Veroshpiron androgenic effect. "Veroshpiron" - a diuretic or not? "Veroshpiron": reviews

Instructions for use and analogues of Veroshpiron

Veroshpiron - diuretic, designed to increase diuresis in the treatment of many diseases, which also has a potassium-sparing property, rare for diuretics. The effect of taking veroshpiron lasts up to several days, and the medicine itself is well tolerated by most patients.

Composition and release forms

The drug Veroshpiron has a pronounced diuretic effect due to spironolactone, an analogue of the hormone produced by the adrenal cortex. Spironolactone, in turn, suppresses the hormone aldosterone, preventing the retention of water and sodium in renal tubules. At the same time, Veroshpiron does not impair renal blood circulation, reduces the acidity of urine and reduces the leaching of potassium from the body.

The latter property of the drug is very valuable and rare for diuretics, so Veroshpiron is also prescribed in cases where the patient is prone to hypokalemia.

When using Veroshpiron:

• urine acidity decreases;
• the amount of potassium and urea excreted in the urine decreases:
• excess sodium, chlorine and water are removed from the body;
• the synthesis of the permease enzyme responsible for the reabsorption of sodium is prevented.

Verospiron is produced by the Hungarian company Gedeon Richter exclusively in the form of tablets or capsules. The tablet form is available in blisters of 20 pieces of 25 mg each, and capsules are produced in blisters of 20 pieces of 50 mg each and in blisters of 10 pieces of 100 mg each. The tablets have a chamfer and the inscription VEROSPIRON, and the capsules are enclosed in a two-color gelatin case.

International generic name(INN) diuretic - spironolactone, according to the name of the active substance.

The price for the drug and its analogs is approximately the same and currently remains at 100-250 rubles per package of 20 tablets or capsules.

Mechanism of action and indications for use

When taking the drug, it is rapidly absorbed in the gastrointestinal tract, and this process is not affected by food intake and Veroshpiron can be taken both before and after meals.

Although the bioavailability of the drug is almost 100%, the maximum effect of the drug develops on the 2nd or 3rd day of administration and lasts up to 3 days after its discontinuation. During the biotransformation of spironolactone in the liver, metabolites containing sulfur are formed: alpha-thiomethylspironolactone and canrenone. Decomposition products are excreted in urine and partially in feces.

The main purpose of Veroshpiron as a diuretic is to reduce fluid levels during arterial hypertension (high blood pressure), but in addition, the drug is used for:

• edema syndrome (with heart failure);
• hyperaldosteronism (Conn's syndrome);
• nephrotic pathologies accompanied by edema;
• hypokalemia (or hypomagnesemia);
• myasthenia gravis;
• gynecological diseases (in particular, polycystic ovary syndrome).

Veroshpiron should not be combined with a number of other medications:

• coagulants (heparin, coumarin, etc.);
• cardiac glycosides (for example, glycoside);
• potassium-containing drugs;
• PPVS (anti-inflammatory non-steroidal drugs- painkillers).

Spironolactone also enhances the effectiveness of other diuretics and antihypertensive drugs.

In most cases, Veroshpiron is used in combination with other medications, but sometimes monotherapy is prescribed, especially as a diuretic.

Veroshpiron for gynecological diseases

The main purpose of the drug is a diuretic. However, due to the multiple properties of spironolactone, this medicine is also used to treat other diseases.

The drug Veroshpiron, along with a purely diuretic effect, has antiandrogynous properties and therefore is successfully used in the composition complex therapy gynecological pathologies.

The medicine acts in organs that produce male hormones (including follicles, sebaceous and sex glands), reduces skin hair growth during hyperandrogenism and, ultimately, helps increase female fertility.

It is important that treatment of women with Veroshpiron does not cause side symptoms from the endocrine system.

The drug Veroshpiron is prescribed in gynecology most often for the following diseases:

Hyperandrogenism

A pathology in which a woman’s body actively produces androgen, which is largely considered masculine. Increased production of this hormone by the female body leads to disruption of hormonal levels and the synthesis of the hormone tarragon, which is responsible for libido. This pathology is common - about 5% of women are susceptible to it.

Treatment is carried out with glucocorticosteroids, or non-steroidal antiandrogens (flutamide), with additional nootropic drugs and Veroshpiron. In case of hyperandrogenism, Veroshpiron works not only as a diuretic, but also as a suppressor of testosterone, converting it into estradiol, and normalizing the condition of the skin. Treatment of this pathology is long-term, at least 3-6 months, while spironolactone is prescribed according to the schedule (according to the menstrual cycle), at a dosage of 100 mg/day, increasing the tablet intake if necessary to 400 mg/day.

Polycystic ovary syndrome

Pathology of the ovaries, which is associated with disruption of their functioning resulting from neurometabolic disorders. In other words, this is a disease in which multiple cysts form on the surface of the organ itself - the ovary. This syndrome often leads to infertility.

Veroshpiron in the treatment of polycystic disease is prescribed to block male sex hormones, 100 mg 2-4 times a day, for up to six months. Therapy for polycystic disease should be comprehensive, since Veroshpiron only eliminates the external manifestations of the disease (oily skin, hair growth, etc.).

Interestingly, the symptoms of the disease disappear in women along with the normalization of weight, if it is elevated or excessive.

Menstrual irregularities

One of the indicators of changes in the functioning of both the genital organs and the entire female body. In general, disruption of the menstrual cycle is one of the most common problems with which women of reproductive age turn to a gynecologist. The disorder may be caused for various reasons, which only the attending physician can help determine. If he deems it necessary to add Veroshpiron to therapy, the drug is prescribed in the first phase of the menstrual cycle, at a dosage of 50 mg/day. Spironolactone is combined with oral contraceptives (not for the purpose of contraception, but to normalize the body’s hormonal levels).

Hirsutism

Excessive hair growth on the body of women according to the male pattern is a female disease associated with disruption of the normal functioning of the endocrine system: it manifests itself through excess hair growth on the body or face. Also, along with these syndromes, such syndromes as menstrual irregularities, anemia, and possible uterine bleeding and infertility.

For hirsutism, Veroshpiron can be taken according to two regimens: either from the 4th to the 22nd day of the cycle, in a dosage of up to 200 mg, or outside of the cycle, 75-100 mg daily. Moreover, after 3-6 months of treatment, the symptoms of hirsutism decrease by an average of 30%, which is a good result.

Tissue swelling in combination with hypertension

A disease such as hypertension is itself a disease of cardio-vascular system, characterized by a stable increase in pressure, the levels of which decrease only after taking medications. A common occurrence is swelling of the hands, feet or face, which occurs due to sodium and water retention in the body. Spironolactone is used in this case because of its diuretic properties. The dosage and regimen are determined by the doctor, based on the severity of the disease.

Indications for the use of Veroshpiron may be the presence in women of some cosmetic problems caused by excess content in the body male hormones. These problems include:

• increased oiliness and porosity of the skin;
• profuse formation of acne (blackheads);
• hair loss, increased greasiness, etc.

Most of these problems are due to the fact that hair follicles, like the sebaceous glands, depend on the normal production of androgen hormones and respond to increased levels of them in the body. female body. It is not recommended to use the drug for weight loss, as this is fraught with dehydration, disruption of the endocrine system and other complications.

When treating cosmetic imperfections, Veroshpiron also acts as a blocker of male sex hormones, and to normalize a woman's hormonal levels, oral contraceptives are added to it.

Important: Veroshpiron should not be used during pregnancy (existing or planned), since in this case there is a high risk of developing fetal abnormalities.

Contraindications and side effects

Just like anyone else medication, the diuretic Veroshpiron has a number of contraindications. These include a number of diseases for which the use of spironolactone is completely prohibited, as well as diseases for which the use of products containing spironolactone is recommended with extreme caution. It is better to replace Veroshpiron with a drug similar in action to it in the presence of pathologies such as:

• hyponatremia (low potassium levels in the blood);
• hyperkalemia (increased potassium content in the provi);
• anuria (various disturbances in urine excretion);
• lactase deficiency;
• lactose intolerance.

A complete list of diseases for which the use of Veroshpiron is not recommended is given in the instructions for use of the drug.

It is important to remember that diuretics are prohibited for children under the age of three years old, as well as people who have hypersensitivity to the components that make up the drug. It is prohibited to take Veroshpiron for Addison's disease ( chronic failure adrenal cortex) and in severe renal failure.

Under no circumstances should a diuretic be used during pregnancy or lactation, however, if treatment is necessary and directly prescribed by a doctor, the drug prescribed to eliminate edema can be used with caution during pregnancy - in the second and third trimester.

