Allergy to pimafucin. Pimafucin: a comfortable pregnancy without thrush

The drug "Pimafucin" is presented in three forms:

• cream in aluminum tubes weighing 30 g;
• tablets in a plastic bottle in the amount of 20 tablets per 1 bottle;
• vaginal suppositories in a contour pack of 3 pcs. and in a cardboard box.

Compound

"Pimafucin" is a representative of the class of broad-spectrum antifungal drugs. The main active ingredient in this case is natamycin, which belongs to the group of macrolides. 100 g of cream contains 2 g of this component, one suppository - 100 mg and one tablet - 100 mg. In addition, all forms of Pimafucin include a whole list of excipients that ensure better absorption of the drug.

Indications

A drug in the form of suppositories intended for the treatment of various forms of vaginal candidiasis. Pimafucin cream is used for dermatomycosis, candidiasis of the mucous membranes and skin, as well as for external otitis media complicated by the presence of Candida fungi.

Pimafucin tablets are prescribed for various conditions caused by yeast-like fungi. This list includes candidiasis, intestinal candidiasis, otomycosis, fungal infections of the nails and skin.

pharmachologic effect

Both tablets, cream, and suppositories “Pimafucin” have a local effect. External preparations are not adsorbed deep into the skin, and tablets are practically not absorbed through the intestines.

The main active ingredient of the drug, natamycin, is an antifungal component with a wide spectrum of action. It is most active against fungi such as Candida. In addition, dermatophytes are sensitive to it. Penetrating inside the microorganism, natamycin damages its membrane tissue and causes the death of the fungus.

Terms of use

Pimafucin cream is used only as an external remedy. It is applied to all skin affected by the fungus and nearby areas. In most cases, I use the drug 2-4 times a day.

Suppositories "Pimafucin" are used as an intravaginal remedy. For various forms of vaginal and vulvar candidiasis, it is recommended to take one suppository per day. The course depends on the characteristics of the disease and ranges from 3 days to one week.

Pimafucin tablets are taken 1 tablet four times a day. The duration of the course depends on the specific pathology:

• vaginal candidiasis - from 10 to 20 days;
• candidiasis of the nail plate - up to 3 months;
• intestinal candidiasis - one week;
• extensive dermatomycosis - 60-90 days.

All dosage forms"Pimafucin" can be used in combination. This is especially true in the case of a chronic, often relapsing form of the disease. An integrated approach enhances the effect of the active substance and speeds up recovery.

Contraindications

A direct contraindication to Pimafucin is intolerance to its components.

special instructions

When using the drug in the vagina or genitals, a slight burning sensation may be felt, which is caused by the cetyl alcohol included in its composition.

When using candles, you do not need to avoid sexual intercourse. During menstrual bleeding, stop taking suppositories.

There is no evidence that natamycin has a teratogenic or other negative effect on the fetus. Therefore, the practice of treating pregnant women with Pimafucin is quite common. The same applies to women who are breastfeeding.

The drug is used in pediatrics, including for the treatment of newborns.

There is no information about the interaction of Pimafucin with other drugs.

Side effects

The most common adverse reaction to the use of Pimafucin cream or suppositories is a local allergy in the form of redness, itching and increased sensitivity of the skin.

Taking Pimafucin tablets in rare cases may be accompanied by mild nausea. It is usually observed at the beginning of therapy and then disappears.

Overdose

Since the active substance of the drug is almost not adsorbed, cases of overdose are unknown.

Proper storage conditions

The maximum shelf life of Pimafucin is 4 years. Store all forms of this drug in a dry place where the temperature does not exceed 25 degrees.

Candidiasis or thrush is a serious infectious disease caused by the Candida fungus. The disease occurs due to infection or weakened immunity after long-term use of antibiotics. To combat candidiasis, you need to strengthen your immune system and carry out comprehensive treatment. Only in this case will treatment of candidiasis give positive dynamics.

Pimafucin - a drug for the treatment of thrush

In 99 cases out of 100, treatment is carried out with antifungal drugs. In the treatment of this disease, pimaf ucin is used for thrush. This is one of the safe medicines. Its formula includes the antibiotic natamycin. It performs the function of an active substance. Its action affects the cell membranes of fungi.

Use of the drug

Thrush spreads to internal and external organs. Pimafucin for thrush is used for diseases:

• skin;
• genital organs;
• intestinal tract;
• middle ear infections;
• vaginitis, trichomoniasis and vulvitis;
• dermatomycosis.

The disease is quite serious and does not go away on its own, but requires treatment.

In patients with intestinal damage, the following is observed:

• lack of appetite;
• fatigue;
• loose, persistent stools that cause dehydration.

Thrush of the skin can cause candidal tonsillitis and damage to the mucous surface of the genital organs. In women, this manifests itself as vaginal candidiasis with unpleasant sensations: burning, itching and discharge. If you detect even one symptom, you should immediately contact a specialist. Advanced forms of thrush take a very long time to treat and can lead to serious health hazards. You should not self-medicate in such situations, it will only make the situation worse.

Thrush in women is accompanied by a number of unpleasant symptoms

Pharmacological release form

Cream, tablets and suppositories are the form in which pimafucin is produced.

