Dex gentamicin drops instructions for use. Dexa-Gentamicin: instructions for use of ointment and drops

Eye drops Dexa-Gentamicin is a combination drug that is actively used in ophthalmology. Its components have anti-inflammatory and antimicrobial properties.

Dex-Gentamicin eye drops are an antibacterial drug

The product is used when infections occur that may be sensitive to genamicin bacteria. It can also be used to avoid allergic reactions and after operations.

Effect of the drug

Dex-Gentamicin is used as an antimicrobial agent. This is due to the fact that it contains broad-spectrum antibiotics. They allow you to get rid of inflammation and germs. All this is determined by the active substance that is included in the composition - glucocorticosteroid.

When are they appointed?

Dex-Gentamicin eye drops are prescribed in the following situations:

1. If allergic processes have begun. This could be: blepharitis or conjunctivitis, which occurs against the background of an infection caused by bacteria.
2. To prevent inflammatory processes that may occur after surgery to remove cataracts and glaucoma.
3. During infectious lesions anterior part of the eye and its adnexa.

There are several diseases for which Dex-Gentamicin would be appropriate:

• Stye on the eye.
• Keratitis.
• Blepharitis.
• Conjunctivitis.

Dex-Gentamicin eye drops instructions for use

The installation must be performed at intervals of two to six times a day, everything depends on the doctor’s prescription. Add one or two drops at a time.

The average course duration is two to three weeks. Here everything depends only on the person’s condition. For example, if there are no side infections, and you managed to get rid of all possible bacteria. In such a situation, you should stop taking the drug, but this can only be done after the appropriate decision of the attending physician.

Contraindications for use

Dex-Gentamicin eye drops should not be used in the following situations:

1. Tuberculosis of the eye.
2. Fungal infection of the eyes.
3. Viral infection of the cornea or conjunctiva.
4. Purulent-ulcerative lesions of the corneal epithelium.
5. If you are allergic to one of the components.

Side effects

After reception eye drops The following problems may occur:

1. Allergy to one of the components.
2. Increased pressure in the eye.
3. Burning.
4. A tingling sensation may occur.
5. Steroid cataract.

Directions for use

Before installing the drug, be sure to remove your contact lenses in advance. If this is not done, the burning sensation cannot be avoided.

Temporary blurred vision may occur after administration. This means that you cannot work with small objects or drive. As a rule, this effect lasts several minutes and occurs within half an hour after administration.

The shelf life of the product is three years. If the bottle is opened it must be used within 6 weeks. Store at room temperature in a dark place.

A drug with antibacterial and anti-inflammatory effects for topical use in ophthalmology

Active ingredients

Dexamethasone sodium phosphate (dexamethasone)
- gentamicin

Release form, composition and packaging

Eye drops colorless, transparent.

Excipients: benzalkonium chloride (preservative) - 0.05 mg, potassium hydrogen phosphate - 1.88 mg, potassium dihydrogen phosphate - 5.86 mg, - 5 mg, water for injection - up to 1 ml.

5 ml - polymer dropper bottles (1) - cardboard packs.

Eye ointment white with a yellowish tint, translucent.

Excipients: white petrolatum - 775.98 mg, liquid paraffin - 149.13 mg, lanolin - 69.9 mg.

2.5 g - aluminum tubes (1) with a polyethylene tip - cardboard packs.

pharmachologic effect

Combined preparation for local use in ophthalmology. It has anti-inflammatory and antibacterial effects.

Dexamethasone– GCS has antiallergic and pronounced anti-inflammatory effects. The index of its relative anti-inflammatory activity is 30.

– an antibiotic of the aminoglycoside group, characterized by a wide spectrum of action. Active against most gram-positive and gram-negative microorganisms, incl. Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Salmonella spp., Proteus spp., Serratia spp. Moderately active against Staphylococcus spp.

