Sirdalud is an effective drug for pain and spasms in the back and muscles. Sirdalud: instructions for use (tablets and capsules) Tablets at night for relaxation sirdalud instructions

Sirdalud is a centrally acting muscle relaxant drug produced in Switzerland by the pharmaceutical company Novartis Pharma AG. The therapeutic effect is provided by the skeletal muscle relaxant tizanidine, which has a moderate analgesic property and is effective in combating acute and chronic spastic conditions provoked by injuries of the spinal cord or brain.

Sirdalud has contraindications and side effects. To avoid negative manifestations during the use of the drug, the patient should read the instructions for use attached to it.

Components of the drug

Sirdalud is available in the form of white flat pills with bevels and risks. Tablets are packaged in 10 pieces in plates with separate cells. Each cardboard pack contains 3 plates with the product and a medical annotation on its use.

The active ingredient in Sirdalud is tizanidine. In the medicine, it is presented in the form of hydrochloride. The mass content of the active substance in one tablet can be 0.002 g or 0.004 g. In addition to tizanidine, the composition medication stearic acid, lactose monohydrate, microcrystalline cellulose and colloidal silicon dioxide are included as additional ingredients.

What can Sirdalud be prescribed for?

The mechanism of action of Sirdalud is due to its effect on the spinal cord. The agent supports presynaptic alpha2-adrenergic receptors and blocks the release of amino acids that excite sensitive to N-methyl-D-aspartate nerve endings. As a result of such an impact, the polysynaptic transmission of excitation is suppressed in the spinal cord, leading to a decrease in muscle tone and intensity. pain syndrome and improve blood circulation.

The medical annotation lists the indications for the use of Sirdalud. The tool is recommended for use when:

• cerebral palsy, multiple sclerosis, myelopathy spinal cord and other diseases of neurological origin, accompanied by spasm of skeletal muscles;
• discomfort in the muscles that occur against the background of static and functional pathologies of the spine (with osteochondrosis of the cervical or lumbar);
• the need to relieve pain in the postoperative period (with surgical interventions during hernia treatment intervertebral department, arthrosis, etc.).

Requirements for the use of the drug

The dosage and duration of use of the drug Sirdalud should be determined by a specialist, taking into account the diagnosis and the individual characteristics of the patient's body. The medicine should be taken regardless of food, drinking the necessary amount of water or tea.

For back pain and other diseases accompanied by muscle spasm, treatment with Sirdalud should be started with minimal doses, taking pills at regular intervals. Through this approach, the patient will be able to minimize the likelihood of adverse reactions from the drug. In the absence of a therapeutic effect, a single dose is gradually increased until the drug begins to help. In this case, the doctor must ensure that the dosage of the drug does not exceed the maximum allowable.

Some patients are interested in whether it is permissible to drink with a hernia of the spine Sirdalud or should it be taken only after it surgical removal. Specialists often prescribe the drug in question for the relief of pain caused by a hernia of the lumbar spine, but it should be used for this pathology for a short time.

The abrupt cancellation of Sirdalud after its prolonged use can provoke an increase in the patient's heart rate and increase blood pressure. To prevent this from happening, it is recommended to reduce the dosage of the drug gradually.

Contraindications

Sirdalud tablets can not be prescribed to all groups of patients. From the use of the drug should refrain from persons who have:

• hypersensitivity to its main or auxiliary components;
• severe hepatic pathology;
• galactosemia;
• lactose deficiency;
• malabsorption of glucose-galactose.

The use of the drug during pregnancy is highly undesirable, since the experience of its use in this group of patients has not been sufficiently studied. Prescribe it to expectant mothers cervical osteochondrosis and other diseases is allowed only in a situation where the benefits of it significantly outweigh the potential harm to the child.

Lactation is an absolute contraindication to taking Sirdalud. If a nursing mother needs to use it, she needs to transfer the baby to artificial feeding for the entire duration of treatment.

Adverse reactions

The use of Sirdalud for joints or for back pain in the elderly is associated with a high likelihood of developing undesirable consequences from treatment. To avoid side effects of the drug on the body, it should be used by elderly patients under the constant supervision of a specialist.