The active substance spironolactone, which is the basis of the drug Veroshpiron, is contraindicated during pregnancy because it can penetrate the placental barrier. In this case, the drug goes directly into the children's circulatory system.

The use of Veroshpiron during breastfeeding is also not recommended due to high activity the main ingredient, absorbed into all biological fluids of the body, reaching almost complete concentration.

Veroshpiron can also be used with caution for such disorders and diseases as:

• AV block;
• hypercalcemia;
• diabetic nephropathy;
• metabolic acidosis;
• menstruation disorders;
• liver failure;
• cirrhosis of the liver.

Particular attention should be paid to the age of the patient, whether he has diabetes, as well as on the ones he recently transferred surgical interventions.

Most side effects Veroshpiron medications can be classified as so-called “traditional”:

• dizziness;
• nausea;
• general weakness and drowsiness;
• confusion;
• headache;
• pain in the abdomen;
• bowel disorders.

More specific side effects usually include digestive disorders:

• colic;
• vomit;
• gastritis;
• intestinal or stomach bleeding;
• liver dysfunction.
• Possible disorders of the circulatory system:
• agranulocytosis;
• megablastosis;
• thrombocytopenia.
• Problems related to endocrine organs:
• menstrual irregularities;
• pain in the mammary glands;
• hirsutism;
• mammary cancer;
• gynecomastia (in men).
• Complications associated with immune system:
• allergic reactions;
• hives;
• rash.

Disturbances in the functioning of the muscular system:

• muscle spasms;
• convulsions.

Metabolic disorders such as a decrease in the level of sodium in the blood and the level of urea, uric acid and creatinine in the blood are also possible. It is impossible to completely protect yourself from side symptoms when treating with Veroshpiron, as with any other medicine.

If unpleasant symptoms do not go away within 2-3 days after starting to take the medication, you should notify your doctor to decide on replacing the drug or adjusting the dose taken.

Analogues of Veroshpiron

If it is not possible to purchase Veroshpiron, you can replace it with tablets with the same active substance. Veroshpiron and its analogues act almost identically.

The following drugs can replace Veroshpiron:

• Vero-Spironolactone (Russia);
• Veroshpilakton (Russia);
• Hypothiazide (Russia);
• Spirix (Denmark);
• Aldactone (manufactured in the UK).

The main substance in these drugs is also spironolactone, sometimes with a combination of another drug. Thus, Aldactone retains not only potassium, but also magnesium in the body, and Veroshpilaktone combines the properties of Veroshpilaktone and Aldactone.

Veroshpiron for gynecological diseases, due to its diuretic and antiandrogynous effects, helps against a wide range of pathologies.

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Treatment of PCOS: surgery, hormones, medications

After making a diagnosis, the doctor, according to clinical picture and ultrasound features will determine how to treat PCOS in your case. When treating, it is not always possible to resort to surgery using a complex of drugs. Although, if medications do not provide progress over 6-12 months, laparoscopic treatment may be recommended.

Treatment of this pathology involves an integrated approach. This includes not only medications or surgery, but also lifestyle changes. Often, these measures help almost as well as therapeutic ones. First of all, you need to increase your physical activity and critically reconsider your diet, especially considering the tendency towards obesity as one of the symptoms of PCOS. It is necessary to play sports or fitness, follow a diet with a limit on “light” carbohydrates (sugar, sweets) and an increase in the amount of protein and plant foods. It is important not to starve, but to reduce the calorie content of food consumed so that the weight comes off smoothly and evenly, without fluctuations in blood sugar. Often, weight loss significantly increases the effects of medications, and after stabilizing the weight, the desired pregnancy quickly occurs.

One of the main questions is: can PCOS be cured? By carefully following the doctor’s recommendations and carrying out all procedures, it is often possible to overcome all barriers to pregnancy. Many of those who suffered from polycystic disease, after successful treatment and the birth of their first child, note the normalization of hormonal levels and the disappearance of PCOS.

What is used in therapy for PCOS? Treatment includes several groups of drugs. To normalize carbohydrate metabolism and increase tissue sensitivity to insulin, PCOS treatment with metformin is used. This drug restores metabolic disorders, and the use of metformin for PCOS can lead to normalization of glucose and carbohydrate metabolism, weight stabilization, and normalization of the concentration of male sex hormones. All this ultimately leads to normalization of ovarian function and restoration of ovulation. If the body is insensitive to metformin, a regimen of glucophage is often used for PCOS. Its action is similar to the previous drug.

Metypred can also be prescribed for PCOS. It is used to suppress the activity of male sex hormones and normalize the functioning of the adrenal glands. It is taken strictly under the control of an ultrasound picture of the condition of the ovaries. In addition to therapy, cyclodinone may be prescribed for PCOS. This is a drug from the group of dietary supplements that helps normalize the menstrual cycle. Data on its effectiveness vary. However, it is worth remembering that this drug does not treat PCOS, it only has an additional effect and is used in combination with other drugs.

Hormones for PCOS

In order to stabilize hormonal background and normalize the menstrual cycle against the background of polycystic disease, treatment regimens are used hormonal drugs. Special COCs (combined oral contraceptive pills) are usually prescribed. Drugs are selected that contain special anti-androgenic components. These substances block the formation and effect of male sex hormones on tissue. While taking COCs, the ovaries are unloaded, they can “rest” and normalize their structure. This regimen helps in treatment and stops the progression of PCOS. When these drugs are discontinued, ovulation often occurs, and pregnancy occurs in the first months after treatment.

If, after a course of contraceptives, the functioning of the ovaries is not fully restored, they resort to stimulating ovulation with the help of special drugs. They begin their administration with a small dose, gradually increasing it. Ovulation is monitored by ultrasound, measuring the size of the follicles.

Duphaston for PCOS

Against the background of ovarian stimulation, for the purpose of support, treatment of PCOS with duphaston is used. This is a preparation of progesterone, which is necessary during the menstrual cycle for the egg to mature, ovulation and conception to occur. It also supports implantation and early development of the embryo. If there is a deficiency of progesterone, which often happens with PCOS, even if conception has taken place, pregnancy failure may occur. This cannot be allowed.

Veroshpiron for PCOS

In order to correct the level of angrogens (male hormones in the blood), veroshpiron can be additionally prescribed. In addition to normalizing hormonal levels, it gives a slight diuretic effect, reduces the formation of acne and oily skin, and helps hair growth.

Borovaya uterus with PCOS

You can often find recipes on the Internet. PCOS treatment boron uterus. These methods of therapy must be taken very critically, since this herbal remedy does not have hormonal activity. It can only be used in combination with other drugs; taking only decoctions or infusions of this plant will be useless.

Laparoscopy for PCOS

If ineffective drug treatment PCOS can be treated with laparoscopic surgery. It is carried out through small incisions in abdominal cavity, with special instruments under anesthesia. In this case, incisions (wedge resection method) or holes (diathermocauterization) are made on the surface of the ovaries, covered with a dense membrane, through which eggs can leave the ovary during ovulation. After such an operation, the effect lasts for 9-12 months, which makes it possible to get pregnant.

Often it is the operation that leads to the fact that ovulation finally occurs and the desired pregnancy occurs.

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Veroshpiron in gynecology

The drug Veroshpiron has been famous in gynecology for a long time high efficiency and positive properties. It is aimed at removing excess fluid from tissues. Its advantage is that (unlike other diuretics) Veroshpiron does not flush out chlorine, potassium and sodium from the body, but only enhances their accumulation. Usually this effect is noticeable already on the fifth day of use.

Indications for use in gynecology: irregular menstruation, hyperandrogenism, increased hair growth, polycystic ovary syndrome,

Cosmetic problems caused by excess amounts of male hormones (acne, hair loss, oily skin).

From everything written above, it becomes clear that this drug also has antiandrogenic properties. Its effect is manifested in a decrease in the intensity of hair growth in patients with hyperandrogenism. Also, during its use there are no side effects from the endocrine system.

Contraindications: 1) individual intolerance to the components, 2) breastfeeding and pregnancy, 3) hyponatremia and hyperkalemia, 4) renal failure, 5) excess calcium, 6) planning surgical interventions, 7) diabetes mellitus, 8) old age.

In most cases, taking the drug is accompanied by complications: drowsiness, diarrhea, vomiting, constipation, liver problems, convulsions calf muscles, allergies, pain in the mammary glands, menstrual irregularities,

Changes in laboratory parameters.

It is necessary that the duration of treatment, dosage and the necessary phase of the cycle suitable for treatment are strictly prescribed by the treating gynecologist depending on the severity of the disease, type, as well as the individual characteristics of the body. Sometimes, as a preventive measure for menstrual irregularities, Veroshpiron is recommended in gynecology to be taken together with oral contraceptives.

