Tobradex drops are an effective remedy for eye inflammation. Eye drops Tobradex - instructions, reviews, analogues Tobradex eye drops can be

Tobradex — combination drug, which has antibacterial, anti-inflammatory action.

Compound

Tobradex eye drops contain active substances: tobramycin and dexamethasone.

• Tobramycin is an antibacterial agent. Refers to the type of natural antibiotics. Reduces growth and prevents the development of pathogenic microorganisms.
• Dexamethasone is a glucocorticosteroid, hormonal drug. It has anti-inflammatory, anti-allergenic action. Acts as an immunosuppressant. When used topically, it soothes itching, constricts blood vessels. Reduces capillary permeability. Leads to a stable state of the cell membrane.

The tandem of these two components significantly reduces infectious processes.

Price

Tobradex drops are available in dropper bottles. The volume of the drug is 5 ml.

Price varies from 360 to 520 rubles.

Indications for use

Tobradex is used to treat diseases of the eyes and the area around it caused by viruses.

Helps with the following inflammations:

• the edges of the eyelids ();
• conjunctiva ();
• cornea ().

This medication is shown for the prevention of infections after surgery.

Do not drip Tobradex in the inner corner of the eye. There passes lacrimal canal. The medicine will go down his nose. It will be absorbed and spread throughout the body.

In addition to the occurrence of side effects, viruses can easily be introduced. Treatment with this method will not come.

To prevent the spread of infection, instill the medicine in both eyes.

Instructions for use

How to use eye drops:

• take your medicine with clean hands;
• check the expiration date;
• before dripping, warm in your hands (if stored in the refrigerator);
• prepare a napkin or cotton pad;
• shake the medicine;
• tilt your head back and pull the lower eyelid;
• look up;
• press the vial and squeeze out 1 drop;
• close your eyes;
• gently, without opening your eyes, press the inner corner;
• hold for a few minutes;
• blot excess medication or tears with a tissue.

In mild forms of the disease, 1-2 drops are squeezed out of the vial with Tobradex. This procedure is repeated with a period of 5-6 hours.

In the first two days, an increase in the frequency of instillation is allowed. These days drip every 2 hours. The dose is not increased.

In severe form

In acute infections, the same dose is dripped, but every hour.

Do this until the severity of the condition decreases.

Then drip administration is continued for another three days, but with a period of 2 hours. Further, the frequency of administration is adjusted to 4 hours.

After operation

Preventing inflammation after the operation, drip 1 drop 4 times a day.

Duration - 23 days.

For prevention, therapy can be started before surgery:

• the day before surgery - 1 drop 4 times;
• on the day of surgery - 1 drop.

Do not interrupt the treatment prescribed by your doctor on your own. Tobradex contains powerful components and for their complete absorption, it is necessary to conduct a course of treatment.

Overdose

In case of any deviation, rinse eyes with water. Further application of symptomatic therapy.

Teratogenic effect

Taking a large dosage of tobramycin leads to a violation of the development of the embryo. Overdosing of dexamethasone exposes the fetus to defects.

Application in pediatrics

Tobradex children can drip from 12 years old.

Do not use drops for small children!

When using a bubble dropper, you must adhere to the following rules:

• do not touch the eyedropper;
• shake well before use;
• store vertically;
• close after use.

Cautions

Reviews

Simonenkova E.I., ophthalmologist. Experience - 15 years:

In most cases, I prescribe Tobradex for my patients. Antibiotic and corticosteroid, which are part of the drug, are very effective.

Orlova T.N. , ophthalmologist, doctor of the highest category. Experience - 22 years:

Tobradex - good drug. It is based on a second-generation antibiotic and GCS. However, its application is limited. In fungal infections or diseases produced by Herpes simplex, it is not effective.

Kuzovenkov I.V., chemist. Experience - 5 years:

As a chemist, I can say that the drug is effective.

The range of its use in the treatment of diseases of the organs of vision is much wider than that presented in the instructions. I would add its use in immune, allergic diseases.