Before starting treatment, the patient should be aware that Sirdalud may cause side effects from the side nervous system, gastrointestinal tract, heart, blood vessels, etc. The undesirable symptoms most often observed in patients during therapy include:

• drowsiness or insomnia;
• headache;
• dizziness;
• arterial hypotension (in severe cases - fainting and collapse);
• abdominal pain;
• diarrhea;
• nausea;
• dryness of the oral mucosa;
• feeling of weakness in the muscles;
• lethargy.

Sometimes people taking Sirdalud may experience bradycardia, hepatitis, hallucinations, clouding of consciousness, decreased visual acuity and vertigo.

In many patients, adverse reactions from the drug are mild and disappear after treatment is completed, but they should not be ignored. If undesirable symptoms occur, the patient should consult a doctor about the possibility of further continuation of therapy.

Overdose symptoms

An overdose of Sirdalud is manifested in the form of:

• dysfunction of the respiratory system;
• nausea;
• vomiting;
• arterial hypotension;
• constriction of the pupils;
• nervous breakdown.

Severe overdose can cause a coma in the patient. To stabilize the condition, the patient is prescribed sorbents, forced diuresis and symptomatic therapy.

Combination with drugs and influence on driving

Sirdalud is not prescribed to people taking ciprofloxacin, fluvoxamine or other drugs of the cytochrome P450 inhibitor group. The simultaneous use of these drugs leads to an increase in the content of tizanidine in the blood and can provoke overdose symptoms in a person.

The combination of Sirdalud with norfloxacin, mexiletine, pefloxacin, propafenone, amiodarone, enoxacin, cimetidine, ticlopidine and oral contraceptives is undesirable. Parallel treatment with the listed drugs should be carried out only when absolutely necessary and under the supervision of a physician.

The compatibility of Sirdalud and alcohol can lead to sad consequences, provoking a sharp decrease in pressure in a person and slowing down the speed of mental reactions. To prevent this from happening, the patient needs to stop drinking alcohol for the entire duration of the medication.

Persons who experience drowsiness, dizziness or decreased visual acuity during treatment with Sirdalud should refrain from driving or performing potentially hazardous activities until the end of therapy.

Cost and storage requirements

Sirdalud can be purchased at a pharmacy with a medical prescription. The price of one pack of tablets with a dosage of the active ingredient of 0.002 g is an average of 190 rubles. The cost of Sirdalud with a tizanidine concentration of 0.004 g reaches 280 rubles.

Sirdalud as a remedy for muscle and joint pain has received mixed reviews. Patients like its affordable cost and effectiveness, however, due to the development of drowsiness, muscle weakness and other adverse reactions, many people are forced to abandon its use in favor of other drugs.

Sirdalud must be protected from moisture and direct sunlight. It must be stored in its original packaging at an air temperature not exceeding 25°C. Subject to the necessary storage requirements, the shelf life of the tablets is 5 years.

Contemporary pharmacological agent from the subgroup of muscle relaxants of central action - tablets "Sirdalud". What do they help? The drug has proven itself in the complex treatment of muscle spasms various etiologies. The medicine "Sirdalud" instructions for use recommends taking with muscle hypertonicity, with myelopathy, cerebral palsy.

The main composition and form of release

In the pharmacy chain, the drug is presented in cardboard packages, with blisters of 10 tablets placed inside each. There may be 3 blisters in the package.

In direct dependence on the form of release, Sirdalud tablets, from which they help with spasms of muscle structures, may contain 2 mg or 4 mg of the active substance Tizanidine. It is he who has a muscle relaxant effect.

Of the auxiliary components, lactose monohydrate and MCC, stearic acid and anhydrous colloidal silicon dioxide are listed. Their main task is to maintain and enhance the healing properties of the active substance.

Pharmacological effects

They are based on the main active component of the drug "Sirdalud" - Tizanidine. More precisely, its ability to influence certain receptors, which results in the suppression of the activity of neurons in the structures of the spinal cord responsible for muscle tone. Against this background, the required muscle relaxant effect is formed, which makes it possible to eliminate pathological muscle blocks causing intense pain.

The drug has proven itself to be an effective assistant for chronic spasms of spinal and cerebral origin. When taken in therapeutic doses, clonic convulsions and pathological spasticity are markedly reduced. This has a beneficial effect on the volume of active movements - they increase significantly, and the resistance to passive movements also decreases.

