Antipyretics for children are prescribed by a pediatrician. But there are emergency situations for fever when the child needs to be given medicine immediately. Then the parents take responsibility and use antipyretic drugs. What is allowed to give to infants? How can you bring down the temperature in older children? What medicines are the safest?
Nasonex - medical preparation, is available in the form of drops and spray. The main purpose is to combat allergic reactions of varying severity, rhinitis, polyps, adenoids. Nasonex can be used by adults and children, but in different dosages. The drug is based on the potent substance mometasone furoate.
The drug is guaranteed to have a beneficial effect, helps in alleviating the condition of a person with a runny nose caused by allergies and other diseases.
The composition of the drug
The Nasonex spray contains (per 1 g of the product):
- Mometasone furoate 0.5 mg (main active ingredient);
- Dispersed cellulose;
- Citric acid monohydrate;
- Glycerol;
- sodium dihydrate;
- Phenylethanol;
- Benzalkonium chloride;
- Polysorbate;
- Water.
The appearance of the spray is a transparent whitish suspension.
About the active ingredient
Mometasone furoate is of synthetic origin. The substance belongs to potent glucocorticosteroids. After entering the nasal cavity, the substance is absorbed through the walls of the vessels, processed by the body and decomposed into mometasone. It is mometasone that has anti-inflammatory and anti-allergic effects.
Possible side effects
After using Nasonex or analogues with mometasone in the composition, there is a risk of developing side effects:
- Burning sensation, itching in the nose.
In rare cases, allergic contact dermatitis develops.
Indications for the use of Nasonex
According to the instructions for Nasonex, it is recommended to use the product for:
- Rhinitis in seasonal or chronic form (can be used by adults and children over 2 years old);
- Sinusitis in the chronic and acute stages (used from the age of 12 in children, therapy includes antibiotic treatment);
- Prevention of seasonal rhinitis in moderate and severe form (use by adults and children over 12 years old is acceptable);
- Polyps, adenoids that prevent normal breathing (can be used by people over 18 years old).
Contraindications
Absolute contraindications to the use of Nasonex:
- Intolerance to the active substances in the composition of the drug;
- Infectious diseases of the nasal mucosa, open wounds;
- Postoperative period, nose injuries until complete healing of the skin;
- Age restrictions: up to 2 years for allergies, up to 12 years for sinusitis, up to 18 years for the formation of polyps.
Relative contraindications:
- Tuberculosis;
- Infectious diseases;
- Herpes;
- Fungus.
With relative contraindications, the spray can be used only under the supervision of a physician.
Instructions for use, dosage
Instructions for the use of Nasonex vary depending on the goals of therapy, disease, age and physical condition of the person.
For adults
The absorption of the active substance of the drug is not more than 0.1% of the amount of the applied agent. For this reason, Nasonex is widely used in various diseases and even as a remedy for snoring.
For allergies:
- Adults and adolescents over 12 years of age 1 time per day (maximum 2 times);
- Permissible dose 400 mcg, one-time 200 mcg;
- 12 hours after inhalation, all symptoms disappear completely.
Subsequently, when the symptoms of allergic rhinitis decrease, Nasonex is used at a dosage half as much as in the first inhalation - 100 mcg with a single application.
At chronic runny nose in acute form:
- It is used against the background of anti-cold and antibacterial drugs;
- Inhalations are done twice a day;
- The maximum dose is 800 mcg per day, with subsequent treatment, the dosage is gradually reduced.
Along with lowering the dosage, the number of Nasonex doses per day also decreases.
For polyps:
- When polyps appear, the drug is prescribed to be taken twice a day;
- Dose of inhalation 200 mcg;
- After the onset of relief, the number of applications is reduced to 1 time per day;
- The termination of inhalations is recommended after complete elimination of polyps.
For children
Synthetic mometasone 
as part of Nasonex is a hormone. The substance has a minimal effect on the adult body, it is practically not monitored in the blood even after complete absorption. Children can use the drug continuously for a long time, but only in accordance with the instructions. Neither reviews of Nasonex nor clinical studies have confirmed the effects of the spray on the physical condition of children, development, and growth.
The drug does not act immediately, but only after the splitting of the synthetic hormone. Within 12 hours after inhalation, no effect may be observed, but after that it will come. Children should not be re-applied.
Babies
The spray has not been tested on infants. For this reason, Nasonex is not prescribed in pediatrics for children under 2 years of age. It is also not recommended to use the drug on babies on their own, because. active substances can cause serious harm to the body of babies.
As with infants, no clinical trials have been conducted in pregnant women. However, the manufacturer claims that the ingestion of the active substance is minimal, so use during pregnancy is acceptable.
If the drug is used, it is necessary to control the hormonal state of the mother's body. Possible side effects in the form of increased activity of the adrenal glands, which will negatively affect the development of the fetus.
Also, caution should be taken when breastfeeding. There are no studies proving or refuting the passage of mometasone into breast milk. If possible, it is better not to use Nasonex during pregnancy and breastfeeding.
Sprayer Care
The drug is produced by a Belgian company in plastic bottles with a dispenser. The dispenser performs the function of a sprayer, allows you to apply the recommended amount of suspension to the mucous membrane of the nasal sinuses. The product is in the package under pressure, when pressed, the dispenser sprays it.
The spray can only be used in combination with a spray dispenser. It is strongly not recommended to use Nasonex as nasal drops due to the risk of side effects, overdose.
Caring for your dispenser 
is an important step in therapy. Before each use, shake the vial of the suspension to mix it. Each time you press the dispenser, 100 micrograms of the drug are ejected, half of which is the active ingredient mometasone. For effective treatment without side effects, it is necessary to take care of the removable dispenser:
- Make a few test pressures in the air to adjust the atomizer;
- If the drug has not been used for more than 2 weeks, test pressing should be repeated;
- After use, remove the nozzle, rinse in running water under a tap and dry;
- Close the nozzle with a cap every time so that dust does not get inside the bottle;
- In no case should you clean the spout of the dispenser with sharp or cutting objects, this provokes an expansion of the hole and an increase in dosage.
With proper care and use, Nasonex will not harm the body.
Nasonex for snoring
According to most studies, snoring occurs most often in people with chronic rhinitis. Over time, there was a relationship between the use of the spray and improving the quality of sleep, breathing at night. Nasonex from snoring is used quite widely, but the manufacturer did not think of such an effect from the drug.
According to reviews of Nasonex from snoring, one can judge the effective result of the remedy with regular preventive use. Also, in 2004, a large-scale study was conducted that revealed a stable decrease in snoring in subjects who used the drug against the background of rhinitis, sleep apnea, and allergies. The recommended dose to eliminate snoring is 200 mcg per day, you need to irrigate the nasopharynx 1 time.