Analogues

You can change the prescribed drug analogue or synonymous.

Synonyms

Every medicine contains active chemical elements. They are the ones that have a healing effect. They are called - active substance. This is the "certificate" of birth.

Any pharmaceutical company can buy out a patent for the production of a drug with this active ingredient. But it produces already under its trade brand. Thus, one drug has different names.

These drugs are called synonyms or generics.

For Tobradex, a synonym is Tobrazon and Dexatobropt . They differ only in price.

Analogues

Analogues have the same pharmachologic effect, but active ( current) other substances.

At intolerance any component included in medicinal product, appoint exactly the analogue. At high price for a medicine, you can buy its synonym at a lower price.

It is impossible to replace the medicine prescribed by the doctor with an analogue. Despite the same therapeutic effects, side effects or contraindications may be different.

But you can change it to a synonym without consulting a doctor.

Cheap analogues eye drops Tobradex:

Tobrex and Tobradex: what's the difference?

General properties:

• the same pharmacological action;
• similar therapy;
• almost identical methods of application.

Differences

1. Structure. The main and fundamental difference is in the compositions. Tobradex includes 2 main active substances: tobramycin and dexamethasone, and it has one - tobramycin. Such an important component as a corticosteroid is absent.

1. Wide list of side effects. When using Tobradex, undesirable effects occur much less frequently and are local in nature. Whereas the list of side effects is increased

1. The frequency of instillation changes. In case of severe illness, Tobradex is dripped after 2 hours, and Tobrex - after an hour.

Tobrex or Tobradex to choose for the treatment of the disease - everyone decides for himself.

Why do many people choose Tobradex?

Thanks to these eye drops, it became possible to:

• rapid relief of inflammation;
• prevent infection from entering postoperative period;
• reduce the transition of inflammation to other layers of the eyes;
• prevent vision loss.

Despite the wide popularity of the use of eye drops, they should not be used without the recommendation of a specialist.

It is necessary to find out which pathogen caused the disease. To do this, it is recommended to pass laboratory tests.

If a pathogen is detected, exactly the medicine that will lead to the destruction of this infection will be prescribed.

Video

Additional components reduce the negative impact of active substances, while maintaining the therapeutic activity of the drug, and allow it to be used in pediatric practice. Tobradex is equally effective both in the treatment of inflammation and as a prevention of secondary infections.

Composition and impact

Eye drops are a finely dispersed whitish solution, poured into 5 ml bottles with a dropper. The medication is packaged in cardboard boxes and provided with an annotation.

The composition of the ophthalmic agent Tobradex includes dexamethasone and tobramycin in the amount of 1 mg and 3 mg per 1 ml of solution, respectively. Additionally, the preparation contains: Trilon B, antiseptic benzalkonium chloride, anhydrous sodium sulfate, hydroxyethyl cellulose ether, sodium hydroxide and chloride and / or sulfuric acid, distilled water, tyloxapol.

The effectiveness of Tobradex eye drops is due to the properties of each of its ingredients.

Tobramycin is a broad spectrum antibiotic from the aminoglycoside class. Active against gram-positive and gram-negative microorganisms: streptococci, staphylococci, Escherichia coli, Proteus, Enterobacter bacteria. Under its influence, a violation of protein production occurs and the permeability of the walls of pathogenic cells increases.

Dexamethasone is a synthetic steroid that does not exhibit mineralocorticoid activity. It has desensitizing and anti-allergic properties, reduces irritation and swelling, inhibits the release of mediators (mediators) of inflammation. In combination with tobramycin, it reduces the likelihood of infection of the visual apparatus.

When applied externally, Tobradex drops are slightly absorbed into the bloodstream, which significantly reduces the harmful effect of the drug. The maximum concentration of the antibiotic in the blood serum is 8 times less than required for the manifestation of its nephrotoxicity.

Indications and contraindications

Tobradex eye drops are prescribed for the following ophthalmic pathologies:

• blepharitis (inflammation of the eyelids);
• dacryocystitis;
• infectious keratitis (without damage to the epithelium).

