Antipyretics for children are prescribed by a pediatrician. But there are emergency situations with fever when the child needs to be given medicine immediately. Then the parents take responsibility and use antipyretic drugs. What is allowed to be given to infants? How can you lower the temperature in older children? What medications are the safest?
Instructions for medical use of the drug
Description of pharmacological action
Stabilizes the membrane of mast cells and reduces the release of histamine, leukotriene C4, PG D2 and other biologically active substances from them.
Indications for use
Diseases respiratory tract with reversible obstruction: bronchial asthma of various origins, asthmatic bronchitis, exercise asthma, bronchospastic reactions caused by a number of stimuli, such as cold air, inhaled allergens, atmospheric pollution.
Release form
aerosol for inhalation dosed 2 mg/dose; bottle (bottle), box (box) 1;
Aerosol for inhalation dosed 2 mg/dose; bottle (bottle), box (box) 1;
Pharmacodynamics
Blocks the release of inflammatory mediators from various cells (eosinophils, mast cells, neutrophils, macrophages, monocytes and platelets), incl. histamine, cytokines, leukotriene C4, PGD2, chemotactic factors, enzymes (beta-glucuronidase, etc.).
After inhalation it settles on the walls bronchial tree and inhibits the development of the early and late stages of the asthmatic reaction caused by inhalation of the allergen.
Reduces increased vascular permeability and has a local anti-inflammatory effect on the bronchial mucosa.
Affects the endings of afferent nerves in the lungs, suppresses the axon reflex and promotes the release of sensory neuropeptides (substance P, neurotoxin A, etc.).
Continuous long-term use reduces the hyperreactivity of the respiratory tract to nonspecific bronchoconstrictors, improves external respiration, reduces the intensity and frequency of asthma attacks and the severity of cough.
Effective for mild and moderate forms of asthma. Improves nocturnal symptoms and reduces the need for daytime bronchodilator medications.
When administered 30 minutes before exposure to a chemical irritant, allergen or physical activity, it prevents the development of an acute asthmatic reaction and suppresses its late phase, observed 6–12 hours after provocation.
The therapeutic effect develops by the end of the first week, maximum improvement clinical condition and pulmonary function is usually observed within 2–4 weeks after the start of treatment.
Pharmacokinetics
After inhalation it settles on the walls of the bronchial tree. 5% of the administered dose enters the systemic circulation. A small amount (2–3%) is subsequently absorbed from the gastrointestinal tract.
Plasma protein binding - up to 89%.
Not metabolized, excreted unchanged from the body in urine (about 70%) and feces (about 30%).
Use during pregnancy
Prescribe with caution in the first trimester of pregnancy.
Contraindications for use
Hypersensitivity, age (up to 12 years).
Side effects
Headache, cough, bronchospasm, nausea, vomiting, abdominal pain, other dyspeptic disorders.
Directions for use and doses
Inhalation. For adults (including the elderly) and children over 12 years of age, the initial dose is 2 inhalations (4 mg) 4 times a day. If necessary, the dose of the drug can be increased to 2 inhalations 6–8 times a day.
An additional dose may be immediately before physical activity for the prevention of asthma using physical action. Once adequate control of the symptoms of the disease is achieved, a transition to maintenance therapy of 2 inhalations 2 times a day is possible.
The therapeutic effect develops by the end of the first week of taking the drug.
Overdose
The likelihood of an overdose is extremely low. If it develops, symptomatic treatment is carried out.
Interactions with other drugs
Compatible with oral and inhalation forms stimulants of beta-adrenergic receptors and corticosteroids, theophylline and other methylxanthine derivatives, as well as ipratropium bromide (with all such combinations a potentiation effect is possible).
Precautions for use
Regular daily intake is required. Do not use to relieve an acute attack of suffocation.
Storage conditions
List B.: In a place protected from light, at a temperature not exceeding 30 °C (do not freeze).
Best before date
ATX classification:
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Tilade MintCompound
1 dose of the drug (1 spray) contains:
active ingredient:
nedocromil sodium – 2 mg;
auxiliary components: povidone K30, levomenthol, macrogol (polyethylene glycol) 600, propellant HFA-227.
pharmachologic effect
Tailed Mint is an antiallergic medicinal product, which is used to reduce allergic manifestations in the respiratory system.
