The use of Grandaxin for VSD. Grandaxin: instructions, use and general information about the drug Grandaxin course duration

Before using many serious medications, people carefully scour the World Wide Web in search of information about them. After all, reviews from other patients help to understand how a medication can affect your health, what possible positive and negative consequences from taking it, and what it is better to pay close attention to. There are especially many questions raised by medications that affect the mental state. The tranquilizer Grandaxin is one of these. We will talk about how Grandaxin makes people feel, tell who is prescribed it and why, and give real reviews about its action.

Grandaxin is a drug that is designed to have a pronounced anxiolytic effect. In other words, it copes with feelings of fear, anxiety and nervous tension.

What is Grandaxin used for??

Such a medication can be prescribed to those readers of Popular About Health who are concerned about neuroses or neurosis-like conditions that occur with a number of specific symptoms. The latter can be represented by a variety of fears, inexplicable and/or increased anxiety, incomprehensible nervous tension, or, on the contrary, apathy, lethargy, and also a feeling of indifference to the environment.

TO possible indications For the appointment of Grandaxin, impaired psychological adaptation is considered if this problem arose as a result of stress. In addition, it can be prescribed to relieve the reaction to stress, which manifests itself as depression with symptoms of psychopathy.

In some cases, the use of Grandaxin may be indicated for patients with premenstrual syndrome, as well as with excessive nervous excitability due to menopause. In addition, this drug is sometimes prescribed for painful sensations in the heart of various origins.

Among the indications for the use of Grandaxin, it is worth highlighting the development of a hangover syndrome, which is also called withdrawal symptoms if it occurs against the background of a chronic form of alcoholism.

This medication can also be prescribed to patients with neurotic disorders that have developed as a result of myopathy, myasthenia gravis, or muscle atrophy. In other words, its use is justified if there are contraindications for the use of tranquilizers that relax muscles.

Reviews of Grandaxin

User Roxxana_k from Cherepovets writes that she was prescribed Grandaxin for the treatment of vegetative-vascular dystonia, which was manifested by very diverse symptoms (dizziness, constant weakness, interruptions in heart function, panic attacks). The girl took the medicine for a week, but it had an amazing effect, quickly eliminating half of the symptoms. Four years have passed since Grandaxin, and the girl practically does not remember the manifestations of VSD.

User zombie from Moscow writes that she was prescribed Grandaxin to take for symptoms of severe exhaustion and fatigue. The girl was worried about insomnia, excessive irritation, tearfulness, etc. She continued taking Grandaxin for a week and a half, and the medicine did not cause any side effects. After only three days of treatment, the girl began to sleep normally, optimism and adequacy returned to her.

To user ek9345 from Yekaterinburg, Grandaxin was prescribed by a nutritionist after severe food breakdowns, when a woman began to eat enough to the point of vomiting. While taking the medication, she no longer had any breakdowns, but the drug caused some fogginess and, as it were, a feeling of “weightlessness.” The user stopped taking the medicine gradually, gradually reducing the dosage. Among the side effects that appeared, the woman noted the appearance of dry mouth and disturbances in night rest.

Xerapendra from Kazakhstan took Grandaxin for almost two weeks and writes that she did not feel any effect from this treatment at all. Taking the drug caused increased irritability, caused sleep problems and respiratory depression.

User with the nickname “Citizen 2017” from Yekaterinburg writes that a psychotherapist prescribed Grandaxin to him to correct the influence of neurotic symptoms on disturbances in the functioning of the digestive tract. The medicine had to be taken for a month, combined with other drugs and weekly therapy with a psychotherapist. Grandaxin helped eliminate panic attacks, sadness, melancholy, incomprehensible fear of death, irritability and depression, and also corrected irregular heartbeats. Then the doctor prescribed him to take the medicine according to the same regimen, but in the second month of taking the man he encountered side effects, namely difficulty breathing, shortness of breath and constant yawning. After some time, a rash appeared on the man’s skin, similar in appearance to burst blood vessels. To eliminate side effects, the user took antihistamines in combination with Polysorb.

User Miss Rush from Penza writes that she was prescribed Grandaxin during the correction of a depressive state. And at first the medicine gave a positive effect without causing any side effects. But pretty soon the medication stopped helping the girl without causing any results.

Only a doctor can prescribe Grandaxin. This is a serious medication that should not be taken on your own initiative.

In this article you can read the instructions for use of the drug Grandaxin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Grandaxin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications were observed and side effects, perhaps not stated by the manufacturer in the annotation. Analogues of Grandaxin in the presence of existing structural analogues. Use for the treatment of neuroses, stress and menopause in adults, children, as well as during pregnancy and breastfeeding.

Grandaxin- tranquilizer. A drug from the group of benzodiazepine derivatives (atypical benzodiazepine derivative). It has an anxiolytic effect, not accompanied by a sedative, muscle relaxant, or anticonvulsant effect. It is a psycho-vegetative regulator, eliminates various forms of autonomic disorders. Has moderate stimulating activity.

Due to the lack of a muscle relaxant effect, the drug can be used in patients with myopathy and myasthenia.

Due to the atypical chemical structure, unlike classical benzodiazepine derivatives, Grandaxin in therapeutic doses does not potentiate the effect of alcohol and practically does not cause the development of physical, mental dependence and withdrawal syndrome.

Grandaxin is a daytime tranquilizer.

Pharmacokinetics

After oral administration, it is quickly and almost completely absorbed from the gastrointestinal tract. Tofizopam (the active substance of the drug Grandaxin) does not accumulate in the body. It is excreted mainly in the urine (60-80%) in the form of conjugates with glucuronic acid and to a lesser extent (about 30%) in feces.

Indications

• neuroses and neurosis-like states (conditions accompanied by emotional stress, vegetative disorders, moderate anxiety, apathy, decreased activity, obsessive experiences);
• reactive depression with moderately severe psychopathological symptoms;
• mental adjustment disorder (post-traumatic stress disorder);
• menopausal syndrome (as an independent remedy, as well as in combination with hormonal drugs);
• premenstrual tension syndrome;
• cardialgia (as monotherapy or in combination with other drugs);
• alcohol withdrawal syndrome;
• myasthenia gravis, myopathies, neurogenic muscle atrophy and other pathological conditions with secondary neurotic symptoms in cases where anxiolytics with a pronounced muscle relaxant effect are contraindicated.

Release forms

Tablets 50 mg.

Instructions for use and dosage regimen

They are set individually, taking into account the patient’s condition, the clinical form of the disease and individual sensitivity to the drug.

Adults are prescribed 50-100 mg (1-2 tablets) 1-3 times a day. For irregular use, you can take 1-2 tablets. The maximum daily dose is 300 mg.

Elderly patients and patients with renal failure daily dose reduced by approximately 2 times.

Side effect

• headache;
• insomnia;
• increased irritability;
• psychomotor agitation;
• confusion;
• seizures in patients with epilepsy;
• decreased appetite;
• constipation;
• flatulence;
• nausea;
• dry mouth;
• itchy skin;
• muscle tension;
• muscle pain.

Contraindications

• conditions accompanied by severe psychomotor agitation, aggressiveness or deep depression;
• respiratory failure in the stage of decompensation;
• sleep apnea syndrome (history);
• simultaneous use with tacrolimus, sirolimus, cyclosporine;
• 1st trimester of pregnancy;
• lactation period ( breastfeeding);
• hypersensitivity to the components of the drug or any other benzodiazepines.

Use during pregnancy and breastfeeding

Grandaxin is contraindicated for use in the 1st trimester of pregnancy and during lactation (breastfeeding).

special instructions

It should be taken into account that in patients with delayed mental development, elderly patients, patients with impaired renal and/or liver function may experience side effects more often than other patients.

It is not recommended to use tofisopam for chronic psychosis, phobias or obsessive disorders. In these cases, the risk of suicide attempts and aggressive behavior increases. Therefore, Grandaxin is not recommended as monotherapy for depression or depression accompanied by anxiety.

Caution is required when treating patients with depersonalization, as well as with organic brain damage (for example, with atherosclerosis).

In patients with epilepsy, tofisopam may increase the seizure threshold.

Each Grandaxin tablet contains 92 mg of lactose, which should be taken into account in patients with lactose intolerance.

Impact on the ability to drive vehicles and operate machinery

Grandaxin does not significantly reduce attention and the ability to concentrate.

Drug interactions

The simultaneous use of tacrolimus, sirolimus, cyclosporine and Grandaxin is contraindicated. Plasma concentrations of drugs that are metabolized by the CYP3A4 isoenzyme may increase when taken concomitantly with tofisopam.

The use of Grandaxin with drugs that suppress the functions of the central nervous system (analgesics, general anesthesia, antidepressants, histamine H1 receptor blockers, sedatives, hypnotics, antipsychotic drugs) enhances their effects (for example, sedation or respiratory depression).

Inducers of liver enzymes (ethanol, nicotine, barbiturates, antiepileptic drugs) can increase the metabolism of tofisopam, which can lead to a decrease in its concentration in the blood plasma and weakening therapeutic effect.

Some antifungal drugs(ketoconazole, itraconazole) can slow down the hepatic metabolism of tofisopam, which leads to an increase in its concentration in the blood plasma.

Some antihypertensive drugs (clonidine, calcium channel blockers) may enhance the effects of Grandaxin.

Beta blockers may slow the metabolism of tofisopam, but this effect is not clinically significant.

Tofisopam, when used concomitantly, can increase the level of digoxin in the blood plasma.

Benzodiazepines, incl. Grandaxin may affect the anticoagulant effect of warfarin.

Long-term concomitant use of disulfiram may inhibit the metabolism of tofisopam.

Antacids may affect the absorption of tofisopam.

Cimetidine and omeprazole, when used simultaneously, inhibit the metabolism of tofisopam.

Oral contraceptives may reduce the rate of metabolism of Grandaxin.

Tofisopam weakens the inhibitory effect of ethanol on the central nervous system.