While taking this medication, it is prohibited to: a) eat foods high in potassium (prunes, apricots, bananas and tomatoes), b) drink alcoholic beverages, c) perform activities that require increased attention.

Inna, 25 years old: “A year ago I was diagnosed with polycystic disease, plus my testosterone level was almost doubled. After taking veroshpiron tablets, the hormonal levels were restored, and everything was fine on the ultrasound. There is only one conclusion: it really helps.”

Yulia, 31 years old: “My doctor recommended this remedy to me after I complained that I was getting very full before menstruation. I took the course and noticed that there was no more swelling.”

Alla, 21 years old: “Veroshpiron helped me restore my menstrual cycle. I was also pleasantly surprised to find that my skin gradually began to clear up and my pimples and blackheads disappeared.”

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Veroshpiron

Veroshpiron is a popular medicine prescribed for severe hypertension that does not respond to conventional treatment, as well as for edema in heart failure and cirrhosis of the liver. Women take Veroshpiron to treat polycystic ovary syndrome, hair loss and other problems caused by elevated testosterone levels. Below you will find instructions for using this medicine, written in clear language. Study its indications, contraindications and side effects. Find out how to take Veroshpiron: in what dosages, how many days in a row, before or after meals. Read about Inspra tablets, which have a similar effect, but do not cause impotence and breast growth in men. Find out whether Veroshpiron is compatible with alcohol, whether this medicine helps with acne and for weight loss. The drugs Veroshpiron and Inspra can improve the results of treatment of heart failure and high blood pressure. Read more below.

Instructions for use

How to take Veroshpiron

Veroshpiron needs to be taken for a long time, for life, like other medications for hypertension and heart failure. It is not recommended to take any breaks without consulting your doctor. Unauthorized withdrawal or reduction of dosage can cause deterioration of the condition, even death. Mild side effects are not a reason to independently adjust your medication regimen. And if you are concerned about serious side effects, discuss them with your doctor quickly. Veroshpiron can be taken before or after meals, whichever is more convenient for you. Taking this medication with food may reduce the risk of nausea and diarrhea compared to taking it on an empty stomach.

It may be worth taking Veroshpiron before 6 pm so that you have to get up to go to the toilet less often at night. However, in many patients the diuretic effect of this medication is weak or absent altogether. This is normal, don't worry. Blood pressure may not begin to decrease immediately, but after 2-3 weeks. It is not recommended to drink any alcoholic beverages while you are taking spironolactone. This medicine increases the risk of getting into an accident while driving a car or driving dangerous machinery. It is recommended to take blood tests for potassium and creatinine levels 2-3 days after starting to take Veroshpiron, then again after 4-5 days. Then they are rented out for 3 months every month, then once every 3 months. If the doctor changes the dosage of Veroshpiron, then the level of potassium and creatinine in the blood should be checked after a week.

Below are answers to questions that patients often have.

Veroshpiron or Inspra: which is better?

Inspra (eplerenone) is a relatively recent drug, in the early 2000s. It is similar in action to Veroshpiron (spironolactone), but does not cause impotence and breast enlargement (gynecomastia) in men. It is also less likely to cause hyperkalemia, an elevated level of potassium in the blood. Men who are afraid of the side effects of Veroshpiron tablets should pay attention to Inspra. But do not change one pill for another without consulting your doctor.

The drug Inspra has fewer indications for use than Veroshpiron. It is prescribed for heart failure II-IV functional class, as well as after a heart attack. Arterial hypertension in the absence of heart failure is not an indication for the use of Inspra, nor is cirrhosis of the liver. Inspra tablets are expensive. They don't yet have cheap analogues. Due to their high cost, they are not popular in Russian-speaking countries, despite their significant advantages. Discuss with your doctor whether you should switch from Veroshpiron to Inspra. Don't do this yourself.

Veroshpiron or Indapamide: which is better?

Veroshpiron and Indapamide are different drugs. They have similar indications for use, but they are prescribed in different situations. It cannot be said that Indapamide is better than Veroshpiron, or vice versa. Indapamide is one of the first choice drugs for hypertension. A competent doctor will not prescribe Veroshpiron for high blood pressure in the first place. This remedy is sometimes added to more popular blood pressure pills if they don't help enough. You may be prescribed to take Indapamide and other medications at the same time for hypertension, and later Veroshpiron will be added to them. Indapamide is formally a diuretic drug, but in practice it is used as a vasodilator. Veroshpiron does not have a vasodilator effect.

Heart failure is an indication for the use of Indapamide tablets, but they are rarely prescribed because they are considered weak. If a patient with heart failure only needs to take Indapamide to compensate and does not need stronger diuretics, then he is unlikely to be prescribed Veroshpiron. As a rule, for heart failure, it is not Indapamide that is used, but a stronger loop diuretic, for example, Diuver (torasemide). And if necessary, Veroshpiron is added to it. Do not take any of the medications listed above on your own. To treat hypertension and heart failure, find an experienced doctor and follow his recommendations.

Diuver or Veroshpiron: which is better? How to take these medications at the same time?

It cannot be said that Diuver is better than Veroshpiron, or vice versa, because these are different medicines. They are prescribed for different purposes. Both drugs are diuretics, but they belong to different groups. Diuver is a loop diuretic, and Veroshpiron is a potassium-sparing one. Diuver is one of the popular medications for heart failure. It actively acts on the kidneys, stimulating them to excrete more fluid and salt. Thanks to this, swelling in patients decreases and their well-being improves. Veroshpiron is sometimes prescribed for severe heart failure in addition to Diuver tablets and other basic medications.

For hypertension not complicated by heart failure, Diuver and other loop diuretics are usually not used. Because these medications cause significant side effects. Doctors usually prescribe drugs that act more mildly for high blood pressure. It happens that even the simultaneous use of several medications does not allow blood pressure to drop to 140/90 mmHg. Art. Many patients with severe hypertension benefit from adding Veroshpiron to standard treatment. It is not recommended to use Diuver in such situations.

Patients often have to take Diuver and Veroshpiron simultaneously for heart failure, along with other medications. Take all prescribed medications in the dosages prescribed by your doctor or as provided in the instructions for use. Do not attempt to arbitrarily reduce dosages or discontinue any medications. This can worsen the patient's condition or even lead to death. If you suspect that any pills are causing side effects, discuss this with your doctor. In addition to taking your medications, follow the heart failure treatment guidelines found in the links below on this page.

Veroshpiron or Hypothiazide: which is better?

It cannot be said that Veroshpiron is better than Hypothiazide, or vice versa, because these are different drugs, they have different indications for use. Hypothiazide is a thiazide diuretic, and Veroshpiron is a potassium-sparing diuretic. Hypothiazide is one of the main drugs for high blood pressure. It can be prescribed as soon as hypertension is diagnosed. As a rule, Hypothiazide is prescribed together with some other medications. The patient may be prescribed combination tablets that contain hydrochlorothiazide (dichlorothiazide), the active ingredient in Hypothiazide. If a medication regimen that includes Hypothiazide does not reduce blood pressure to at least 140/90 mmHg. Art., then they can add Veroshpiron. Patients with hypertension sometimes have to take Hypothiazide, Veroshpiron and other medications at the same time. Nobody likes to take a lot of pills. But this is better than suffering a heart attack or stroke.

Hypothiazide may also be prescribed for edema in heart failure. But more often they use Diuver (torasemide) or another loop diuretic. Because these are more potent medications than thiazide diuretics. Veroshpiron is prescribed for severe heart failure in addition to basic medications. It rarely happens that a patient is prescribed both Hypothiazide and Veroshpiron. If the patient is helped enough by Hypothiazide to compensate for heart failure, then there is usually no need to add more Veroshpiron. Do not take any of the medications listed above on your own. Both Hypothiazide and Veroshpiron can cause significant side effects. They are not suitable for self-medication.

How to take Veroshpiron and Asparkam at the same time?

You should not take Veroshpiron and Asparkam or other potassium preparations at the same time. Veroshpiron can cause hyperkalemia - an increase in potassium levels in the blood. This is not useful, but dangerous, and can cause deterioration in health and even death due to cardiac arrest. Taking Asparkam tablets increases the risk. Symptoms of hyperkalemia are weakness, fatigue, nausea, vomiting, tingling sensation, goosebumps, difficulty breathing, chest pain, obvious heart rhythm disturbances.

While you are taking Veroshpiron, do not use Asparkam, other potassium preparations, or salt substitutes rich in this mineral. Veroshpiron interacts negatively with many medications. To reduce your risk, tell your doctor in advance about all the medications, herbs, and dietary supplements you take.

Why is Veroshpiron prescribed to children?