Tablets "Sirdalud": what helps the medicine and when it is prescribed

The manufacturer in the instructions indicates that the drug "Sirdalud" helps with the following conditions:

• muscle hypertonicity caused by pathologies of the spinal column, for example, degenerative modifications in its lumbar, cervical sections;
• pathological muscle foci after surgery;
• significantly pronounced spasticity of muscle groups during the formation of various pathologies of the nervous system - the chronic course of myelopathy, or multiple sclerosis, as well as cerebral palsy, or degenerative lesions of the structures of the spinal cord.

Only a specialist should determine the need for taking the medication.

Absolute and relative contraindications

Like everyone pharmaceutical agent, the drug has a number of contraindications. The drug "Sirdalud" instructions for use (price, reviews, analogues will also be presented in the article) prohibits taking with:

• decompensated states of renal structures;
• children's category of patients up to 16 - 18 years;
• combination therapy with ciprofoloxacin or fluvoxamine;
• individual hypersensitivity to the components of the drug;
• of relative contraindications are listed - moderate disturbances in the activity of liver structures, as well as renal elements, as well as elderly age patients.

If the above absolute or relative contraindications are identified, the specialist will select other drugs with a similar mechanism of therapeutic effect.

Medicine "Sirdalud": instructions for use

According to the annotation attached to the package, the medication is taken orally. The dose is determined by the attending physician based on the individual characteristics of the patient's body and his age. In order to minimize the risk of side effects, it is recommended to start with 1 tablet or 1/2 tablet three times a day. In severe cases of muscle spasm, it is possible to additionally take an additional tablet of the drug "Sirdalud" before a night's rest.

If spasticity of the skeletal muscles is due to any neurological pathologies, the starting dose should be 6 mg / day, in three divided doses. Increasing the dose is carried out gradually, no more than 2 mg at a time, with an interval of 4-7 days. The desired therapeutic effect will be observed at a dose of 12-24 mg / day for 3 doses. The maximum dose of the drug for knocking should not exceed 36 mg.

People aged 65–75 years should start the treatment course with the minimum starting dose of a muscle relaxant, with a gradual increase in doses to the given parameters - to achieve the desired therapeutic effect while minimizing side effects.

With existing failures in the activity of the kidneys, the treatment course should begin with 1 pc. per day. The dose is then gradually increased - taking into account the effectiveness, as well as the tolerability of the medication.

Capsules "Sirdalud" contain 6 mg of Tizaniside, so the starting dose of the drug is 1 pc. per day. It can increase with an interval of 3 - 7 days. For most people, the optimal dose is 2 pcs. in a day. Rarely do you need to increase the dose to 4 pcs. per day.

Parenteral administration of the drug should be prescribed only by the treating specialist individually.

Possible side effects

Most people therapy with the drug "Sirdalud" is well tolerated. Rarely, people experience the following negative effects:

• previously uncharacteristic dizziness;
• tendency to increased drowsiness;
• dry mouth tissues;
• dyspeptic disorders;
• myalgia;
• excessive fatigue.

In addition, among the side effects of the drug, there may be insomnia, a decrease in pressure parameters, as well as an increase in the activity of hepatic transaminases.

Analogues of the drug "Sirdalud"

According to the structure and composition, analogues are distinguished:

1. "tizanidine hydrochloride".
2. "Tizanil".
3. Sirdalud MR.
4. "Thezalud".

Patients often ask: "Mydocalm" or "Sirdalud" - which is better? Doctors say that the analogs are similar in action, have the same side reactions. However, the drug "Mydocalm" has been studied better and has a wider range of applications. "Sirdalud" is a medicine of a new generation, according to indications, it is enough to take it 1-2 times a day.

Price

Tablets "Sirdalud" in Moscow can be bought for 220 rubles. The price in Minsk reaches 7-31 Bel. rubles. In Kyiv, the product costs 214 hryvnia, in Kazakhstan - 1200 tenge. The recipe in Latin looks like - Rp .: Tab. Sirdalud 0.002 (0.004).

• Latin name: Sirdalud
• ATX code: M03BX02
• Active substance: Tizanidine hydrochloride
• Manufacturer: NOVARTIS Saglik Gida ve Tarim Urunlery Sanayi ve Ticaret, A.S., Türkiye

Compound

Depending on the form of release, 1 tablet of Sirdalud contains 4 mg or 2 mg tizanidine . Also, the composition contains excipients:

• MCC ;
• lactose monohydrate ;
• stearic acid ;
• silicon dioxide anhydrous colloidal .