Another important aspect is the elimination of snoring in children with the help of Nasonex. You can use the tool from the age of 2 years.
Over time, the drug began to be prescribed by doctors to patients with complaints of night snoring. Now Nasonex is one of the most common means in the fight against snoring.
You can use the medicine for people with snoring without complications. In some cases, snoring is caused by lung disease, of cardio-vascular system etc. Snoring is a symptom, not a problem. Before use, you should consult with your doctor.
For the prevention of snoring, Nasonex can be used for a long time (up to 1 year) at a low dosage.
Interaction with other drugs
IN official instructions to Nasonex from the manufacturer there are no indications regarding the negative effects of the drug with other substances. The spray is used together with antibiotics, antihistamines and other drugs without the risk of side effects.
The only thing 
noted in the instructions - an improvement in the action of the antiallergic drug Loratadine against the background of irrigation with a nasopharyngeal spray. For this reason, the spray is especially recommended for the formation of an allergic rhinitis, if the treatment is carried out using Loratodin.
About overdoses
It has already been said above that it is necessary to use the drug in accordance with thoughtful dosages and medical prescriptions. Overdoses occur due to prolonged use of the spray in quantities exceeding the norm. Increased intake of mometasone causes oppression of the adrenal system.
A single overdose does not lead to tangible consequences. If the person taking the drug is not sure about the duration of taking higher doses, it is recommended to undergo a medical examination.
Precautionary measures
Despite the minimal number of side effects, in advance of measuring doses with a spray, precautions must be taken when using a nasal spray for a long time:
- Treatment for more than 2-3 months. It is necessary to conduct an examination of the nasopharynx for the occurrence of pathologies, changes in the state of the mucosa, the development of fungal formations. If any changes are confirmed, stop spray irrigation or apply additional drugs.
- More than 1 month. Regular follow-up with a therapist or pediatrician. Periodic visits to the doctor are especially important for children and adolescents under 18 years of age, pregnant and lactating women.
- After discontinuation of Nasonex. It is recommended to check the function of the adrenal glands and prescribe treatment in case of detection of pathologies. In rare cases, patients experience depression, a feeling of fatigue, drowsiness after stopping the use of the spray. Any change in the condition becomes a signal to see a doctor as soon as possible.
- Drug replacement. In the case of changing the nasal spray, some people develop allergic eczema, conjunctivitis, and dermatitis. Previously, such diseases were suppressed due to the antihistamine action of Nasonex.
- Until the spray is cancelled. The immune system of patients is in an elevated state against the background of regular use of the drug. A few weeks before the planned cancellation of the spray, it is recommended to take a vitamin course in order to strengthen the immune system. Otherwise, the risk of developing infectious and / or colds increases.
The listed circumstances occur in rare cases, however, as a precautionary measure, it is recommended to follow them.
Storage conditions
- Stored for 3 years;
- The recommended storage temperature is from +2 to +25 degrees;
- Keep away from sunlight, moisture.
Open vial:
- Apply within 1-year;
- Store in a dark place, out of the reach of children, sun, humidity;
- Rinse the dispenser regularly.
It is also necessary to regularly recheck the operation of the spray button.
Cost in pharmacies
The price for Nasonex in pharmacies depends on the volume of the bottle. Average cost:
- 10 ml - 390 rubles;
- 15 ml - 450 rubles;
- 40 ml - 760 rubles.
Nasonex's analogs
Based on mometasone 
other drugs developed similar action. The lists contain sprays - analogues of Nasonex.
Cheap analogues:
- Rinoklenil - 370 rubles. (200 doses). The analogue is used according to a scheme similar to Nasonex. Improves performance immune system, stops the development of rhinitis on the background of allergies.
- Nazarel - 400 rubles. (200 doses). Reduces the feeling of itching in the nose, quickly eliminates congestion. Not to be used by small children.
- Flixonase - 780 rubles. (120 doses). Most cheap analogue, has an additional effect. Eliminates tearing, swelling of the nasopharynx. Can be used without antihistamines for allergies.
- Avamys - 725 rubles. (120 doses). The closest analogue in composition and action. Cannot be used as a prophylactic.
- Polydex - 295 rubles. (200 doses). Combined analogue, used for a wide range of diseases. There are serious contraindications. Not to be used by children under 15 years of age.
- Nasobek - 180 rubles. (200 doses). Increases human immunity. Improves the production of mucus, which makes it easier to clear the sinuses. It is strictly forbidden to take pregnant women up to the 12th week.
- Tafen nasal — 420 rubles. (200 doses). You can feel the effect of the analog only 2-3 days after taking it. Eliminates inflammation, reduces allergic reactions.
Suitable for children:
- Avamys from 2 years old;
- Nazarel, Flixonase from 4 years old.
The selection of a replacement drug can only be carried out by a doctor. Analogs do not fully correspond to the composition of Nasonex, may cause unforeseen side effects.
Even after the medical appointment of one of the analogues, Nasonex, generics cannot be combined with each other. Also, drugs containing glucocorticoids should not be used.
Basic physical and chemical properties
White or almost white opaque suspension.
Compound
1 spray dose contains mometasone furoate monohydrate in an amount equivalent to 50 mcg mometasone furoate (anhydrous);
Excipients: dispersed cellulose, glycerin, sodium citrate dihydrate, citric acid, polysorbate-80, benzalkonium chloride, purified water.
Pharmacotherapeutic group
Remedies inflammatory edema(decongestants) and other agents for topical use in rhinology. Corticosteroids.
ATC code - R01A D09.
Pharmacological properties"type="checkbox">
Pharmacological properties
Pharmacodynamics
Mechanism of action
Mometasone furoate is a topical glucocorticosteroid with a local anti-inflammatory effect, manifested in doses at which systemic effects do not occur.
It is likely that the main mechanism of the anti-allergic and anti-inflammatory action of mometasone furoate is associated with its ability to inhibit the release of mediators. allergic reactions. Mometasone furoate significantly reduces the release of leukotrienes from the leukocytes of patients suffering from allergic diseases. Mometasone furoate demonstrated in cell culture high activity in relation to the inhibition of the synthesis/release of IL-1, IL-5, IL-6 and TNFα. It is also a potent inhibitor of leukotriene production. In addition, it is also a potent inhibitor of the production of Th2 cytokines, IL-4 and IL-5 from human CD4* T cells.
Pharmacodynamics
In studies with provocative tests with the application of antigens to the nasal mucosa, the anti-inflammatory activity of Nasonex nasal spray was revealed both in the early and late stages of an allergic reaction. This was confirmed by a decrease (compared with placebo) in histamine levels and eosinophil activity, as well as a decrease (compared to baseline) in the number of eosinophils, neutrophils and epithelial cell adhesion proteins.