Pharmacodynamics
Nedocromil is the active component of the drug, stabilizes the membranes of mast cells, inhibits the allergic reaction (both in the early and late stages of manifestation) by inhibiting the process of degranulation of mast cells and the release of inflammatory mediators (histamine, bradynnin, slow-reacting substance, leukotrienes, prostaglandin D2) .
The indicated properties of the active component of the drug Tailed Mint contribute to:
- preventing the development of bronchospasm, which can occur as a result of contact with an allergen or in the presence of other endogenous/exogenous factors ( low temperature inhaled air, excessive physical activity, stressful situation);
- suppression of antigen-induced allergic reactions of immediate and delayed types in patients suffering from bronchial asthma;
- suppression of bronchial hyperreactivity if the patient has bronchial asthma;
- anti-inflammatory activity regarding the respiratory system (when applied topically);
- reducing bronchial hyperreactivity, normalizing respiratory function, reducing the severity and frequency of asthma attacks and cough intensity with prolonged constant use.
The results of tests of Tailed Mint aerosol showed the greatest antiasthmatic effectiveness in mild and moderate forms of the disease.
A decrease in the manifestation of asthma symptoms at night and a decrease in the need to use bronchodilators during the day was also found.
The expected therapeutic response is observed on the 5th–7th day of drug use.
Pharmacokinetics
Absorption of nedocromil during inhalation occurs directly in the respiratory tract and is relatively low - about 10%. The remaining amount of the drug settles in oral cavity and nasopharynx, entering the gastrointestinal tract, where only 2% of the dose is absorbed. Consequently, nedocromil detected in plasma mainly enters there through local absorption in the respiratory tract. The maximum plasma concentration of underfed (C max) is determined 1 hour after administration of the drug, T ½ is 1–2 hours.
The binding of this substance to plasma proteins is reversible and amounts to 89%. Metabolism of nedocromil is not observed. Subject to systemic absorption, nedocromil is excreted in its original form mainly by the kidneys (about 70%) and intestines (about 30%).
Indications for use
Tailed Mint is prescribed to patients over 2 years of age for:
- therapy and for the purpose of prevention of bronchial asthma of any etiology;
- elimination of bronchospasm, which arose due to the negative influence of various endogenous and exogenous factors (low temperature of inhaled air, the effect of allergens, atmospheric pollution, etc.);
- therapy of bronchial asthma as an additional agent in combination drug treatment.
Mode of application
Aerosol Tailed Mint is prescribed by a doctor for a long course with daily regular use and is not prescribed for the relief of acute bronchospasm.
Dosage schedule:
In pediatrics (from 2 years old) and adult patients, the drug is first prescribed 2 inhalations 2-4 times a day. After the expected response to therapy occurs, the initial dose is gradually reduced to a maintenance dose, which is 2 inhalations 2 times a day.
It is also allowed to perform 2 additional inhalations (4 mg of nedocromil) once before starting intensive physical exercise, contact with substances of an allergenic nature (for the prevention of asthma).
The maximum therapeutic dose (MTD) of the drug is 8 inhalations/day.
The desired response to drug therapy is observed after 5–7 days of administration.
Rules for using the inhaler:
Before the first use, you must shake the inhaler and press the dosing valve 4 times, thus ensuring uniform dosing of the drug during further use. The same should be done if the inhaler has not been used for more than 7 days (it is recommended to press the metering valve twice).
Step-by-step instructions for using the inhaler:
- Remove the cap from the inhaler.
- Carry out a check inspection of the plastic body of the inhaler (exclude the presence of mechanical damage, make sure it is clean).
- Shake the inhaler vigorously with vertical and horizontal movements.
- Ensure the inhaler is in a vertical position by placing thumb on the base of the can.
- After exhaling as completely as possible, insert the mouthpiece into the mouth between the teeth (without biting it) and tightly clasp this device with your lips (to avoid dosage violations).