Release form

The package contains 30 tablets of 2 and 4 mg, the blister itself contains 10 tablets, and the package contains 3 blisters.

2 mg tablets: white, flat, round, line on one side, code "OZ" on the other.

4 mg tablets: white, flat, round, on one side the inscription "RL", on the other - crossed lines.

pharmachologic effect

It is a centrally acting muscle relaxant.

Pharmacodynamics and pharmacokinetics

Tizanidine is a skeletal muscle relaxant and its main site of action is the spinal cord. This drug reduces increased skeletal muscle tone, relieves spasm, increases the strength of voluntary contractions. Sirdalud is effective for chronic spasticity cerebral And spinal genesis and at acute muscle spasm. In addition, it also provides light analgesic effect.

Tizanidine is absorbed fairly quickly and virtually completely. The highest level of drug concentration in plasma can be observed about an hour after taking it. The substance is excreted by the kidneys.

Indications for use Sirdalud

What are Sirdalud tablets for? Indications for use are as follows:

• muscle spasm , which is associated with diseases of the spine (these include lumbar And cervical syndromes ), or which appeared after the intervention of the surgeon;
• spasticity of the skeletal muscles when manifesting neurological diseases (multiple sclerosis , chronic , cerebral palsy , degenerative diseases of the spinal cord ).

Contraindications

This medicine has a number of known contraindications:

• individual intolerance to the component present in the preparation;
• significant violations of the liver;
• children and adolescents under 18 years of age.

With extreme caution, it is necessary to take the drug to patients whose age over 65 years old as well as patients with kidney dysfunction.

Side effects

Side effects of Sirdalud include:

• , sleep disorders , ;
• bradycardia , ;
• indigestion , nausea , dry mouth ;
• fatigue , ;
• increased activity hepatic transaminases .

As a result of abrupt discontinuation of Sirdalud after a long period of treatment may develop , an increase in pressure, which can lead to a violation of the blood circulation of the brain, so that the dose of the drug should be reduced gradually, up to its complete abolition.

As a result of clinical studies, the following adverse events were identified, the frequency of which was not revealed:

• confusion , , vertigo ;
• blurred vision ;
• liver failure , hepatitis ;
• withdrawal syndrome , asthenia .

Instructions for use Sirdalud (Method and dosage)

The medicine is taken orally, the dose is determined based on the individual characteristics of the human body. To minimize the risk of side effects, you should start with a dose of 1 tablet (2 mg) or half a tablet (4 mg) 3 times a day.

At severe muscle spasm tablets of 2 mg or 4 mg are prescribed 3 times a day. In especially severe cases, you can take an additional dose of 2 mg or 4 mg at bedtime.

When manifested skeletal muscle spasticity , which can be caused by neurological diseases, the initial dose is 6 mg per day, taken in 3 divided doses. It is necessary to increase the dose gradually, by 2-4 mg, an interval of 3 to 7 days. The optimal effect is achieved when taking 12-24 mg per day 3-4 times a day. Do not take a dose higher than 36 mg per day.

Patients with impaired renal function it is necessary to start the course of treatment with a dose of 2 mg per day at a time. The dose is increased gradually, in small steps, taking into account the effectiveness and tolerability of the drug.

Instructions for use of the drug Sirdalud MR

The drug is a capsule containing 6 mg. The initial dose of Sirdalud is 1 capsule per day. Gradually, the dose can be increased by 6 mg at intervals of 3 to 7 days. For most patients, the optimal dose is 12 mg per day. In rare cases, the dose can be increased to 24 mg (4 capsules) per day.

Injections of this drug can only be prescribed by a doctor.

Overdose

An overdose of Sirdalud Tinazidin can be expressed as follows:

• decline blood pressure ;
• vomit , nausea ;
• drowsiness , dizziness , anxiety , miosis ;
• , respiratory failure .

Treatment: repeated taking and forced diuresis accelerate the elimination of the drug from the body. After removal, carry out symptomatic treatment.

Interaction

Concomitant use of the drug with inhibitors of cytochrome CYP1A2 leads to an increase in plasma levels of tizanidine, which in turn leads to symptoms of overdose. Simultaneous consumption of Sirdalud with CYP1A2 inducers leads to a decrease in the level of tizanidine, which causes a decrease medicinal properties drug.