Pharmacokinetics

When applied topically, dexamethasone penetrates well into the corneal epithelium and conjunctiva; at the same time, therapeutic concentrations are achieved in the aqueous humor of the eye; with inflammation or damage to the mucous membrane, the penetration rate increases.

Gentamicin sulfate, when applied topically, is found in therapeutic concentrations in the corneal stroma, in the aqueous humor of the anterior chamber, vitreous body within 6 hours. Gentamicin sulfate does not penetrate into the systemic circulation through intact corneal epithelium

Indications

- infections of the anterior segment of the eye caused by sensitive microflora (conjunctivitis, keratitis, blepharitis, barley);

- allergic processes in the anterior segment of the eye, accompanied by bacterial infection;

- prevention and treatment inflammatory phenomena in the postoperative period (after cataract removal and anti-glaucoma operations).

Contraindications

- keratitis caused by Herpes simplex and Varicella zoster viruses (dendritic keratitis);

— viral diseases cornea and conjunctiva (including with chicken pox);

— fungal diseases eye;

- mycobacterial eye infections;

- spicy purulent diseases eyes with damage to the corneal epithelium;

— corneal epitheliopathy;

- injuries and ulcerative lesions of the cornea;

- increased intraocular pressure;

— I trimester of pregnancy;

- children and adolescents under 18 years of age (due to the lack of data on effectiveness and safety);

- wearing contact lenses;

- hypersensitivity to the components of the drug.

Dosage

Eye drops are instilled into the conjunctival sac, 1-2 drops 4-6 times a day.

A strip of ointment 1 cm long is placed in the conjunctival sac 2-3 times a day. When applying the ophthalmic ointment, avoid contact of the tube with the surface of the skin or conjunctiva.

The duration of treatment with Dex-Gentamicin usually does not exceed 2-3 weeks. The duration of therapy is determined by the effectiveness of the drug, the severity of symptoms and the likelihood of side effects.

With the simultaneous use of several ophthalmic medicines It is recommended to administer Dex-Gentamicin in the form of an eye ointment no earlier than 15 minutes after using eye drops.

Side effects

Rarely: allergic reactions, burning sensation in the eye after using the drug.

Maybe: contact dermatitis, herpetic keratitis, perforation of the cornea in the presence of keratitis, fungal infection, increased severity of bacterial infection of the cornea, ptosis, mydriasis. Use after corneal injuries may slow down its healing. With long-term use - the development of secondary glaucoma and steroid cataracts.

Overdose

When using the drug Dex-Gentamicin, an overdose is unlikely.

Drug interactions

When used together with atropine, other cholinergic drugs, and drugs that cause mydriasis, intraocular pressure may increase.

When applied topically, gentamicin is incompatible with amphotericin B, heparin, sulfadiazine, cephalothin and cloxacillin. Topical use of these drugs together with gentamicin may lead to the deposition of precipitates in the conjunctival cavity.

special instructions

When using the drug for more than 2 weeks, as well as in patients with a history of glaucoma, it is recommended to regularly monitor intraocular pressure.

If the use of contact lenses is necessary, they should be removed before using Dexa-Gentamicin in the form of eye drops and reinserted no earlier than 20 minutes later.

The patient should be informed that if side effects occur, treatment should be stopped immediately and contact an ophthalmologist.

Use in pediatrics

To date, there are no data from clinical studies of the safety and effectiveness of the drug Dexa-Gentamicin in children. The use of the drug in pediatrics is possible if the expected therapeutic effect exceeds the potential risk of adverse reactions.

Impact on the ability to drive vehicles and operate machinery

Immediately after using the drug Dex-Gentamicin, you may experience short-term disturbance visual acuity, leading to a slowdown in psychomotor reactions. Therefore, it is not recommended to use the drug immediately before working with machinery or driving vehicles. For 30 minutes after instillation, you must refrain from activities that require increased attention.