Analogues of the drug Grandaxin

Structural analogues of the active substance:

• Tofisopam.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

All psychotropic drugs must be issued by prescription only. Understand, you cannot experiment with the head, it is the main human organ and we have only one - it will be impossible to transplant it.

You have decided to use medications to resolve your internal conflicts and balance your condition. But neurotic disorders belong to borderline conditions and, accordingly, need to be dealt with in psychological ways. Yes, psychotropic pills can balance the biochemistry of the brain for some time, but they do not change our thoughts and our perceptions.

These problems need to be dealt with by a psychotherapist, who prioritizes internal work on oneself, and in rare cases, prescribes pills.

Drug treatment can only remove the consequences of mental discomfort: emotional imbalance, depression, disturbed sleep, signs of anxiety. But this is just a crutch for a restless brain.

It is much more important to understand in what situations the condition worsens, change your attitude towards vital moments, try to express yourself in a new way, learn to quickly calm down and keep your mood tone at the desired level, accumulate resources for all the necessary changes, etc., etc. . P.

All this is possible during psychotherapy sessions in person or via Skype.

How to take Grandaxin correctly and what can replace it?

Stress, emotional overstrain, and mood swings negatively affect a person’s condition. To eliminate neuroses and vegetative disorders, tranquilizers are used. One of the popular drugs in this group is Grandaxin.

Composition, properties and release form

Grandaxin is a drug that has anxiolytic properties

Grandaxin belongs to the group of tranquilizers and has an anxiolytic effect. This remedy helps eliminate feelings of fear, anxiety, and nervous tension.

The active active substance of the drug is tofisopam. The drug has a calming effect and also produces disinhibiting, activating effects.

Unlike most tranquilizers, it does not have a hypnotic effect and can be used in daytime. The effect of the drug is observed within 2 hours. Absorption occurs in the gastrointestinal tract and is then excreted from the body along with urine.

The active substance does not accumulate in tissues and organs.

Grandaxin is sold in tablet form. They are flat, round and white. One tablet contains 50 mg of tofisopam, the active substance. In addition to tofisopam, the drug contains some excipients: stearic acid, magnesium stearate, talc, potato starch, gelatin, etc.

When is the drug prescribed?

Most often, the drug is indicated for VSD, neurosis and depression.

Grandaxin is a sedative and can be used in the following conditions:

1. Neuroses.
2. Climax.
3. Premenstrual syndrome.
4. Cardialgia.
5. Muscular atrophy of a neurogenic nature.
6. Post-traumatic syndrome.
7. Reactions to strong external stimuli.

It is advisable to use the product for various pathologies nervous system accompanied by depression, emotional stress, anxiety and tension.

The drug can be prescribed for neuromuscular diseases, autonomic disorders, and withdrawal syndrome. In addition, Grandaxin can be used together with other drugs in the treatment of bulimia.

Grandaxin in cardiology

Cardiologists can prescribe the use of Grandaxin for vegetative-vascular dystonia or for patients after a stroke. Autonomic disorders are characterized by anxiety, depression, and dysfunction of cardio-vascular system. Ischemic disease, hypertension in most cases is accompanied by autonomic disorders.

More information about the drug Grandaxin can be found in the video:

Grandaxin with the active substance tofisopam has been successfully used to treat autonomic disorders. When using this drug, the signs of VSD noticeably decrease. Typically, Grandaxin is prescribed for exacerbation of the syndrome.

In cardiological practice, the drug Grandaxin is prescribed for pain in the heart of a neurotic nature.

This condition is called cardiac neurosis. Frequent stress and a tense life rhythm cause disruptions in the nervous system and, against the background of a neurotic reaction, a rapid heartbeat appears. The drug to eliminate heart pain against the background of neurosis and symptoms of vegetative-vascular dystonia should only be prescribed by a cardiologist.

Dosage and rules of use

Dosage depends on the clinical form of the disease

Grandaxin can be taken without food intake. It should be noted that it does not cause addiction, mental or physical dependence.

The dosage is selected individually in each case. It depends on the clinical indications and the patient’s condition. The dose for adults is mg per day, which is 1-2 tablets. Should be taken 1-3 times a day. The dosage per day should not exceed 300 mg.

Elderly people and patients with kidney pathologies are prescribed a reduced dose. The duration of treatment depends on the severity of the patient’s condition and this should only be determined by a doctor. Grandaxin is prescribed only to children over 14 years of age. The recommended dose for them is 1-2 tablets per day. The dosage per day should not exceed 200 mg.

When using any medicines not recommended for use alcoholic drinks.

The combined use of tranquilizers with alcohol is undesirable due to the negative consequences on the body. The effect on the nervous system is enhanced, resulting in severe adverse reactions.

Contraindications and adverse reactions

Improper use may cause side effects

Before using Grandaxin, you should read the instructions. In some cases, the drug is contraindicated in:

• Intolerance to the active substance.
• Lactose or galactose intolerance.
• Respiratory failure.
• Apnea syndrome.
• Pregnancy in the 1st trimester.
• Breastfeeding.

In case of organic brain damage, convulsive seizures, respiratory distress syndrome, as well as increased intraocular pressure, the drug is used with caution. Do not take the drug simultaneously with cephalosporins and immunosuppressants (Sirolimus, Tacrolimus).

Adverse reactions when taking Grandaxin may occur from various systems body: headache, sleep disturbance, agitation, nausea, flatulence, constipation. An allergic reaction in the form of urticaria, rash and itching, and Quincke's edema may occur.

If these symptoms appear while taking Grandaxin, it is necessary to reduce the dose or stop using it.

Exceeding the dosage of the drug can lead to breathing problems and drowsiness. In severe cases, an overdose can cause coma. In this case, drugs with benzodiazepime are used.

Interaction with other drugs

The simultaneous use of sirolimus, cyclosporine, tacrolimus and tofisopam is contraindicated!

Before using the drug Grandaxin, you need to know how the drug is combined with other drugs:

• In the treatment of affective-shock reactions and psychosis, it is advisable to use Grandaxin together with antidepressants.
• The absorption of Grandaxin is enhanced by the use of Metoclopramide. The therapeutic effect of the first occurs faster.
• When using drugs that suppress the function of the central nervous system and simultaneous use of Grandaxin, their effect is enhanced. While taking painkillers and sleeping pills, sedatives and tranquilizers, respiratory depression may occur.
• Antifungal agents increase the concentration of Grandaxin in the blood. Antihypertensive drugs have the same effect. However, antiepileptic drugs, nicotine, and barbiturates reduce the concentration of the active substance in the blood and weaken the effect of Grandaxin.

This drug is also capable of increasing the concentration of Digoxin in the blood of a person.

Analogs

It is not always possible to buy medicine at a pharmacy. Grandaxin is also highly expensive, so you have to look for a cheap analogue.

A similar drug in terms of active substance and therapeutic effect is Tofisopam.

Medicines that have the same effect as Grandaxin:

• Phenazepam. It has a hypnotic, muscle relaxant and anticonvulsant effect. It is actively used in neurology and psychiatry for the treatment of acute and chronic mental disorders.
• Relanium. A strong tranquilizer with the active substance diazepam. It has a large number of contraindications.
• Afobazol. A sedative that helps eliminate anxiety and improve a person’s mental and physical well-being. In addition, it helps improve memory and concentration.
• Neurol. An anxiolytic drug that has a sedative-hypnotic effect. The drug reduces neurotic symptoms and emotional stress.
• Tazepam. The drug with the active substance oxazepam is used to treat neuroses.

Above are common drugs that can be used instead of Grandaxin. However, replacement of the drug should be done only after consultation with a doctor.

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How long can Grandaxin be taken?

How long can you take grandaxin?

How long can you take Grandaxin without a break?

How long can you take Grandaxin?

How long can you take Grandaxin?

Treatment with Grandaxin is prescribed by a doctor individually, taking into account the patient’s condition, the clinical form of the disease and individual sensitivity to the drug. For example, I was prescribed to take the drug for a month, one tablet in the morning and in the evening. The tablets have many contraindications and side effects. Therefore, it is better not to get carried away with them. In addition, taking these pills, you gain weight well.

A doctor prescribed Grandaxin to my husband when his parents' house burned down and he fell into depression. He said that this drug, unlike any phenozepams, acts gently and is not addictive, and does not interfere with driving a car. This is in fact true .

My husband first took Grandaxin twice a day - morning and evening, then only in the morning, for about a month. Then, when the depression passed and my husband began to smile, we stopped it completely.

But everyone has their own health and individual characteristics of the body, so it is better not to self-medicate (although the drug is sold without a prescription), or cancel it immediately if you feel discomfort. Grandaxin, like any medicine, has contraindications. It is a symptomatic remedy and not intended for continuous use.

Good afternoon. The drug "Grandaxin" is used for people who experience emotional stress and moderate fear. The drug is prescribed for the following human problems:

If we talk about the possible timing of its reception, then there are none. Since each disease is individual and each person requires its own treatment, the period falls under the competence of the attending physician. If your doctor prescribed you Grandaxin, but did not indicate a period for taking it, it is better to go to him again and find out how much you need to take this drug. And of course, do not prescribe this drug yourself, do everything through a doctor.

The drug Grandaxin is indicated for use in cases of emotional stress, moderate fear and apathy; it is included in the group of tranquilizers.

Quite often it is prescribed by neurologists during an exacerbation, and that is why the time and amount of the drug taken should be determined by the doctor.

But it should be remembered that while taking Grandaxin you should not drink alcoholic beverages; the drug combined with ethanol increases all side effects.

Grandaxin - instructions for use, analogues, reviews, price

The drug Grandaxin

Release forms and composition

Instructions for use of Grandaxin

Indications for use

• Neuroses (as well as neurosis-like conditions), accompanied by various fears, anxiety, nervous tension or, on the contrary, apathy, lethargy, and indifference to the environment.
• Violation of psychological adaptation due to stress.
• Reaction to stress in the form of depression with elements of psychopathy.
• Premenstrual syndrome.
• Increased nervous excitability during menopause.
• Heart pain of various origins.
• Hangover (withdrawal) syndrome in chronic alcoholism.
• Neurotic disorders in myopathy, myasthenia gravis, muscle atrophy (i.e. in cases where tranquilizers that relax muscles are contraindicated).