In 28% of patients with seasonal allergic rhinitis, Nasonex nasal spray showed a clinically significant onset of action within 12 hours after the first dose. On average (in 50%), relief occurred within 35.9 hours.
Children
In a placebo-controlled clinical trial in which children (n=49/group) received 100 mcg daily of Nasonex nasal spray for one year, growth rate retardation was not observed.
There are limited data on the safety and efficacy of Nasonex Nasal Spray in children aged 3 to 5 years and an appropriate dose range cannot be established. In a study of 48 children aged 3 to 5 years treated with mometasone furoate intranasally at 50, 100, or 200 mcg/day for 14 days, there were no significant differences compared with placebo in mean change in plasma cortisol levels in response to for a stimulation test with tetracosactrin.
Pharmacokinetics
The bioavailability of mometasone furoate when administered as an aqueous nasal spray is< 1 %, в плазме крови, при использовании метода количественного определения с порогом чувствительности 0,25 пг/мл.
Distribution
Not considered because mometasone is very poorly absorbed when administered intranasally.
Metabolism
A small amount of the drug, which can be swallowed and absorbed, undergoes active primary metabolism in the liver.
breeding
The absorbed amount of mometasone furoate is actively metabolized, and the metabolites are excreted in the urine and bile.
Indications for use
Seasonal or year-round treatment allergic rhinitis in adults and children over the age of 2 years.
Preventive treatment of moderate and severe allergic rhinitis in adults and children from 12 years of age (it is recommended to start 2-4 weeks before the expected start of the dusting season).
Treatment of symptoms of acute rhinosinusitis without evidence of severe bacterial infection in adults and children 12 years of age and older.
Treatment of nasal polyps and related symptoms, including nasal congestion and loss of smell, in patients 18 years of age or older.
Dosage and administration
Treatment for seasonal or perennial allergic rhinitis: adults (including the elderly) and adolescents over the age of 12 years, the recommended preventive and therapeutic dose of the drug is 2 injections (50 mcg each) in each nostril 1 time per day (total daily dose - 200 mcg). After achieving a therapeutic effect for maintenance therapy, it is advisable to reduce the dose to 1 injection in each nostril 1 time per day (total daily dose - 100 mcg).
If the symptoms of the disease cannot be relieved by using the drug at the recommended therapeutic dose, the daily dose can be increased to the maximum: 4 injections in each nostril 1 time per day (total daily dose - 400 mcg). After easing the symptoms of the disease, a dose reduction is recommended.
In some patients with seasonal allergic rhinitis, this drug has demonstrated a clinically significant onset of action within 12 hours after the first dose. However, the full benefit of the treatment cannot be obtained in the first 48 hours, so the patient must continue regular use to achieve full therapeutic effect.
Nasonex nasal spray treatment may be started a few days before the start of the pollinating season in patients with a history of moderate to severe seasonal allergic rhinitis.
For children aged 2-11 years, the recommended therapeutic dose is 1 injection (50 mcg each) in each nostril 1 time per day (total daily dose - 100 mcg).
Acute rhinosinusitis. For adults (including the elderly) and children aged 12 years and older, the recommended therapeutic dose is 2 injections (50 mcg) in each nostril 2 times a day (total daily dose - 400 mcg).
nasal polyps. For patients over the age of 18 (including the elderly), the recommended dose is 2 injections (50 mcg each) in each nostril 1 time per day (total daily dose - 200 mcg). If after 5-6 weeks of treatment there is no improvement in the symptoms of the disease, the dose
can be increased to two sprays in each nasal passage 2 times a day (total daily dose - 400 mcg). The dose should be gradually reduced to a lower dose that provides effective control of the symptoms of the disease. If after 5-6 weeks of treatment there is no improvement in the symptoms of the disease, the patient's condition should be reviewed and alternative methods of treatment should be considered.
Preparing the nasal spray for use
Nasonex nasal spray has a dust cap that protects the sprayer and keeps it clean. Don't forget to take it off before spraying and put it back on after use.
Before the first use, it is necessary to “calibrate” the spray by 10 clicks of the dosing device until the spray begins to spray:
1. Gently shake the vial.
2. Place your index and middle finger on either side of the atomizer and thumb under the vial. Don't pierce nasal applicator.
3. Point the sprayer away from you, and then press down with your fingers 10 times until the spray begins to spray.
If the nasal spray has not been used for 14 days or more, a re- "calibration" is necessary, which is carried out by pressing the dosing device 2 times until the spray appears.
How to use the nasal spray
1. Gently shake the vial and remove the dust cap (Figure 1).
2. Gently blow your nose.
3. Close one nostril and place the nebulizer in the other nostril as shown (Figure 2). Tilt your head slightly forward, holding the vial upright. 
4. Start inhaling gently or slowly through the nose and at the same time inject the spray into the nostril by pressing the dosing device once.
5. Exhale through your mouth. Repeat step 4 to spray a second time in the same nostril, if applicable.
6. Pull the nebulizer out of that nostril and exhale through your mouth.
7. Repeat steps 3-6 for the second nostril (Figure 3). 
Wipe the sprayer thoroughly with a clean handkerchief or tissue after using the spray, put on the dust cap.
Nasal spray cleaning
It is important to clean your nasal spray nozzle regularly or it will not work properly.
Remove the dust cap and carefully remove the atomizer.
Wash the atomizer and dust cap with warm water and then rinse under running water.
Do not attempt to clean the dispenser with a needle or other sharp object, as this may damage the device and result in incorrect dosing medicinal substance.
Dry the atomizer and dust cap in a warm place.
Place the sprayer on the spray bottle and put on the dust cap.
Re- "calibrate" by pressing the dispenser 2 times before use after cleaning.
If you have used Nasonex more than you should
Tell your doctor if you have accidentally used more than what you were told. Using steroids for a long time or in large amounts can sometimes affect some of your hormones. In children, it can affect growth and development.
If you forget to use Nasonex
If you forget to use the nasal spray at the right time, use it as soon as you remember and then continue as before. Do not take a double dose to make up for a forgotten dose.
Side effect
Brief summary of the security profile
Nosebleeds tended to resolve spontaneously, were mild, and occurred slightly more frequently than with placebo (5%) but less frequently than with other intranasal corticosteroids used as active controls in allergic rhinitis clinical trials (in some of of them, the incidence of nosebleeds was up to 15%. The frequency of occurrence of all other adverse reactions was comparable to that of placebo. In patients treated for nasal polyps, the overall incidence of adverse reactions was similar to that observed in patients with allergic rhinitis.
Systemic effects may occur with the use of nasal corticosteroids, especially at high doses and with prolonged use.