The tablets are effective in treating the disease. They are prescribed for intestinal candidiasis. Treatment of other types of thrush occurs in combination with other forms of medications that can enhance the effect.

Suppositories are prescribed for vaginal thrush. If suppositories do not give the desired result in treatment, then tablets are prescribed. They enhance the effect of the antibiotic. How long it will be and the duration of the course depends on the patient’s condition.

But mostly the tablets are taken for 7-9 days. In advanced stages, longer treatment is necessary. Pimafucin has no contraindications, but can cause an allergic reaction.

It can be prescribed to children, pregnant women and the elderly. Pimafucin does not affect fetal development and is safe to use.

If an allergy occurs to pimafucin tablets or suppositories, stop taking the drug. The attending physician must select another to continue treatment. Pimafucin has analogues that also effectively fight thrush.

Pimafucin in the form of suppositories is prescribed for vaginal thrush

Treatment with candles

One of the methods of therapy is vaginal suppositories and . The duration of treatment is no more than 9 days. In order for the active substance to be distributed evenly, they must be administered in a horizontal position. One candle is designed for one day. If, after completing the course, the treatment did not improve or there are signs of a newly emerging disease, then the doctor prescribes ki tablets. The use of tablets will complete the course of treatment. They should be taken for 7 to 10 days.

Candidiasis can also appear on the outside of the genitals. Then it is advisable to use the cream as an addition to the prescribed therapy. The partner is also undergoing treatment. During this period, sexual relations are excluded. Vaginal suppositories should not be used during the menstrual cycle.

Pill therapy

The tablets are prescribed to patients who have the intestinal form of thrush. Lethargy, weakness, loss of appetite and loss of strength may be the first signs of the disease. Later, the person begins to complain of bloating, loose stools, nausea and abdominal pain. The cause of intestinal candidiasis can be damage to the kidneys, urinary system and genitals.

Candidiasis of the genital organs can serve as a factor for infection of the digestive tract, and vice versa. You can recover from this disease if you use suppositories and tablets at the same time. The duration of the course of treatment will be determined by the attending physician.

Pimafucin tablets are produced in a special coating and act only on the site of the disease.

The tablet form must be accompanied by instructions that specify all the indications and contraindications for use. How much the tablets cost, their scope of application and effect can be found on the websites of online pharmacies, at pharmacy kiosks and directly from the attending physician who prescribes the prescription.

Using the cream

The use of the cream is prescribed to people of different age category and gender. So, in men, the disease occurs with inflammation of the glans penis and burning sensation when urinating. The affected areas are treated with cream several times a day. But there are also cases of asymptomatic disease.

If a man suffers from candidiasis, he has a weakened immune system due to a sexually transmitted disease or a problem with urology.

Females are recommended to use the cream until complete recovery. Pimafucin is common among otolaryngologists. It is prescribed for middle ear disease. Cream is placed into the ear canal and covered with a cotton swab. This procedure is repeated four times a day. Instructions for using the cream are included with the medicine.

Pimafucin cream can be used by both men and women

Dosage

The drug is taken 4 times a day. I distribute the dose evenly throughout the day. The dosage does not depend in any way on the degree of the disease or general condition sick. The medicine is taken throughout the course. It cannot be interrupted when symptoms disappear. This may lead to a relapse, and then treatment will have to be started again.

For vaginal thrush, both partners are treated. Since in most cases the carrier of the fungus is male, but they themselves do not get sick. If a woman is treated alone, the disease will soon return. Suppositories are attributed to vaginal candidiasis.

For children, a dose of 1-2 tablets per day is provided. The use of tablets is contraindicated for infants. Because they still have difficulty swallowing.

On average, the course duration is about 7 days. The medicine gives an excellent effect if prescribed in combination with suppositories or cream.

After treatment, it is necessary to take all measures to prevent the recurrence of the disease. Therefore it is recommended:

1. Restore microflora with ecofemi-balance medicine. It is taken for 20 days, 1-2 capsules per day.
2. A balanced diet will also help ensure the success of your treatment. Salty, smoked, sweets and baked goods should be excluded from the menu. It is advisable not to drink alcohol, strong tea and coffee. You should refrain from all this during the course and for some time after it.
3. Women who have undergone treatment should wear cotton underwear and avoid thongs.

Ecofemin-balance will help restore microflora

Use of the drug

• not for use by girls under 16 years of age;
• It is forbidden to give to infants.

An overdose will not cause harm to health. For each release form: tablets, suppositories or cream, instructions are required. Regardless of how much candles or cream cost, you need to buy them only at the pharmacy, and in the original packaging. It is necessary to consult a doctor before starting to use the medicine.

Many women during pregnancy are faced with the problem of choosing medications. Medicines for expectant mothers must be safe and effective. One of these medications that doctors prescribe at all stages of pregnancy is Pimafucin. This is a local antibiotic with a broad spectrum of antifungal action. Most often, pregnant women encounter Pimafucin when vaginal candidiasis, or thrush, occurs.

Indications for use

Thrush in pregnant women

Before talking about Pimafucin, it is necessary to dwell in more detail on the disease for which it is often prescribed, namely, vaginal candidiasis. Thrush received this official name from the name of the fungi that cause it.