- Simultaneously with a deep and long inhalation (inhalation must be done through the mouth), press the base of the can to spray the dose the required number of times.
- Next, you should hold your breath, remove the inhaler from your mouth and continue to refrain from exhaling for as long as possible.
Features of caring for the inhaler:
To ensure uninterrupted operation of the inhaler (clogging of the mouthpiece hole with powder), it is necessary to regularly (once every 3 days) wash the plastic body of the inhaler and constantly keep it clean. It is recommended to carry out this procedure in the evening before going to bed, as it takes a long time to dry the device.
To do this you need:
1. Remove the dust cap and remove the metal can from the plastic case.
2. Thoroughly rinse the plastic device under hot running water (at a temperature of at least +45°C) for 1 minute.
3. Turn the plastic case over and wash it on the other side.
4. Using mechanical movements, shake off any remaining water from the plastic device.
5. Leave the thoroughly washed plastic case to dry for a long time (overnight). If there are two plastic devices in a package, use them alternately to keep them clean.
6. After making sure that the plastic case is clean and dry, you should insert a metal can into it, ensuring that the rubber ring is positioned correctly on the can.
7. After each use of the device, close it tightly with the plastic dust cap.
If the release of the drug from the inhaler is blocked when pressed, place the plastic case in hot water for 20 minutes, then rinse and dry it according to the above recommendations.
Before using the inhaler, you must ensure that the plastic housing is dry. If the outlet of the drug is blocked, it is prohibited to clear the hole using a needle (or other similar sharp object), as this will result in further unsuitability of the device for use. It is also prohibited to place a metal can in water and disturb the position of the rubber ring on it.
Side effects
Contraindications
Tailed Mint is not prescribed:
- pregnant women who are in the first trimester;
- patients with established hypersensitivity to the components of the drug;
- in pediatrics up to 2 years.
Pregnancy
It is allowed to use this drug for the treatment of asthma in pregnant women (II and III trim.) only if necessary, as determined by the attending physician.
When studying the drug, the ability of the active ingredient to be excreted in breast milk was established. For this reason, it is not recommended to combine lactation and taking Tailed Mint.
The possibility of using this drug by pregnant and breastfeeding women is determined by the doctor after assessing the ratio of benefit to the mother/risk to the fetus (infant).
Drug interactions
Tailed Mint is compatible with a number of other drugs, but there are some features of their joint use:
Other features of the combined use of Tailed Mint with various drugs pharmacological groups was not observed.
Overdose
To date, no cases of overdose have been reported.
Given the low level of toxicity of nedocromil, the risk of overdose and signs of intoxication is low.
Release form
Tailed Mint is a metered aerosol for inhalation. 1 dose (spray) – corresponds to the release of 2 mg active substance. One aerosol can contains 112 doses. The contents of the aerosol are fine powder.
1 aerosol aluminum can with dispenser (with or without synchronizer) in a cardboard box with annotation.
Storage conditions
The drug should be stored in accordance with the requirements for drugs that belong to list B.
The storage temperature should not exceed 30° C. The storage location should be dark, protected from direct sunlight, and away from children. The drug should also not be stored in a refrigerator and should not be frozen. Do not use after 2 years from the date of production.
Additionally
The drug Tailed Mint is dispensed from pharmacies with a doctor's prescription.
The patient must be informed by the attending physician that regular use of the drug is necessary to achieve the expected therapeutic effect. The patient should also pay attention to the fact that the effect occurs after 5–7 days of use.
After the onset of positive dynamics (even complete disappearance of the symptoms of the original pathology), Tailed Mint should also be used regularly to avoid a decrease in the therapeutic effect.
The appearance of bronchospasm (as a side effect) requires immediate discontinuation of the drug and seeking medical advice. medical care. This condition requires immediate use of short-acting inhaled bronchodilators. After treating the adverse effect that has occurred, the attending physician will prescribe an alternative drug to treat the original pathology.
If bronchospasm occurs again, a bronchodilator should be inhaled before using the drug. Any cough that occurs should be calmed by drinking a glass of water after inhalation.