Veroshpiron is prescribed to children for the treatment of heart failure, fluid accumulation in the abdominal cavity (ascites), and primary hyperaldosteronism. This drug helps reduce pulmonary congestion in newborns with lung diseases. Failing to take diuretics or amphotericin can lower your child's potassium levels. In such cases, in addition to other measures, Veroshpiron is prescribed. The doctor selects the dosage of the drug taking into account the age and body weight of the child. Veroshpiron should never be given to children for self-medication. All the diseases listed above are serious. They are treated in a hospital setting.

Can I drink alcohol while taking this medicine?

Is it possible to drink Veroshpiron during pregnancy?

Pregnancy and period breastfeeding- official contraindications to the use of the drug Veroshpiron. Animal studies have shown that this medicine has negative effects on the fetus. Taking Veroshpiron for edema during pregnancy is a bad idea. Study the article “High blood pressure in pregnant women.” Find out what medications you can take, how to get by with the minimum amount of them, what to do to prevent preeclampsia and eclampsia. Discuss with your doctor how to reduce swelling or get rid of it completely without using dangerous drugs.

Can I take this drug when planning a pregnancy?

No more shortness of breath, headaches, pressure surges and other symptoms of HYPERTENSION! Our readers are already using this method to treat blood pressure. To learn more...

There is no data on how dangerous or safe it is to take Veroshpiron when planning pregnancy. If your illness is so serious that you need to take this medicine, then postpone planning a pregnancy.

Use of the drug Veroshpiron

Veroshpiron (spironolactone) is a medicine that is often prescribed to seriously ill patients with hypertension and heart failure. It helps reduce swelling caused by heart problems or cirrhosis of the liver. Sometimes women take Veroshpiron to treat polycystic ovary syndrome and other manifestations of high testosterone. Spironolactone tablets may help with acne and hair loss in women. But this is not confirmed by the results of clinical studies. Official indications for use are only severe hypertension, heart failure, liver cirrhosis and also a disease of the adrenal glands, which is called primary hyperaldosteronism. Veroshpiron definitely does not help men with acne or hair loss.

It is known that Veroshpiron in dosages of 100 mg per day causes impotence and breast enlargement (gynecomastia) in some men. Many men would benefit from taking Veroshpiron for hypertension and heart failure. But they refuse to take this medicine, fearing the side effects listed above. Such patients should pay attention to the drug Inspra. It has an effect similar to the therapeutic effect of Veroshpiron tablets, but does not pose a threat to men. This medicine is described in detail above. Read the answer to the question “Veroshpiron or Inspra: which is better?” Do not change Veroshpiron to Inspra without permission. Discuss this possibility with your doctor.

With high blood pressure

Veroshpiron is not the first choice drug for high blood pressure. But it is often prescribed to people whose standard hypertension treatment does not help lower blood pressure below 135-140/90 mmHg. Art. In many patients, severe hypertension is caused by elevated levels of the hormone aldosterone in the blood. In such cases, it is worth adding Veroshpiron to more popular medications for high blood pressure. It is advisable for patients to undergo blood and urine tests for aldosterone and other hormones produced by the adrenal glands. But Veroshpiron is often prescribed without testing, and this helps many patients.

Veroshpiron and other spironolactone drugs have been used to treat severe hypertension since the 1960s. Currently, interest in this medicine is not decreasing, but rather increasing. Malignant hypertension is when a patient's blood pressure is above 140/90 mmHg. Art., despite the fact that he takes 3-4 antihypertensive medications belonging to different groups, one of which is a diuretic. About 10% of patients suffer from malignant hypertension. There is still no effective and safe remedy that would help most of them. However, Veroshpiron is beneficial in many cases of malignant hypertension.

In November 2015, the reputable medical journal Lancet published English language results of the PATHWAY-2 study. We compared spironolactone (Veroshpiron), bisoprolol and doxazosin as an add-on drug for malignant hypertension refractory to standard treatment. The study involved more than 300 patients whose blood pressure was above 135-140/90 mm Hg. Art., despite 3 months of taking ACE inhibitors, calcium antagonists and thiazide diuretics. Spironolactone has proven to be more effective effective medicine than bisoprolol and doxazosin. More new drug Inspra, which does not cause serious side effects in men, has no evidence base regarding high blood pressure. Hypertension not complicated by heart failure is not an indication for its use.

A competent doctor will not prescribe Veroshpiron for high blood pressure to a patient who has recently been diagnosed with hypertension. Because side effects can be serious, and they happen often. First of all, safer medications are prescribed than Veroshpiron. In most cases, it is enough to take them to keep blood pressure normal. Moreover, if the patient tries to lead healthy lifestyle life. But for malignant hypertension, Veroshpiron should be prescribed, because the possible benefits are higher than the danger of side effects. Veroshpiron helps many patients with severe hypertension. The effect of adding this drug to standard treatment usually does not appear immediately, but after 2-3 weeks.

Heart failure

Veroshpiron (spironolactone) should be prescribed to patients with severe heart failure of functional class III–IV and ejection fraction

Watch also the video: Almost all patients with heart failure receive a powerful diuretic drug, a loop diuretic, Diuver (torasemide) or similar drug. Veroshpiron is prescribed not to enhance the diuretic effect, but to block the action of the hormone aldosterone. As a rule, in heart failure there is an increased concentration of this hormone in the blood. Aldosterone removes potassium and magnesium from the body, retains salt, and also promotes the replacement of the heart muscle with scar tissue. Taking the medication Veroshpiron reduces the negative processes listed above. Due to this, the prognosis for patients improves.

40-50% of patients with heart failure are patients whose ejection fraction is not reduced, but normal. Unfortunately, doctors do not really know how to treat such patients. Medicines commonly prescribed for heart failure do not improve prognosis, rigorous studies have shown. A large trial was conducted to test the effectiveness of spironolactone (Veroshpiron) in patients with heart failure who have a normal ejection fraction. This study was called Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT). Several thousand patients from different countries peace. For some reason, spironolactone helped patients from the USA a little, but not at all for Russian patients. You can read an article in English about this. The reason is that the criteria for diagnosing “heart failure” are different in Russian-speaking and foreign countries.

Men who have developed heart failure after a myocardial infarction should pay attention to the drug Inspra. This is a newer drug that helps, like Veroshpiron, but does not cause breast growth and probably does not affect male potency. More details about this medicine are described above. Study the answer to the question “Veroshpiron or Inspra: which is better?” Unfortunately, Inspra costs tens of times more than Veroshpiron. This is an original imported drug that does not yet have cheap analogues. You cannot change your medication regimen for heart failure on your own. If you want to switch from Veroshpiron tablets to Inspra, discuss this with your doctor.

Polycystic ovary syndrome

Veroshpiron is not the main medicine that women take for polycystic ovary syndrome. Perhaps taking these pills helps control hirsutism - excess hair growth on the chin and torso. Women who do not have hirsutism probably do not need to take Veroshpiron if they have polycystic ovary syndrome. If your doctor has prescribed Veroshpiron for you, then take it at the indicated dosage, 25-200 mg per day. Perhaps the doctor will first prescribe low dose spironolactone, and later increase it. Blood tests for potassium show whether the patient is tolerating treatment with this drug.

According to patient reviews, Veroshpiron for polycystic ovary syndrome needs to be taken for a long time - 6-9 months - before a decrease in hirsutism becomes noticeable. Possible side effects include nausea, menstrual irregularities and increased breast size. If you stop taking the medicine, excess hair growth will begin again. To solve the problem of hirsutism, other drugs are used, not just Veroshpiron. But this topic goes beyond the scope of the site about the treatment of hypertension. A diagnosis of polycystic ovary syndrome means that a woman increased risk diabetes mellitus type 2. It is useful for such patients to follow a low-carbohydrate diet, which is also used to prevent cardiovascular diseases.

For swelling

Veroshpiron is often used for swelling of the legs caused by pulmonary hypertension, or if the cause of fluid accumulation has not been established. Swollen legs can be a warning sign that life-threatening heart or kidney failure is just around the corner. Therefore, you should not try to treat them yourself by taking spironolactone or stronger diuretics.

Contact your doctor to find the cause of the swelling and, if possible, eliminate it. If venous insufficiency is detected, you will need to keep your legs elevated at night, wear compression stockings, and most importantly, quit a job that requires you to be on your feet for a long time. Horse chestnut extract is also popular. For deep vein thrombosis lower limbs The doctor will prescribe low molecular weight heparin.

Before taking Veroshpiron, make sure that the cause of edema is not heart or kidney failure or liver disease. You need to undergo a thorough examination. If it does not help determine the cause of the edema, the doctor may diagnose “idiopathic edema” and prescribe Veroshpiron. Take this medication at the dosage directed by your doctor. At the same time, regularly take blood tests to check potassium levels and other indicators.