Change hormonal levels during pregnancy significantly weakens women's immunity. Previously harmless fungi of the genus Candida, which are normally present on the mucous membranes of the vagina in all women, begin to multiply rapidly, causing thrush.

With candidiasis, inflammatory processes affecting the vagina and external genitalia are accompanied by such unpleasant symptoms as:

• itching and burning;
• mucous or curdled discharge of white or yellowish color with a sour odor;
• discomfort during sexual intercourse.

If such symptoms occur, the expectant mother should consult a doctor. A simple vaginal smear will dispel fears and doubts. But even when positive results Doctors do not advise you to panic - in most cases, thrush does not pose a particular danger to the woman and the fetus.

However, if the disease is severe, the membrane of the embryo may become thinner, which in rare cases leads to its rupture. In addition, during passage through the birth canal, the child can become infected with candidiasis. Therefore, it is necessary to treat thrush.

Candidiasis, colpitis and other problems

In most cases, Pimafucin is prescribed to expectant mothers when signs of vaginal candidiasis are detected. However, the effectiveness of the drug is not limited only to thrush. Due to its wide spectrum of action and the presence of several dosage forms, Pimafucin is prescribed for diseases such as:

• colpitis;
• vaginitis;
• vulvitis;
• vulvovaginitis;
• candidiasis of the skin and nails;
• otitis media of fungal origin;
• intestinal candidiasis;
• skin infections.

The drug is approved at any stage of pregnancy, including the first trimester, when many medications are prohibited. In addition, Pimafucin does not interact with other drugs, so it can be taken together with medicines prescribed by the attending doctor.

Composition and action of the drug

Pimafucin is an antifungal drug whose active substance is an antibiotic from the macrolide group natamycin. This component increases the permeability of the cell membrane of fungal cells and disrupts its integrity, which ultimately causes the death of the fungus. Natamycin is effective against yeast and mold fungi of the genus Candida, Aspergillus, Fusarium and Penicillium. Dermatophytes are less sensitive to the active substance.

One of the advantages of this medicine is that during therapy, microorganisms do not become accustomed to the antibiotic.

The safety of the drug is due to the fact that it is not absorbed into the blood through the skin and mucous membranes, even when taken orally, acting locally on the affected areas. That is why Pimafucin can be used without fear during pregnancy and lactation.

The medicine is available in three dosage forms:

• pills,
• cream,
• vaginal suppositories.

Photo gallery: Pimafucin release forms

Pimafucin tablets are prescribed for intestinal candidiasis Pimafucin cream is used to treat vaginitis Pimafucin suppositories are the most commonly prescribed form of medication for pregnant women

Thus, the drug can be used both externally and internally. The choice of the appropriate form of medication, dosage, and duration of treatment depends on the severity of the disease and the severity of symptoms.

Instructions for safe use during all stages of pregnancy

Is the drug harmful for women and babies: contraindications and side effects

Despite the fact that the active ingredient of the drug is an antibiotic with a wide spectrum of action, Pimafucin has practically no contraindications, it is not harmful to the expectant mother and baby and is prescribed even for early dates pregnancy. The drug is prohibited only in case of individual intolerance to its components.

should not be excluded and undesirable consequences from taking the drug. Side effects include:

• burning and itching, irritation of mucous membranes (when using cream and suppositories);
• nausea and vomiting, dyspepsia (when taking pills).

Such conditions are short-lived and usually do not require stopping the medication. If the listed side effects do not disappear, and the pregnant woman’s condition worsens, it is necessary to seek help from a doctor.

Treatment with candles

If the fungal infection does not affect the organs gastrointestinal tract, doctors prefer local therapy. For thrush, treatment with vaginal suppositories is usually prescribed. Pimafucin suppositories are used once a day before bedtime. The duration of the course is set individually for each woman. Usually it lasts 3–6 days, but to avoid relapse, the doctor may consider it necessary to continue treatment for another three days.

The suppository is inserted into the vagina as deeply as possible in a lying position. It is best to do this before falling asleep, since to achieve a therapeutic effect you should not get up. The candle quickly melts, forming foam that evenly covers the vaginal mucosa. If a woman stands up during the procedure, the medicine will leak out.

Taking pills

In case of transition of candidiasis to chronic form or the presence of a focus of infection in the intestines, the doctor, in addition to suppositories, may prescribe a tablet form of Pimafucin to the woman. Comprehensive treatment is necessary to eliminate the possibility of re-infection with fungi that can enter the vagina from the intestines.

The duration of the therapeutic course is determined by the attending doctor. As a rule, it does not exceed two to three weeks and depends on the severity of the disease and the speed of elimination of negative symptoms.

Cream therapy

With inflammation of the external genitalia (vulvitis), as well as with infectious diseases apply Pimafucin cream to the skin, treating fungal-infected areas several times a day. The duration of the course is calculated individually.

In addition, Pimafucin cream is also prescribed to a woman’s sexual partner, who may also be a carrier of the fungus, to prevent recurrence of the infection. In this case, the cream should be applied to the head of the penis and the foreskin area.