Contraindications

• Increased individual sensitivity to the drug or to one of its components;
• neurotic states with severe aggression, excessive emotional and motor arousal or deep depression;
• pregnancy in the first trimester;
• breastfeeding period;
• sleep apnea (ever occurred before);
• simultaneous use with drugs such as cephalosporins, Sirolimus, Tacrolimus;
• malabsorption of galactose and glucose, congenital lactase deficiency, galactose intolerance.

Grandaxin should be used with caution when:

• epilepsy;
• severe cerebral atherosclerosis;
• other organic brain lesions;
• angle-closure glaucoma;
• history of acute respiratory failure;
• chronic RDS syndrome (respiratory distress syndrome) in the stage of decompensation.

Side effects

• From the side of the central nervous system– headaches, sleep disturbances, increased nervous excitability, irritability. Confusion may develop. In patients with epilepsy - increased seizures.
• From the digestive tract– decreased appetite, feeling of dry mouth, nausea, flatulence (increased gas formation in the intestines), constipation. Rarely, the development of congestive jaundice occurs.
• From the respiratory system– respiratory depression.
• From the musculoskeletal system– muscle pain, tension in various muscle groups.
• Allergic reactions: itching, various skin rashes (including scarlet fever).

Treatment with Grandaxin

Grandaxin is taken regardless of meals. The drug does not cause addiction, mental or physical dependence. There is no withdrawal syndrome either. The drug does not reduce reaction speed and concentration, so there are no professional restrictions during treatment with Grandaxin. To prevent sleep disturbances (falling asleep), it is recommended to take the drug no later than an hour later.

The doctor selects the dose of Grandaxin for the patient individually, depending on the clinical indications, the severity of the condition and the patient’s sensitivity to the drug.

Instructions for use of Grandaxin: pharmacological action, indications for use, contraindications, dosage - video

Grandaxin for children

Use during pregnancy and lactation

Alcohol compatibility

Grandaxin or Afobazol?

Drug interactions

• Metoclopramide enhances the absorption of Grandaxin, and therefore its effect occurs faster.
• Grandaxin increases the blood concentration of Cyclosporine, Sirolimus, Tacrolimus when used simultaneously, so these drugs are not used together.
• Grandaxin enhances the effect of drugs that suppress the function of the central nervous system (painkillers, antidepressants, general anesthesia, hypnotics, antipsychotics and sedatives), up to respiratory depression.
• Enhancers (inducers) of the production of liver enzymes (barbiturates, nicotine, antiepileptic drugs, alcohol) cause a decrease in the concentration in the blood and a weakening of the action of Grandaxin.
• Antifungal drugs (Itraconazole, Ketoconazole) slow down the conversion of Grandaxin in the liver and help increase the concentration of the drug in the blood.
• The therapeutic effect of Grandaxin can be enhanced by some antihypertensive drugs (calcium channel blockers, Clonidine).
• Grandaxin may increase the concentration of Digoxin in the blood.
• Benzodiazepines (including Grandaxin) can change the anticoagulant effect of Warfarin.
• Antacids may have an inhibitory effect on the absorption of Grandaxin.
• Long-term concomitant use of Disulfiram may suppress the conversion (metabolism) of Grandaxin.
• Omeprazole, Cimetidine, and tablet contraceptives reduce the intensity of Grandaxin transformations.

Grandaxin's analogs

Reviews about the drug

Price of the drug in Russia and Ukraine

• Grandaxin tablets No. 20 – from 220 to 260 rubles. per packaging;
• Grandaxin tablets No. 60 – from 475 to 538 rubles. per package.

• Grandaxin tablets No. 20 – 150 UAH. per packaging;
• Grandaxin tablets No. 60 – 215 UAH. per package.

Read more:

Reviews

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You can add your comments and feedback to this article, subject to the Discussion Rules.

I saw something

I take Grandaxin as prescribed by a doctor, but not systematically. The doctor prescribed Grandaxin again. I liked the drug Grandaxin. Each Grandaxin tablet contains 92 mg of lactose. Grandaxin helps me a lot. Your doctor has prescribed you a normal average therapeutic dosage of Grandaxin and you can take 1 tablet 3 times a day at once without gradually increasing the dosage. In this article you can read the instructions for use of the drug Grandaxin.

Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Grandaxin in their practice are presented.

Grandaxin is a daytime tranquilizer. After oral administration, it is quickly and almost completely absorbed from the gastrointestinal tract. Tofizopam (the active substance of the drug Grandaxin) does not accumulate in the body. Therefore, Grandaxin is not recommended as monotherapy for depression or depression accompanied by anxiety. Grandaxin does not significantly reduce attention and the ability to concentrate. Medicines such as Grandaxin, of course, must be taken under the supervision of a doctor and side effects must be reported to him quickly and without fail.

I was prescribed Grandaxin and I’ve been taking it for the second day, so far everything is fine. The doctor prescribed Grandaxin half a tablet in the morning and evening + magnesium B6 - on the first night I slept like a baby and finally felt that I was starting to get enough sleep. Then the doctor advised Grandaxin, the effect after treatment was and this was a state of calm and uplifting spirit after treatment, not for one day, but for months!

Only Grandaxin helps me get rid of hot flashes, anxiety and weakness. Grandaxin works very well for me. I take it in courses for my nerves. I've been taking Grandaxin for 5 days. Sleeping became worse. I can’t say yet that there is a positive effect. Snezhana and others, I am giving you a warning for advertising the drug Grandaxin, albeit mildly, in reviews under the guise of ordinary visitors.

Another question is that tachycardia can be treated with Grandaxin if there was an episode of stress. Grandaxin, for example, did not work for me. I took Grandaxin without prescription after my father’s death, twice a day. I felt good, there were emotions, but there were no heavy thoughts in my head and I accepted the world as it is. They helped a lot... I took a Grandaxin tablet yesterday at lunch. By 17:00 I wanted to sleep. I slept for 3 hours and woke up feeling weak.

Lidija, You can. Even in clinical studies that tested methods of curing tobacco addiction using the drug Grandaxin, focus groups of men and women were used. I read the reviews and now I’m scared to take this drug. I don’t see anything wrong with Grandaxin if it is recommended to the patient by a doctor, and side effects can occur when taking any medications, although the percentage will be small.

The nervous system is trying to tell you about this with alarm, but you grab Grandaxin! I decided to try Grandaxin, prescribed by a doctor 2 years ago before bed. Good luck right away! Firstly, I slept 2 hours longer and secondly, there is no chest pain or heart failure. Grandaxin is a drug that acts on the central nervous system and belongs to the group medicines called benzodiazepines.

Therefore, the use of Grandaxin is not recommended during breastfeeding. The dose of Grandaxin tablets depends on the type of disease and the patient’s condition, so it should be determined individually. If you feel that the effect of Grandaxin is too strong or too weak, consult your doctor or pharmacist.

Grandaxin - instructions for use, reviews, analogs and release forms (50 mg tablets) of a drug for the treatment of neuroses, stress and menopause in adults, children and pregnancy

Analogues of Grandaxin in the presence of existing structural analogues. Due to the lack of a muscle relaxant effect, the drug can be used in patients with myopathy and myasthenia. In these cases, the risk of suicide attempts and aggressive behavior increases. Plasma concentrations of drugs that are metabolized by the CYP3A4 isoenzyme may increase when taken concomitantly with tofisopam.

But I read the reviews and it became scary. You need to focus on your condition, given that you are already taking this drug, and not on reviews. After my mother’s death, everything hurt at once (I realized what it was - all diseases are caused by nerves), only after a course of Grandaxin did life begin to improve; one of the side effects was palpitations.

Most drugs have never helped me, including herbal drugs (valerian, motherwort, mint...), as well as afobazole and novopassit. ELENA, Grandaxin is available by prescription, like many other medications, including antibiotics. It’s just that many pharmacists dispense without a prescription, knowing the problems our patients experience in terms of access to doctors. Therefore, this is good and bad at the same time; many patients bring themselves to the point of inappropriate treatment serious problems With their health, only then do they turn to doctors.

This is the first drug that has an effect. There was itching and rashes. The neurologist diagnosed VSD and prescribed this drug. And so it happened. Didn't understand anything, what was it? I mean, I didn’t feel any effect... The arrhythmia doesn’t bother me, my sleep is normal, and there’s no anxiety. I don’t take it all the time, but for two weeks, and then a break, and if I feel nervous or excited again, I start taking it.

If the drug does not help you personally, this only means that you need to choose the right one for yourself. This is understandable and acceptable, but you have been living with tachycardia for 4 years. I think you are better advised to consult a cardiologist. Good luck with your treatment and recovery.

The simultaneous use of tacrolimus, sirolimus, cyclosporine and Grandaxin is contraindicated. Grandaxin is contraindicated for use in the 1st trimester of pregnancy and during lactation (breastfeeding). I’ve been taking Grandaxin just recently, prescribed by a neurologist for accumulated stress.

Grandaxin and addiction. Replacement

In ordinary life, when I don’t have emotions, i.e. I don't like the calm state. Dullness of thinking, no motivation to do something, or rather it happens, but not very pronounced. And I don’t like this about myself. When I don’t have strong emotions, I feel bad. And when there are a lot of them, it’s also not very good.

Is it possible to somehow replace it with something safe? And don’t such pills harm internal processes?

Without them, a kind of spiritual emptiness sets in.

And in a relationship, there is no desire for sex, somehow intensely

Those. when love and passion - I like this state more

And when the emotions go away, I become very sad and I stop doing a lot, I don’t feel life and everything

Psychologist, Clinical Psychologist

I didn’t find myself getting used to it.

Who prescribed Grandaxin to you? How long did you drink?

And now I drink once a week to lift my emotions

Who prescribed Grandaxin to you? How long did you drink?