If Veroshpiron does not help enough, after a few weeks Hypothiazide, Indapamide or another thiazide diuretic may be added in a low dose. In this case, it is better to avoid diuretic drugs, which are classified as loop diuretics. In addition to taking medications, your doctor will recommend limiting your salt intake and avoiding overexposure to the sun. It is advisable for patients who are overweight to lose weight. Don't take swollen feet lightly. Get tested to determine the cause and try to eliminate it rather than dull the symptoms with diuretics.

To reduce testosterone

Testosterone is the main male sex hormone. It is present in the body of women, not just men. But in women it is normally much less than female sex hormones. For some endocrine diseases The level of testosterone in women's bodies is increased. This causes menstrual irregularities, acne and excess hair growth where there shouldn't be any. It is possible that testosterone may cause some women to experience less hair on their heads after menopause. Polycystic ovary syndrome is not a consequence, but one of the causes of increased testosterone in women. Other causes are congenital adrenal hyperplasia, ovarian tumor.

If a woman is concerned about the symptoms of high testosterone, she needs to find a competent endocrinologist and contact him. The doctor will recommend leading a healthy lifestyle, prescribe medications and possibly prescribe surgical treatment. Veroshpiron is one of the medications that can be prescribed to reduce the effects of increased testosterone levels in a woman’s body. Perhaps this drug helps middle-aged women with scalp hair loss. But this has not been officially confirmed.

Veroshpiron often causes serious side effects - fatigue, dizziness, headaches and decreased libido. Therefore, do not take it for self-medication. Other popular medications - Siofor (metformin), glucocorticosteroids, carefully selected birth control pills. Increased testosterone in women is serious problem which is impossible to solve on your own. Find a smart doctor and consult with him. Do not take the medications listed above on your own initiative.

For cirrhosis of the liver

A common complication of liver cirrhosis is ascites, an accumulation of fluid in the abdominal cavity. When a lot of fluid accumulates, patients experience symptoms - heaviness in the abdomen, shortness of breath, a decrease in the amount of food needed to satiate. To relieve the symptoms of ascites, diuretic medications are prescribed - most often Veroshpiron along with furosemide (Lasix). You can start with a dosage of 100 mg of Veroshpiron and 40 mg of furosemide per day. If this dosage does not help enough, after 3-5 days it is increased to 200 mg of spironolactone and 80 mg of furosemide.

Maximum possible daily dose diuretics for liver cirrhosis - Veroshpiron 400 mg and furosemide 160 mg. It is recommended to prescribe these drugs in a ratio of 100:40 to maintain a normal balance of electrolytes in the blood. In 5-10% of patients, fluid accumulation in the abdominal cavity does not decrease, even despite taking spironolactone and furosemide in maximum dosages. Or ascites is restored to its previous level immediately after discontinuation of diuretic drugs. The prognosis for such patients is poor.

Diabetes

It is advisable to prescribe Veroshpiron for hypertension to patients with type 1 and type 2 diabetes mellitus, in whom ACE inhibitors, angiotensin-II receptor blockers and other basic medications do not help reduce blood pressure to 135-140/90 mm Hg. Art. Preparations containing spironolactone are used as an additional drug, and not to replace the main blood pressure tablets. Several clinical trials have been conducted that have confirmed the feasibility of this treatment. Their results were published in reputable medical journals. See for example the article “Beneficial effects of adding spironolactone to recommended antihypertensive treatment in diabetic nephropathy: a randomized, double-masked, cross-over study” in the journal Diabetes Care, September 2005.

Read the article “High Blood Pressure in Diabetes”. Understand the difference between the treatment tactics for hypertension in type 2 and type 1 diabetes. Find out in detail which tablets are prescribed for the treatment of hypertension in diabetes mellitus. Read what a low-carb diet is, how it differs from a standard “balanced” diet, and what benefits it brings. A low-carbohydrate diet allows you to maintain stable normal blood sugar, like healthy people. It will give you the opportunity to minimize the amount of hypertension medications you need to take, or even stop taking them altogether.

For hair loss

Many women face the problem of hair loss on their scalp after menopause, or even earlier. The main medicine used in such cases is Minoxidil, a vasodilator drug for hypertension. Sometimes women also take Veroshpiron or other spironolactone drugs for hair loss. Spironolactone tablets are thought to help some women who have not benefited from the drug Minoxidil.

Veroshpiron is not officially approved for use against hair loss in women, much less in men. Possible side effects from taking it by women are weight gain, decreased libido, depression, and fatigue. Women of reproductive age who take Veroshpiron for hair loss are advised to use reliable methods of contraception. Because spironolactone can have negative effects on the fetus.

For acne

Abroad, Veroshpiron is often prescribed for acne to women who have already completed puberty. This is not the first choice acne treatment. The possibility of treatment with this drug should be considered for patients who do not respond to simple methods without the use of hormonal drugs. Veroshpiron against acne only helps women, and not everyone. It is not prescribed to teenage girls. You need to take this medicine for at least 3 months before it becomes clear whether it helps you or not.

Dermatologists sometimes prescribe veroshpiron tablets to women for acne. Clinical trials have confirmed the effectiveness of this method. But there is still no treatment for acne official testimony to the use of the drug Veroshpiron. The fact is that this drug stimulated the development oncological diseases in laboratory animals that received it in very high doses. Therefore, the US Department of Health (FDA) does not want to expand the list of indications for the use of spironolactone.

Do not take Veroshpiron for acne on your own initiative. Find a competent dermatologist and consult with him. An intelligent specialist, before prescribing Veroshpiron or other treatment, will force the patient to take blood tests for male sex hormones and aldosterone. A common side effect is a drop in blood pressure, associated weakness and dizziness. Menstrual irregularities are also possible. If acne bothers you, consider taking zinc and vitamin A tablets.

For weight loss

Taking Veroshpiron for weight loss is a bad idea. This medicine acts as a diuretic and may reduce appetite. However, its diuretic effect is weak, does not appear immediately, and in many patients is completely absent. There is not the slightest reliable evidence that spironolactone tablets help you lose excess weight. Your body weight may even increase due to the hormonal changes this drug causes. No specialist in his right mind would approve of taking Veroshpiron tablets for weight loss, or other diuretic drugs.

Many women try to take diuretics to quickly lose a few pounds. The most popular diuretic drug for weight loss is furosemide (Lasix). This medicine may cause serious side effects. However, they will quickly go away after stopping the medicine if the kidneys have not been irreversibly damaged. The side effects that Veroshpiron will cause may remain with you for a long time even after stopping the drug. If you are interested in weight loss medications, then pay attention to Siofor (metformin). Of course, it is better to focus on healthy eating and physical activity.

lechenie-gipertonii.info

2018 Blog about women's health.

Latin name: Verospiron
ATX code: C03DA01
Active substance: Spironolactone
Manufacturer: Gedeon Richter JSC, Hungary
Conditions for dispensing from a pharmacy: On prescription

"Veroshpiron" or known by its INN spironolactone is a good diuretic that inhibits the excretion of potassium from the body. The drug is available in pharmacies upon presentation of a prescription.

Compound

The key element in the composition of the tablet and capsule form is spironolactone (international name “Veroshpirona”). Additional ingredients of tablets and capsules vary.

The tablets additionally contain lactose, sodium lauryl sulfate, as well as corn starch and magnesium stearate. In addition to these ingredients, capsules of 50 mg contain E-additives (E171, E 104) and gelatin, and 100 mg also contain additive E 110.

Indications for use

A diuretic can be prescribed by various medical specialists for individual therapy or as part of complex treatment. The main indications for use include:

• Idiopathic and secondary hyperaldosteronism
• Low level of potassium in the blood.

Spironolactone is sometimes prescribed to patients to diagnose primary hyperaldosteronism. As a prophylactic agent, Veroshpiron can be used for hypomagnesemia and hypokalemia.

"Veroshpiron" in gynecology is usually auxiliary medical drug aware of the treatment of certain gynecological problems. The medicine is recommended for polycystic ovary syndrome, menstrual irregularities, hirsutism, excess male hormones in the female body, hyperandrogenism.

Due to its effective diuretic effect, many suggest that Veroshpiron can be used for weight loss. However, doctors do not recommend this medicine for this purpose.

Release forms

Tablets and capsules are dosage forms release of spironolactone. Pharmacists have developed such forms of release of spironolactone, taking into account various dosages during treatment individual states and diseases, as well as age category patients.

Average price from 90 to 120 rubles.