Often, Tobradex drops are used to prevent postoperative ophthalmic complications and in the treatment of traumatic lesions of the organs of vision.

You should not start antimicrobial therapy with individual intolerance to the components of Tobradex or the presence of idiosyncrasy (inadequate reaction) to its individual ingredients.

Other contraindications for use:

• viral keratitis caused by Herpes simplex;
• mycobacterial infection, the causative agent of which is Koch's wand;
• fungal lesions of the cornea;
• purulent eye disease;
• increased susceptibility to any of the components of the solution;
• children's age up to a year;
• the period of bearing a child and breastfeeding.

And this is not all the contraindications to the use of Tobradex eye drops. There are a number of painful conditions that require the use of an ophthalmic agent only under the supervision of a physician. These include keratoconus (thinning of the cornea).

Instruction and dosage

The instructions for use for Tobradex drops indicate that the solution should be injected strictly into the conjunctival sac. The optimal dosage is 1 drop every 4-6 hours. Before use, the medicine is warmed to body temperature and shaken well. If there are lenses, they are removed and put back in place after 15-20 minutes.

On the first day, a single instillation can be increased to two drops with an administration interval of 2 hours.

After each use, the bottle should be screwed tightly and the pipette tip should not be touched with foreign objects, hands or eyelids. Long-term use of Tobradex drops should be accompanied by regular monitoring of the condition of the cornea. With the joint appointment of an eye remedy with aminoglycosides, monitoring of the main blood parameters is required.

For pregnant and lactating

To date, the effect of Tobradex eye drops on the fetus has not been studied enough, so experts avoid prescribing the drug during pregnancy. However, if the expected result outweighs the likely risk, the drug is included in the therapy regimen.

As for the lactation period, here the opinion of experts is unequivocal - Tobradex should not be used. If circumstances nevertheless force such therapy, doctors advise to abandon breastfeeding for this period.

For adults

The use of Tobradex drops depends on the type of lesion and the severity of the inflammatory process. In acute infection, the following treatment regimen should be followed:

• to reduce severe symptoms, inject 2 drops of the solution into each eye every two hours;
• the next day, treatment can be reduced to 6 instillations;
• for the next 5 days, drip Tobradex every six hours.

If necessary, the course of therapy can be extended up to 10 days.

To prevent postoperative complications, the drug is prescribed 1 drop four times a day. Instillations should begin the day before the intervention and continue for 3 weeks. On the recommendation of a specialist, a single dosage and frequency of use can be increased.

After the introduction of Tobradex drops, visual impairment, vagueness of objects is possible. Drivers should be aware of this.

For children

Tobradex drops are allowed to be used to treat babies older than 12 months. Before administering the drug, you should consult a specialist and read the instructions.

Children, as a rule, are assigned an individual treatment regimen, which may differ from that of an adult. How much, when and how to bury the medicine, the pediatric ophthalmologist decides.

If after a week the child does not feel better, you should consult a doctor and replace the drops with others.

To reduce the risk of developing adverse reactions after the introduction of Tobradex, it is recommended to press a finger several times on the inner corner of each eye. In order not to cause discomfort in the baby from the treatment, the solution is warmed to body temperature before use.

Overdose

Drops in the eyes of Tobradex rarely cause an overdose, but if this happens, the patient most often complains of the following symptoms:

• irritation and redness of the mucous membrane;
• itching, lacrimation and profuse secretion from the nose;
• in rare cases, dry mucous membranes are observed.

There is no specific antidote for Tobradex drops, so the only thing you can do in case of an overdose is to rinse your eyes with cool water and go to an ophthalmologist.

Side effects

Treatment with Tobradex rarely causes unwanted reactions, however, with individual intolerance to drops, unpleasant sensations may occur:

• increased intraocular pressure;
• photophobia;
• copious discharge from the nose;
• metallic taste in the mouth;
• headache;
• feeling of sand in the eye;
• blurred vision;
• prolonged pupillary dilation.