What can replace

The effectiveness of Pimafucin is beyond doubt among experts. However, this drug does not always help relieve a pregnant woman from the unpleasant symptoms of thrush. If discharge and others unpleasant symptoms persist after a course of Pimafucin or expectant mother appeared allergic reactions on the medicine, it is replaced with another antifungal agent.

Table: analogues of Pimafucin based on clotrimazole and other antibiotics

Photo gallery: antifungal drugs for the treatment of thrush

Livarol should not be used in the first trimester of pregnancy Clotrimazole is the most affordable broad-spectrum antifungal agent. The active substance in the drug Candida is clotrimazole
Terzhinan is a broad-spectrum drug that has been successfully used to treat many gynecological diseases. Primafungin is a pharmacological analogue of Pimafucin based on natamycin.

The drug "Pimafucin" is available in the form vaginal suppositories, tablets and ointments. This is an antifungal agent with a broad spectrum of action. It is intended for the treatment of diseases of the female reproductive system that are caused by yeast-like fungi. In reviews of Pimafucin tablets for thrush, they are called the number one choice.

The drug demonstrates maximum effectiveness against candidiasis. Therefore, doctors begin therapy for thrush by prescribing this remedy. The principle of action of the medicine is to use pronounced fungicidal properties. Its active substance disrupts the integrity of pathogenic membranes and destroys microorganisms. Maximum resistance to Pimafucin suppositories, reviews and instructions confirm this, is shown by dermatophytes.

Purpose

Most often, the drug is prescribed for the treatment of skin and mucous membranes affected by fungal infections of various types. Its use is also justified in the treatment of candidiasis. The agent is practically not absorbed from the gastrointestinal tract, from the surface of the skin and mucous membranes. Brief list of indications:

• fungal infections of the nail plates;
• trichomoniasis;
• inflammation of the vulva;
• vaginitis;
• otomycosis;
• dermatological candidiasis.

Oral form

Reviews and instructions for use of Pimafucin tablets state that the product has shown excellent results in the treatment and prevention of colonization of the intestines by fungi of the Candida family. Their uncontrolled reproduction provokes long-term use of antibiotics, hormonal drugs containing corticosteroids, cytostatics.

The cost of a package of 20 enteric-coated tablets in pharmacies is approximately 600 rubles.

Soft dosage form

The cream is prescribed to patients suffering from candidiasis of skin and mucous tissues. And also in cases of damage by dermatophytes and other yeast-like fungi. Reviews of Pimafucin cream say that the average cost of the drug in Russian pharmacies is 360 rubles. The medicine is supplied in metal tubes. Cream weight - 30 g.

suppositories

The main indication for taking suppositories is infectious and fungal infection of the vulva. They are produced in two configuration options. One is designed for short-term treatment of thrush and involves a set of three suppositories packaged in a cardboard box. Its price is 300 rubles.

Reviews and instructions for using Pimafucin suppositories say that when treating advanced vulvitis and vaginitis of fungal origin, it is advisable to purchase a second set. It consists of six suppositories. The cost of the set is 520 rubles.

Choice of dosage

At inflammatory processes caused by yeast-like fungi in the vulva and vagina, one suppository is prescribed for six days. In some cases, the drug can be used for nine days. To insert a suppository into the vagina as deeply as possible, you need to take horizontal position and relax.

Reviews on the use of Pimafucin suppositories say that the standard prescription regimen is not always effective. In this case, treatment can be supplemented with an oral form. Take four tablets a day. The oral form is responsible for the sanitation of the inner surface of the intestine, which can also serve as a source of colonization of yeast-like fungi.

The duration of the therapeutic course is ten days. To enhance the effect of therapeutic measures, a mild form of the drug is prescribed. The instructions and reviews of the Pimafucin ointment state that it has proven its effectiveness in destroying fungal infections of the skin of the partner’s genitals. The cream is applied once or several times a day.

Balanoposthitis

As part of drug therapy for the disease, the use of ointments has become widespread. It is used to lubricate areas of the skin that have been colonized by fungi. The procedure is performed once a day. It is possible to increase the dosage. Instructions and reviews of “Pimafucin” in the form of cream prove high efficiency drug.

Intestinal tissue damage

Thrush of the excretory system is treated with an oral form of medication. Adults are recommended to take four tablets every day. The duration of treatment is seven days. For children, the dose is halved. They need to take two tablets. In reviews of Pimafucin, women give high marks to the results of treatment. They report the absence of side effects and good health during the therapeutic course.

Mycoses of the skin

For dermatological lesions, a mild form of the medicine is used. The ointment is applied to the affected area of ​​the skin once a day. If necessary, the number of procedures can be increased. Women's reviews of Pimafucin mention that this remedy has found application in pediatric practice. It is used to treat diaper rash in infants.

Otomycosis

Fungal infection of the ear organs is subject to treatment with natamycin, the main active ingredient of the mild form of Pimafucin. With open access to the affected areas, they are regularly lubricated with ointment. The instructions and reviews of Pimafucin recommend pre-cleaning auricle. A tampon is used to introduce the drug into the middle section. Its surface is generously lubricated with cream and carefully inserted into the ear canal.

The duration of therapy is determined individually. Treatment should not be stopped after the main symptoms disappear. Reviews of the use of Pimafucin say that the best results are achieved in cases where patients used the ointment for several days after the complete disappearance of the pathological manifestations of the underlying disease.