List of adverse reactions
Table 1 presents treatment-related adverse reactions (≥ 1%) reported in clinical studies in patients with allergic rhinitis or nasal polyps and in post-marketing reports, regardless of indication. Adverse reactions are presented according to the main class of the MedDRA organ system. Within each organ system class, adverse reactions are categorized according to frequency. Frequency categories were as follows: very common (≥ 1/10); often (≥ 1/100 and< 1/10); нечасто (≥ 1/1000 и < 1/100). Частота постмаркетинговых побочных реакций определена как “неизвестно (невозможно установить по имеющимся данным)”.
| Table 1: Known treatment-related adverse reactions by organ class and frequency | |||
| Often | Often | unknown | |
| Infections and infestations | Pharyngitis Upper infections respiratory tract + |
||
| Immune System Disorders | Hypersensitivity including anaphylactic reactions, angioedema, bronchospasm and dyspnea | ||
| Violations by nervous system | Headache | ||
| Visual disturbances | Glaucoma Increased intraocular pressure Cataract Blurred vision |
||
| Violations by respiratory system, organs chest and mediastinum | Nose bleed* | Nose bleed Burning sensation in the nose Irritation of the nasal mucosa Ulcerative changes in the nose |
Perforation of the nasal septum |
| Violations by digestive system | Sore throat* | Taste and smell disorders | |
+ Noted with unknown frequency at twice daily dosage in association with nasal polyps.
Children
In children, the frequency of reported adverse reactions in clinical trials, i.e., nose bleed (6 %), headache(3%), nasal irritation (2%) and sneezing (2%) was comparable to placebo.
Contraindications
Hypersensitivity to the active substance, mometasone furoate, or any of the excipients.
Nasonex Nasal Spray should not be used in the presence of an untreated localized infection involving the nasal mucosa, such as herpes simplex.
Because corticosteroids delay wound healing, intranasal corticosteroids should not be given to patients who have recently undergone surgery or trauma to the nose until the wound has completely healed.
Overdose
Symptoms
Inhalation or oral administration of excessive doses of corticosteroids can lead to depression of the function of the hypothalamic-pituitary-adrenal system.
Treatment
Due to the fact that the systemic bioavailability of Nasonex nasal spray is< 1 % , маловероятно, что при передозировке будут необходимы другие меры, помимо наблюдения за состоянием пациента, с последующим возобновлением применения препарата в соответствующей предписанной дозировке.
Precautionary measures
Immunosuppression
Nasonex nasal spray should be used with caution or not at all in patients with active or latent tuberculosis infection of the respiratory tract, as well as in untreated fungal, bacterial or systemic viral infection.
Patients using corticosteroids have the potential to have reduced immune reactivity and should be warned about increased risk infection through contact with sick people infectious diseases(For example, chicken pox, measles), as well as the need to consult a doctor if such contact has occurred.
Local nasal effects
In a study involving patients with perennial rhinitis, after 12 months of treatment with Nasonex nasal spray, there were no signs of atrophy of the nasal mucosa; in addition, mometasone furoate contributed to the normalization of the histological picture of the nasal mucosa. However, patients using Nasonex nasal spray for several months or longer should be periodically examined for possible changes in the nasal mucosa. If a local fungal infection of the nose or pharynx develops, it may be necessary to stop therapy with Nasonex nasal spray or to undergo special treatment. Irritation of the nasal and pharyngeal mucosa, which persists for a long time, may also be an indication to stop treatment with Nasonex Nasal Spray.
The use of Nasonex is not recommended in case of perforation of the nasal septum.
In clinical studies, nosebleeds were observed at a higher frequency than with placebo. Nosebleeds stopped spontaneously and were moderate. Nasonex nasal spray contains benzalkonium chloride, which can cause irritation of the nasal mucosa.
Systemic effects of corticosteroids
Systemic effects may occur with the use of nasal corticosteroids, especially when administered at high doses and with long-term use. These effects are less likely than with oral corticosteroids and may differ between patients and between different corticosteroid agents. Potential systemic effects may include Cushing's syndrome, Cushingoid symptoms, adrenal suppression, growth retardation in children and adolescents, cataracts, glaucoma, and, less commonly, psychiatric or behavioral disorders including psychomotor agitation, hyperactivity, sleep disturbances, anxiety, depression, or aggression (especially in children).
After the use of intranasal corticosteroids, cases of increased intraocular pressure have been reported.
With the use of systemic and local corticosteroids (including intranasal, inhalation and intraocular administration), visual disturbances may occur. If symptoms such as blurred vision or other visual disturbances occur, the patient should be examined by an ophthalmologist to evaluate possible causes visual disturbances, which may include cataracts, glaucoma, or rare diseases such as central serous chorioretinopathy, have been reported after the use of systemic and topical corticosteroids.
Patients switching to Nasonex Nasal Spray after long-term treatment with systemic corticosteroids should be closely monitored. Discontinuation of systemic corticosteroids in these patients may lead to adrenal insufficiency, for several months before restoration of the function of the hypothalamic-pituitary-adrenal system. If these patients show signs and symptoms of adrenal insufficiency or withdrawal symptoms (eg, joint and/or muscle pain, initial fatigue, and depression) despite improvement in nasal symptoms, systemic corticosteroids should be restarted, other therapies, and appropriate measures taken. This change in therapy may also reveal pre-existing allergic conditions such as allergic conjunctivitis and eczema that have developed earlier and were masked by systemic corticosteroid therapy. Treatment with doses higher than those recommended may result in clinically significant adrenal suppression.
If there is evidence that higher than recommended doses are used, then the use of an additional systemic corticosteroid during periods of stress or elective surgery should be considered.
nasal polyps
The safety and efficacy of Nasonex Nasal Spray in the treatment of unilateral polyps, polyps associated with cystic fibrosis, or polyps that completely obstruct the nasal passage have not been studied.
Unilateral polyps with an unusual or irregular shape, especially those that are ulcerated or bleeding, require a more in-depth examination.
Effect on growth in children
It is recommended that growth be carefully monitored in children receiving long-term treatment with nasal corticosteroids. If growth is retarded, treatment should be reconsidered to reduce the dose of nasal corticosteroid, if possible, to the lowest dose that provides effective control of symptoms of the disease. In addition, referral of the patient to a pediatrician should be considered.
Non-nasal symptoms
Although Nasonex Nasal Spray will provide control of nasal symptoms in most patients, concomitant use of an appropriate additional treatment may provide additional relief of other symptoms, in particular eye symptoms.
Children. When conducting placebo-controlled clinical trials in children using Nasonex in daily dose 100 mcg for a year, growth retardation in children was not observed. However, the long-term effects of intranasal/inhaled steroids have not been definitively investigated. The physician should carefully monitor the growth and development of children receiving long-term treatment with glucocorticosteroids.