Private psychotherapist for anxiety

But the anxiety subsided as I began to communicate regularly with the man, and I expressed everything that was in my heart

Grandaxin is a “daytime tranquilizer” that blocks benzodiazepine receptors without a pronounced hypnotic effect. Therefore, addiction to it rarely develops, but it is still not recommended to drink it for more than a month in a row.

Grandaxin does not cause physical dependence.

And psychological dependence can arise from anything.

Therefore, yes, psychotherapy is indicated for you

Psychotherapist, Supervisor, Psychiatrist

I like the way the side effects appear

How do you determine that it is physical?

Sensations in the body

Psychotherapist, Psychoanalytic psychotherapist

Psychotherapist, Psychoanalytic psychotherapist

I take a pill. After a couple of hours, my body begins to feel nervous (shaking) and I want to be more physically and mentally active.

Sensations in the body

The line between physical and psychological dependence is often arbitrary. The main criterion is the presence of withdrawal syndrome.

I took Grandaxin, there was no dependence. And the doctor prescribed it as a safe drug in this regard. Perhaps your addiction is far-fetched?

I feel nervous excitability of my body (shaking), I want to be more active physically and also mentally

more like a side effect

From the state it gives

At what dose does this effect occur?

And if this doesn’t happen, and it happens all the time, then I feel bad

Also often dependent on negative emotions

Psychotherapist, Psychoanalytic psychotherapist

Psychotherapist, Psychoanalytic psychotherapist

Psychotherapist, Psychoanalytic psychotherapist

How can psychotherapy help? Passed

Yes, it's bad. Treatment of all addictions is complete withdrawal of the drug, prescription of symptomatic drugs + psychotherapy.

It sounds like you have extreme sensitivity to psychotropic drugs. What is your height, weight and age?

Psychotherapy helps improve brain function, the production of neurotransmitters, and often normalizes the functioning of the entire body.

I only feel negative

Psychotherapist, Psychoanalytic psychotherapist

I read about neurotransmitters that antidepressants and tranquilizers, on the contrary, make things worse

How can I work with neurotransmitters if I don’t feel positive emotions? I feel it physically, but no way

I lost sensitivity to life, events and people

I only feel negative

And when it’s cool, I feel bad and it hurts my chest

I’m not sure about “making it worse.” But the absence of positive emotions is most often a purely psychological situation that requires understanding and elaboration.

But I don't feel

Psychotherapist, Psychoanalytic psychotherapist

What if you take half a tablet of Grandaxin 3 times a week or one tablet, but constantly?

You feel something like this in your relationship with a man. I think this is where we need to “dig”!

And often there is no desire for life either

Psychotherapist, Psychoanalytic psychotherapist

Question for doctors. What does the formation of addiction depend on? I'm taking Diazepam like " ambulance". The feeling from it is like after a glass of wine. You feel slightly intoxicated. Relaxation in the muscles, the mood improves, stress resistance increases. I like this condition, but there is no “withdrawal”, I can calmly refuse it. This is due to some physiological characteristics body?

Psychotherapist, Psychoanalytic psychotherapist

And I like it when my brain activity and sensations in my body are increased

And I don’t get them without pills

The lower the dose, the faster you can “wean off the habit.”

You feel something like this in your relationship with a man. I think this is where we need to “dig”!

How long ago did this start? and what do you attribute the onset of such symptoms to?

Although this happened from the age of 17, I went into communication, but I was not able to develop professionally and have not yet succeeded

Psychotherapist, Psychoanalytic psychotherapist

I don't want to get out of the habit. I like the condition

🙂 So, of course! But someday, you still have to. The earlier the better!

Psychotherapist, Psychoanalytic psychotherapist

But there probably won’t be any point in contacting you via Skype, or is there?

There are plenty of options! Especially among tablets. But “cross” dependencies develop much faster. When switching from alcohol to sedatives, from sedatives to barbiturates, and so on, so on, so on.

But I want to separately work out many issues

Use of Grandaxin for VSD

Anxiety, panic attacks, uncontrollable fear, a feeling of lack of air and suffocation - hundreds of people face all these conditions every day.

Cases of vegetative-vascular dystonia (VSD) are observed in various age groups. The disorder is accompanied not only by the symptoms listed above, but also by many other unpleasant conditions.

Grandaxin for VSD is one of the drugs that neurologists often prescribe during exacerbations, as well as to maintain the nervous system.

• All information on the site is for informational purposes only and is NOT a guide to action!
• Only a DOCTOR can give you an ACCURATE DIAGNOSIS!
• We kindly ask you NOT to self-medicate, but to make an appointment with a specialist!
• Health to you and your loved ones!

Compound

The main active ingredient of the drug is tofisopam. One tablet of Grandaxin contains 50 mg of the active ingredient.

• talc;
• magnesium stearate;
• octadecanoic acid;
• gelatin;
• microcrystalline cellulose;
• potato starch;
• lactose monohydrate.

Pharmacodynamics and pharmacokinetics

The drug belongs to the group of tranquilizers and is a benzodiazepine derivative. The action of the drug is aimed at eliminating various forms of autonomic disorders. Grandaxin also has psychostimulating activity. The drug is prescribed to patients suffering from myasthenia gravis and myopathy.

The drug does not cause mental or physical dependence; after a course of treatment, withdrawal syndrome does not occur. The medicine is a daytime anxiolytic (sedative).

Quite quickly and almost completely absorbed into the blood from the gastrointestinal tract after oral administration. After two hours, the maximum concentration of the active substance in the blood occurs.

The half-life is six to eight hours. More than half of the ingested substance (about 60%) is excreted in the urine, the rest - during bowel movements.

Indications for use

The main indication for use is conditions that are accompanied by emotional stress and moderate fear. The drug is taken for disorders accompanied by vegetative disorders and apathy.

In addition, the drug is taken:

• in conditions accompanied by reduced activity;
• obsessive experiences;
• premenstrual syndrome;
• during menopause;
• for post-traumatic stress disorders;
• impaired psycho-emotional adaptation;
• myasthenia gravis;
• myopathies;
• chronic alcoholism.

The entry of any drug into the body does not mean that the mental state will immediately improve, consciousness will become clearer, and thoughts will normalize. U healthy person the function of the cerebral cortex is inextricably linked with the functional state of the subcortical regions.

In people suffering from VSD, the situation is different: with the development of the disorder, the subcortical sections do not cope with their function - the self-preservation of the body under various conditions. Because of this, indications for taking Grandaxin are determined by the state of consciousness where thoughts are formed.

How much Grandaxin to drink for VSD is a question that falls under the competence of the doctor. The dosage is prescribed individually depending on the patient's condition.

Usually one or two tablets are prescribed up to three times a day, and to maintain the condition you can take one tablet at a time

Contraindications

The main contraindication is hypersensitivity to the components of the drug.

Also, taking the drug is prohibited in the following cases:

• with respiratory failure in decompensated form;
• psychosis and psychopathy, accompanied by severe psychomotor agitation;
• pregnancy and breastfeeding.

Side effects of Grandaxin in VSD

Adverse reactions from taking Grandaxin:

It should be noted that the medicine negatively affects the ability to drive vehicles and other machinery.

Treatment with myasthenia gravis should be carried out under close medical supervision.

Alcohol compatibility

Doctors warn that Grandaxin should not be taken together with alcoholic beverages. The reason lies not only in the danger of development adverse reactions, which when taking an anxiolytic can manifest themselves in the form of insomnia, headache, confusion and irritability.

If the patient suffers from liver disease, side effects may be more pronounced and occur more often.

Grandaxin has a special effect on those who like to drink, i.e. it causes more severe side reactions. The effects are enhanced by ethanol. This must be taken into account if this drug is prescribed by a neurologist.

The symptoms of VSD are listed in this article.

Grandaxin eliminates anxiety, and alcohol, by reducing the effectiveness of medications, neutralizes this effect. For this reason, Grandaxin and alcohol cannot be combined.

Moreover, when they are used together, the load on the liver increases. After 6-8 hours, the medicine enters the liver, from where it is excreted in processed form through urine and feces. Alcohol is eliminated in the same way, i.e. the organ has a double load.

The unpredictability of taking a tranquilizer and alcohol together is also explained by the fact that in people suffering from alcoholism, the functioning of all organs is impaired. Therefore, it is impossible to predict how the body will behave when combining the drug with ethanol.

Similar drugs

Drugs that have a similar effect:

• is a selective non-benzodizepine tranquilizer;
• does not cause addiction or adverse reactions such as weakness or drowsiness;
• has a gentle effect on the central nervous system without depressing it;
• the drug triggers a natural compensatory and protective mechanism, which allows the body to cope with stress more easily.

• refers to anxiolytics;
• reduces emotional stress, eliminates anxiety and restlessness;
• does not weaken intellectual activity, does not reduce physical activity;
• does not cause drowsiness.

• is a combination drug with a sedative effect;
• used for headaches associated with nervous tension, irritability, anxiety, fear, migraines, sleep disorders, VSD and during menopause.

• a drug that has antidepressant, anti-anxiety and antiasthenic effects;
• the drug regulates the activity of the S100 protein, which normalizes metabolic processes and mechanisms of activation and inhibition of the central nervous system;
• the product helps improve the functional state of the central nervous system, increases concentration and memory, ensures the body's resistance to stress, hypoxia and intoxication;
• does not cause drowsiness.

• modern medicine, developed by Russian scientists;
• the components of the drug provide a natural revelation of the hidden capabilities of the brain, increases mental activity, improves memory, relieves psycho-emotional stress, and helps deal with stressful situations.

About the benefits physical exercise for vegetative-vascular dystonia, read here.

We will tell you how to behave during the heat with VSD at the link.

I was prescribed Grandaxin twice, the first time for treatment, the second for prevention. So, the first time Grandaxin worked only towards the end of the dose, and I took it for a month, 4 tablets per day (divided into two doses), but then I had a very bad feeling. I had a constant headache, I didn’t sleep well at night, I had nightmares, I was nervous and tired during the day, then I started feeling dizzy, weak, and numb in my arms and legs. I won’t tell you what was “spinning” in my head at that time. But after a course of treatment with Grandaxin, my condition returned to normal, bright thoughts appeared, my health improved, and all negative symptoms disappeared.