Use during pregnancy

The product is recommended by leading obstetricians and gynecologists for the treatment of thrush during pregnancy and breastfeeding. The dosage of the drug is indicated by the attending physician. Today, this medication is included in the group of first choice in the treatment of damage to the mucous membranes and skin by fungal infections in pregnant women and during lactation. Judging by the reviews, every second woman takes Pimafucin in the 1st trimester.

Side effects

Despite the good tolerance of the drug by patients, doctors recorded the following negative manifestations:

• burning in the vagina and on the skin;
• diarrhea;
• attacks of nausea.

All of the above side effects do not require special treatment and do not lead to discontinuation of the drug. They go away on their own a few days after the start of the therapeutic course.

Contraindications

The main obstacle to treatment may be individual intolerance to the active component. In this case we are talking about natamycin. Another contraindication, which is indicated in the instructions for use of Pimafucin tablets and in reviews, is porphyria.

Special cases

Uniform distribution of natamycin contained in suppositories over the inner surface of the vagina is ensured by foaming of the excipients under the influence of natural body temperature. In some cases, this drug may be included in the plan complex therapy dermatomycosis of various origins.

The burning and irritation of the vaginal mucosa that occurs during the use of suppositories occurs due to the amount added to the drug. Its proportion in the composition of the medicine is insignificant, but sensitive patients may feel tingling and dryness. This is stated in reviews of Pimafucin suppositories.

If the fungal infection recurs after a certain period of time after using suppositories, then the administration of an oral form of natamycin is recommended. During menstruation, suppositories are not used, as their effectiveness is minimal. During the therapeutic course, partners are recommended to use barrier contraception and undergo a thorough examination by specialized specialists.

Women who use suppositories do not need to give up their sex life. The safety of the active substance has been proven. Therefore, natamycin is prescribed for the treatment of newborns. In reviews of Pimafucin suppositories, young parents mention that pediatricians prescribed this drug to their children.

Storage rules

All forms of the drug must be stored in dry rooms. The recommended air temperature in the warehouse varies in the range of 15-25 °C. The shelf life of the oral and soft forms of the drug established by the manufacturer Temmler Italia S.r.L. is four years.

Suppositories should be used after twenty-four months. The instructions and reviews of the use of Pimafucin say that if the storage temperature is exceeded, the candles are destroyed. Suppositories foam. Their shape changes.

Composition of tablets

List of components:

• 100 mg natamycin;
• 80 mg potato starch;
• 5 mg PVP;
• 2.5 mg magnesium stearate;
• 66 mg lactose;
• 3 mg gelatin;
• 7 mg gum arabic;
• 30 mg calcium carbonate;
• 14 mg taolin;
• 21 mg talc;
• 18 mg phthalate;
• 122 mg sucrose.

Excipients:

• methyl p-hydroxybenzoate;
• triacetin;
• beeswax.

Composition of vaginal suppositories

Main components:

• 700 mg fat;
• 100 mg natamycin
• 460 mg sorbitol;
• 690 mg cetyl alcohol.

Excipients:

• polysorbate;
• sodium bicarbonate;
• adipic acid.

Soft form composition

Main components:

• 20 mg natamycin;
• 100 mg decyl oleate;
• 135 mg cetostearyl alcohol;
• 150 mg propylene glycol.

Excipients:

• wax;
• sodium lauryl sulfate.

Patient reviews

Reviews and instructions for use of Pimafucin indicate that the therapeutic course is generally not associated with the occurrence of side effects. The treatment is effective. Patients highlight the following benefits of using this drug:

• proven safety;
• almost complete absence of contraindications;
• availability;
• sale without a doctor's prescription;
• abundance of analogues;
• prompt disposal of thrush;
• Possibility of use during pregnancy and breastfeeding.

Analogues

Preparations that contain natamycin:

• "Primafungin";
• "Pimafukort".

"Primafungin"

Primafungin is produced by Avexima OJSC ( Russian Federation). Suppositories are packaged in a cardboard box of three pieces. The dosage of this drug completely coincides with the instructions listed in the instructions for use of Pimafucin. Customer reviews confirm this.

One suppository contains 100 mg of natamycin. The drug has virtually no systemic effect on the body. If a pronounced burning sensation occurs during use, you should stop using this product and seek additional advice from your doctor.

Primafungin is sold in pharmacies without a prescription. Its price is about 200 rubles. List of indications:

• inflammation of the vulva;
• vaginitis, regardless of etiology;
• damage to the skin and mucous membranes by fungi of the Candida family.
• The medication is approved for use during lactation and pregnancy.

"Pimafukort"

This drug is considered an analogue of Pimafucin. Reviews and instructions say that it also contains neomycin and hydrocortisone. These components provide comprehensive therapeutic effect. The drug is produced by the Italian pharmaceutical company Temmler Italia S.r.L.

According to the manufacturer's description, this product has a pronounced anti-inflammatory effect. It perfectly fights fungal infections of the skin and mucous membranes. Used externally. Packed in cardboard boxes. The metal tube contains 15 g of cream.