Patients with hereditary or acquired thinning of the cornea may develop perforation.

With prolonged use of Tobradex drops, it is not uncommon for a weakening of local immunity, followed by the addition of a secondary infection. A typical feature invasions can be poorly healing wounds and ulcers on the cornea.

Interaction with other drugs

In the case of simultaneous use of Tobradex drops with antibiotics of the aminoglycoside class, systemic adverse reactions may increase.

When using the drug in conjunction with other ophthalmic medicines, it is necessary to maintain a break between them for at least 15-20 minutes.

Price

Tobradex eye drops 0.3% 5 ml can be bought at any pharmacy for 390–420 rubles.

Analogues

In some cases, Tobradex has to be replaced with drugs that are similar in effect. The selection of the optimal remedy should be done by a specialist, taking into account the age and severity of the patient's disease.

Most often, as an analogue, they appoint:

• Dexatobropt 5 ml fl - 185–200 rubles.
• Dexon 5 ml - 120-150 rubles.
• Garazon 5 ml - 180–250 rubles.

Despite such a number of analogues, Tobradex confidently holds the palm in the treatment of eye pathologies. Due to the combined composition and bright therapeutic effect, it is an indispensable tool in the fight against ophthalmic infections.

Useful video on how to put drops in the eyes

Tobradex is a combination drug with antimicrobial and anti-inflammatory action. Eye drops are used topically for the treatment and prevention of various infectious and inflammatory complications, including in the postoperative period.

Composition and form of release

Tobradex is available in the form of eye drops, 1 ml of which contains the following active substances:

• tobramycin - 3 mg;
• dexamethasone 1 mg.

Auxiliary components are presented:

• benzalkonium chloride 0.1 mg;
• edetate disodium 0.1 mg;
• hydroxyethylcellulose - 2.5 mg;
• sodium chloride 3 mg;
• special purified water 1 ml.

To bring the pH to neutral values, small amounts of sulfuric acid or sodium hydroxide are added to the solution.

Tobradex is a white suspension, 5 ml of which is placed in a special polyethylene dropper "Droptainer tm". The bottle itself, together with paper instructions, is packed in a cardboard box.

pharmachologic effect

Tobradex is a combined medicine belonging to antibiotics (aminoglycoside) and glucocorticosteroid hormones.

Its action is associated with the activity of the constituent components.

Tobramycin belongs to antibacterial drugs wide spectrum of activity. It is an aminoglycoside and disrupts the synthesis of certain proteins, and also increases the permeability of the cytoplasmic membrane of a bacterial cell. Its effectiveness extends to gram-negative and gram-positive microbes: staphylococcus (aureus, epidermidis, etc.), as well as varieties of bacteria that are resistant to methicillin; streptococcus (beta-hemolytic from group A, non-hemolytic, pneumonie); Pseudomonas aeruginosa; Escherichia coli; Klebsiella pneumonia; Enterobacter spp. Proteus mirabilis; Morganella morganii; Citrobacter spp. haemophilus influenza; Moraxella spp.; Acinetobacter spp. Serratia marcescens.

Dexamethasone is a synthetic glucocorticosteroid hormone that does not have a mineralocorticoid effect. It has a pronounced anti-inflammatory effect, has a desensitizing and anti-allergic effect. By inhibiting the release of inflammatory mediators by eosinophil cells, reducing the migration of mast cells, dilating blood vessels and reducing the permeability of the capillary wall, it quite actively inhibits various inflammatory reactions and processes.

When used in combination, these substances help to cope with the infection or prevent its occurrence.

Indications

Tobradex is prescribed for various inflammatory diseases eye apparatus, when the cause of development is a microflora sensitive to an antibiotic:

• conjunctivitis;
• blepharitis;
• keratoconjunctivitis;
• keratitis;
• blepharoconjunctivitis;
• iridocyclitis.

It is also used for the prevention of the infectious process in the postoperative period after the removal of the lens in cataracts.