But the second time I took Grandaxin, I noticed the effect earlier, after about a week, and by the way, I took it in a different dosage, only 1 tablet a day. But I also very quickly felt a surge of strength, my sleep improved, and I even got up in the morning with ease and in a good mood. And somehow I felt calmer, less worried, less nervous.

It all depends on the individual characteristics of the body. On average, the effect of Grandaxin after taking the tablets appears within two hours and the duration of the effect is 6-8 hours.

Both a course appointment and a one-time appointment are possible. Take 1-2 tablets one to three times a day. There are serious contraindications and a prescription from a doctor is required to purchase.

What is important is that Grandaxin does not accumulate in the body and is not addictive.

Grandaxin is unique in that its effect is felt within 2-5 minutes and lasts for quite a long time, about 3-6 hours. Depending on the characteristics of your body. Its course consists of taking 1-2 tablets once or three times a day.

Grandaxin: application, instructions, reviews

General description of Grandaxin

Grandaxin is a tranquilizer. Being a vegetotropic drug, it differs from “its own kind” in its activating and vegetative-normalizing ability, that is, it makes a person more resistant to stressful situations. Its main component is considered to be tofisopam, due to which an anxiolytic effect is achieved, not accompanied by muscle relaxant, sedative, or anticonvulsant effects.

It is quickly absorbed from the gastrointestinal tract, and after a couple of hours its concentration in plasma can be considered maximum. Excreted in urine after 8 hours.

Grandaxin is available in the form of marked white round tablets.

The medical drug Tofisopam is considered a complete analogue of Grandaxin.

Indications and contraindications for the use of Grandaxin

The use of Grandaxin is simply irreplaceable for neuroses varying degrees intensity and etiology, reactive depression and mental adaptation disorders after a stressful or shock situation. In addition, this medication is directly involved in the period of menopausal syndrome, acting as the main treatment agent, or as part of a combination hormone therapy. Its use is also appropriate for diagnoses such as myasthenia gravis and myopathy. Often becomes an integral part complex therapy alcohol withdrawal syndrome.

The drug is quite serious, so before prescribing it you should study a significant list of contraindications. Thus, such treatment is not indicated for deep depression, accompanied by excessive overexcitation or aggression, respiratory failure at the stage of decompensation, at the beginning of pregnancy and lactation. It is also necessary to remember the specifics of your own body, where hypersensitivity to the active components of Grandaxin may predominate.

Prescribe with caution for epilepsy, angle-closure glaucoma, organic brain disorders, as well as in late pregnancy.

Side effects and overdose of Grandaxin

The drug has a more gentle effect in the body, but this does not exclude the possibility of side effects. The main blow goes to the central nervous system, where the following anomalies are possible: migraines, insomnia, confusion, emotional overexcitation and increased activity. In addition, mild digestive disorders occur, in particular, dry mouth, loss of appetite, flatulence, severe constipation, nausea, and less commonly, jaundice. Allergic reactions of the skin are also possible, where redness, rash, swelling and itching are observed. Stopping the use of Grandaxin eliminates all side effects.

In case of an overdose of Grandaxin, an increase in all side effects is observed. Here, gastric lavage by artificial vomiting and taking sorbents are urgently required. Further treatment is symptomatic with the participation of a doctor.

Instructions for use of Grandaxin

How to take this medication, in what quantities and for how long is decided exclusively by a knowledgeable specialist. The detailed instructions for Grandaxin indicate that adults are prescribed two tablets up to three times a day, but no more than 6 tablets for the whole day. For elderly patients and patients with liver diseases, the recommended dose is halved.

Features of the use of Grandaxin

Side effects during treatment with Grandaxin increase in patients with liver and kidney problems, mental retardation, atherosclerosis, and in old age.

At chronic form psychosis, phobias or obsessions, such a prescription is strictly prohibited, otherwise the risk of exacerbation of aggressive behavior and suicide attempts increases.

The use of Grandaxin does not reduce the patient’s vital activity, so driving, as well as engaging in high-energy activities, is acceptable.

Drug interactions. The combination of Grandaxin with tacrolimus, sirolimus, and cyclosporine is prohibited. In complex treatment with the participation of antidepressants, analgesics, sedatives, antipsychotics and hypnotics, as well as histamine H1 receptor blockers, an increase in their effectiveness is observed.

Ethanol, barbiturates, nicotine, and antiepileptic drugs significantly accelerate the breakdown of tofisopam, which reduces its concentration in plasma and entails a weakening of the therapeutic effect. Certain antifungal agents, on the contrary, slow down the hepatic metabolism of tofisopam, increasing its concentration in the blood plasma. Certain antihypertensive drugs enhance the effect of Grandaxin, while disulfiram, on the contrary, inhibits it. Oral contraceptives weaken the rate of metabolism of tofisopam, which, in turn, prevents the increased pressure of ethanol on the central nervous system.

Reviews of Grandaxin, price

There are quite often mediocre reviews about Grandaxin on the Internet, from which we can conclude that the drug is very weak. It really does not cause side effects, but the desired effect on the central nervous system is also absent. Those who have experienced its effectiveness honestly admit that they took it as part of complex treatment, but by itself it is rather weak.

You can also find many reviews regarding the complete uselessness of Grandaxin, since even after prolonged use, improvements did not occur.

Therefore, it is not advisable to advise Grandaxin; it is better to consult your doctor yourself.

Price for Grandaxin tablets. 50 mg No. rubles

Today, not all patients with nervous disorders decide to take tranquilizers, preferring more harmless sedatives, but their effect is not always sufficient to obtain the desired result. Grandaxin, being a tranquilizer, acts gently in the body, avoiding a large number of side effects provided for by this pharmacological group. general description Grandaxina Grandaxine is a tranquilizer. Being a vegetotropic drug, it differs from [. ]

Attention!

The information posted on the site is for informational purposes only and is not a reason for self-medication.

Prescribing medications and monitoring the progress of treatment should be carried out only by a qualified specialist within the medical institution, taking into account the individual characteristics of the patient’s body.

Responsibility for all possible negative consequences obtained during use medical supplies without the consent of the attending physician, lies entirely with the person who self-medicated.

Copying and any use of information from the site farminfoservice.ru is permitted only with the written permission of the copyright holder - the site administration.

2 reviews

Honey helps me a lot with loss of strength and low mood. drug Biotredin. Moreover, it begins to act very quickly - within 10 minutes! And this despite the fact that he does not have side effects

Biotredin also starts to work on me almost immediately. It is very comfortable. After a few minutes you feel almost like a different person. More restrained, more concentrated, more clearly understanding everything. Somehow unusual, as for everyday reality, but true!

Who took the drug Grandaxin?

Is this the only drug you were prescribed?

And what specialization is the doctor?

Almaty (Kazakhstan)

To understand how correctly the treatment is prescribed, in the right dosage, is possible only by knowing the condition of a particular patient, all the symptoms and reasons that led to the prescription of a particular drug.

severe stress before the operation affected

Almaty (Kazakhstan)

Psychologist, Inner Reality Therapy

I was very worried before the operation, and after it too, in the intensive care unit, when there was a tube in my throat, I couldn’t breathe, I thought, I’m going to suffocate, that same evening my heart started beating, I started shaking a little, and I felt anxious. And now every day I don’t understandable anxiety. 13 years ago I already had depression with panic attacks, as long as it didn’t develop into it

When a traumatic situation remains unprocessed, it is subsequently much more difficult to cope with.

Psychologist, Inner Reality Therapy

Yes, a state of panic. Now that everything is over, it would seem to live and be happy, but the feeling of anxiety does not go away. The doctor diagnosed neurosis.

The smallest signals, for example:

Stitching in the throat or elsewhere on the body;

Choke in throat;

Psychotherapist, Homeopathic Doctor Skype Consultant

If the drug causes deterioration in health, then it must be discontinued!

Psychologist, Inner Reality Therapy

To be honest, I don’t remember exactly, then I began to recover from anesthesia, I only remember the panic fear that I would suffocate because the tube did not allow me to breathe.

I asked you to remember all the sensations that arose before the operation.

Psychologist, Inner Reality Therapy

Before the operation there was tension that radiated into chest, in There seemed to be no sensation in my throat.

Psychologist, Inner Reality Therapy

The night before the operation I slept very poorly, I even dreamed about how it was performed on me.

Psychologist, Inner Reality Therapy

I was afraid of the operation itself, what if something went wrong, what if my heart couldn’t stand the anesthesia, etc., etc. I tried to calm myself down, but it didn’t work out well.

Psychologist, Inner Reality Therapy

They admitted me to the hospital the day before the operation, and that’s when I was in this condition. Days. When they took me to the operation, I didn’t shake much at all.

Psychologist, Inner Reality Therapy

There was only one thought - if only everything went well! And only images of relatives, how they would be without me, if suddenly I was gone.

Psychologist, Inner Reality Therapy

But a feeling of anxiety began to come, out of nowhere, I myself seemed to understand that everything was fine with me, but the anxiety began to put pressure on my chest.

What precedes its occurrence?

Did you take it?

Mogilev (Belarus)

What was it taken from?

Psychologist, Cognitive Behavioral Therapist

Mogilev (Belarus)

13 years ago I already had depression with panic attacks

when there was a tube in my throat, I couldn’t breathe, I thought I was going to suffocate, that same evening my heart started palpitating, shaking a little, and a feeling of anxiety.

Grandaxin

The drug Grandaxin

Release forms and composition

Instructions for use of Grandaxin

Indications for use

• Neuroses (as well as neurosis-like conditions), accompanied by various fears, anxiety, nervous tension or, on the contrary, apathy, lethargy, and indifference to the environment.
• Violation of psychological adaptation due to stress.
• Reaction to stress in the form of depression with elements of psychopathy.
• Premenstrual syndrome.
• Increased nervous excitability during menopause.
• Heart pain of various origins.
• Hangover (withdrawal) syndrome in chronic alcoholism.
• Neurotic disorders in myopathy, myasthenia gravis, muscle atrophy (i.e. in cases where tranquilizers that relax muscles are contraindicated).