"Pimafucort" is not a complete analogue of "Pimafucin", the instructions for use, as mentioned in the reviews, are different. It states that the level of absorption of hydrocortisone through the skin without wound lesions is three percent. If the integrity of the epidermis is violated, this value doubles. If there is an infection on the skin, the absorption rate reaches 15%.

When using Pimafukort in the treatment of children, it must be taken into account that their susceptibility is higher than that of adults. The older the child, the lower the absorption rate. There are few side effects. In reviews of Pimafucin and Pimafucort, some patients with sensitive skin insist that they feel a pronounced burning sensation and dryness of the skin on which the ointment was applied. Local redness was noted. Sometimes women complained of itching.

If you note one of the above actions associated with taking Pimafucort, then we are talking about the manifestation of allergic reactions. In this case, the therapeutic course is canceled and the drug must be replaced. However, usually such symptoms subside on the third day of using the cream. Patients describe similar points in their reviews of Pimafucin.

With prolonged use of the cream, children are diagnosed with adrenal suppression syndrome. Such a reaction occurs rarely and only in those patients who applied occlusive dressings and applied the product to large areas of the skin.

Instructions for use

When using Pimafucort in the eyelid area, you need to remember the possibility of increasing intraocular pressure, which can lead to further development of cataracts. At therapeutic treatment open wound surfaces allow the risk of toxic effects. Reviews of Pimafucin, produced in soft form, indicate the safety of the drug for children.

"Pimafucort" can also be used in pediatrics, but under the supervision of a doctor. The list of indications includes all kinds of dermatoses, complications after fungal and bacterial infections. Contraindications include juvenile acne, anogenital itching, allergic reactions to the administration of allergic vaccines. You should not use the cream if you have ichthyosis, open wound surfaces, viral diseases epidermis.

Pimafucort is prescribed with caution to children under one year of age. And in the instructions, reviews of “Pimafucin” confirm this, there is no such restriction. The interaction of Pimafucort with other drugs has not been described. Cross-type hypersensitivity has been recorded when neomycin was used with paromomycin, kanamycin, aminoglycosides, and gentamicin.

Dosage

For adults and adolescents, the cream is applied twice a day. The course of treatment should not exceed fourteen days. Pimafucort ointment is the number one choice for the treatment of dermatoses. Occlusive dressings are contraindicated in young children. No cases of drug overdose were identified.

Doctors admit the possibility of toxic effects when applying cream to the surface of the middle ear if the integrity is damaged eardrum. In this case, Pimafucin is recommended. User reviews confirm the absence of side effects. To enhance the effect, other forms of the drug are used.

"Natamycin"

This drug is considered one of the most effective antibiotics aimed at combating fungal infections. Most often, this remedy is prescribed for the treatment of thrush. In pharmacies it is presented in suppositories, oral and soft forms. Like the Pimafucin tablets, reviews say this, Natamycin rarely causes side effects. It is almost non-toxic, therefore it is indicated for the treatment of pregnant women. The number of contraindications is minimal.

Instructions for use

The drug belongs to the group of tetraenes. Its main property is aimed at destroying fungal infections. Its spectrum of action includes almost all known pathogenic organisms of similar origin. Like the Pimafucin tablets, reviews of which are advisory in nature, Natamycin is prescribed by a doctor.

The main active ingredient is natamycin. It is obtained by production using an actinomycete. The drug breaks the membrane cells of the pathogenic flora of yeast and similar fungi, dermatomycetes and trichomonas. Gram-positive cells show resistance to this drug.

Natamycin is produced by Russian, European and Asian pharmaceutical companies. The antibiotic is sensitive to sunlight, so it is packaged in dark, opaque containers. The active substance natamycin does not dissolve in water. It is produced in the form of a powder that is yellowish or white in color. Dissolves in acetic acid, cooled to the lowest possible temperature, and in dimethylformamide.

If necessary, natamycin can be diluted with methyl alcohol. Like the Pimafucin tablets, the instructions and patient reviews confirm this; it does not have a systemic effect on the body. The substance is not absorbed from the gastrointestinal tract and from the surface of the skin. Natamycin is not prescribed to patients suffering from tuberculosis. Persons with individual intolerance to medicinal components should avoid using the medication.

Side effects of Natamycin

Doctors note the presence of adverse effects that may be associated with the use of the drug:

• diarrhea varying degrees expressiveness;
• vomit;
• nausea;
• burning;
• dryness.

There are no facts of overdose. Itravaginal suppositories are sold in pharmacies without a prescription. In other cases, pharmacists ask to present the attending physician's prescriptions. The cost of Natamycin, produced in the form of a cream, is 260 rubles. Candles are sold at a price of 250 rubles. The oral form will cost 470 rubles. It is prescribed not only to women, but also to men.

Treatment of thrush

modern medicine has a wide range of products intended for the treatment of fungal infections. In addition to analogues of Pimafucin, pharmacological companies offer drugs based on fluconazole:

• "Flucostat";
• "Fluconazole-Teva";
• "Fluconazole-OBL";
• "Fluconazole-Stada";
• "Diflucan";
• "Mikosist";
• "Diflazon".

This active ingredient is also contained in Vagisept and Safocid.

