium stearate.
1 ml syrup:
- thymogen sodium - 0.15 g;
- ascorbic acid - 12 mg;
- dibazole - 1.25 m;
- Excipients: sucrose - 800 mg, purified water - up to 1 ml.
1 ml syrup:
- thymogen sodium - 0.15 g;
- ascorbic acid - 12 mg;
- dibazol - 1.25 m.
12. Terms of dispensing from pharmacies
The drug is released according to the prescription of the attending physician.Found an error? Select it and press Ctrl + Enter
* Instructions for medical use for the drug Tsitovir published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, IT IS NECESSARY TO CONSULT WITH A SPECIALIST
Children are the most frequent visitors to clinics and hospitals. What is it connected with? The fact is that the baby’s still fragile body is very quickly attacked by various viruses and infections.
To make the child's immune system stronger and stronger, many parents use one of them is the drug "Tsitovir-3". Price, reviews, instructions for use and forms of this medicine will be presented below.
Description, packaging, composition and forms
Antiviral "Tsitovir-3" is produced in different forms. Let's take a look at them right now.
- "Citovir-3" - a powder intended for the preparation of an oral aqueous solution for children. It has a white or yellowish color and a characteristic orange, strawberry or cranberry aroma. The active ingredients of this medicine are alpha-tryptophan-glutamyl sodium, bendazole hydrochloride and ascorbic acid. Also, the agent under consideration includes auxiliary elements in the form of fructose and a flavor identical to natural (“Orange”, “Strawberry” or “Cranberry”). The “Citovir-3” powder for influenza goes on sale in vials (20 g each), and also has a dosing pipette or (spoon) in the kit, which are placed in packs of cardboard.
- No. 3 gelatin hard capsules with orange cap and white body. Their content is a white or yellow powder without any odor. The composition of the drug "Citovir-3" includes alpha-tryptophan-glutamyl sodium, bendazole hydrochloride and ascorbic acid. Lactose monohydrate and calcium stearate are used as additional elements. As for the capsule shell, the body consists of 2% titanium dioxide and gelatin, and the cap is made of sunset yellow dye, 2% titanium dioxide, azorubine dye and gelatin. You can buy such a tool in contour cells, which are packaged in cardboard boxes.
- Syrup "Tsitovir-3" for children. This form of the drug may be colorless or have a yellow color. Its active ingredients are sodium alpha-tryptophan-glutamyl, bendazole hydrochloride and ascorbic acid. Also, the composition of the drug includes sucrose and purified water. In what packaging can the product in question be purchased? What do the reviews say about it? "Citovir-3" (syrup for children) is available in 50 ml dark glass bottles. In the kit, this drug has a dosing device in the form of a measuring cup, spoon or pipette.
The mechanism of action of the drug
What is the medication in question? What do medical reviews say about this? "Citovir 3" (syrup for children) is also a means of immunostimulating and etiotropic therapy. It has an indirect antiviral effect against influenza B and A viruses, as well as other viruses that cause acute respiratory infections.
According to the instructions, bendazol is able to induce the production of endogenous interferon in the human body. It also exhibits an immunomodulatory effect, that is, it normalizes the immune response.
It should also be noted that the enzymes that are produced by inducing interferon in cells internal organs able to inhibit viral replication.
Ascorbic acid activates the humoral link of the immune system, normalizes the permeability of blood vessels and capillaries, reducing inflammation. In addition, this component exhibits antioxidant properties. As you know, it neutralizes oxygen radicals that accompany inflammation, and also increases the patient's resistance to infections.
As for alpha-tryptophan-glutamyl, it is a synergist of the immunomodulatory action of bendazole. The mentioned substance is able to normalize the T-cell link of the immune system.
Kinetic features
Where is the absorption of the drug in question? What do the reviews say about it? "Citovir-3" (syrup for children), when taken orally, is completely absorbed from the digestive tract.
The bioavailability of bendazole is approximately 80%, ascorbic acid is 70%, and alpha-tryptophan-glutamyl is approximately 15%.