Mode of application

Apply the drug Tobradex topically, thoroughly shaking the solution before instillation.

The dose is 1-2 drops every 4-6 hours. In the first 1-2 days, it is possible to increase the frequency of use up to 12 times a day.

In severe cases of an acute infectious process, it is allowed to instill 1-2 drops every hour. As the severity of symptoms of inflammation decreases, the frequency of taking the drug should also be reduced (3 days - every 2 hours, 5-8 days - every 4 hours).

For prophylactic purposes in the postoperative period, the drug is prescribed 1 drop 4 times a day. The duration of priming can be up to 24 days.

Another scheme is also possible, when the drug is started the day before the operation (4 times), and then continued for the next 23 days.

If necessary, you can increase the frequency of admission in the first two days after the intervention (up to 12 times a day).

After placing a drop of the drug in the conjunctival sac, you should lightly press your finger in the area of ​​​​the lacrimal sacs (near the inner corner of the eye) for a couple of minutes. This helps to reduce the resorption of the drug into the systemic circulation and reduces the likelihood of side effects.

Sometimes Tobradex drops are combined with the appointment of the same ointment. In this case, the drops are used during the day, and the ointment is applied at night. The overall receive frequency must be maintained.

Contraindications

The appointment of the drug Tobradex is contraindicated in:

• individual intolerance;
• viral diseases with eyeball(herpes, keratitis, chickenpox);
• the presence of a fungal or bacterial infection of the eyeball;
• purulent diseases;
• in the period after removal of a foreign body from the corneal layer;
• lactation;
• under the age of 12.

Since there is no sufficient clinical material on the use of Tobradex in pregnant women, it can be prescribed in individual cases. In a number of experimental studies on animals, an adverse effect of high doses of the drug on the fetus (nephrotoxicity, ototoxicity) was found. With prolonged use of high doses, developmental anomalies developed.

In children, Tobradex can be used from the age of twelve, while the duration of use should not exceed seven days.

Side effects

When using Tobradex drops, side effects may develop.

Local reactions include:

• pain, irritation, discomfort in the application area occurs in 1-10%;
• allergies, hypersensitivity, intraocular hypertension, keratitis, itching, redness of the conjunctiva, erythema of the eyelid, sensation of a foreign object, blurred vision, swelling of the conjunctiva and eyelids, increased lacrimation, or vice versa, dry eye syndrome is observed in 0.1-1%;
• glaucoma, decreased visual acuity, cataracts, photophobia, mydriasis occur with an unknown frequency.

Systemic complications include:

• headache;
• laryngospasm;
• dysgeusia;
• rhinorrhea.

They develop in 0.1-1% of patients.

In the case of frequent or prolonged use (more than 24 days), the development of:

• intraocular hypertension;
• steroid glaucoma;
• subcapsular posterior cataract;
• slowing down the regeneration processes;
• secondary infection resulting from a decrease in local immunity under the influence of immunosuppressive dexazone.

Fungal infection of the cornea develops with prolonged use of the drug. In this case, corneal ulcers appear, which are difficult to heal. In purulent processes, the use of the drug can enhance the existing process, or mask the symptoms.

Overdose

With an overdose of the drug Tobradex, redness of the conjunctiva, increased lacrimation, swelling and itching of the eyelids, punctate keratitis and erythema occur. To reduce symptoms, rinse the eyes with warm water and treat symptomatically.

Interactions

When co-administered with other drugs for local use an interval between instillations of at least 5 minutes should be observed.

special instructions

The composition of the drug Tobradex includes a preservative (benzalkonium chloride), which can be deposited on the surface of contact lenses. Therefore, before instillation, the lens should be removed. It will be possible to return it to its place after 20 minutes.

If long-term use is necessary, the stratum corneum should be monitored for ulceration. If systemic antibiotics from the group of glycosides are additionally prescribed, attention should be paid to general analysis blood.