The use of Sirdalud together with , . The result of simultaneous use can be a significant decrease in blood pressure, which is accompanied by dizziness and drowsiness, in some cases - loss of consciousness.

It is not recommended to take the medicine with antiarrhythmic drugs(such as , mexiletin , amiodarone ), some fluoroquinolones ( , enoxacin , perfloxacin ), cimetidine , ticlopidine , , rofecoxib .

Sirdalud should be taken with caution with those drugs that prolong the QT interval ( , and etc.).

The use of Sirdalurd together with reduces the content of tizanidine in plasma and, accordingly, reduces the therapeutic effect of the drug.

Treatment with the drug in men who smoke may require an increase in dose. Alcohol intake should be avoided, as the drug may increase the negative effect of alcohol on the central nervous system. The sedative effect of Sirdalud can be enhanced by hypnotics, sedatives and antihistamines.

Terms of sale

The medicine is dispensed by prescription.

Storage conditions

Store at a temperature not exceeding 25 ° C, out of the reach of children.

Best before date

The shelf life is 3 years.

special instructions

The drug is not recommended for patients with galactose intolerance as well as those suffering from severe insufficiency lactase or glucose /galactose malabsorption due to the presence of lactose.

Since one of the side effects of the drug is drowsiness , it is highly recommended to refrain from driving a car or performing work related to mechanisms or machines.

Sirdalud's analogs

The analogue of Sirdalud in terms of release form and composition is. Also in composition, Mydocalm is an analogue, which is available both in film-coated tablets and in the form of a solution for injection.

Price for analogues of Sirdalud: Tizalud costs from 55 to 72 UAH; depending on the form of release - from 67 to 98 UAH.

Mydocalm or Sirdalud: which is better?

Sirdalud is more modern drug having dosage form, allowing you to take it once a day, while Mydocalm is more studied by doctors, has wider indications for use. The side effects of both drugs are similar.

Reviews for Sirdalud

Patients leave feedback on Sirdalurd tablets different ages. The average rating on the forums for this drug is 3.9 points out of 5. Many patients report the occurrence of side effects such as drowsiness and fatigue. There are also reports of the effect of the drug on the liver.

Reviews of doctors about Sirdalud: the drug is used for symptomatic treatment, it allows you to reduce spasms of the muscles of the skeleton. With a strong manifestation of side effects or the absence of a result for 3 days of taking the medicine, you should contact your doctor in order to adjust the treatment regimen.

Sirdalud price

The price for tablets of 2 mg is on average 80 UAH, the price of 4 mg is 120 UAH.

The cost in Russia of such tablets is 220 rubles, respectively. and 360 rubles.

• Internet pharmacies in Russia Russia
• Internet pharmacies of Ukraine Ukraine
• Internet pharmacies in Kazakhstan Kazakhstan

ZdravCity

Sirdalud tab. 2mg n30 Novartis Urunleri

Sirdalud mr caps. with mod. release 6mg n30Novartis Saglik Gida ve Tarim Yuryunleri Sanayi ve Ticaret A.S.

In the article, we will consider what the Sirdalud tablets are from.

The drug can affect the tone of the skeletal muscles, showing a moderate analgesic effect. This drug belongs to the group of muscle relaxants. Its active component is the well-known substance tizanidine in pharmacology.

About the drug

Not everyone knows what Sirdalud tablets help from. This medicine affects the skeletal muscles, against the background of its use, a moderate analgesic effect is manifested. The scope of this remedy is the presence in the body of a spastic disorder of cerebral and spinal origin. Failure can be expressed in chronic and acute form.

The drug "Sirdalud" reduces the manifestation of spasms and clonic convulsions. The active substance in the framework of oral administration is absorbed fairly quickly and almost completely. Its maximum concentration in plasma is observed, as a rule, within an hour after the use of the drug. The drug is excreted along with the urine. Eating at the same time as pills does not affect the pharmacokinetic process and absorption. Now let's talk more about pharmacological properties of the presented medical device, and also consider the indications of "Sirdalud" below.