The safety and efficacy of Nasonex have not been studied in the treatment of nasal polyps in children and adolescents under 18 years of age, symptoms of rhinosinusitis in children under 12 years of age, seasonal or perennial allergic rhinitis in children under 2 years of age.
The use of high doses or long-term treatment with glucocorticosteroids can lead to systemic side effects, including growth retardation in children. The long-term effect of intranasal/inhaled steroids in children has not been fully investigated. The physician should carefully monitor the growth and development of children receiving long-term treatment with glucocorticosteroids. In a study of 49 children who received 100 mg of Nasonex daily for 1 year, no decrease in growth rate was observed.
Use during pregnancy and lactation
Pregnancy
Information regarding the use of mometasone furoate in pregnant women is either absent or limited. Animal studies have shown reproductive toxicity. As with other intranasal corticosteroids, Nasonex nasal spray should only be used in pregnant women if the expected benefit justifies the potential risk to the mother, fetus or infant. Infants whose mothers used corticosteroids during pregnancy should be carefully examined for possible hypofunction of the adrenal glands.
Lactation
It is not known whether mometasone furoate is excreted in human breast milk. As with other intranasal corticosteroids, a decision should be made regarding discontinuation breastfeeding or withdrawal/abstention from Nasonex Nasal Spray therapy, taking into account the benefits of breastfeeding for the baby and the benefits of treatment for the woman.
Interaction with other drugs
Clinical interaction studies with loratadine have been conducted. No interaction was observed.
Mometasone furoate is metabolized by CYP3A4. Co-administration with potent inhibitors of CYP3A4 (eg, ketoconazole, itraconazole, clarithromycin, ritonavir, drugs containing cobicistat) may increase plasma corticosteroid concentrations and potentially increase the risk of systemic corticosteroid adverse reactions. Consideration should be given to the benefits of concomitant use of corticosteroids and the potential risk of systemic reactions to corticosteroids, as well as to monitor the patient's condition regarding the occurrence of the above adverse reactions.
Manufacturer
Schering-Plough Labo N.V., Industriepark 30, Heist-op-den-Berg, 2220, Belgium.
Schering-Plough Labo NV, Industriepark 30, Heist-op-den-Berg, 2220, Belgium.
Owner registration certificate
Schering-Plough Central East AG, Weistrasse 20 CH-6000 Lucerne 6, Switzerland.
Schering-Plough Central East AG, Weystrasse 20 CH-6000, Lucerne 6, Switzerland.
Usually these are vasoconstrictor and antiseptic drugs.
When a runny nose takes sharp shape, to reduce inflammation in the treatment is administered antibacterial agents and medications containing glucocorticosteroids. One of the best hormonal drugs that help fight sinusitis, rhinitis and adenoid hypertrophy is Nasonex.
The composition of the medicinal product
Nasonex is an original Belgian drug. Goes like local medicine with anti-inflammatory and anti-allergic action for the relief of inflammatory processes. The active substance in it is synthetic GCS.
The agent in one dose contains 50 mcg of anhydrous mometasone furoate and supplements: glycerol, benzalkonium chloride; dispersed cellulose, polysorbate 80; phenyl alcohol, citric acid, sodium citrate, purified water, monohydrate.
The peculiarity of the drug is that it performs its action only in the area of the mucous layer. It does not enter the systemic circulation, and this affects the fact that there are no consequences.
So, this feature of the drug allows you to avoid insufficiency of the hypothalamic-pituitary-adrenal system, even when the remedy is used for a long time. And when the drug penetrates from the nasopharynx into the stomach, mometasone quickly breaks down and is excreted by the kidneys or liver.
It is permissible to use the drug only in the dose when there are no systemic manifestations. The treatment regimen and the duration of the use of the drug Nasonex are established only by the doctor based on the data of the laboratory tests passed, taking into account individual tolerance to the drug.
Numerous clinical studies of the drug have shown that it is safe for different age groups and effective at all stages. inflammatory diseases nasal cavity. Through comparative studies, it was found that mometasone is 10 times stronger than other corticosteroids: beclomethasone, betamethasone, hydrocortisone and dexamethasone.
The drug is produced in two forms: Nazones and Nasonex Sinus. The suspension itself of both forms is whitish. Note that the substance must be used precisely as an aerosol, but not dripping like drops. If you are wondering what is the difference between Nasonex and Nasonex sinus, then we will touch on this issue in more detail.
Difference of forms and rendered effect
In terms of effect, both drugs are the same. The main difference is the number of doses in the vials. Dosed spray Nasonex is available in a plastic container, has a weight of 18 g. A nozzle is attached to the bottle for convenient spraying. Funds are enough for 140 applications.
Dosed spray Nasonex Sinus in a vial contains 10 g of the drug. A spray bottle is also included. The contents of the bottle are enough for 60 doses. This form of the drug has a volume of 2.5 times less, so the price is proportional.
The principle of action of drugs is that the active substance has an overwhelming effect on the production of mediators that trigger the inflammatory process in the body when an irritant enters it. This reduces the mass of mucus in the sinuses, and reduces the processes of infiltration and granulation.
The medicine copes with any stage of allergy. It blocks histamine and prostaglandins, inhibits cell proliferation. By blocking the reaction to the irritant, the manifestations of standard allergic reactions are prevented: runny nose, itching, swelling, redness, sneezing.
Nasonex is also actively used for vasomotor rhinitis, which is most often accompanied by complications in the form of sinusitis, as well as polyps. The spray copes well with swelling and inflammation. In addition, Dizrinit is used in the treatment of the common cold. What is the difference between the drugs read here.
If the wrong therapy of the disease is prescribed or the immune system is reduced, the runny nose of an infectious appearance can be relocated to chronic form or worsen sinusitis.
Use in pregnancy
Since no studies have been conducted on the effects of nasal spray on the fetus, it should be taken during pregnancy in extreme cases, and only after the recommendation of a specialist. The only thing known about it is the low absorption of the components into the bloodstream, therefore, the effect of the drug on the fetus will be minimal, and reproductive toxicity will be very low.
If a woman used GCS during gestation, then after the birth of a child, a series of tests should be performed to eliminate the development of hypofunction of the adrenal glands. When breastfeeding, the risk of getting the moment zone into milk has not been proven.
The instructions indicate that it is better not to use the drug during this period or take it as prescribed by the doctor when the use of the drug is justified. Let's look at how to take Nasonex nasal drops.
Instructions for use
When a runny nose takes a chronic form, the inflammatory process becomes constant and sluggish. The patient is tormented by the standard manifestations of a runny nose, but when, in addition, chronic sinusitis begins, the mucus coming out of the nose becomes purulent, and the voice sits a little.