Quite often you have to deal with a disease such as conjunctivitis. The most common type is bacterial. It develops when hit or streptococcus. Bacteria infect the mucous membrane of the eye. At the same time, hyperemia, constant lacrimation and sharp pain. The named disease can be complicated by blepharitis. In this case, it will be more difficult to cure it. Therefore, when the first signs of the disease appear, you should seek help from an ophthalmologist.

One of the most popular and affordable drugs for eliminating conjunctivitis is Tobradex ( eye drops). Instructions, analogues, dosage - the doctor will inform you about all this. There are many high-quality substitutes on sale, which do not differ in composition. These are drops "Tobrazon", "Dexamethasone", "Dexatobropt" and others. Further detailed information will be provided about them.

Release form and composition of drops

Tobrazon, Dexamethasone, Dexatobropt, Torbadex are used for local treatment in ophthalmology. They have antibacterial and anti-inflammatory effects.

Eye drops "Tobradex" are available in the form of a white suspension. Before instillation, it is recommended to shake the medicine bottle thoroughly, because the suspension tends to crystallize and sink to the bottom. Drops "Tobrazon" and "Dexamethasone" - transparent. They should also be shaken before use.

The main components in the composition of these drops are dexamethasone and tobramycin. Excipients may be benzalnonium chloride, disodium edatate, saline, sulfuric acid and purified water. As a rule, they are produced in plastic bottles with a dispenser of 5 ml, packed in a cardboard box. Any analogue of "Tobradex" has an identical effect and indications for use to the original

The action of the drugs "Tobradex", "Dexamethasone", "Tobrazon" and "Dexatobropt"

"Tobradex" is a combination drug that is used to treat the eyes. Tobramycin, which is part of it, is considered a broad-spectrum antibiotic. It belongs to the group of aminoglycosides and has a high degree of activity against gram-positive and negative microorganisms.

Dexamethasone is a hormone. It has an anti-inflammatory anti-allergic effect. Removes swelling and hyperemia. It is applied only locally, so it does not enter the bloodstream.

Like Tobradex (eye drops), cheap analogues also give good effect during treatment. However, you should first consult with your doctor. Drops "Tobrazon", Dexomitasone", "Dexatobropt", like any other drugs, are not suitable for self-medication.A diagnosis must be made initially.

Overdose of drugs based on tobramycin

If you use the listed medicines in an increased dosage, there will be profuse lacrimation, the eyes will become red, itching will appear. Swelling of the eyelids is another alarming symptom.

In such cases, it is necessary to rinse the eyes with warm and clean water. Additionally, you should take an antihistamine. In more severe situations, an antiallergic drug is administered intravenously.

Be sure to report the reaction to the doctor. Remember that the joint appointment of eye drops with antibiotics may increase side effects. Any analogue of "Tobradex" can lead to the development of the listed side effects if used incorrectly. It is necessary to use drops "Tobrazon", "Dexamethasone", "Dexatobropt" strictly according to the instructions.

How to use drugs

Wash your hands well before using Tobradeex, Dexamethasone or Tobrason drops. Then you need to take a bottle of drops and shake it. Then one or two drops are instilled into each bag of the conjunctiva. In the acute period, treatment is carried out every 4 hours.

It is necessary to drip even in healthy eye for prevention, since the disease is of bacterial origin and in a day it can appear in the other eye.

After opening any of these drugs should be used within a month. The sterile and closed vial has a shelf life of 2 years. As well as "Tobradex" (eye drops), it is not advisable to use analogues of the drug without the recommendation of a specialist.

Indications for use

To protect patients after eye operations of infection and inflammation, specialists often prescribe Tobradex, Dexamethasone or Tobrazon eye drops. They are widely used to treat conjunctivitis and blepharitis. And if there is no damage to the epithelium, then the medicine is also dripped with keratitis.

"Tobradex" ointment is also considered popular in ophthalmology. Its analogues ("Tobrazon" and "Dexa Tobropt") are widely used in the treatment of inflammation and infection in patients of any age. Medicines of this series are contraindicated only for pregnant women and children under 12 years of age.