Pharmacological effect of the drug

The substance tizanidine is primarily a muscle relaxant of the central effect. The base point of application of its influence is located directly in the spinal cord. This drug stimulates presynaptic receptors by inhibiting the release of the excitatory amino acid that stimulates methyl and aspartate. As a result of this effect, the polysynaptic transmission of excitation at the level of spinal cord neurons is suppressed in the body. Since it is this mechanism that is responsible for excessive muscle tone, it decreases against the background of its suppression. In addition to the muscle relaxant property, tizanidine may additionally also have a moderate analgesic central effect.

It should be noted that the drug "Sirdalud" is very effective in acute painful muscle spasms, exactly as in chronic spasticity of cerebral and spinal origin. This drug reduces the manifestation of clonic convulsions, as a result of which the resistance to passive movement decreases and the volume of active actions increases. The muscle relaxant effect, along with the side reactions of the drug, directly depend on the concentration of the drug in the patient's blood plasma. Next, find out for what purposes doctors usually prescribe this medication to their patients.

What are the tablets "Sirdalud" from?

Let's take a closer look at this issue. Indications for its use are:

• The patient has spasticity of the skeletal muscles due to a neurological disorder. It can be cerebral palsy along with degenerative pathologies of the spinal cord, multiple sclerosis, problematic cerebral circulation, myelopathy and so on. Indications for the use of tablets "Sirdalud" must be strictly observed.
• The occurrence of functional diseases of the spinal column.
• As part of postoperative period for recovery after surgery, for example, after surgery to eliminate the intervertebral hernia.

Indications for the use of the drug "Sirdalud" are described in the instructions.

Nuances of use in neurological diseases

The drug is allowed to be used in conditions of excessive excitability of the nervous system in order to eliminate spasms with convulsions and convulsions of the limbs. The drug can also be used to combat the appearance of nervous cough and spasms of the diaphragm. The transmission of excitation through nerve cells is blocked at the level of the nervous system, which occurs due to the intermediate spinal neurons. The effect in this case comes quickly enough. Pathologies of spinal and cerebral genesis in various forms of their manifestation are also amenable to treatment with this medication.

It is worth noting that this drug has a high bioavailability. For example, the maximum concentration in the human body occurs, as a rule, thirty minutes after using the tablet. The drug is excreted from the body by the kidneys within one day, so it is used with great care in the presence of nephrological diseases.

It is necessary to pay attention to the fact that it is strictly forbidden to use this medication in therapy with drugs that include a substance called fluvoxamine. When the patient needs a very fast effect from the application this tool, it is best to use not the form of tablets, but a suspension intended for intramuscular and intravenous administration.

Why "Sirdalud" is prescribed, you can check with the doctor.

What is the rationale for using the drug?

The main active ingredient of these tablets, as already reported, is tizanidine. This active ingredient contributes to the process of muscle relaxation of the spinal cord, without any visible consequences for the human nervous system. It is thanks to this that it is possible to achieve relaxation of skeletal smooth muscles and eliminate convulsions with spasms.

How to take Sirdalud?

Instructions for using tablets

With spasms of skeletal muscles that have arisen due to neurological pathology, the dosage is selected depending on the patient's response to the drug, and, in addition, on the severity of general symptoms:

• It is worth emphasizing that the initial dosage of this medicine is three times 2 mg of Sirdalud.
• After a few days, you can increase the dosage and take 3 or even 6 milligrams.
• The optimal daily allowance is from 12 to 24 milligrams.
• Doses above 36 milligrams per day are fraught with the development of side effects in the patient.

It is also necessary to mention the dosage for elderly patients. Such for this category of persons is always adjusted. Such patients should be under the regular supervision of medical personnel. Often the dose is reduced because in elderly patients, renal clearance is slowed down (we are talking about the rate of renal excretion of various substances from the blood). Large amounts of the drug can cause the accumulation of metabolites in the blood along with the development of an overdose and the appearance of all sorts of adverse reactions.

There are also nuances for taking this medicine in case of kidney failure. Thus, with this ailment, the average rate of the drug is usually three times 2 mg of Sirdalud. Depending on the subsequent clinical picture and from the general tolerance of this or that patient of this drug, the dosage with the frequency of administration is adjusted.

Side effects

When using a therapeutically justified dose of Sirdalud according to the instructions for use, adverse reactions almost never develop in patients. Very rarely, nausea with indigestion can occur. Somewhat more often, hypotension is usually manifested in combination with drowsiness, weakness, dry mouth, and the like.