Pregnancy and lactation

Adequate and strictly controlled clinical studies of the safety of the drug Dexa-Gentamicin during pregnancy and lactation have not been conducted. In the second and third trimesters of pregnancy and during breastfeeding the drug can be used when the expected benefit of therapy for the mother outweighs the potential risk to the fetus or child. Contraindicated in the first trimester of pregnancy.

The drug should be stored out of the reach of children.

Available in other dosage forms: eye ointment.

Price

Average price online*, 171 rub. (5 ml)

Where can I buy:

Instructions for use

Each pack of medicine contains an insert with instructions. It contains information about indications, method of administration, drug combinations, side effects, overdose, contraindications, composition. In addition, the instructions also contain reviews.

Indications

The drug is prescribed for the treatment of conditions such as:

• Keratitis, stye, blepharitis, conjunctivitis;
• prevention inflammatory diseases in the postoperative period.

Method of administration

Attention! Before starting to use Dex-Gentamicin drops, you should consult your doctor.

Treatment should proceed according to the following scheme:

• It is necessary to drop 1-2 drops into each eye once;
• The interval between instillations depends on the patient’s condition, as well as the severity of the inflammatory process. If the condition is severe, drops should be instilled every 4 hours. If the condition is not critical, then instillation should be done every 6 hours;
• Treatment should in no case exceed 20 days, because otherwise, any complications begin to develop. It is also extremely important to follow all doctor’s recommendations during treatment.

Contraindications

• Mycoses of the eyes;
• Viral infections eye;
• Erosion of the corneal epithelium (as a result of taking the drug, these lesions may become deeper);
• Increased intraocular pressure;
• Tuberculosis of the eyes;
• Allergy to certain components of the drug.

In addition, contact lenses should not be worn during treatment.

Pregnancy

Allowed to use this tool during pregnancy, however, the girl should be regularly monitored by a doctor.

During breastfeeding, you should stop taking the drug. If for some reason it is impossible to refuse, then the use of the drug is allowed, however, natural feeding should be excluded.

Overdose

When using the drug Dex-Gentamicin, an overdose is unlikely. However, if it occurs, then you need to carry out symptomatic treatment.

Side effects

As a result of taking the medication, the patient may experience side effects, the appearance of which must be reported to your doctor so that he can decide whether you can continue to use this drug or not.

Perhaps he will choose a safer analogue.

TO side effects conditions include:

• The appearance of a burning sensation and itching. These conditions may occur immediately after instillation;
• Any allergic effects;
• A sharp increase in intraocular pressure;
• Clouding of the lens or blurred vision.

Compound

Dex-Gentamicin drops are colorless.

They contain active substances such as gentamicin sulfate, as well as dexamethasone sodium phosphate. The auxiliary elements are potassium hydrogen phosphate and benzalkonium chloride.

Pharmacology

Dex-Gentamicin is a topical glucocorticosteroid.

At local use Dexamethasone quickly penetrates through the tissue of the cornea and conjunctiva, providing the desired effect.

When used topically, gentamicin sulfate is detected in the eye structure after 6 hours.

Other

Dispensed by prescription.

The medicine should be stored out of the reach of children, at a temperature not exceeding 25 degrees.

You should also find out about the drug combination of Dexa-Gentamicin with other medications.

When taken simultaneously with atropine, cholinergic drugs, as well as drugs that cause mydriasis, a sharp increase in intraocular pressure can be observed.

When used topically, gentamicin is incompatible with amphotericin B, sulfadiazine, cloxacillin, heparin, and cephalothin. Ignoring this point may lead to the deposition of precipitates in the conjunctival sac.

Dex-gentamicin belongs to drugs that have an antibacterial effect and also have an anti-inflammatory effect; the drug is used topically in ophthalmic practice. I'll look at its instructions for use.

What is the composition and release form of Dex-gentamicin?

The drug is produced in transparent eye drops. The active substances are dexamethasone sodium phosphate and gentamicin sulfate. Auxiliary components of Dex-gentamicin: preservative benzalkonium chloride, sodium chloride, potassium hydrogen phosphate and dihydrogen phosphate, water for injection.