Side effects

When using eye drops "Tobradex", "Tobrazon", "Dexamethasone", "Dexa Tobropt" often develop side effects. There may be allergic reactions in the form of redness, itching, hyperemia, swelling of the eyelids. On the part of the organs of vision, an increase in intraocular pressure can be observed. Often there are signs of cataracts.

If there is a significant slowdown in the healing process, you should contact a specialist for a consultation. Besides:

• due to malfunctions immune system re-infection may occur;
• possible development of ulcers. This phenomenon is observed after prolonged treatment with eye drops;
• Another one unpleasant symptom- fungal infection of the eyes.

Any analogue of "Tobradex" should be started after studying the instructions for use.

Contraindications for treatment with eye drops

Both the drug "Tobradex" and its analogues have the same contraindications.

• You can not use any of the presented medicines for diseases of the cornea and conjunctiva caused by herpes and chickenpox viruses.
• It is not recommended to drip the product after removing a foreign object from the eye.
• Fungal eye infections are also a contraindication.

In some cases, hypersensitivity to the main substance of the drug and its additional components may develop.

Any of these drops can not be used for more than two weeks - they contain dexamethasone, which can cause drug addiction.

Each analogue of "Tobradex" can harm the body if used improperly. Using drops "Tobrazon", "Dexamethasone", "Dexatobropt", it is worth carefully studying the instructions for use.

special instructions

During treatment with the presented eye drops, certain rules must be observed.

• With the simultaneous appointment of eye drops of different composition, there should be a break of 5 minutes between their use.
• When instilling an eye, it is not recommended not to touch the cornea with a pipette, otherwise a relapse of the disease may occur, which is more difficult to treat.
• As well as Tobradex drops, cheap or expensive analogues require the appointment of a specialist and his observation of the result of treatment.

Eye drops "Tobrazon"

This substitute for drops "Tobradex" is the most popular among specialists. Therefore, it is worth describing in more detail.

Eye drops "Tobrazon" have antibacterial and anti-inflammatory effect. They also include tobramycin and dexamethasone. The drug narrows the blood vessels well and relieves itching. It stabilizes cell membranes and reduces the permeability of capillary walls.

It is quite possible to replace Tobradex with drops of "Tobrazon". Analogues cheap and expensive give the same pronounced therapeutic effect.

In this article, you can read the instructions for use medicinal product Tobradex. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Tobradex in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications were observed and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Tobradex in the presence of existing structural analogues. Use for the treatment of conjunctivitis, blepharitis and keratitis in adults, children, as well as during pregnancy and lactation. The composition of the drug.

Tobradex- a combined drug with antibacterial and anti-inflammatory action for topical use in ophthalmology.

Tobramycin is a broad-spectrum antibiotic from the aminoglycoside group. Active against gram-positive and gram-negative microorganisms: Staphylococcus spp. (including Staphylococcus aureus (staphylococcus aureus), Staphylococcus epidermidis (including strains resistant to penicillin)), Streptococcus spp. (Streptococcus) (including some group A beta-hemolytic species, some non-hemolytic species and some strains of Streptococcus pneumoniae), Pseudomonas aeruginosa, Escherichia coli (E. coli), Klebsiella pneumoniae (Klebsiella), Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, Proteus vulgaris (Proteus), Haemophilus influenzae, Haemophilus aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus, and some strains of Neisseria spp.

Dexamethasone is a glucocorticosteroid (GCS). It has a pronounced anti-inflammatory, anti-allergic and desensitizing effect. Has an anti-exudative effect.

Compound

Tobramycin + Dexamethasone + excipients.

Pharmacokinetics

With topical application of Tobradex, systemic absorption of dexamethasone is low. About 77-84% of dexamethasone entering the systemic circulation binds to plasma proteins. With topical application of Tobradex, systemic absorption of tobramycin is low. The concentration of tobramycin in blood plasma after using 1 drop of Tobradex in each eye 4 for 2 days was below the detection threshold in 9 of 12 patients. It is excreted by the kidneys, mainly unchanged.