Tablets “Veroshpiron”

Tablets in a standard round, flat, white form have a special odor. On one side there is an inscription of the name of the medicine in Latin letters. The dosage of the main substance is 25 mg. One package contains 20 pieces.

Capsules “Veroshpiron”

Capsules are offered in dosages of 50 mg and 100 mg. Each capsule is filled with a white powdery, fine granular composition. The capsule shell is 50 mg hard gelatin. The lid is painted in an opaque yellow color, and the body is painted in an opaque white color. The 100 mg version has color differences: the cap is opaque orange, and the body is opaque yellow.

Average price from 220 to 310 rubles.

In addition to the dosage, the capsules differ in size. Smaller dose in size No. 3, larger dose in size No. 0. Typically, capsules of 10 pieces are packed in a blister. Each pack contains 3 blisters. The average price for a package of 50 mg is 240 rubles, 100 mg - 300 rubles.

Mode of application

"Veroshpiron" in the form of tablets or capsules is taken orally in the prescribed dose after meals. During pregnancy, the drug is strictly prohibited. If there is a need to take spironolactone during lactation, the child should be switched to artificial nutrition and stop feeding. Use alcoholic beverages Diuretics are not allowed while taking them, as they can increase orthostatic hypotension.

For children who already know how to swallow, the doctor may prescribe capsules. Otherwise, the child should be given crushed tablets.

Depending on the condition or existing disease, the following drug intake is recommended, respectively, after meals:

• Hypertension of the first stage in the presence of hypokalemia

The daily dose of the drug is 50-100 mg. Number of doses: 1. Sometimes the dose can be increased to 200 mg. The reception should last at least two weeks.

• Cirrhosis of the liver, in which there is swelling or accumulation of transudate in the abdominal cavity

Dose per day 100-200 mg. Take 1 or 2 times a day. In this case, dose adjustment is determined individually.

• Conditions of kidney damage in which protein is excreted in the urine, increased swelling is observed and the metabolism of proteins and fats is disrupted

Daily dose 100-300 mg once or twice.

• Tissue swelling during cardiac decompensation in the chronic stage

100-200 mg of the substance in 2-3 doses per day. Take daily for 5 days. The maintenance dose is selected individually.

• Idiopathic hyperaldosteronism

Daily dose 100-400 mg. It is taken in 2-3 doses.

• Low levels of potassium and/or magnesium in the blood

The required dose of the substance is 25-100 mg. It is taken in one dose or in some cases in several. Sometimes it is possible to increase the dose taken (the maximum can reach 400 mg).

• Polycystic ovary syndrome and hirsutism

100 mg of the substance per day in two doses.

• As a diagnostic tool

400 mg of the substance is taken once (sometimes more). In such cases, the number of doses and duration depends on the type of test

• Edema in children

1-3.3 mg/kg. The number of doses is from 1 to 4. 5 days later, the dosage is subject to adjustment.

"Veroshpiron" for weight loss will allow you to lose only a few kilograms, but will not lead to positive results.

Contraindications

"Veroshpiron" has a number of contraindications, which the doctor should be aware of before prescribing tablets to a specific patient:

• Chronic adrenal insufficiency (Addison's disease)
• The entire period of pregnancy and lactation
• Severe renal failure
• Intolerance to the main substance or additional components included in the composition
• The potassium content in the blood is significantly higher than normal
• Children under three years of age
• Hyponatremia
• Anuria
• Lactose intolerance.

It is prohibited to prescribe spironolactone simultaneously with potassium-retaining diuretics and potassium supplements taken for preventive purposes.

In the following cases, the medicine should be taken with extreme caution:

• Elderly people
• Hypercalcemia
• Irregular menstrual bleeding
• On the eve of upcoming surgical interventions
• Presence of diabetes mellitus
• Painful enlargement of the mammary glands
• For any type of anesthesia
• Diabetic nephropathy.

Failure to comply with the listed contraindications will not only not provide effective action, but can also lead to dire consequences and unforeseen reactions.

Adverse reactions and overdose

When taking this medication you can expect adverse reactions from almost all body systems.

1. Digestive system: upset stomach with nausea and vomiting, constipation, colic and abdominal pain, gastritis, functional disorders liver
2. Endocrine system: in men - decreased potency, gynecomastia, deepening of the voice; in women - increased growth of male-type hair, deepening of the voice, painful sensations in the chest area, dysmenorrhea, uterine bleeding during menopause, instability or long absence of the monthly cycle
3. Central nervous system: increased drowsiness, muscle spasms, dizziness, inhibited reactions, lethargy
4. Urinary system: acute renal failure
5. Musculoskeletal system: involuntary contraction of the calf muscles
6. Hematopoietic system: neutropenia, pathological reduction in the number of platelets in the blood
7. Allergies: various types of rashes, itching, Stevens-Johnson syndrome
8. Skin: spontaneous hair loss or excessive hair growth in different areas.

According to laboratory indicators, the water-salt and acid balance may be disrupted, and the content of uric acid in the blood may increase.

In case of overdose, standard symptoms of poisoning may be observed, such as vomiting, frequent bowel movements, dry mouth, and weakness.

Conditions and shelf life

Veroshpiron should be stored at temperatures not exceeding +30 °C. The drug must be in a place where access to children is prohibited!

The shelf life of the drug is five years. Expired medicine should be thrown away.

Analogues

TO to modern analogues According to the radar encyclopedia, drugs include the following:

Despite the fact that each medication is an effective diuretic that relieves swelling in certain diseases, there are some differences between them.

PFIZER PHARMACEUTICALS, LLC, Puerto Rico
Price from 2500 to 2650 rub.

Used as an additional agent to reduce the risk of developing cardiovascular diseases and mortality in patients with stable left ventricular dysfunction. The main active ingredient is Eplerenone.

pros

• Less severe side effects
• Retains potassium

Minuses

• Very expensive drug
• Contraindicated in children under 18 years of age.

PLIVA HRVATSKA D.O.O., Croatia
Price from 250 to 1000 rub. (depending on packaging)

It is used for high blood pressure and swelling of various etiologies. The main active ingredient is Torasemide.

pros

• Various volumes of product produced - you can optimally select the amount for a course of treatment
• Has a long lasting effect

Minuses

• Take with caution during pregnancy and prohibited during lactation
• Doesn't retain potassium
• Prohibited for use by children under 18 years of age.

"CHINOIN" Pharmaceutical and Chemical Works Co.Ltd., Hungary
Price from 90 to 130 rub.

The main active ingredient is hydrochlorothiazide. The drug is used for high blood pressure, edema due to heart and vascular insufficiency, or impaired functioning of the liver or kidneys.

pros

• The effect appears 2 hours after administration
• With long-term use of the drug, its effectiveness remains

Minuses

• On initial stage while taking the drug, driving is prohibited
• In the 1st trimester and during lactation it is prohibited; in the 2nd and 3rd trimester it should be taken with caution.

Analogues are not always an ideal replacement, so it is not recommended to use an equivalent without medical prescription.

The drug is a competitive antagonist of the mineralocorticoid aldesterone. The medicine is prescribed for liver cirrhosis, heart failure, blood pressure, acne, hyperandrogenism, high testosterone and other ailments. The dosage depends on the nature of the disease and is prescribed individually. The instructions for use explain in detail how to take the tablets and what they help with. Wikipedia defines the drug as a potassium-sparing diuretic. The international name by international name is Spironolactone (in Latin). Acts as a diuretic.

What is it prescribed for, indications for use

The purpose of the drug is determined by its diuretic effect. The drug has the following indications: adrenal adenoma, primary hyperaldosteronism, edema during pregnancy, hirsutism during polycystic disease, liver damage, nephrotic syndrome. The product is widely used for edema. Women take pills for menstruation and for weight loss.

Compound

The active ingredient of the drug is spironolactone. In addition, the composition includes magnesium stearate, colloidal silicon dioxide, corn starch, lactose monohydrate. The capsules contain sodium lauryl sulfate. The gelatin capsule consists of quinoline dye, gelatin and titanium dioxide.

How long can you take Veroshpiron?

The duration of taking the drug depends on the diagnosis. So, for essential hypertension, the medicine must be taken for at least two weeks, and the daily dosage should be from 50 to 100 mg. To treat primary hyperaldosteronism, tablets should be taken for four days at 400 mg per day. During long-term diagnostic tests, the medicine is taken for three to four weeks.

Analogues, synonyms

The pharmacological group contains other analogues of the drug. Such agents as furosemide, indapamide, diuver, veroshpilactone, prolactin, triampur and others are widely used. Funds are available in Ukraine, Perm, St. Petersburg, Omsk and other cities of the Russian Federation.

Veroshpiron or Furosemide, which is better?