"Flucostat"

The capsules are produced by the Russian pharmaceutical company Pharmstandard. Minimum packaging - 1 piece. Packs of two and seven capsules are available for sale. The minimum cost is 200 rubles. For seven capsules they ask for 360 rubles. The main component of the drug is fluconazole. Its weight in Flucostat capsules is 50 mg. Excipients:

• sodium lauryl sulfate;
• lactose;
• refined corn starch;
• magnesium stearate;
• Aerosil;
• gelatin;
• food coloring;
• acetic acid;
• titanium dioxide.

Side effects of Flucostat

While taking the medication, patients may experience the following pathological conditions:

• headache in different locations;
• convulsions;
• dizziness;
• nausea;
• leukopenia;
• ventricular flutter;
• thrombocytopenia;
• agranulocytosis;
• skin rash;
• anaphylactic shock;
• alopecia;
• erythema;
• necrolysis;
• disruption of the urinary system.

Basic information about Flucostat

The drug is sold in pharmacies without a prescription. It is prescribed for the treatment of cryptococcosis and candidiasis. Also used to prevent bacterial infection in patients suffering from AIDS. The product has a lot of contraindications:

• renal failure;
• liver dysfunction;
• combined use with homeopathic medicines;
• alcohol addiction;
• organic diseases facilities;
• pathological changes electrolyte balance.

"Fluconazole"

This medicine is produced by many international and Russian pharmacological companies. The approximate price is 280 rubles. It contains 50 mg of fluconazole. The active substance is excreted in a volume of 80%. The drug is sold in pharmacies upon presentation of a prescription.

Indications:

• cryptococcal meningitis;
• mycoses of the epidermis;
• candidiasis of various origins.

Contraindications:

• children under 16 years of age;
• individual intolerance;
• lactation;
• taking cisapride;
• lactase deficiency;
• use of terfenadine;
• congenital cardiac disorders.

"Diflucan"

This medicine is produced by the world famous French company Pfizer. This is also an effective antifungal agent that is aimed at treating thrush. The main component is fluconazole. Packages may contain 12, 7 or 4 capsules.

"Mikosist"

The medicine is sold in cardboard packs. They contain 4 capsules. Manufacturer: Russian branch of the Gedeon Richter concern. Estimated cost - 730 rubles. The drug contains 150 mg of active substance. Dispensed with a doctor's prescription.

Indications:

• cryptoccosis;
• candidiasis;
• fungal infections.
• Contraindications:
• lactation;
• use of astemizole;
• lactose deficiency.

"Diflazon"

This prescription drug is produced by Vector-Pharm LLC, which is based in Slovenia. Available in glass bottles with a capacity of 100 ml. The recommended storage temperature is 20 °C. Effective antifungal drug intended for infusion. An aqueous solution of sodium chloride is used as excipients.

Side effects:

• headache;
• convulsions;
• neutropenia;
• cardiac dysfunction;
• swelling of the face;
• skin rash;
• necrolysis

"Vagisept"

The medication contains fluconazole and metronidazole. The medicine is produced in Russia by the Firn-M company. The drug is dispensed by prescription. The estimated cost is 350 rubles. A cardboard box contains ten vaginal suppositories.

"Safocide"

A package of 12 tablets of the drug is sold at a price of 1,681 rubles. Manufacturer - Nizhpharm JSC (Russia). There are Indian analogues. In addition to fluconazole, the medicine contains the antibiotic azithromycin and secnidazole.

Since Safocid is a set of individual tablets, the set of ingredients for each is different.

Indications:

• various infections of the genitourinary system;
• trichomoniasis;
• urethritis;
• cervicitis;
• gonorrhea;
• vaginosis of bacterial origin;
• cystitis;
• inflammation of the tissues of the vulva;
• vaginitis

Pimafucin is intended to relieve the symptoms of thrush and prevent relapses of the disease. The drug has a fast action. Relief occurs on the second day of treatment.

Pimafucin is available in the form of tablets, suppositories and cream. Drugs of different release forms can be combined in one therapeutic course.

The high degree of effectiveness of the drug is ensured by the substances included in its composition. The components not only eliminate the manifestation of thrush, but also have a detrimental effect on the causative agent of the infection.

The drug is safe and approved for use at any stage of pregnancy. In some cases, the medication is prescribed for complex treatment of both partners.

1. Instructions for use

A detailed scheme for using different forms of release of Pimafucin is described in the instructions. The duration of the course depends on the severity of thrush and the form of the disease. The manufacturer offers information about indications, contraindications, possible side effects and the nuances of combining the drug with drugs from other groups. Additionally, the instructions contain special instructions(you should pay attention to this point in the presence of serious pathologies or chronic diseases).

pharmachologic effect

Pimafucin is a strong antifungal agent from the group macrolide antibiotics polyene series. The active ingredient of the drug blocks sterols in the fungal cell membrane, which causes their death. The maximum sensitivity of the drug is manifested in relation to the species of fungi Candida spp, and the least - in relation to dermatophytes. At the moment, clinical practice has not revealed fungal resistance to natamycin.

Natamycin is not absorbed in the gastrointestinal tract and is not absorbed on the skin and mucous membranes. Various dosage forms of Pimafucin provide successful control of fungi in all affected areas.