It is at such moments that you can resort to antibacterial and corticosteroid medication. Hormonal nasal spray begins to regulate inflammation and has a beneficial effect on the microflora of the nose. After unpacking the spray, a “calibration” is done, that is, they press the dispenser 6-7 times. With each subsequent use, the medicine must be shaken.
The instructions say that the spray can be dripped on adults and children over two years old. For rhinosinusitis:
- persons over 12 years old - 50 mcg 1 time per day, two injections in each nostril. Produce no more than 200 mcg per day;
- children from two to 10 years old are given one injection of 50 micrograms twice a day. Permissible daily dose up to 100 mcg.
During an infectious inflammation of the nose:
- adults - 50 mcg 2 times a day. Daily dose up to 400 mcg;
- children - one inhalation of 50 mcg three times a day, the maximum dose is 150 mcg. Use only under the supervision of a doctor.
Improvements appear within the first 12 hours after using the spray. When symptoms decrease, the dose is reduced to 100 mcg per day, that is, 1 injection once a day. And for children, 50 mcg 1 time per day.
Reviews about the drug
The child often suffers from allergic reactions, especially in spring. The doctor prescribed Nasonex for us, the drug showed a good result, I am satisfied. After use, the symptoms noticeably go away and the child stops choking and sneezing.
Nasonex has become my savior from the long-term use of vasoconstrictors. The fact is that I have been suffering from chronic vasomotor rhinitis for a long time. Drops to relieve swelling had to be taken every day, because without them it is impossible to work normally and even sleep.
The doctor insisted on the operation, but I was afraid, I decided to turn to another specialist. He advised me to try Nasonex. I used the spray for about a month, after which the disease receded, the operation was not needed.
Conclusion
As you can see, the drug has proven itself well in combating seasonal attacks, as well as in year-round rhinitis, however, it should be used only when less weak drugs are powerless. When you use the remedy without informing the doctor, all responsibility for the consequences lies solely with you.
Directory of major ENT diseases and their treatment
All information on the site is for informational purposes only and does not claim to be absolutely accurate. medical point vision. Treatment must be carried out by a qualified doctor. By self-medicating, you can harm yourself!
Nasonex - all about the drug
Nasonex is a drug of local action, which has in its composition the active substance - mometasone, which belongs to the group of potent synthetic glucocorticosteroids and is therefore an anti-inflammatory, vasoconstrictor, antiallergic and antipruritic agent. For this reason, it provides effective treatment allergic and inflammatory processes of the nasopharynx, nasal cavity and complex treatment of protracted inflammatory processes in the paranasal sinuses, and is also used in the treatment of nasal polyps.
Pharmacological properties of nasonex and mechanism of action
Nasonex has a fast, pronounced and sufficiently long anti-inflammatory and anti-allergic effect on the nasal mucosa, as well as a vasoconstrictor (vasoconstrictor) effect on the vessels of the mucous membranes of the nasal cavity and paranasal sinuses, and therefore also reducing swelling and inflammation in the nasal cavity and paranasal sinuses.
Its anti-inflammatory action is based on the action and inhibition of mediators of allergic reactions and inflammation, and as a result, there is a decrease in edema and hyperemia of the mucous membranes.
The mechanism of action of Nasonex is associated with inhibition of cytokine synthesis and induction of the release of proteins - lipocortins, which are inhibitors of phospholipase A2 and control the synthesis of leukotrienes and prostaglandins - potent inflammatory mediators, by inhibiting the release of arachidonic acid, which is their common precursor. Mometasone furoate has ten times more activity than other steroid drugs, including dexamethasone, betamethasone, hydrocortisone and beclomethasone dipropionate, in terms of inhibition of the synthesis and release of IL-6, IL-1 and is six times more active than beclomethasone and beclomethasone dipropionate. regarding the inhibition of IL-5 production.
Clinical studies of Nasonex
In accordance with the clinical studies of Nasonex intranasal spray with the application of antigens to the nasal mucosa and provocative tests, a high activity of this drug was established at any stage of the allergic process. This is confirmed by a decrease in the level of the number of eosinophils, compared with their baseline level and a decrease in their activity, a decrease in epithelial cell adhesion proteins and the number of neutrophils, as well as a decrease in the level of histamine, compared with placebo
Clinical effect medicinal product occurs within 12 hours after the use of intranasal spray in 28% of patients suffering from seasonal allergic rhinitis, and in 50% of patients improvement occurred within 35.9 hours. Nasonex also reveals a high activity in reducing eye symptoms in patients and eliminates lacrimation, redness of the conjunctiva and itching.
In clinical studies of the effectiveness of the use of nasonex in patients with nasal polyps, there was a significant effectiveness of this drug in eliminating nasal congestion, restoring the sense of smell and reducing the size of polyps.
Clinical studies have also been conducted to compare the effectiveness of nasonex, amoxicillin and placebo in groups of patients > 12 years for the treatment of rhinosinusitis for 15 days. The evaluation of the results was assessed on the Major Symptom Score scale according to the following main symptoms: a feeling of pressure in the paranasal sinuses, pain when pressing on the projection of the paranasal sinuses, pain in the face, rhinorrhea, and mucus flow down the back of the pharynx. Nasonex was used at 200 mg twice a day, and amoxicillin was prescribed at 500 mg three times a day. According to these studies, the efficacy of amoxicillin was practically no different from placebo in terms of symptomatic relief on the MSS scale, due to its pronounced antibacterial and minimal anti-inflammatory effect. And the use of Nasonex showed high efficiency this drug to treat the main symptoms of rhinosinusitis. And with further observation of patients in this group, it was noted that relapses of rhinosinusitis after the use of Nasonex were observed much less frequently than after treatment with amoxicillin and in the placebo group.
Indications for the use of the drug
Indications for the use of Nasonex are - treatment of year-round and seasonal allergic rhinitis, treatment to prevent exacerbations of seasonal rhinitis with its moderate and severe degree with frequent relapses, symptomatic treatment rhinosinusitis without signs of bacterial infection in children over 12 years of age and in adults, treatment of nasal polyps in patients over 18 years of age. And also as an aid in the treatment of acute sinusitis aggravated by a bacterial infection in combination with antibacterial drugs in children over 12 years of age and in adults.
The use of Nasonex
Nasonex is available as a nasal spray of 18 ml in a vial containing 50 mcg of the active substance mometasone furoate in a single dose of the drug. The vial contains 140 doses of the drug.
Before using the Nasonex vial, it is necessary to calibrate it, which is carried out by ten clicks on the dosing device of the vial, and at the same time, the stereotypical supply of the drug substance is established and one dose of the drug is ejected, which corresponds to 100 mg of suspension and contains 50 mcg of mometasone. When using intranasal spray for more than fourteen days, it is necessary to repeat the calibration of the vial.