In this matter, everything depends on the goals pursued by the patient. Furosemide is a cheaper analogue of veroshpiron. It helps remove fluid from the body, but only veroshpiron has a potassium-sparing mechanism. Therefore, questions about choice should be decided individually.

Veroshpiron or Diuver, which is better?

According to cardiologists, the first drug is best taken to prevent heart failure. It is preferable to take Diuver for the direct treatment of this pathology. In any case, before replacing one medicine with another, consult your doctor, as the difference between taking them can be significant.

Instructions for use Veroshpiron

When a diagnosis of hyperaldosteronism is made, the drug is recommended in a dosage of 100 to 400 mg per day, one to four times a day. In other cases, the medicine is taken orally at 0.05 - 0.3 grams per day. The dose is usually divided into two to four doses. If the patient's condition has improved, then the dose is reduced to 0.025 g per day. People suffering from Parkinson's syndrome are prescribed twenty-day courses with breaks of five months. For hypertension, the medicine is prescribed at 0.025 g. four times a day.

Teenagers can obtain and take medication in any form only with a prescription.

For edema dosage

During edema that occurs with nephrotic syndrome, the adult dose is 100 to 200 mg per day. Edema syndromes in heart failure are treated with doses of one hundred and two hundred mg per day for five days. Edema in liver cirrhosis is relieved with a daily dosage of 100 mg. To relieve edema in children, the dose is from 1 to 3.3 mg per kilogram of the child’s weight. After 5 days, the dosage is adjusted.

During pregnancy, when planning

When planning pregnancy and during fetal development, taking the drug is contraindicated. In addition, the medicine should not be taken during lactation or while breastfeeding. If therapy with veroshpiron is necessary, breastfeeding should be stopped.

In gynecology

The drug is indicated in gynecology to reduce androgens in women suffering from polycystic ovary syndrome. The medicine can cause bleeding and disrupt the menstrual cycle. It is better to take the pills together with contraceptives.

For newborns

This drug is officially prohibited for newborns and children under three years of age. However, in some cases, the attending physician may prescribe medication in an inpatient setting.

Reviews, overdose, contraindications for women

In professional circles and among patients, reviews of the drug are positive. Contraindications for women: hypersensitivity, renal failure and diabetic nephropathy. Compatibility with alcohol is negative.

In this article you can read the instructions for use of the drug Veroshpiron. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Veroshpiron in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Veroshpiron in the presence of existing structural analogues. Use for the treatment of arterial hypertension and diuretic effect in adults, children, as well as during pregnancy and lactation. Composition of the drug.

Veroshpiron- potassium-sparing diuretic, competitive aldosterone antagonist.

IN distal sections nephron Veroshpiron prevents the retention of sodium and water by aldosterone and suppresses the potassium-removing effect of aldosterone, reduces the synthesis of permeases in the aldosterone-dependent area of ​​the collecting ducts and distal tubules. By binding to aldosterone receptors, it increases the excretion of sodium, chlorine and water ions in the urine, reduces the excretion of potassium and urea ions, and reduces the acidity of urine.

The hypotensive effect is due to the diuretic effect. The diuretic effect appears on days 2-5 of treatment.

Compound

Spironolactone + excipients.

Pharmacokinetics

After oral administration, it is quickly and completely absorbed from the gastrointestinal tract. Bioavailability is about 100%, and food intake increases it to 100%. Spironolactone does not penetrate well into organs and tissues, while spironolactone itself and its metabolites penetrate the placental barrier, and canrenone passes into breast milk. In the process of biotransformation in the liver, active sulfur-containing metabolites 7-alpha-thiomethylspironolactone and canrenone are formed. It is excreted mainly by the kidneys (50% - in the form of metabolites, 10% - unchanged) and partially through the intestines.

Indications

• essential hypertension (as part of combination therapy);
• edematous syndrome in chronic heart failure (can be used as monotherapy and in combination with standard therapy);
• conditions in which secondary hyperaldosteronism can be detected, incl. cirrhosis of the liver, accompanied by ascites and / or edema, nephrotic syndrome and other conditions accompanied by edema;
• hypokalemia / hypomagnesemia (as an adjuvant for its prevention during treatment with diuretics and when other methods of correcting potassium levels cannot be used);
• primary hyperaldosteronism (Conn's syndrome) - for a short preoperative course of treatment;
• to establish the diagnosis of primary hyperaldosteronism.

Release forms

Tablets 25 mg.

Capsules 50 mg and 100 mg.

Instructions for use and dosage

With essential hypertension, the daily dose for adults is usually 50-100 mg once and can be increased to 200 mg, while increasing the dose should be gradual, 1 time in 2 weeks. To achieve an adequate response to therapy, the drug must be taken for at least 2 weeks. If necessary, adjust the dose.

In idiopathic hyperaldosteronism, the drug is prescribed at a dose of 100-400 mg per day.

With severe hyperaldosteronism and hypokalemia, the daily dose is 300 mg (maximum 400 mg) for 2-3 doses, with improvement in the condition, the dose is gradually reduced to 25 mg per day.

With hypokalemia and / or hypomagnesemia caused by diuretic therapy, Veroshpiron is prescribed at a dose of 25-100 mg per day, once or in several doses. The maximum daily dose is 400 mg if oral potassium supplements or other methods of replenishing potassium deficiency are ineffective.

When diagnosing and treating primary hyperaldosteronism, Veroshpiron is prescribed as a diagnostic tool for a short diagnostic test for 4 days, 400 mg per day, dividing the daily dose into several doses per day. If the concentration of potassium in the blood increases while taking the drug and decreases after its discontinuation, the presence of primary hyperaldosteronism can be assumed. For a long-term diagnostic test, the drug is prescribed in the same dose for 3-4 weeks. When correction of hypokalemia and arterial hypertension is achieved, the presence of primary hyperaldosteronism can be assumed.

Once the diagnosis of hyperaldosteronism has been established using more accurate diagnostic methods, as a short course of preoperative therapy for primary hyperaldosteronism, Veroshpiron should be taken in a daily dose of 100-400 mg, divided into 1-4 doses throughout the entire period of preparation for surgery. If surgery is not indicated, then Veroshpiron is used for long-term maintenance therapy, using the lowest effective dose, which is selected individually for each patient.

When treating edema due to nephrotic syndrome, the daily dose for adults is usually 100-200 mg. There was no effect of spironolactone on the main pathological process and therefore the use of this drug is recommended only in cases where other types of therapy are ineffective.

In case of edema syndrome against the background of chronic heart failure, the drug is prescribed daily for 5 days, 100-200 mg per day in 2-3 doses, in combination with a loop or thiazide diuretic. Depending on the effect, the daily dose is reduced to 25 mg. The maintenance dose is selected individually. The maximum daily dose is 200 mg.

For edema due to liver cirrhosis, the daily dose of Veroshpiron for adults is usually 100 mg if the ratio of sodium and potassium ions (Na+/K+) in the urine exceeds 1.0. If the ratio is less than 1.0, then the daily dose is usually 200-400 mg. The maintenance dose is selected individually.

For edema in children, the initial dose is 1-3.3 mg/kg body weight or 30-90 mg/m2 per day in 1-4 doses. After 5 days, the dose is adjusted and, if necessary, increased by 3 times compared to the original.

Side effect

• nausea, vomiting;
• diarrhea;
• ulcerations and bleeding from the gastrointestinal tract;
• gastritis;
• intestinal colic;
• abdominal pain;
• constipation;
• ataxia;
• lethargy;
• dizziness;
• headache;
• drowsiness;
• confusion;
• agranulocytosis, thrombocytopenia, megaloblastosis;
• hyperuricemia, hypercreatininemia, increased urea concentration, hyperkalemia, hyponatremia;
• deepening of the voice;
• in men - gynecomastia (the likelihood of development depends on the dose, duration of treatment and is usually reversible and disappears after discontinuation of Veroshpiron, only in rare cases breast remains slightly enlarged);
• decreased potency and erection;
• in women - menstrual irregularities;
• dysmenorrhea;
• amenorrhea;
• metrorrhagia during menopause;
• hirsutism;
• pain in the mammary glands;
• hives;
• drug fever;
• alopecia;
• acute renal failure;
• muscle spasm;
• cramps of the calf muscles.

Contraindications

• Addison's disease;
• hyperkalemia;
• hyponatremia;
• severe renal failure (creatinine clearance less than 10 ml/min);
• anuria;
• lactose intolerance, lactase deficiency, glucose/galactose malabsorption syndrome;
• pregnancy;
• lactation period (breastfeeding);
• children under 3 years of age;
• hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

The use of Veroshpiron is contraindicated during pregnancy and lactation.

special instructions

When using Veroshpiron, a temporary increase in the level of urea nitrogen in the blood serum is possible, especially with reduced renal function and hyperkalemia. It is also possible to develop reversible hyperchloremic metabolic acidosis.