The drug is one of the few medications that are not prohibited for use to combat thrush in pregnant and lactating women, since they do not have a negative effect on the fetus and breast milk.

Indications for use

Pimafucin is used in the presence of the following pathologies:

Mode of application

Depending on the form of release, Pimafucin is used as follows:

1. Tablets (take 1 piece 4 times a day):

• For nail candidiasis (together with cream) – for 2-3 months;
• For vulvovaginal candidiasis (together with vaginal suppositories for the purpose of sanitizing the candidomycosis lesion in the intestine) - for 10-20 days;
• In case of intestinal candidiasis (children: 1 tablet 2 times a day) – for a week;
• For onychomycosis (together with Pimafucin cream) - for 2-3 months.

2. Cream:

• For dermacomycosis (including lesions of the skin or nails), apply the cream to the affected area 1-4 times a day. The course of treatment lasts 2-3 weeks;
• When treating candidiasis lesions in a partner, the drug is applied to the anogenital area (for fungal diseases of the intestines along with taking Pimafucin tablets).

3. Suppositories used in the case of vulvovaginal candidiasis, 1 pc. inserting deeply into the vagina before bedtime 1 time per day (administer in a supine position). The course of treatment is determined individually (usually 3-6 days). Intravaginal administration continues for 2-3 days after the disappearance of external signs.

After administration, suppositories quickly melt at body temperature to form a voluminous foaming mass, which improves the distribution of the drug along the vaginal walls.

When treated with suppositories, it is not necessary to interrupt sexual activity. When critical days occur, the administration of the drug is suspended.

After the signs of candidiasis disappear, you should not immediately stop using Pimafucin, since the fungus may not be completely destroyed. The tablets are taken for at least 2-3 days. after signs of the disease disappear (burning, itching, presence of cheesy clots).

The most acceptable solution is to consult a doctor, who, after prescribing certain tests, will determine the advisability of continuing to take the drug or stopping it.

Release form, composition

Pimafucin, depending on the form of release, has the following composition:

1. Tablets – round, white, enteric-coated, placed in a dark glass bottle, which contain:

• The active ingredient is natamycin (100 mg);
• Auxiliary ingredients - magnesium stearate, polyvinylpyrrolidone, starch, lactose, talc, gelatin, gum arabic, kaolin, methyl parahydroxybenzoate, titanium dioxide, triacetin, beeswax, cellulose acetal, sugar.

2. White or light yellow cream in 30 g tubes, 1 g of which contains:

• Active ingredient – ​​natamycin (20 mg);
• Auxiliary ingredients: propylene glycol, diceloleate, cetostearic alcohol, sodium lauryl sulfate, propyl parahydroxybenzoate, cetyl ether.

3. Vaginal suppositories of an oblong shape, white or yellow, each of which contains:

• Active ingredient – ​​natamycin (100 mg);
• Auxiliary ingredients: cetyl alcohol, sorbitan trioleate, sodium bicarbonate, polysorbitol 80, adipic acid, solid fat.

Interaction with other drugs

At the moment, there are no facts of interaction of Pimafucin with other drugs.

2. Side effects

After using Pimafucin, some side effects may occur:

• Signs of allergy in the form of itching and burning, irritation in the genital area after administration of the suppository;
• Indigestion, diarrhea;

Overdose

Severe cases of overdose of Pimafucin have not been recorded in medical practice, but doctors do not exclude the risk of side symptoms if the dosage of the drug is exceeded. From the outside digestive system may experience vomiting or pain different localization. In some cases, an overdose may cause the development of hypersensitivity to the drug.

Contraindications

Pimafucin has no contraindications, but before starting use you should pay attention to the following restrictions:

• Suppositories can be used by girls only from the age of 16;
• Tablets for the treatment of candidiasis in newborns are prohibited (there are special suspensions for this).

During pregnancy

3. Special instructions

Impact on the ability to drive vehicles and operate machinery

The ability to impair psychomotor reactions or affect nervous system Pimafucin does not have.

Pregnancy and lactation

Pimafucin can be taken at any stage of pregnancy. There is no potential harm to the fetus. If it is necessary to take the drug during lactation, additional consultation with your doctor is necessary.

Use in childhood

Pimafucin is used in pediatric practice only on the basis of specialist testimony (there are no age restrictions for the drug).

For impaired renal function

There are no special instructions in the instructions.

For liver dysfunction

There is no need to adjust the course of therapy.

Terms of dispensing from pharmacies

Over-the-counter sale.

4. Storage conditions and periods

The medicine in its entire package is stored at temperatures up to 25°C, avoiding direct sunlight, for 2 years.

Video on the topic: Pimafucin

5. Price

Depending on the location of the pharmacy and its pricing policy, the cost of Pimafucin is as follows:

1. Average price in Russia:

• Tablets – 470-525 rubles;
• Cream – 290-315 rubles;
• Suppositories – 277-495 rub.

2. Average cost in Ukraine:

• Tablets – 139-152 UAH;
• Cream – 81-94 UAH;
• Suppositories – 91-97 UAH.

6. Analogs

The following drugs are analogues of Pimafucin: Nystatin; Alpha normix; Dificlir; Nystamycin; Primafungin.