Tailed Mint is not prescribed for acute attacks of bronchial asthma.
Authors
Attention!Description of the drug " Tailed Mint"on this page is a simplified and expanded version official instructions by application. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
1 dose of aerosol contains nedocromil sodium 2 mg; 112 doses in cans in a plastic case with a mouthpiece, 1 can in a cardboard box.
Pharmacokinetics
Absorbed from the respiratory tract into the systemic circulation and excreted unchanged in bile and urine. Part of the drug that settles in the oropharynx is swallowed and excreted through the gastrointestinal tract (it is very poorly absorbed from the gastrointestinal tract). Does not accumulate in the body even with prolonged use.
Pharmacodynamics
Prevents bronchospasm, cough and other effects that arise from direct exposure to specific and nonspecific stimuli.
Clinical pharmacology
The effect in most cases appears within a week after the start of treatment. Long-term therapy leads to a decrease in bronchial hyperreactivity and an improvement in objective indicators of pulmonary function.
Indications for use of Tiled Mint
Bronchial asthma of various forms and origins (allergic, non-allergic, with bronchial hyperreactivity, caused by specific and nonspecific stimuli), especially with insufficient effectiveness of bronchodilators.
Contraindications to the use of Tailed Mint
Hypersensitivity to the drug.
Tailed Mint Use during pregnancy and children
Prescribed with caution in the first trimester.
Tailed mint Side effects
Headache, nausea, vomiting, abdominal pain and other dyspeptic disorders, cough, bronchospasm.
Drug interactions
Strengthens (mutually) the effect of bronchodilators.
Dosage of Tiled Mint
Aerosol for inhalation - adults and children over 12 years of age at the beginning of treatment are prescribed 3.5 mg (2 doses) 4 times a day at regular intervals, the daily dose is 14 mg. Then, provided the patient's clinical condition is satisfactory, daily dose It is recommended to reduce to 10.5 mg with a frequency of use 3 times a day, and after a few weeks - to 7 mg with a frequency of use 2 times a day.
Precautionary measures
Regular daily intake is required. Cannot be used to relieve an acute attack of suffocation. It is not recommended to stop taking the drug before completing the course of treatment or re-use it without consulting a doctor. The aerosol can must not be pierced (the contents are under pressure).
aerosol for inhalation. dosage 2 mg/1 dose: 112 dose balloon with or without synchronizer Reg. No.: P N015676/01
Clinical and pharmacological group:
Mast cell membrane stabilizer. Antiallergic drug
Release form, composition and packaging
Excipients: povidone K30, levomenthol, macrogol (polyethylene glycol) 600, propellant HFA-227.
112 doses - aluminum aerosol cans with a dosing device (1) - cardboard packs (complete with synchronizer).
112 doses - aluminum aerosol cans with a dosing device (1) - cardboard packs.
Description of the active components of the drug " Tailed ® mint»
pharmachologic effect
Tailed Mint is an anti-allergic drug. The active substance in this drug is nedocromil. When used systematically, it leads to a reduction in the symptoms of allergic inflammation in the respiratory system. Nedocromil is a stabilizer of mast cell membranes, inhibits both the early and late stages of the allergic reaction, preventing degranulation of mast cells and the release of inflammatory mediators from them (histamine, bradykinin, slow-reacting substance, leukotrienes, prostaglandin D2). Thanks to these properties, Tailed Mint prevents bronchospasm caused by contact with an allergen or other provoking factor (cold air, physical stress, stress). In patients with bronchial asthma, nedocromil suppresses antigen-induced allergic reactions immediate and delayed types, and also reduces bronchial hyperreactivity. When applied topically at the level of the bronchial tree, it has an anti-inflammatory effect. Long-term continuous use reduces bronchial hyperreactivity, improves respiratory function, reduces the intensity and frequency of asthma attacks and the severity of cough. It is more effective for mild and moderate forms of asthma. When taken, nighttime symptoms are reduced and the need for daytime bronchodilator drugs is reduced. The therapeutic effect develops by the end of the first week.