The drops are placed in polymer dropper bottles of five milliliters. They must be stored in a dark place. The shelf life of the medicine is three years; after opening the container, the product must be used within six weeks.

In addition to drops, Dex-gentamicin is produced in a translucent ophthalmic ointment; its color can be white or with a slight yellowish tint. The active compounds are dexamethasone and gentamicin sulfate. Auxiliary form-building compounds: white petroleum jelly, lanolin, and liquid paraffin.

The ointment is available in 2.5 gram quantities in aluminum tubes with an attached polyethylene tip. The entire set is placed in cardboard boxes. Keep this dosage form recommended at a temperature of no more than 25 degrees, the shelf life of the medicine is limited, it is three years.

Let's talk in more detail about Dex-gentamicin with dexamethasone and gentamicin sulfate (eye drops, eye ointment), let's find out what else the instructions for using the drug say.

What is the effect of Dex-gentamicin?

The combined drug Dexa-gentamicin has an antibacterial, antiallergic, and, in addition, anti-inflammatory effect on the body, thanks to the active substances present.

One of the active substances is dexamethasone, it belongs to glucocorticosteroids and has anti-allergic and anti-inflammatory effects. Gentamicin belongs to the antibiotics belonging to the group of aminoglycosides. It is active against the following microorganisms: Pseudomonas aeruginosa, Klebsiella spp., Salmonella spp., Escherichia coli, Proteus spp., Serratia spp., as well as many others.

When used topically, the medicine penetrates well directly into the corneal epithelium, in addition to the conjunctiva. Therapeutic concentration is achieved quite quickly.

What are the indications for use of Dex-gentamicin?

Dex-gentamicin is prescribed for the following pathology:

For infections of the organ of vision that are caused by microflora that are sensitive to the drug, such as blepharitis, conjunctivitis and keratitis;
The drug is used for allergic processes localized in the eye and accompanied by infection of bacterial origin.

In addition, the drug is prescribed for the prevention and also for the treatment of inflammation that may occur in the postoperative period, such as after cataract removal, as well as after some anti-glaucoma operations.

What are the contraindications for use of Dex-gentamicin?

The instructions for use prohibit the use of the drug Dex-gentamicin in the following situations:

For keratitis (inflammation of the cornea) of viral origin caused by Herpes simplex, as well as Varicella zoster;
In case of fungal infection of the organ of vision;
During pregnancy;
In case of acute purulent eye damage with damage to the cornea;
For injuries and ulcers of the cornea;
When wearing contact lenses;
With increased intraocular pressure;
Do not use ointment and cream under 18 years of age.

In addition, in case of hypersensitivity to Dex-gentamicin substances.

What are the uses and dosage of Dex-gentamicin?

Eye drops should be instilled into the conjunctival sac up to six times a day, one or two drops, after prior consultation with a qualified ophthalmologist.

Dex-gentamicin ointment is applied to the conjunctival sac, and the dosage form is squeezed out up to one centimeter in length; the frequency of use is two or three times a day. During application of the drug, it is necessary to avoid contact of the aluminum tube directly with the surface of the conjunctiva and skin. The duration of therapy should not exceed three weeks.

Overdose of Dex-gentamicin

When using Dex-Gentamicin, the development of an overdose is unlikely.

What are the side effects of Dex-gentamicin?

Sometimes side effects may occur, they are expressed allergic reactions, some tingling and burning may be felt in the eye. Contact dermatitis rarely develops, herpetic keratitis is associated, and corneal perforation, fungal infection, and ptosis (drooping of the eyelid) may occur.

special instructions

If the medicine will be used for more than two weeks, in this case it is necessary to monitor intraocular pressure. Immediately after using the ophthalmic drug, the patient may experience a short-term impairment of visual acuity, leading to a slight slowdown in psychomotor reactions. Therefore, it is recommended to refrain from driving during the treatment period.

What are Dex-gentamicin analogues?