Before each use of the drug, shake the vial with the drug.
When clogging the nozzle, you need to remove the plastic cap, avoiding pressing the white ring, remove the nozzle from the bottle and rinse it with warm water, then dry it and install it in its original place. Do not clean the nozzle with sharp objects, because in connection with these actions, damage to the dispenser occurs.
Regular cleaning of the nozzle is also very important.
And before each use of the drug, it is necessary to clear the nose of mucus.
The use of Nasonex for the treatment of year-round or seasonal rhinitis
The recommended therapeutic and prophylactic dose of the drug for children over 12 years old, adolescents and adult patients is two doses (injections) of 50 mcg once a day in each nostril, while the total daily dose is not more than 200 mcg. After the onset of the therapeutic effect, it is recommended to reduce the dose to 100 mcg per day - one dose (injection) in each nostril once a day.
In the event that the application of the average therapeutic dose of Nasonex does not achieve a therapeutic effect, the daily dose of the drug can be increased to a maximum of 400 mcg per day. This amounts to four injections in each nostril once, followed by a gradual decrease in dose after the symptomatology of seasonal rhinitis decreases.
In pediatric practice, the use of the drug is possible only for children over 2 years of age and the recommended therapeutic dose is 100 mcg - one dose (injection) in each nostril once a day.
Nasonex for the treatment of acute sinusitis
In the treatment of patients with acute episodes of sinusitis, Nasonex is used as an adjuvant to reduce the severity of the main symptoms of the disease. It is used in children over 12 years of age, in adults, as well as in elderly patients and the recommended therapeutic dose is two doses (injections) in each nostril twice a day, which is a total daily dose of kg. In the absence of a decrease in the severity of symptoms and relief of the patient's well-being, the therapeutic dose of the drug can be increased to four doses (injections) twice a day in each nostril and the total daily dose will be 400 mcg, followed by a dose reduction with a decrease in the severity of symptoms of rhinosinusitis.
The use of Nasonex in the treatment of acute rhinosinusitis
Nasonex for the treatment of acute rhinosinusitis aggravated by a bacterial infection is used as an adjuvant in combination with antibacterial drugs in children over 12 years of age and adults and consists of two doses (injections) of fifty mcg each twice a day in each nostril with a total daily dosemkg.
The use of Nasonex for the treatment of nasal polyps
Nasonex for the treatment of nasal polyps is used only in patients over 18 years of age to reduce nasal congestion, restore the sense of smell, and also reduce polyps in size. It is prescribed in the average therapeutic dose, which is two injections into each nostril twice a day. After achieving the expected therapeutic effect, it is recommended to reduce the dose of the drug to two doses (injections) once a day with the recommended total daily dose of 200 μg of the active substance.
Contraindications
Contraindications to the use of Nasonex are - individual hypersensitivity to any active or inactive substance of the drug, children under two years of age.
The drug is not used or is used with extreme caution in latent or active tuberculosis infection, with localization inflammatory process in the respiratory tract, untreated bacterial fungal or viral infection and with herpes simplex eye damage.
Side effects of Nasonex
Side effects of this drug are: weakness, headache, recurrent dryness and burning of the mucous membranes of the nose and pharynx
allergic reactions with increased individual sensitivity to the components of the drug, bronchospasm, dyspnea, pharyngitis, burning in the nose, bloody mucous discharge from the nasal cavity or obvious nosebleeds that stop on their own.
All these side effects are typical for the use of an intranasal spray containing the active substance - a corticosteroid. As well as the occurrence in some cases of a violation of smell and taste.
Special instructions for using Nasonex nasal spray
The use of Nasonex intranasally in young children should be carried out with the help of adults.
Nasonex, like all other topical drugs containing corticosteroids, is not prescribed to patients who have recently had a nose injury or surgery, due to the fact that drugs in this group slow down wound healing.
This drug is prescribed for a long time in severe cases of allergic rhinitis in the minimum maintenance dosage and during clinical trials during the treatment with Nasonex for a year - there were no signs of changes in the histology of the nasal mucosa, and there were no atrophic changes. Patients who use this drug for a long time must be periodically examined by an ENT doctor to exclude possible atrophic changes in the nasal mucosa, and in the event of a fungal infection of the nasopharynx, it is necessary to stop taking Nasonex. An indication for the abolition of Nasonex intranasal spray is also long-term irritation of the nasal mucosa.
Patients who switch to the use of Nasonex after long-term use of systemic steroids need constant and long-term medical supervision. In connection with the withdrawal of systemic steroid drugs, patients may develop symptoms of adrenal insufficiency, and this may lead to repeated therapy with systemic drugs or other treatment. Sometimes the abolition of systemic steroids can lead to the development of allergic diseases in a patient: eczema, allergic conjunctivitis, which have developed in the body for a long time, but were masked and restrained by corticosteroid therapy.
Also, when switching from treatment with systemic corticosteroid drugs to Nasonex nasal spray therapy, patients may experience symptoms of hormone withdrawal - depression, fatigue, and muscle and joint pain. In such cases, it becomes necessary to convince the patient that this symptomatology is not associated with side effect intranasal spray to prolong nasonex therapy.
It is necessary to warn patients about the need to urgently contact their doctor if there are signs of a severe bacterial infection - severe unilateral tooth or facial pain, with fever, deterioration in general well-being, or the occurrence of periorbital swelling or edema.
The use of Nasonex in children
Nasonex nasal spray is used in pediatric practice in patients older than two years of age.
When conducting clinical studies using placebo using Nasonex at a daily dose of one hundred micrograms, growth retardation in patients was not observed.
The use of Nasonex during pregnancy and lactation
Studies of the use of the drug Nasonex during pregnancy and lactation have not been conducted, and therapy with this nasal spray is possible only if it is used under the supervision of a doctor, and only if possible risk for the fetus, newborns and infants, significantly lower than the therapeutic effect for the mother. But it should be noted that the concentration of mometasone in the blood plasma after intranasal use of nasonex at an average therapeutic dose is not determined, and therefore the effect of this drug on the fetus will be minimal, and reproductive toxicity will be very low. All newborns whose mothers received local hormonal preparations, it is necessary to examine in order to exclude the possible development of hypofunction of the adrenal glands.
Overdose
Due to the low systemic bioavailability of the drug when used in the form of an intranasal adsorption spray and active metabolism, mainly with bile, an overdose of the drug is unlikely.
Nasonex storage conditions
Like all medicines, Nasonex is not recommended to be used after the expiration date and stored out of the reach of light and children. Do not freeze.