When prescribing Veroshpiron to patients with impaired renal and liver function, and elderly patients, regular monitoring of serum electrolytes and renal function is necessary.

It is believed among ordinary people that Veroshpiron is capable of losing weight, but the weight loss caused by the drug can only be correlated with the number of kilograms of excess weight lost in liquid and nothing more. It has nothing to do with diets or actual weight loss.

Taking Veroshpiron makes it difficult to determine the concentration of digoxin, cortisol and adrenaline in the blood.

Despite the absence of a direct effect on carbohydrate metabolism, the presence of diabetes mellitus, especially with diabetic nephropathy, requires special caution when prescribing Veroshpiron due to the possibility of developing hyperkalemia.

When treated with non-steroidal anti-inflammatory drugs while taking Veroshpiron, kidney function and blood electrolyte levels should be monitored.

During treatment with Veroshpiron, alcohol consumption is contraindicated, and food rich in potassium should be avoided.

During treatment, alcohol consumption is contraindicated.

Impact on the ability to drive vehicles and operate machinery

During the initial period of treatment, it is prohibited to drive a car or engage in activities that require increased concentration and speed of psychomotor reactions. The duration of restrictions is set individually.

Drug interactions

Veroshpiron reduces the effect of anticoagulants, indirect anticoagulants (heparin, coumarin derivatives, indanedione) and the toxicity of cardiac glycosides (since normalizing the level of potassium in the blood prevents the development of toxicity).

Enhances the metabolism of phenazole.

Reduces the sensitivity of blood vessels to norepinephrine (requires caution during anesthesia).

Increases T1/2 of digoxin, so digoxin intoxication is possible.

Strengthens the toxic effect of lithium due to a decrease in its clearance.

Accelerates the metabolism and excretion of carbenoxolone.

Carbenoxolone promotes sodium retention by spironolactone.

Glucocorticosteroids (GCS) and diuretics (benzothiazine derivatives, furosemide, ethacrynic acid) enhance and accelerate the diuretic and natriuretic effects.

Enhances the effect of diuretic and antihypertensive drugs.

GCS enhance the diuretic and natriuric effect in hypoalbuminemia and/or hyponatremia.

The risk of developing hyperkalemia increases when taking Veroshpiron with potassium preparations, potassium supplements and potassium-sparing diuretics, ACE inhibitors (acidosis), angiotensin 2 antagonists, aldosterone blockers, indomethacin, cyclosporine.

Salicylates and indomethacin reduce the diuretic effect.

Ammonium chloride and cholestyramine contribute to the development of hyperkalemic metabolic acidosis.

Fludrocortisone causes a paradoxical increase in tubular secretion of potassium.

Reduces the effect of mitotane.

Enhances the effect of triptorelin, buserelin, gonadorelin.

Analogues of the drug Veroshpiron

Structural analogues of the active substance:

• Aldactone;
• Vero-Spironolactone;
• Verospilactone;
• Spirix;
• Spironaxane;
• Spironol;
• Spironolactone;
• Spironolactone (Unilan);
• Urakton.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

If a doctor has prescribed Veroshpiron tablets, instructions for use are usually located inside the drug package. If for some reason it was not there, then it will be useful to read the following information, which describes the indications and contraindications for the use of Veroshpiron, side effects and drug analogues.

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What is the medicine?

Veroshpiron is a 25 mg tablet with a diameter of 9 mm. Externally, these are white round preparations with markings. Sometimes the drug is available in 50 mg capsules. The capsules consist of a white powder-like mixture with a characteristic mercaptan odor. There are also 100 mg capsules, as well as gelatin versions of an opaque yellow color. The medicine is very quickly absorbed into gastrointestinal tract and is excreted naturally. As a rule, the diuretic effect of the drug appears on the second day of taking the medicine.

The drug is produced in blisters of 20 tablets, capsules of 50 and 100 mg are produced in blisters of 10 pieces. The medication is dispensed in pharmacies only with a doctor's prescription.

Composition information

The main active ingredient in this medicine is spironolactone, which is respectively contained in tablets of 25 mg, 50 mg and 100 mg. Additionally, the product contains the following excipients:

• anhydrous colloidal silicon dioxide;
• magnesium stearate;
• talc;
• corn starch;
• lactose monohydrate.



Thanks to all of the above components, the drug Veroshpiron has a good diuretic effect.

Indications and contraindications for use

You can take the medicine, as the instructions say, in the following cases:

• with high blood pressure;
• with primary hyperaldosteronism (large amounts of the hormone aldosterone);
• for swelling;
• with fluid retention in the body;
• for kidney and liver diseases;
• with a lack of potassium in the body.



In addition to the indications for use, like any other drug, Veroshpiron has contraindications, including hypersensitivity of the body and personal intolerance to one of the components that make up the drug. You should not take it if you have severe kidney problems or kidney failure.

The drug should be used with caution by people with hepatitis and severe liver diseases, if the acid-base balance in the body is disturbed and the presence of diabetes mellitus.

It is strictly forbidden to use the medicine during pregnancy, lactation and children under 6 years of age. Taking into account the fact that the drug helps increase the amount of potassium in the patient’s body, the dosage must be strictly observed during treatment. Otherwise, an uncontrolled increase in potassium in the blood will negatively affect the functioning of the cardiovascular system and cause a number of side effects.



Side effects

If the dosage of the drug is not correct, patients may experience an increase in heart rate, decreased sex drive, enlarged breasts in men, problems with erectile function, and an inability to conceive a child. Women experience nausea, vomiting, dizziness and menstrual irregularities. A common symptom is confusion, decreased blood pressure, lethargy, decreased performance and hemoglobin levels, exacerbation chronic diseases.In rare cases, it may develop:

• muscle paralysis;
• excessive hair growth in women on the body;
• inflammation of blood vessels;
• liver inflammation;
• itching, urticaria;
• increased temperature, fever;
• change in voice timbre in women;
• baldness in men;
• diarrhea;
• intestinal colic;
• gastritis;
• lethargy, drowsiness;
• eczema and other skin reactions;
• renal failure.



The chance of developing the above side effects is only 1%, and most of them go away as soon as the patient stops taking the medicine. If you have any health changes that are not listed above, tell your doctor. He will definitely change the diuretic or reduce the dosage of the drug. In case of overdose of the drug, immediate gastric lavage is required.

Interaction with other medications

If you have used or are using other medications, you also need to warn your doctor about this, because when Veroshpiron is prescribed and its dosage is developed, the doctor must take into account all the characteristics of the patient’s body. Negative reaction the patient can receive it if he takes the following drugs simultaneously with Veroshpiron:

• Cholestyramine;
• Acetylsalicylic acid;
• Mefenamic acid;
• Digoxin;
• Carbenoxolone;
• Triptorelin;
• Gonadorelin;
• Cyclosporine.



It is important to note that the drug may affect concentration, so it is not recommended to administer vehicles while using the product.

Each Veroshpiron tablet contains a certain amount of milk sugar. If a person has lactose intolerance, it is possible allergic reaction for the drug.

Method of taking a diuretic

The daily dose of the drug should be indicated by the doctor depending on the severity of the disease. As a rule, the first dose of the medicine should be taken in the morning before meals. You can take the drug with a small amount of water or juice, but in no case with coffee.



In the treatment of high blood pressure, the drug is taken 2 times a day along with other antihypertensive drugs. Veroshpiron is a diuretic and is used as complementary therapy. In the treatment of edema caused by kidney and liver diseases, the doctor prescribes large doses of the drug. This diuretic drug is often used in gynecology and urology, when preparing a person for surgery. When treating children, the dosage is selected depending on the weight and age of the patient.

If it happens that you forget to take the medicine at the right time, under no circumstances take a double dose at once, just try to follow the administration method in the future. Do not use the drug after the expiration date indicated on the package and do not take tablets from damaged packaging.

The international nonproprietary name of the drug is Spironolactone, although it is sold in pharmacies under the name Veroshpiron. INN is usually used in medical practice, pharmacologists sell the drug and its analogues under proprietary names. Among the analogues of the drug, the following drugs can be noted:

• Inspra;
• Decriz;
• Renial;
• Eridanus;
• Epplepres;
• Espiro.



Each of the above medications can be purchased at a pharmacy at an affordable cost, but only with a doctor’s prescription. Before using the drug, in any case, read the instructions and follow the storage conditions for the drug indicated on the package.

This publication is for informational purposes only and is not a call for self-medication or the purchase of the above drugs. Only a doctor should prescribe the dosage!