Vitamin C is absorbed primarily from small intestine. Its connection with plasma proteins is 25%, and the maximum concentration is observed after four hours.
This substance quite easily penetrates the placental barrier, into platelets and leukocytes, and then into all tissues of the body. Gastrointestinal diseases such as ulcers, helminthic invasion, intestinal motility disorders and giardiasis, as well as the use of fresh fruit and vegetable juices, alkaline water, significantly reduce the binding of vitamin C in the intestine.
Ascorbic acid is metabolized mainly in the liver. In this case, deoxyascorbic acid is formed, and then oxaloacetic and diketogulonic acids. This substance is excreted by the kidneys, with sweat, through the intestines and breast milk in unchanged form, as well as in the form of derivatives.
The products of the biological transformation of bendazole in the blood are two conjugates that are formed during carboethoxylation and methylation of the imino group of the imidazole ring: one-carboethoxy-two-benzylbenzimidazole and one-methyl-two-benzylbenzimidazole. These metabolites are excreted from the body along with urine.
Under the influence of peptidases, alpha-tryptophan-glutamyl is cleaved into L-tryptophan and L-glutamic acid. They are used by the human body for protein synthesis.
Indications for taking the drug
In what cases can the patient be prescribed the drug "Cytovir-3"? For the prevention and complex therapy of influenza and SARS, this remedy is used:
- for children over six years old and adults in the form of capsules;
- babies from one year in the form of an oral solution and syrup.
Contraindications to taking the drug
In what cases is the drug in question not prescribed? What do the reviews say about it? "Citovir-3" (syrup for children, capsules and solution) is not used under the following conditions:
- in children under six years of age (in the form of capsules);
- at diabetes(as syrup and oral solution);
- in children under one year of age (in the form of syrup and oral solution);
- with increased sensitivity to the elements of the drug;
- during pregnancy.
With extreme caution, the mentioned remedy is recommended during the period breastfeeding(if the benefit to the mother is greater than the risk to the baby).
The drug "Citovir 3": instructions for use
The dosage of this drug should be selected by a specialist.
How to take "Citovir 3"? The medicine is taken orally half an hour before a meal. For treatment and for the purpose of prevention, adults and children from six years of age, this drug is prescribed one capsule three times a day. It should also be noted that preventive and therapeutic use this tool is absolutely identical.
The drug in the form of an oral solution or syrup is prescribed to babies aged 1-3 years in an amount of 2 ml three times a day. A child of 3-6 years old is given this drug in 4 ml with the same multiplicity, children of 6-10 years old - 8 ml, and adolescents from 10 years old - 12 ml three times a day.
The prophylactic course or course of treatment with this drug is four days. If necessary, it is repeated after 3-4 weeks.
How to prepare an oral solution
To prepare the Cytovir 3 solution, the price of which is indicated below, about 40 ml of boiled, but cooled to room temperature, water is added to the vial with the powder. After that, the contents of the container are well shaken. In this case, the powder should completely dissolve.
As a rule, the volume of the drug after adding water does not exceed 50 ml.
Side Effects
What negative consequences can occur after taking the drug "Citovir-3"? Instructions for use states that from the side of cardio-vascular system this medicine may cause a short-term decrease in blood pressure. Also, sometimes it provokes the appearance of allergic reactions in the form of urticaria. In this case, the use of the drug is stopped, symptomatic treatment and prescribed antihistamines.
Medicine overdose
Taking excessive doses of the drug "Cytovir-3" can cause the following symptoms: sweating, short-term hypotension, nausea, dizziness, headache and fever.
Such conditions are treated symptomatically. However, before this, you should definitely consult a doctor to decide whether you need to continue taking the medication.
Interaction with other drugs
Drug interactions of alpha-tryptophan-glutamyl with other drugs have not been identified.
Bendazole enhances the hypotensive effect of diuretic and antihypertensive drugs, and also prevents the increase in peripheral vascular resistance, which is caused by non-selective beta-blockers. It should also be noted that "Fentolamine" enhances the hypotensive properties of bendazole.