Contraindications

• Increased individual sensitivity to the drug or to one of its components;
• neurotic states with severe aggression, excessive emotional and motor arousal or deep depression;
• pregnancy in the first trimester;
• breastfeeding period;
• sleep apnea (ever occurred before);
• simultaneous use with drugs such as cephalosporins, Sirolimus, Tacrolimus;
• malabsorption of galactose and glucose, congenital lactase deficiency, galactose intolerance.

Grandaxin should be used with caution when:

• epilepsy;
• severe cerebral atherosclerosis;
• other organic brain lesions;
• angle-closure glaucoma;
• history of acute respiratory failure;
• chronic RDS syndrome (respiratory distress syndrome) in the stage of decompensation.

Side effects

• From the side of the central nervous system– headaches, sleep disturbances, increased nervous excitability, irritability. Confusion may develop. In patients with epilepsy, there is an increase in seizures.
• From the digestive tract– decreased appetite, feeling of dry mouth, nausea, flatulence (increased gas formation in the intestines), constipation. Rarely, the development of congestive jaundice occurs.
• From the respiratory system– respiratory depression.
• From the musculoskeletal system– muscle pain, tension in various muscle groups.
• Allergic reactions: itching, various skin rashes (including scarlet fever).

Treatment with Grandaxin

Grandaxin is taken regardless of meals. The drug does not cause addiction, mental or physical dependence. There is no withdrawal syndrome either. The drug does not reduce reaction speed and concentration, so there are no professional restrictions during treatment with Grandaxin. To prevent sleep disturbances (falling asleep), it is recommended to take the drug no later than an hour later.

The doctor selects the dose of Grandaxin for the patient individually, depending on the clinical indications, the severity of the condition and the patient’s sensitivity to the drug.

Instructions for use of Grandaxin: pharmacological action, indications for use, contraindications, dosage - video

Grandaxin for children

Use during pregnancy and lactation

Alcohol compatibility

Grandaxin or Afobazol?

Drug interactions

• Metoclopramide enhances the absorption of Grandaxin, and therefore its effect occurs faster.
• Grandaxin increases the blood concentration of Cyclosporine, Sirolimus, Tacrolimus when used simultaneously, so these drugs are not used together.
• Grandaxin enhances the effect of drugs that suppress the function of the central nervous system (painkillers, antidepressants, general anesthesia, hypnotics, antipsychotics and sedatives), up to respiratory depression.
• Enhancers (inducers) of the production of liver enzymes (barbiturates, nicotine, antiepileptic drugs, alcohol) cause a decrease in the concentration in the blood and a weakening of the action of Grandaxin.
• Antifungal drugs (Itraconazole, Ketoconazole) slow down the conversion of Grandaxin in the liver and help increase the concentration of the drug in the blood.
• The therapeutic effect of Grandaxin can be enhanced by some antihypertensive drugs (calcium channel blockers, Clonidine).
• Grandaxin may increase the concentration of Digoxin in the blood.
• Benzodiazepines (including Grandaxin) can change the anticoagulant effect of Warfarin.
• Antacids may have an inhibitory effect on the absorption of Grandaxin.
• Long-term concomitant use of Disulfiram may suppress the conversion (metabolism) of Grandaxin.
• Omeprazole, Cimetidine, and tablet contraceptives reduce the intensity of Grandaxin transformations.

Grandaxin's analogs

Reviews about the drug

Price of the drug in Russia and Ukraine

Latest

Hello. For several months now I have been having difficulty breathing, there is not enough air.

Hello. I was short of breath and couldn’t sleep.

Hello. please tell me how to use Grandaxin?, 1 tablet each.

Hello, Doctor! Elena is addressing you. I am 39 years old. I live in a village. IN.

I am 43 years old. I have headaches, sometimes redness in my left eye, and nervousness.

Good afternoon. For the third day now I have had a fever of 5 degrees, no symptoms.

Use of Grandaxin for VSD

Anxiety, panic attacks, uncontrollable fear, a feeling of lack of air and suffocation - hundreds of people face all these conditions every day.

Cases of vegetative-vascular dystonia (VSD) are observed in various age groups. The disorder is accompanied not only by the symptoms listed above, but also by many other unpleasant conditions.

Grandaxin for VSD is one of the drugs that neurologists often prescribe during exacerbations, as well as to maintain the nervous system.

• All information on the site is for informational purposes only and is NOT a guide to action!
• Only a DOCTOR can give you an ACCURATE DIAGNOSIS!
• We kindly ask you NOT to self-medicate, but to make an appointment with a specialist!
• Health to you and your loved ones!

Compound

The main active ingredient of the drug is tofisopam. One tablet of Grandaxin contains 50 mg of the active ingredient.

• talc;
• magnesium stearate;
• octadecanoic acid;
• gelatin;
• microcrystalline cellulose;
• potato starch;
• lactose monohydrate.

Pharmacodynamics and pharmacokinetics

The drug belongs to the group of tranquilizers and is a benzodiazepine derivative. The action of the drug is aimed at eliminating various forms of autonomic disorders. Grandaxin also has psychostimulating activity. The drug is prescribed to patients suffering from myasthenia gravis and myopathy.

The drug does not cause mental or physical dependence; after a course of treatment, withdrawal syndrome does not occur. The medicine is a daytime anxiolytic (sedative).

Quite quickly and almost completely absorbed into the blood from the gastrointestinal tract after oral administration. After two hours, the maximum concentration of the active substance in the blood occurs.

The half-life is six to eight hours. More than half of the ingested substance (about 60%) is excreted in the urine, the rest - during bowel movements.

Indications for use

The main indication for use is conditions that are accompanied by emotional stress and moderate fear. The drug is taken for disorders accompanied by vegetative disorders and apathy.

In addition, the drug is taken:

• in conditions accompanied by reduced activity;
• obsessive experiences;
• premenstrual syndrome;
• during menopause;
• for post-traumatic stress disorders;
• impaired psycho-emotional adaptation;
• myasthenia gravis;
• myopathies;
• chronic alcoholism.

The entry of any drug into the body does not mean that the mental state will immediately improve, consciousness will become clearer, and thoughts will normalize. In a healthy person, the function of the cerebral cortex is inextricably linked with the functional state of the subcortical regions.

In people suffering from VSD, the situation is different: with the development of the disorder, the subcortical sections do not cope with their function - the self-preservation of the body under various conditions. Because of this, indications for taking Grandaxin are determined by the state of consciousness where thoughts are formed.

How much Grandaxin to drink for VSD is a question that falls under the competence of the doctor. The dosage is prescribed individually depending on the patient's condition.

Usually one or two tablets are prescribed up to three times a day, and to maintain the condition you can take one tablet at a time

Contraindications

The main contraindication is hypersensitivity to the components of the drug.

Also, taking the drug is prohibited in the following cases:

• with respiratory failure in decompensated form;
• psychosis and psychopathy, accompanied by severe psychomotor agitation;
• pregnancy and breastfeeding.

Side effects of Grandaxin in VSD

Adverse reactions from taking Grandaxin:

It should be noted that the medicine negatively affects the ability to drive vehicles and other machinery.

Treatment with myasthenia gravis should be carried out under close medical supervision.

Alcohol compatibility

Doctors warn that Grandaxin should not be taken together with alcoholic beverages. The reason lies not only in the danger of developing adverse reactions, which, when taking an anxiolytic, can manifest themselves in the form of insomnia, headache, confusion and irritability.

If the patient suffers from liver disease, side effects may be more pronounced and occur more often.

Grandaxin has a special effect on those who like to drink, i.e. it causes more severe side reactions. The effects are enhanced by ethanol. This must be taken into account if this drug is prescribed by a neurologist.

The symptoms of VSD are listed in this article.

Grandaxin eliminates anxiety, and alcohol, by reducing the effectiveness of medications, neutralizes this effect. For this reason, Grandaxin and alcohol cannot be combined.

Moreover, when they are used together, the load on the liver increases. After 6-8 hours, the medicine enters the liver, from where it is excreted in processed form through urine and feces. Alcohol is eliminated in the same way, i.e. the organ has a double load.

The unpredictability of taking a tranquilizer and alcohol together is also explained by the fact that in people suffering from alcoholism, the functioning of all organs is impaired. Therefore, it is impossible to predict how the body will behave when combining the drug with ethanol.

Similar drugs

Drugs that have a similar effect:

• is a selective non-benzodizepine tranquilizer;
• does not cause addiction or adverse reactions such as weakness or drowsiness;
• has a gentle effect on the central nervous system without depressing it;
• the drug triggers a natural compensatory and protective mechanism, which allows the body to cope with stress more easily.

• refers to anxiolytics;
• reduces emotional stress, eliminates anxiety and restlessness;
• does not weaken intellectual activity, does not reduce physical activity;
• does not cause drowsiness.

• is a combination drug with a sedative effect;
• used for headaches associated with nervous tension, irritability, anxiety, fear, migraines, sleep disorders, VSD and during menopause.

• a drug that has antidepressant, anti-anxiety and antiasthenic effects;
• the drug regulates the activity of the S100 protein, which normalizes metabolic processes and mechanisms of activation and inhibition of the central nervous system;
• the product helps improve the functional state of the central nervous system, increases concentration and memory, ensures the body's resistance to stress, hypoxia and intoxication;
• does not cause drowsiness.

• a modern medication developed by Russian scientists;
• the components of the drug provide a natural revelation of the hidden capabilities of the brain, increases mental activity, improves memory, relieves psycho-emotional stress, and helps deal with stressful situations.

Read about the benefits of physical exercise for vegetative-vascular dystonia here.

We will tell you how to behave during the heat with VSD at the link.