When prescribing an increased amount of the drug (to remove severe spasms), side effects can occur much more often, but this is not considered a reason to cancel the medicine. In such cases, side effects in the form of hypotension and bradycardia are often encountered, insomnia is less often recorded in combination with weakness and sleep disturbances. Very rarely, patients may have hepatitis.

Contraindications

This medication is strictly forbidden to take against the background of severe violations of the hepatic and renal functions. In addition, the presented medical device is not suitable for treatment in a number of the following situations:

• Against the background of an overreaction of the patient's body to tizanidine.
• With the combination of tizanidine with the drug "Fluvoxamine".

It is worth noting that some time ago, special animal studies were conducted that did not prove the presence of a teratogenic effect of this drug on the fetus. However, controlled studies on the effect of this drug have not been conducted in pregnant women. Thus, doctors still do not recommend prescribing this medication during the period of gestation. Among other things, it is necessary to take into account that the medication in question passes into breast milk, in this regard, this medicine is also not recommended for nursing women.

What else do Sirdalud tablets help with?

With osteochondrosis

Back pain is a factor in reducing the quality of life. As a rule, these occur in humans due to pathologies that develop in the spinal column. One of the main factors in the occurrence pain in this area is osteochondrosis. Against the background of this disease, people experience degenerative and dystrophic changes in the spine.

To eliminate pain in the presence of osteochondrosis, which are associated with an increase in muscle tone, the Sirdalud muscle relaxant is used in an amount of 2 or 4 milligrams several times a day. The mechanism of action of this drug may differ significantly from the pharmacological effects of other muscle relaxants. The drug is used when other drugs that lower muscle tone do not have the desired effect for patients. The great advantage of the drug in question lies primarily in the fact that when the muscle tone is reduced, it does not affect their strength.

children

As a rule, the appointment of the Sirdalud medical product for children is strictly not recommended. Clinical studies on the safety of using the drug in this age group, unfortunately, have not been conducted.

Preparations "Sirdalud" and "Mydocalm"

A medical preparation called Mydocalm appeared on the pharmaceutical market in Russia much earlier than Sirdalud. Both of these medications are analogues, but have completely different active ingredients. The impact of "Mydocalm" today is much better studied. It, like a muscle relaxant, has a wide range of applications. But the drug "Sirdalud" but in therapeutic doses causes much fewer adverse reactions in patients.

Should it be taken with alcohol?

The use of the presented medicinal product in combination with alcohol is highly undesirable for all patients. The fact is that alcohol enhances the sedative and hypnotic effects of Sirdalud.

Drug interaction

As for the interaction, once again it must be emphasized that this medicine should in no case be combined with the drug "Fluvoxamine". In addition, quite a lot of caution is required in the context of the combination of the drug in question with such agents as Mexiletin, Amiodarone, Propafenone, Pefloxacin, Norfloxacin, Enoxacin, Cimetidine, Ticlopidin, " Ciprofloxacin”, “Rofecoxib”, as well as with hormonal oral contraceptives. In combination with diuretics or antihypertensive drugs, this drug can cause bradycardia, increasing arterial hypotension.

Overdose

data overdose phenomenon medicine have already met repeatedly in clinical practice. Symptoms of an overdose in this case are respiratory failure along with vomiting, drowsiness, hypotension, anxiety, miosis, dizziness, and the like. In the treatment of overdose manifestations, forced diuresis is considered to be a particularly effective remedy.

Composition and format of release of the drug: tablets of 2 and 4 milligrams

Dosage "Sirdalud" 2mg and 4mg, in a blister, as a rule, contains thirty tablets. The active substance, as already mentioned, is a special component tizanidine. Additional substances are microcrystalline cellulose along with stearic acid, anhydrous lactose, colloidal silicon dioxide, and so on.

additional information

In clinical practice, cases of hepatic dysfunction that were directly related to the use of this drug have been repeatedly described. Therefore, during therapy, it is recommended to periodically monitor liver parameters without fail. In the event that during treatment, patients experience symptoms in the form of loss of appetite and causeless nausea, then the analysis of liver function indicators is carried out much more often. The fact is that such signs sometimes indicate a significant deterioration in liver function. When the patient begins to notice drowsiness while taking this medicine, it means that he should definitely refrain from driving vehicles.

Of course, it is indicated in the instructions for use, from which the Sirdalud tablets help. But there is no information about analogues and cost.