Vitamin C increases the concentration of tetracyclines and benzylpenicillin in the blood. In addition, it improves intestinal absorption of iron preparations, and also reduces the effectiveness of indirect anticoagulants and heparin.
Acetylsalicylic acid, fresh juices, oral contraceptives and reduce digestion and absorption
Vitamin C increases the risk of developing crystalluria during therapy with short-acting sulfonamides and salicylates, and also slows down the excretion of acids by the kidneys, reduces the concentration of oral contraceptives in the blood and increases the excretion of drugs that have an alkaline reaction (including alkaloids).
With the simultaneous administration of ascorbic acid and "Isoprenaline", the chronotropic effect of the latter decreases. Also, vitamin C reduces the effectiveness of antipsychotics and tricyclic antidepressants.
Primidone and barbiturates increase the excretion of ascorbic acid in the urine.
When taking an oral solution or syrup, as well as with repeated courses of treatment, it is necessary to monitor blood glucose levels.
The drug in question does not affect the ability of people to engage in hazardous activities and manage vehicles.
Expiration date, conditions of sale and storage
The drug in question in the form of capsules is dispensed in pharmacies without a doctor's prescription. As for the syrup for children and powder for the preparation of oral solution, a doctor's ticket is required to purchase them.
The medication in the form of capsules must be stored at a temperature of no more than 25 degrees. Its shelf life is three years.
The drug in the form of children's syrup should be kept at a temperature of 25 degrees for two years.
The drug in the form of a powder for oral solution is stored only in a dry place where the air temperature does not exceed 25 degrees. The validity of this form is three years.
The prepared aqueous solution should be stored in a place protected from light and inaccessible to children at a temperature of 0-8 degrees for no more than ten days.
Analogues and price
The price of children's syrup and powder "Tsitovir-3" is about 270 rubles, and capsules - about 245-275 rubles.
In some cases, the medication in question is replaced by analogues. These include the following: Alokin Alpha, Arbivir-zdorovye, Anaferon, Arbidol, Immunal, Glutoxim, Kagocel, Lynchi, Lavomax, Orvirem, Echinacin Madaus", "Timalin".
It should be especially noted that the price of analogues of the mentioned drug may be less or close to the cost of the Cytovir-3 drug itself.
Which drug works best?
Most often, the drug "Tsitovir-3" is compared with the means "Orvirem", "Kagocel" and "Anaferon". It should be noted that the mechanisms of action of all these drugs are completely different. However, they are all immunostimulating. Thanks to such means, the recovery of children and adults comes much faster.
The drug Cytovir-3 is a drug of etiotropic therapy. The drug has an immunostimulating effect and has antiviral activity, it is effective against influenza A and B viruses. It can be used to prevent the manifestation of the activity of pathogenic microorganisms that provoke acute respiratory infections. Active substance induces the process of endogenous production in the body, the agent has an immunostimulating effect, due to its activity, the immune response is normalized.
Dosage form
The drug Cytovir-3 is produced in the form of capsules intended for oral administration.
Description and composition
Capsules Tsitovir-3 have a white color, gelatin body, with an orange cap. The elements are oblong. The composition of the drug contains 3 active ingredients, namely:
- vitamin C;
- alpha-glutamyl tryptophan sodium;
- bendazole hydrochloride.
The list of auxiliary components present in the composition of the drug can be presented in the following form:
- gelatin;
- titanium dioxide;
- calcium stearate;
- dye sunset;
- azorubine;
- lactose monohydrate.
The listed medicinal components provide the necessary dosage form.
Pharmacological group
Cytovir-3 capsules have a pronounced immunostimulating effect, which is provided due to the activity of the active substances.
Bendazole enhances the process of production by immunocompetent cells responsible for various kinds of immunity. The tool inhibits the activity of viruses, and effectively destroys the existing cells inside microbial organisms. enhances the activity of bendazole and normalizes the transmission of impulses through the links of the immune system.