Indications

Inflammatory diseases of the eye and its appendages caused by pathogens sensitive to the drug:

• blepharitis;
• conjunctivitis;
• keratoconjunctivitis;
• blepharoconjunctivitis;
• keratitis;
• iridocyclitis.

Prevention and treatment inflammatory phenomena in the postoperative period after cataract extraction.

Release form

Eye drops.

Ointment for the eyes.

Instructions for use and treatment regimen

Drops

Eye drops are instilled 1-2 drops into the conjunctival sac of the affected eye (or eyes) every 4-6 hours. In the first 24-48 hours, the dose can be increased to 1-2 drops into the conjunctival sac every 2 hours.

Ointment

locally. A strip of ointment 1.5 cm long is placed in the lower conjunctival sac 3-4 times a day with a decrease in the frequency of use as inflammation decreases. You can combine the use of ointment and drops: ointment - in the evening before bedtime, drops - during the day (while maintaining the frequency of using the drug 3-4 times a day).

Side effect

• itching and swelling of the eyelids;
• redness of the conjunctiva;
• increased intraocular pressure;
• formation of posterior subcapsular cataract;
• slowing down the wound healing process;
• the development of a secondary infection (including bacterial), as a result of suppression of the patient's protective reaction;
• the appearance of non-healing ulcers on the cornea after long-term treatment with corticosteroids may indicate the development of a fungal infection.

Contraindications

• viral diseases of the cornea and conjunctiva (including keratitis caused by Herpes simplex (herpes), chickenpox);
• mycobacterial eye infection;
• fungal diseases of the eyes;
• conditions after removal of a foreign body of the cornea;
• children's age up to 18 years (for ointment);
• hypersensitivity to any component of the drug.

Use during pregnancy and lactation

Sufficient experience in the use of the drug during pregnancy and lactation ( breastfeeding) No.

It is possible to use the drug Tobradex in pregnant women in the case when the expected therapeutic effect outweighs the potential risk of side effects.

Animal studies have shown fetal nephrotoxicity and ototoxicity with high doses of tobramycin. Anomalies in the development of the fetus were revealed in the chronic administration of high doses of dexamethasone.

Do not use the drug during breastfeeding.

Use in children

Ointment Tobradex is contraindicated in children and adolescents under the age of 18 years.

special instructions

When prescribing Tobradex simultaneously with antibiotics of the aminoglycoside group for systemic use, the peripheral blood picture should be monitored.

When using the drug Tobradex simultaneously with other eye drops or ointments, the interval between their applications should be at least 5 minutes.

The bottle must be closed after each use. Shake the contents of the vial before use. When instilling, do not touch the tip of the pipette to the eye.

drug interaction

In the case of the simultaneous appointment of Tobradex eye drops with systemic antibiotics from the aminoglycoside group, systemic side effects may increase.

Analogues of the drug Tobradex

Structural analogues according to active substance:

• DexaTobropt;
• Tobrazon.

Analogues for the therapeutic effect (drugs for the treatment of conjunctivitis):

• Berberyl N;
• Bronal;
• Vitabact;
• Garamycin;
• Gentamicin;
• Hydrocortisone;
• Histalong;
• Dexamethasone;
• Zanocin;
• Ilozon;
• Innolir;
• Colbiocin;
• Liprokhin;
• Maxidex;
• Maxitrol;
• Midrum;
• Nakloof;
• Okatsin;
• Oculohel;
• Ofloxacin;
• Plivasept;
• Poludan;
• Prenacid;
• Riboflavin;
• Sulfacyl sodium (albucid);
• Tobrex;
• Totacef;
• Phloxal;
• Furacilin;
• Fucithalmic;
• Cefatrexil;
• Cefesol;
• Ceftidine;
• ciloxane;
• Ciprobay;
• Tsiprosan;
• Ciprofloxacin;
• Cifloxinal;
• Chibroxin;
• Ermiced.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.