Grandaxin - relieves anxiety

Neuroses are one of the most common diseases of our time. Many medications have been developed to treat them. One of the most effective medicines for the treatment of neuroses are anxiolytics or tranquilizers, which are divided into nighttime (they promote sleep) and daytime (they have a slight activating effect).

How does Grandaxin work?

Grandaxin (international generic name– tofisopam) belongs to the daytime tranquilizers of the benzodiazepine group. It relieves anxiety, unreasonable fears, irritable weakness, various disorders internal organs and systems resulting from dysfunction of the autonomic nervous system: moderately increased arterial pressure, palpitations, pain in the heart Pain in the heart - be sure to consult a doctor of a neurotic nature.

But at the same time it does not have a pronounced sedative (calming) effect, does not relax skeletal muscles, and therefore can be prescribed to patients with diseases accompanied by muscle weakness. It also does not have an anticonvulsant effect; on the contrary, under its influence, convulsions may intensify.

However, the threat of addiction still exists if you take Grandaxin for a long time and in large doses.

Grandaxin also does not accumulate (cumulate) in the body.

The action of Grandaxin lasts about eight hours, after which it is decomposed in the liver into metabolites (metabolic products) and excreted in the urine (the main part) and partially in feces.

Who should take Grandactin?

Grandaxin perfectly relieves emotional stress, therefore, first of all, it is indicated for neuroses and neurosis-like conditions (such conditions can arise against the background of any organic diseases, with a violation of the structure of the brain). Anxiety goes away, various experiences lose their relevance. Any manifestations of autonomic disorders are perfectly relieved. Apathy is replaced by activity. Grandaxin is especially indicated for menopause, premenstrual syndrome and neurotic heart pain.

Grandaxin is also taken for mild depression, but if it does not reduce its manifestations, then the doctor should prescribe a more effective combination treatment.

Grandaxin is good for patients who have experienced severe stress. How to overcome stress? Create an oasis for yourself and have difficulty adapting to ordinary life situations.

In patients suffering from chronic alcoholism, after a long binge, a hangover occurs, which can be very difficult, accompanied by anxiety, guilt and various disorders of the internal organs and blood vessels(vegetative disorders). Grandaxin may well cope with not very severe withdrawal symptoms.

Contraindications to the use of Grandaxin

• with increased excitement, aggressiveness;
• with severe depression;
• in case of respiratory dysfunction, including apnea (stopping breathing during sleep);
• in the first 12 weeks of pregnancy; during the rest of pregnancy, it can only be prescribed by a doctor if there are clear indications;
• while breastfeeding Breastfeeding – personal choice breastfeeding (excreted in breast milk);
• in case of individual intolerance to the drug.

Grandaxin is prescribed with caution for epilepsy (convulsions may become more frequent), elderly patients with organic brain damage and any manifestations of respiratory failure, even if the patient has had them in the past. If liver and kidney function are impaired, Grandaxin is prescribed in a lower dosage.

Grandaxin does not have a pronounced effect on concentration, however, in some patients such a reaction may occur, so it is better not to drive vehicles while taking Grandaxin.

Side effects that may occur when taking Grandaxin

Grandaxin may exhibit the following side effects:

• from the central nervous system - headache (very often), sleep disturbances, increased irritability Irritability - try to control your mood and aggressiveness, agitation, confusion, increased frequency of seizures in patients with epilepsy;
• from the outside gastrointestinal tract- loss of appetite, constipation, bloating, nausea, dry mouth;
• from the liver (rarely) - jaundice due to stagnation of bile in the biliary tract;
• allergic reactions – different kinds skin rash accompanied by itching.
• from the musculoskeletal system - muscle tension and pain.

Grandaxin is considered a light daytime remedy that relieves increased emotionality and anxiety. But they take it as prescribed by a doctor.

Why is Grandaxin prescribed and how to take it: indications, instructions, reviews

Grandaxin (active ingredient Tofisopam) is a fast-acting “daytime” anxiolytic. It is an atypical diazepine derivative. It is a white crystalline powder with a yellow tint. Insoluble in water, difficult to dissolve in ethanol. It is not addictive and is prescribed to patients with neuroses, anxiety disorders and autonomic disorders.

Clinical and pharmacological group: anxiolytics (tranquilizers).

Composition and release forms

The tranquilizer Grandaxin is available in the form of round, flattened, white, odorless tablets. On the one hand - the name of the medicine, on the other - the risk.

One tablet contains 50 mg of the active ingredient (Tofisopam).

• octadecanoic acid;
• magnesium salt of octadecanoic acid;
• talc;
• gelatin;
• lactose monohydrate;
• potato starch;

Sold in cardboard packs with two or six blisters of ten tablets each.

Pharmacological profile

Grandaxin is a benzodiazepine tranquilizer. The main effect is anxiolytic (sedative). Unlike other benzodiazepine tranquilizers, it does not have sedative, hypnotic, muscle relaxant, or anticonvulsant effects.

The medication regulates psycho-vegetatives and relieves various autonomic disorders. Has a moderate stimulating effect. Specified pharmacological properties determine that the drug belongs to daytime anxiolytics.

Due to the lack of a muscle-relaxing effect, the drug can be taken by patients with myasthenia gravis and myopathy.

The atypicality of the chemical formula of Tofisopam, which is very different from the structure of classical benzodiazepine anxiolytics, gives the drug a number of advantages:

• in a therapeutic dose does not enhance the effect of ethanol;
• does not cause mental or physiological addiction;
• does not cause withdrawal syndrome.

The mechanism of action is associated with a stimulating effect on benzodiazepine receptors in the brain. Their excitation leads to an increase in the sensitivity of GABA receptors to the neurotransmitter. As a result, chlorine channels begin to work more efficiently, hyperpolarization of nerve cell membranes increases, and neuronal activity is weakened.

After oral administration, the active substance is a short time and is almost completely absorbed from small intestine. The highest concentration in the blood is observed two hours after administration, after which it gradually decreases. Tofisopam does not have the ability to accumulate in the body. Metabolic products are pharmacologically inactive.

The half-life reaches six to eight hours. The active substance is excreted primarily by the kidneys (up to 60-80%) in the form of compounds with a glucose derivative (glucuronic acid) and through the gastrointestinal tract (up to 30%).

Clinical trials

Grandaxin is a unique CNS-active drug that has undergone many clinical trials. The drug does not have a sedative or muscle relaxant effect, and does not impair intellectual and psychomotor activity, unlike other benzodiazepines.

The drug has a mild cognitive-stimulating effect, a powerful drug that is prescribed to reduce autonomic disorders that accompany psychotic and nervous conditions.

Tofisopam does not have an anticonvulsant effect and even in a subtoxic dose does not cause sedation. Subtoxic dosages are potentiated only by barbiturates and ethanol.

The use of a dosage of the active substance in excess of 200 mg/kg in animals caused an effect similar to antipsychotics. When a dose of 10 mg/kg was administered, a normalizing effect on the temporary organization of animal behavior and the prevention of stress dysrhythmia was revealed.

The effectiveness of the drug in neurological practice was revealed during a multicenter study in which clinics from 11 Russian cities took part. The results of the study were based on observation data of 220 older patients with psychovegetative syndrome (PVS).

The effectiveness of taking Grandaxin in psychovegetative syndrome

The main group of patients (140 people) took Grandaxin tablets in addition to traditional treatment. The control group (80 people) was prescribed standard treatment with vascular and metabolic drugs without the participation of drugs. By the second week of treatment, personal and reactive anxiety decreased in both groups, but significant changes were noted specifically in the first group (they took Tofisopam).

Similar dynamics were observed in the fourth week of therapy. If at the beginning of the course both groups did not differ in the level of anxiety, then by the end of the second and especially the fourth week the degree of anxiety decreased much more than in the control group (they did not take Tofisopam).

The degree of vegetative-vascular dystonia was assessed through a questionnaire, during which subjective and objective disorders in patients were identified. The average indicators of the severity of autonomic disorders in both groups at the beginning of treatment did not differ.

By the end of the second and especially the fourth week, the scores in the first group were much lower than in the control group.

Thus, the use of Grandaxin has significantly improved the condition of patients, normalized autonomic imbalance and improved the quality of life.

To study sedatives and hypnotic properties medication, a study was conducted in which 60 aged conscripts with a minimum driving experience of one year participated. The first group of participants took Tofisopam, the second took tablets with a similar placebo effect appearance, then the groups changed.

During the entire study period, not a single minor accident or accident occurred. Twelve individuals noted that while driving a truck they did not feel any stress and were able to cope with difficulties much more easily. 5 people indicated a similar effect when taking placebo, but these positive action were also attributed to the period of adoption of Grandaxin.

Efficiency and safety

The medication is of great interest in the treatment of psychovegetative syndrome. The use of classical anxiolytics is complicated by a number of side effects: negative effects on attention, memory, etc.

There is information about the effectiveness and safety of Tofisopam treatment for menopausal disorders. After using the drug, the quality of life improves in people with autonomic disorders.

When studying the comparative effectiveness of treatment of psychotic disorders with Grandaxin, Diazepam, Metofenazat, it was found that the first drug is the most highly effective remedy for relieving anxiety-depressive syndrome.

The use of the drug in non-hormonal therapy of autonomic and psycho-emotional disorders is pathogenetically justified and effective. The tranquilizing effect in combination with the absence of the effects of muscle relaxation, sedation and dependence allows us to recommend the drug for use as a complex or monotherapy for anxiety disorders.

Therapeutic effect

The therapeutic effect is manifested in eliminating feelings of anxiety and fear, increasing attention, and normalizing sleep.

It should be noted that the latter effect is achieved due to a general improvement in the psycho-emotional state and is not associated with sedative or hypnotic effect.

Treatment of patients with psychovegetative syndrome according to standard regimens with the addition of vascular and metabolic drugs improves indicators of emotional status (elimination of anxiety and depression). Grandaxin also relieves symptoms of autonomic disorders in severe VSD.

Universal soldier - scope of application

Grandaxin has a wide field of use in neurological and psychiatric practice; the indications for use of the drug are as follows:

In narcology, the drug is used not only to relieve ethanol withdrawal; the use of the drug is recommended for the relief of delirious states (elimination of agitation and autonomic disorders), opioid withdrawal syndrome and post-withdrawal conditions.