Analogues and price

This medication, like others, has its own analogues that can be used if a person cannot use this drug for some specific reason for treatment. So, the analogues of the agent under consideration include "Tizanidin" along with "Tizanil", "Tizalud" and so on. The cost of Sirdalud tablets for thirty pieces in a package is approximately five hundred rubles. Now let's look at the reviews of patients and find out what they think and write in their comments about the use of this medication as part of the treatment.

Sirdalud is an effective therapeutic agent that reduces spasmolytic phenomena and eliminates convulsions. Medicinal action of this drug is based on the main component present in its composition - on tizanidine. This substance is a centrally acting muscle relaxant that has a positive effect on the skeletal muscles, from which Sirdalud quickly eliminates spasms, as well as clonic convulsions. Also, this drug affects the presynaptic a2 - receptors of the spinal cord, thereby stimulating the inhibition of amino acid production. As a result of this, the suppression of spinal neurons at the intermediate level, the transmission of excitation in a polysynaptic way, is carried out. As a result, a person notes an improvement in well-being, the disappearance of pain, antispasmodic phenomena, etc.

When ingested, Sirdalud is rapidly absorbed. The maximum concentration of this drug in the blood is observed approximately 8 hours after it enters the human body. Due to the severity of metabolism, as well as passage through the liver, its bioavailability is 34%. According to laboratory research this drug is metabolized in the liver with a high percentage. It is excreted mainly through the kidneys. In the case of renal insufficiency, the highest concentration of this drug in the blood increases approximately several times, and the half-life increases to 14 hours.

What are Sirdalud tablets prescribed for?

1. This drug is prescribed for spasmolytic phenomena of skeletal muscles, which were caused by various neurological pathologies: multiple sclerosis, cerebral palsy, diseases of the spinal cord, cerebrovascular accident, etc.
2. Sirdalud is used in the treatment of painful muscle spasms of various origins.
3. This drug is used to eliminate pain and spasms in static and functional diseases of the spine, as well as to improve the patient's well-being in the postoperative period.

But, like any drug, Sirdalud has contraindications for use - a number of conditions in which you should not use this medicine, but give preference to another similar medication. Remember that this drug should not be taken:

• in severe diseases, as well as violations of the liver;
• in case of hypersensitivity to tizanidine or any other component of this medicinal product;
• when used simultaneously with strong inhibitors of cytochrome P450 1A2 (CYP1A2), such as ciprofloxacin or fluvoxamine.

Rules for admission and features of the use of Sirdalud

Methods of use and dosage of this drug depend on the type of disease, as well as the age of the patient and the individual characteristics of his body. For example, for spasms of skeletal muscles that were caused by a neurological pathology, the medical officer is assigned an individual dosage depending on the clinical picture. As a rule, at the beginning of treatment, Sirdalud is prescribed in a daily dosage not exceeding 6 mg. Doctors recommend dividing such a total dosage into several doses. On the 3rd or 7th day of treatment, doctors advise increasing the dosage by 2-4 mg. The most optimal daily therapeutic dosage of this drug varies from 12 to 24 mg. It is strongly not recommended to take this medication in a dosage exceeding 36 mg. in a day.

Sirdalud should be taken in accordance with the recommendations and instructions of your doctor, as the following adverse reactions may occur with improper treatment:

• weakness,
• drowsiness,
• dizziness,
• dry mouth,
• mild hypotension,
• gastrointestinal disorders: nausea, vomiting, etc.,
• sleep disorder,
• hallucinations,
• muscle weakness,
• acute hepatitis.

Interaction with other drugs

• According to the instructions, Sirdalud should not be drunk by people who also take CYP1 A2 inhibitors and fluvoxamine, since the combination of such substances can lead to dangerous consequences for human health.
• When using oral hormonal contraceptives and substances such as Ciprofloxacin, Cimetidine, Propafenone, Mexiletine, Amiodarone, care must be taken, as psychomotor decreases and dizziness are possible.
• The combination of Sirdalud with antihypertensive drugs or diuretics may be accompanied by arterial hypotension or bradycardia, so it is better not to combine this medication with the use of other medicines.

Sirdalud is a medical remedy that helps to eliminate spasms from skeletal muscles. Such antispasmodic conditions accompany diseases of large joints, as well as the spine, for which Sirdalud is used in the treatment of many diseases.