Indications
- treatment and prevention of bronchial asthma (of various origins, including physical exertion asthma);
- bronchospastic syndrome (caused by a number of stimuli: cold air, inhaled allergens, atmospheric pollution) in children over 2 years of age and adults.
Tailed Mint can also be additionally prescribed to all existing species treatment of bronchial asthma.
Dosage regimen
The drug is intended for regular daily use.
The drug is not intended for the relief of acute bronchospastic attacks.
Adults (including the elderly) and children over 2 years of age
The recommended dose of Tailed Mint is 2 inhalations 2-4 times a day. Once symptom control is achieved, the dose is gradually reduced to a maintenance dose. The usual maintenance dose of the drug is 2 inhalations 2 times a day. In severe cases, as well as with a high concentration of allergens, the dose of the drug can be increased to two inhalations 4 times a day. An additional dose of the drug in the form of two inhalations (4 mg) once can be taken immediately before physical activity to prevent exercise asthma or before contact with suspected allergens. The daily dose of the drug should not exceed 8 inhalations.
The therapeutic effect develops by the end of the first week.
If the use of a bronchodilator is prescribed at the same time, it is recommended to use it before using Tailed Mint.
The addition of Tailed Mint to the treatment of patients receiving GCS may allow the maintenance dose of GCS to be reduced or discontinued completely. During a reduction in the dose of steroids, strict monitoring of the patient is necessary; A weekly dose reduction of 10% is suggested. If reducing the dose of GCS is impossible, then Tailed Mint should not be discontinued until GCS coverage is restored.
Using an inhaler
When using for the first time, shake the inhaler and press the metering valve 4 times (idle). If the inhaler has not been used for 7 days or more, it is necessary to bring it into working condition by pressing the metering valve twice (idle).
When inhaling, you should adhere to the following instructions:
Remove the dust cap. Inspect the inside and outside of the plastic casing of the inhaler to make sure they are clean. Shake the inhaler vigorously. Hold the inhaler upright with your thumb on the base of the canister. Exhale as completely as possible, then insert the mouthpiece into your mouth between your teeth (without biting it) and close your lips tightly. As you begin to inhale through your mouth, press down on the base of the can to release a dose of Tailed Mint; At the same time, continue to breathe calmly and deeply.
Hold your breath and remove the inhaler from your mouth. Continue to hold your breath as much as possible.
The plastic body of the inhaler should be washed and thoroughly dried at least once every three days.
After inhalation, always close the mouthpiece with a dust cap.
Care instructions
To prevent powder particles from blocking the mouthpiece opening, keep the plastic body of the inhaler clean. At least once every 3 days, it must be washed and left to dry overnight. Cleaning the plastic case is carried out as follows:
1. Remove the plastic dust cap and remove the metal can from the plastic device.
2. Rinse the plastic device thoroughly under hot running water (+45°C) for 1 minute.
3. Turn the plastic device over and rinse it from the other end under hot running water for 1 minute.
4. Shake any remaining moisture out of the plastic device by tapping it on a hard surface.
5. Leave the plastic device to dry overnight. If the package contains two devices, use them alternately to keep them clean and dry.
6. Insert the metal can into the plastic casing, making sure it is completely dry and the rubber ring is firmly seated on the metal can.
If the spray outlet from the inhaler is blocked, remove the dust cap, take out the metal can (see step 1) and place the plastic case in hot water for 20 minutes. Then follow the steps described above in steps 2-6.
Before using the inhaler, you should always make sure that the plastic casing is completely dry. Under no circumstances try to clean the inhaler outlet with a needle or sharp object, as this will damage the inhaler. Do not place the metal can into water or remove the rubber ring from it.
Side effect
From the outside respiratory system: irritation and possible infection of the upper respiratory tract, irritation of the pharynx, pharyngitis, dry mouth, hoarseness, cough, short-term bronchospasm, rhinitis.
From the side of the central nervous system: headaches and dizziness.
From the outside digestive system: unpleasant taste in the mouth, nausea, vomiting, pain in the epigastric region.
Contraindications
— I trimester of pregnancy;
- hypersensitivity to any of the components of the drug.
The drug should not be prescribed to children under 2 years of age.