Restrictions and contraindications for use

Contraindications for use:

• conditions in which there is obvious psychomotor agitation with aggression;
• deep depression;
• respiratory failure in the form of decompensation;
• apnea (stopping breathing) during sleep - in the anamnesis;
• undergoing treatment with Tacrolimus, Cyclosporine, Sirolimus;
• first trimester of pregnancy;
• lactation period;
• hypersensitivity to representatives of the benzodiazepine series.

Prescribe with caution in such cases:

How to take Grandaxin: instructions for use

The dosage is selected individually, taking into account the current condition, clinical course of the disease, individual characteristics, and susceptibility to the active substance Grandaxin.

For adults, the drug is prescribed pomg up to three times a day. For occasional use, you can take one or two tablets. The highest daily dosage is 300 mg (six tablets). For elderly people and people with renal failure, the daily dosage is reduced to 150 mg.

The duration of the course is determined by the doctor depending on the existing disease and other factors. Thus, in order to correct vegetative and psycho-emotional disorders during menopause, as well as during surgical menopause, the course duration can be three months.

When treating patients with anxiety and depressive disorders with Grandaxin, the drug begins to act 4-5 days after the start of the course of therapy, signs of improved mood, disappearance of psycho-emotional lability and anxiety disorders (including panic attacks) appear.

The use of the medication is contraindicated during breastfeeding and in the first trimester of pregnancy.

IN official instructions There are no instructions regarding the use of Tofizopam in children. At the same time, neurologists do not practice the use of the drug in children under 14 years of age.

Overdose and adverse reactions

When taking Grandaxin in a dosage of mg/kg, an overdose is possible, which may result in vomiting, disturbances of consciousness, depression of respiratory function, epileptic seizures, and coma. Deep sleep possible.

Treatment consists of restoring respiratory and cardiovascular activity.

Side effects when taking Grandaxin occur in various body systems.

From the side of the central nervous system the following are noted:

From the gastrointestinal tract there is:

• loss of appetite;
• constipation;
• flatulence;
• nausea;
• dry mouth;
• in some cases – yellowness of the skin.

The listed side effects can occur in all groups of patients, regardless of gender and age.

special instructions

It must be taken into account that in patients with mental disorders, elderly people, with impaired liver and kidney function, side effects occur more often than others.

In case of renal failure, the daily dosage is reduced by approximately half.

For chronic psychoses, phobias, and obsessions, it is not recommended to take medicine. In such conditions, suicidal thoughts and aggressiveness may occur. For this reason, the drug should not be prescribed as independent therapy for depression and anxiety-depressive conditions.

In epileptics, the medication increases the seizure threshold.

Since the drug contains lactose, this should be taken into account in patients with intolerance to this component.

The medication does not enhance the effect of alcohol when taken in therapeutic doses; moreover, Grandaxin reduces the inhibitory effect of ethanol on the central nervous system.

Interaction with other drugs

Concomitant use of Tofisopam with Tacrolimus, Cyclosporine and Sirolimus is contraindicated.

The concentration in the blood of substances metabolized with the participation of the CYP3A4 isoenzyme may increase when combined with Grandaxin.

The use of Tofizopam with drugs that depress the functions of the central nervous system (analgesics, anesthetics, antidepressants, antihistamines, sedatives, hypnotics, antipsychotics) potentiates their effect.

Causative agents of liver enzymes can enhance the metabolism of the active component of the drug, which leads to a decrease in the concentration of the substance in the blood.

Some antimycotic drugs can slow down metabolic processes in the liver while taking Tofisopam, resulting in an increase in its concentration in the blood.

Some antihypertensive drugs enhance the effect of the drug. When taken simultaneously with Digoxin, the concentration of the latter increases in the blood plasma.

Benzodiazepine drugs affect the anticoagulant effect of Warfarin. Taking it together with Disulfiram inhibits the effect of the medication. Antacids affect the absorption of the active component.

Oral contraceptives reduce the rate of drug metabolism.

Point of view

Opinion of specialists and reviews of patients who took Grandaxin as a course or spot-on.

Professional opinion

Tofisopam is an affordable, mild daytime anxiolytic. Gives a pronounced effect of vegetative-emotional stabilization. Among the advantages, it is worth noting the possibility of taking it for a short course. In terms of price/quality ratio, this is the most suitable option. Does not give significant side effects.

A fairly mild tranquilizer that eliminates psychovegetative disorders. Effective when high level anxiety, feeling of “exhaustion”, apathy. It does not have a hypnotic effect; when taken as a course, it normalizes sleep.

The drug is widely used in drug treatment practice, occasionally causes a feeling of nausea, and reduces the negative effect of ethanol on the central nervous system. Has proven itself well in recovery from withdrawal symptoms.

The drug belongs to the group of anxiolytics. In my own practice I have been using the drug for several years. As a gynecologist, I recommend it to patients as part of a comprehensive treatment for menopausal syndrome. The drug does not have a sedative or hypnotic effect. I usually prescribe courses for 1-3 months.

After I failed with one potent and effective sedative, I started looking for a replacement for him for the summer! The doctor recommended that I try a tranquilizer Once they prescribed it to me, but then I was afraid of the loud word TRANQUILIZER and did not drink it. Now my nerves were so shaken that I decided to take a risk!

Grandaxin costs approximately 250 rubles for 20 tablets , must be available with a doctor's prescription, but pharmacies sometimes turn a blind eye and sell it for nothing.

Here's the complete one Grandaxin - instructions:

The doctor prescribed me to take it 1 tablet 2 times a day in the morning until 17.00,so that you don't have problems falling asleep. On the Internet they advise to try to take it before 15.00. I had to drink Grandaxin three months.

So, I started taking it!

The Grandaxin tablet itself is completely white without a shell with the engraved inscription GRANDAX. The taste is quite pleasant, if there is a problem with swallowing it (for example, I don’t really like swallowing tablets without a coating), you can chew it, I did not observe any discomfort or bitterness.

I have now taken the first package of Grandaxin of 20 tablets and have already started the second.

What can I say about the effectiveness of this drug.

Indeed, Grandaxin calms the nervous system well, relieves stress and emotional tension. I felt calmer and stopped getting irritated and nervous over trifles.

But the side effects stated in the instructions have already slowly begun to manifest themselves!

There are not so many of them stated in the instructions themselves, but if you spend time and look for information about this on the Internet, you can find the following:

Side effects: From the nervous system: at the beginning of treatment (especially in elderly patients) - drowsiness, feeling of fatigue, dizziness, decreased ability to concentrate, ataxia, disorientation, unsteady gait, slowed mental and motor reactions, confusion; rarely - headache, euphoria, depression, tremor, memory loss, impaired coordination of movements (especially at high doses), depressed mood, dystonic extrapyramidal reactions (uncontrolled movements, including the eye), increased fatigue, myasthenia gravis, dysarthria; extremely rarely - paradoxical reactions (aggressive outbursts, psychomotor agitation, fear, suicidal tendencies, muscle spasm, hallucinations, agitation, irritability, anxiety, insomnia). From the hematopoietic organs: leukopenia, neutropenia, agranulocytosis (chills, hyperthermia, sore throat, excessive fatigue or weakness), anemia, thrombocytopenia. From the outside digestive system: dry mouth or drooling, heartburn, gastralgia, nausea, vomiting, decreased appetite, constipation or diarrhea; liver dysfunction, increased activity of liver transaminases and alkaline phosphatase, jaundice. From the genitourinary system: urinary incontinence, urinary retention, renal dysfunction, decreased or increased libido, dysmenorrhea. Allergic reactions: skin rash, itching, angioedema, broncho-obstructive syndrome. Effect on the fetus: teratogenicity (especially the first trimester), central nervous system depression, respiratory impairment and suppression of the sucking reflex in newborns whose mothers used the drug. Other: addiction, drug dependence; decrease in blood pressure; rarely - visual impairment (diplopia), weight loss, tachycardia. With a sharp reduction in dose or discontinuation of use - withdrawal syndrome (irritability, nervousness, sleep disturbances, dysphoria, spasm of smooth muscles of internal organs and skeletal muscles, depersonalization, increased sweating, depression, nausea, vomiting, tremor, perception disorders, incl. including hyperacusis, paresthesia, photophobia; tachycardia, convulsions, rarely - acute psychosis)

As we see, The list of side effects is frighteningly huge!!!

Which of these did I observe during my ten-day use of the drug?

Very often while taking Grandaxin I was in a bad mood. I agree that this drug is not an antidepressant and does not have to improve our mood, but I think we need to keep in mind that if you are already in a bad mood, bordering on depression, the drug can make it worse!!!

I became inattentive, distracted and forgetful, which had never happened to me before. While taking the drug, I even managed to forget a package with important documents in the store. It’s good that when I ran back, eyes wide, they returned it safely to me! And my husband often began to say to me: Are you forgetting everything? Are you getting old? It’s not particularly pleasant to hear all this…. Apparently, Grandaxin somehow affects our brains and memory.

Slight pain and tension appeared in the back muscles. So far, however, everything is quite tolerable.

From time to time my head hurts a lot, not every day, but much more often than it usually happens to me.

To top it all off, my stomach began to bother me with pain under the ribs, a feeling of fullness and heartburn, and more recently, nausea in the morning was added.

These are the side effects I noticed during this period. And this situation does not make me happy at all!

But what scares me most is the information that you can get used to Grandaxin and become thoroughly addicted to it! I don’t know how fair this is, but I have certain concerns!

For myself, I decided that I would finish the second package I had already purchased and that’s it! Enough! He calmed me down a little, and okay! I'll try to do without it from now on!

If these remedies still do not help, you can move on to more serious sedatives (take only after consulting a doctor!!!):

My disappointments:

And so as not to resort to help with every stress pharmaceutical drugs, let's try to calm ourselves down with a safer method. I hope my video will help you with this!