Analogs include the drug Gentamicin + Dexamethasone.

Conclusion

We reviewed the drug Dexa gentamicin (eye ointment, eye drops), instructions for use, application, indications, contraindications, action, side effects, analogues, composition, as well as their dosage when used. This medicine should be used on the advice of a qualified ophthalmologist.

Often used in the treatment of bacterial infections combination drugs, in which antibiotics are combined with other substances that help eliminate inflammation. One of them is Dex-Gentamicin.

Release form

Compound

Each form of Dex-Gentamicin contains two active ingredients. These are the antibiotic gentamicin (its dosage in 1 ml of drops and 1 g of ointment is 3 mg) and the glucocorticoid dexamethasone (in drops it is presented in a dose of 1 mg/1 ml, and in ointment - 300 mcg/1 g). Additionally, the liquid form of the drug includes potassium hydrogen phosphate and dihydrogen phosphate, a preservative (benzalkonium chloride), sodium chloride and water. If we talk about the ointment, it can be noted that the active substances are supplemented with lanolin, liquid paraffin and white petroleum jelly.

Operating principle

Thanks to the combination of a hormone and an antibiotic, Dex-Gentamicin has both anti-inflammatory and antibacterial effects. This remedy is also used against allergies. The use of drops or ointments inhibits most microbes, including pseudomonas, E. coli, staphylococci, salmonella, klebsiella and many other microorganisms.

Indications

Most often, Dex-Gentamicin is used in ophthalmology. He is prescribed for local treatment pathologies such as keratitis, conjunctivitis, barley or blepharitis, if their causative agent is microbes sensitive to gentamicin.

The medicine is also in demand for allergic eye damage if it is accompanied by a bacterial infection. In addition, the medication is used during postoperative period, if you want to prevent or eliminate eye inflammation after surgical treatment.

ENT doctors can prescribe Dex-Gentamicin for rhinitis, nasopharyngitis, sinusitis or adenoiditis of a bacterial nature. The drug can also be included in complex nasal drops, the recipe of which is selected individually for each patient.

At what age is it allowed to take it?

The annotation for drops and ointments contains information that Dexa-Gentamicin is contraindicated in patients under 18 years of age. However, in practice, this drug is often prescribed to children, but only a specialist should assess the feasibility of such treatment and determine the dosage. It is unacceptable to give medication to a child without the consent of a doctor.

Contraindications

"Dexa-Gentamicin" is not prescribed:

• If you are hypersensitive to any ingredient of the medicine.
• For viral eye infections - for example, chickenpox.
• When the eyes are damaged by fungi.
• For acute purulent lesions, if the corneal epithelium is damaged.
• For corneal injuries.
• With increased intraocular pressure.
• When using contact lenses.

Side effects

The medicine may cause allergies or a burning sensation at the site of use. In rare cases, the use of Dex-Gentamicin leads to a fungal infection, corneal perforation or herpetic keratitis. Very long-term use increases the risk of developing glaucoma or cataracts.

Instructions for use and dosage

For ophthalmological diseases, the Dex-Gentamicin solution is dripped into each eye, 1-2 drops up to 6 times a day. The frequency of use of the ointment is 2-3 times a day, and for one application, take a strip of the drug approximately 1 cm long. The duration of therapy is usually 2-3 weeks and is determined by the doctor individually.

Drug interactions

"Dexa-Gentamicin" is not recommended to be combined with heparin, atropine, amphotericin B and some other drugs noted in the annotation.

Terms of sale and storage

You can purchase Dexa-Gentamicin at a pharmacy only with a prescription. The cost of one bottle of drops or tube of ointment is 120-150 rubles. To store the medicine at home, you need to find a place with a temperature of no higher than 25 degrees Celsius, inaccessible to children and sunlight. The shelf life of any sealed form of Dex-Gentamicin is 3 years, but after opening the eye drops can only be used for 6 weeks, and the ointment should be thrown away after 4 weeks.