– medicine, which has an immunostimulatory effect. The composition of the drug contains 1 active ingredient, namely 12 mg. The tool has a pronounced antiviral efficacy and can be used to treat and prevent influenza and colds. The drug is produced in the form of tablets. The experience of taking the drug in patients of the pediatric age group is limited. can be used for the treatment and prevention of various infectious and inflammatory diseases in adults and children over the age of 6 years. The composition is well tolerated, adverse reactions during administration are extremely rare. The drug is not recommended for long-term use due to the high risk of developing an addiction reaction.
Price
The cost of Tsitovir-3 is an average of 590 rubles. Prices range from 179 to 1040 rubles.
Trade name of the drug: Cytovir®-3
International non-proprietary or grouping name:
Alpha Glutamyl Tryptophan + Ascorbic Acid + Bendazole
Dosage form:
Composition of Cytovir®-3:
per capsule
Active substances:
Alpha-glutamyl-tryptophan sodium (Thymogen sodium) 0.5 mg
Ascorbic acid 50 mg
Bendazole hydrochloride (Dibazol) 20 mg
Excipients:
Lactose monohydrate 97.8 mg
Calcium stearate 1.7 mg
The composition of the capsule shell: Body: titanium dioxide 2%, gelatin up to 100% Lid: titanium dioxide 2%, sunset yellow dye 0.2190% azorubin dye 0.0328%, gelatin up to 100%.
Description of Cytovir®-3:
Hard gelatin capsules No. 3 with a white body and an orange cap The contents of the capsules are a powder from white to yellow, odorless
Pharmacotherapeutic group:
immunostimulant
ATX code:
L03AX
Pharmachologic effect:
The drug is a means of etiotropic and immunostimulating therapy has antiviral action for influenza A and B viruses andother viruses that cause acute respiratory viral diseases Bendazole induces the production of endogenous interferon in the body and has an immunostimulating effect (normalizes the body's immune response). Enzymes whose production is induced by interferon cells various bodies, inhibit viral replication. Alpha-glutamyl-tryptophan (timogen) is a synergist of the immunostimulatory action of bendazole, normalizing the T-cell link of immunity. Ascorbic acid activates the humoral link of immunity; normalizes capillary permeability, thereby reducing inflammation; exhibits antioxidant properties, neutralizing oxygen radicals accompanying inflammatory process; increases the body's resistance to infections
Pharmacokinetics.
When taken orally, the drug is completely absorbed from gastrointestinal tract. The bioavailability of bendazole is about 80%, alpha-glutamyl tryptophan is not more than 15%, ascorbic acid is 90%. Metabolites of ascorbic acid and bendazole are excreted in the urine. Alpha-glutamyl-tryptophan is broken down by peptidases into L -glutamic acid and L -tryptophan, which are used by the body in peptide synthesis.
Indications for use Cytovir®-3:
Prevention and complex therapy influenza and acute respiratory viral infections in adults and children older than 6 years.
Contraindications:
Hypersensitivity to the components of the drug, pregnancy, childhood up to b years.
Carefully: during breastfeeding, use is possible if the intended benefit to the mother outweighs the potential risk to the child.
Dosage and administration of Cytovir®-3:
Adults and children over 6 years of age for the purpose of prevention and treatment inside one capsule 3 times a day 30 minutes before meals.
The course of application is 4 days. The prophylactic course, if necessary, is repeated after 3-4 weeks.
Side effect:
Allergic reactions, short-term decrease in blood pressure.
Overdose:
Symptoms: a short-term decrease in blood pressure in patients with vegetovascular dystonia, the elderly. It is necessary to monitor kidney function, blood pressure and blood glucose concentration.
Interaction with other drugs:
not found.
Special instructions:
The drug does not affect the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Release form:
Cytovir 3 is a combined immunomodulatory drug intended for the treatment and prevention of viral diseases. Available in the form of capsules for oral administration, syrup for children and powder for solution.