Pregnancy and lactation
The drug can be prescribed to pregnant women only if absolutely necessary in the second and third trimesters of pregnancy.
Nedocromil passes into breast milk in small quantities, so it is recommended to stop breastfeeding if it is necessary to prescribe the drug.
Nedocromil can be prescribed by a doctor only when the expected benefit for the pregnant woman exceeds possible risk for the fetus.
Application for children
Contraindicated in children under 2 years of age.
special instructions
It is very important that patients who benefit from Tailed Mint use it regularly, daily, even if they have no symptoms. Patients should also be advised that because multiple doses may be required to achieve beneficial effects, relief may not be immediate and that it may take several weeks to achieve benefits.
As with any inhalation therapy, immediately after inhalation, bronchospasm may unexpectedly develop. This condition requires immediate treatment with a short-acting inhaled bronchodilator and immediate medical attention should be sought. Tailed Mint therapy should be discontinued immediately and alternative treatment initiated.
In case of recurring bronchospasm, a bronchodilator is first inhaled, and the cough is calmed by drinking water immediately after inhalation.
If there is a need to discontinue the drug, it should be done gradually over one week, but asthma symptoms may return.
The drug is not intended for the relief of acute attacks of bronchial asthma.
Protect from direct sunlight. Do not refrigerate or freeze.
Overdose
Tailed Mint has low toxicity, so the risk of overdose and the development of any toxic phenomena is small. No cases of overdose were identified.
Drug interactions
Conditions for dispensing from pharmacies
The drug is available with a prescription.
Storage conditions and periods
List B. At a temperature not exceeding 30° C. Keep out of the reach of children. Shelf life - 2 years.
Drug interactions
No interactions have been identified with Tailed Mint.
Tailed Mint can be used with many medicines, including beta-agonists, glucocorticosteroids, theophylline and other methylxanthines, ipratropium bromide.
When concomitantly treated with bronchodilators, they must be taken before inhalation of Tailed Mint.
RUBELLA BEAUTY S.p.A SANOFI-AVENTIS Aventis Pharma Holmes Chapel Aventis Pharma Holmes Chapel/ Aventis Pharma Ltd. Rhone-Poulenc RohrerCountry of origin
United KingdomProduct group
Respiratory systemAntiallergic agent
Release forms
- 112 doses - aluminum aerosol cans with a dosing device (1) - cardboard packs (complete with synchronizer). 112 doses - aluminum aerosol cans with dosing device (1) - packs of ka
Description of the dosage form
- Aerosol for inhalation dosed
pharmachologic effect
Antiallergic agent. Mast cell membrane stabilizer. Inhibits the release of histamine, leukotrienes and other biologically active substances from mast cells, alveolar macrophages, eosinophils and other cells involved in the inflammatory response of the bronchi. When applied locally at the level of the bronchial tree, it has a specific anti-inflammatory effect. Does not have bronchodilator or antihistamine activity. Long-term continuous use of nedocromil reduces bronchial hyperreactivity, intensity and frequency of asthma attacks.Pharmacokinetics
After inhalation, 10 to 18% of nedocromil sodium is deposited on the walls of the bronchial tree. Systemic absorption is 5%. Absorption from the gastrointestinal tract is 2-3%. Plasma protein binding is 89% and is reversible. Not metabolized. It is excreted unchanged by the kidneys - about 70% and through the intestines - about 30%.Special conditions
Not intended for relief of bronchospasm, especially in status asthmaticus. Safety of use in children under 12 years of age has not been established.Compound
- nedocromil sodium 2 mg Excipients: povidone K30, levomenthol, macrogol (polyethylene glycol) 600, propellant HFA-227.
Tailed Mint indications for use
- Maintenance therapy of respiratory tract diseases with the presence of reversible obstruction (bronchial asthma of various origins; asthmatic bronchitis; bronchospastic reactions caused, among other things, by cold air, inhaled allergens, atmospheric pollution). Allergic rhinitis and conjunctivitis.
Tailed Mint contraindications
- Hypersensitivity to nedocromil, childhood up to 12 years (for aerosol without synchronizer).