Pharmacological action of Cytovir 3
According to the instructions for Tsitovir 3, the active active ingredients of the drug in all forms of release are ascorbic acid, bendazol, thymogen. The excipients of the capsules are calcium stearate and lactose. An additional component of the powder for preparing the solution is fructose. The auxiliary substances that make up the syrup for children are sucrose and purified water.
Cytovir 3 exhibits indirect antiviral activity against type A and B viruses, as well as those that cause acute respiratory infections.
Thymogen affects the T-cell link of immunity and enhances the immunomodulatory effect of bendazole.
Bendazole promotes the production of endogenous interferon and activates the synthesis of enzymes that blunt the replication of viruses.
When using Cytovir 3, ascorbic acid, which is part of it, stimulates the humoral link of immunity and improves capillary permeability, reduces the intensity of the inflammation process and has a pronounced antioxidant property by reducing the negative effect of peroxide compounds and free radicals on cell membranes. Ascorbic acid also increases the body's resistance to infections.
When administered orally, Cytovir 3 is completely and rapidly absorbed from the gastrointestinal tract. The active ingredients of the drug have a high bioavailability. The period of complete elimination of the drug from the body is 6 hours. It is excreted from the body in the form of metabolites through the kidneys.
Indications for use
According to the instructions, Tsitovir 3 is prescribed for the treatment and prevention of influenza and acute respiratory diseases.
Methods of using Cytovir 3 and dosage
The medicine of all forms of release is intended for oral administration - 25-30 minutes before meals. Cytovir 3 is taken 3 times a day. The course of therapy is 4 days.
For the purpose of prevention, children over 6 years of age and adults are recommended to take 1 capsule.
A single dosage of syrup and solution of Cytovir 3 for children aged 1 to 3 years is 2 ml, 3-6 years - 4 ml, 6-10 years - 8 ml, 10-14 years - 12 ml.
To prepare the solution, add 40 ml of boiled water at room temperature to a vial with Cytovir 3 powder, then shake well until it is completely dissolved.
Repeated preventive courses can be carried out with an interval of 3-4 weeks.
Side effects of Cytovir 3
In reviews of Tsitovir 3, it is noted that the drug is usually well tolerated by patients. In individual cases, people with vegetovascular dystonia may develop arterial hypotension.
Also during therapy, there may be allergic reactions in the form of skin rash, urticaria, swelling, burning, itching.
When adverse reactions on the part of the body, it is necessary to cancel the drug and further symptomatic treatment under the supervision of the attending physician.
Contraindications to the use of Tsitovir 3
Absolute contraindications to Cytovir 3 are:
- Hypersensitivity to its components;
- thrombophlebitis;
- Diabetes mellitus (for syrup);
- Tendency to thrombosis;
- Arterial hypertension;
- Atopic form of bronchial asthma;
- Increased muscle tone;
- Pregnancy;
- The period of breastfeeding;
- Children's age up to 6 years (for capsules).
Caution is prescribed Tsitovir 3 with simultaneous anticoagulant therapy.
Overdose
In numerous reviews of Tsitovir 3, there are no reports of cases of drug overdose.
Analogues of Tsitovir 3
By pharmacological action And chemical composition analogues of Cytovir 3 are Actinolysate, Arpetolid, Vitanam, Wobenzym, Gepon, Dezoksinat, Zadaksin, Immunal, Methyluracil, Pyrogenal, Poludan, Ribomunil, Ruzam, T-activin, Timaktid, Timogen, Flaraxin, Engystol, Echinacea.
Additional Information
With prolonged use of Cytovir 3 syrup, regular monitoring of kidney function and blood glucose levels is necessary.
The instructions for Tsitovir 3 indicate that the medicine of all forms of release should be stored in a dark, cool, dry place out of the reach of children.
From drugstores it is released according to the recipe of the attending physician.
The shelf life of capsules and powder for the preparation of a solution is 3 years, syrup - 2 years.