Nasonex: drug number 1 for allergies and not only
Our pharmacies are bursting with antiallergic drugs. Showcases are full of beautiful packages, and TV screens and pages of glossy magazines obsessively talk about happy allergy sufferers who do not care about flowers and herbs after treatment with pills. But not a single advertising medium says how often tablet preparations are powerless in the face of allergies. And the sufferers who do not understand anything, who have tried all the advertised medicines on themselves and continue to sneeze and sniffle, may never know what is the most effective remedy remained unknown. We are talking about Nasonex, the drug of choice for moderate to severe allergies.
>> The site presents an extensive selection medicines for the treatment of sinusitis and other diseases of the nose. Use on health!<<
What is Nasonex?
Nasonex is an original Belgian drug produced by the well-known pharmaceutical corporation Schering Plow. In her laboratories, pharmacists have created a fundamentally new allergy medicine - an intranasal spray with the glucocorticoid mometasone. Yes, yes, do not be alarmed: the composition of Nasonex, beloved by many for its effectiveness and good tolerability, includes a hormonal drug - the glucocorticosteroid mometasone furoate.
How does he work?
Like all other corticosteroids, mometasone has two properties: it has a pronounced anti-inflammatory and anti-allergic effect. The mechanism of antiallergic activity of mometasone is based on its ability to stop the release of allergy mediators. But it is they who bear the main burden of responsibility for annoying sneezing and sniffing.
Mometasone furoate has gone through many comparative studies and has proven to be exceptionally active. So, it turned out that mometasone inhibits the release of allergy mediators 10 times more than other corticosteroids beclomethasone, betamethasone, hydrocortisone and dexamethasone.
In addition, in tests with the application of antigens (provocative substances that trigger an allergic reaction), the drug has shown high anti-inflammatory activity.
Treatment with Nasonex: allergies, nasal polyps and sinusitis.
Allergy
Clinical studies have confirmed that during the first 12 hours after the start of treatment with Nasonex, 28% of patients with allergic rhinitis (simply allergic rhinitis) get a pronounced effect. After 36 hours after the start of therapy, allergy manifestations recede already in half of the patients.
Surprisingly, Nasonex nasal spray can also relieve allergic eye symptoms: redness, itching and watery eyes.
nasal polyps
Mometasone works great not only for allergies. So, in patients suffering from nasal polyps, treatment with Nasonex leads to a marked clinical improvement. In particular, after a course of therapy, nasal congestion, traditional for nasal polyps, is greatly reduced, their size is reduced, and even the sense of smell is restored.
And, of course, sinusitis
Nasonex is also used in the complex therapy of rhinosinusitis, including sinusitis.
The anti-inflammatory effect of mometasone can significantly alleviate the course of the disease. It has been clinically proven that treatment with mometasone can reduce facial pain and sinus pressure, reduce rhinorrhea and nasal congestion. At the same time, the effect in acute and chronic sinusitis is long-lasting, remaining for at least 15 days after the end of treatment.
Distribution Features
Yes, you say, it's wonderful that Nasonex is so effective in diseases of the nasopharynx. But nevertheless, it belongs to not the safest drugs - corticosteroid hormones. It's dangerous!
In fact, only the first sentence is true, the second is partially true, and the third is completely false. Indeed, Nasonex is a hormonal drug. Indeed, long-term use of oral corticosteroids is associated with a high risk of severe side effects. But intranasal drugs behave differently in the body.
It has been established that after intranasal spraying of mometasone, less than 1% of the active substance penetrates into the blood. Even if you somehow miraculously managed to swallow the medicine, it is practically not absorbed from the gastrointestinal tract due to very low absorption. The same trace amounts that are nevertheless absorbed are almost completely excreted in the bile or urine.
Thus, the corticosteroid mometasone administered intranasally, that is, in the form of a nasal spray, does not act systemically. And, therefore, it cannot be the cause of side effects. Therefore, Nasonex is one of the safest drugs for a cold, despite the fact that it contains a real hormonal substance.
Indications for appointment
So, let's list the diseases for which mometasone spray is prescribed. Among them:
- seasonal or perennial allergic rhinitis. We add that Nasonex is used both for the treatment of allergies and for prevention before the allergy season;
- acute sinusitis (including acute sinusitis). Nasonex in such cases is only an integral part of complex treatment, often against the background of concomitant antibiotic therapy;
- nasal polyps with active symptoms (nasal congestion and loss of smell).
Preparing the bottle for use
Nasonex is a dosed drug, so it is very important to properly calibrate the vial. Only after careful calibration, each press will release a strictly adjusted dose of mometasone furoate, which is 50 μg in 100 mg of drug suspension. The calibration itself is quite simple.
Before the first use, you need to sequentially press the sprayer 10 times. As a result of these simple actions, a standardized supply of mometasone furoate is established.
If you have not used Nasonex for two weeks or longer, you need to perform a control calibration. To do this, you need to press the sprayer twice - this is enough to resume the stereotypical supply of the active substance.
Patients need to remember two more nuances:
- firstly, Nasonex spray is a suspension in which the active substance is not dissolved, but unevenly weighed in the solvent. Therefore, before each use, the bottle must be shaken;
- secondly, the nozzle on the bottle can become clogged - after all, we are not dealing with a solution, but with a suspension. If you notice that this has happened, you need to remove the plastic cap, and then the nozzle, which should be rinsed with warm water. Having dried it well, you can install it in place and be treated with Nasonex.
It is strictly forbidden to clean the clogged nozzle with a needle (knitting needle, hairpin, and so on). Doing so may damage the dispenser and cause the dispenser to malfunction. As a result, the final dosage of Nasonex may not correspond to the 50 mcg we need.
How to take Nasonex: doses and frequency of use
No matter what disease you are treating, you need to take care of free nasal breathing before using the medicine. Clear the nose of mucus with a solution of sodium chloride, sea water and, if necessary, vasoconstrictor drops. Only after that you can start treatment with Nasonex.
allergic rhinitis
For allergies, Nasonex is prescribed for adults and children. The average dosage for patients over 12 years of age is 2 injections in each nasal passage once a day. As soon as signs of improvement appear, it makes sense to reduce the dosage by half - to one spray in each nasal passage per day.
If the standard initial dosage does not work enough, you can, on the contrary, increase it to the maximum. According to the instructions for use in such cases, the dose of Nasonex can be up to 4 injections in each nasal passage once a day. And, again, after improvement, the dose is halved.
For children over the age of 2 and under 12 years, one spray in each nasal passage once a day is sufficient.
Positive results of treatment should not be expected earlier than 12 hours after the first dose of Nasonex spray. In full force, the drug begins to work only 48 hours after the start of therapy.
Acute sinusitis (sinusitis) and rhinosinusitis
For the treatment of acute sinusitis, Nasonex is used only in adults and children over 12 years of age. The initial dosage is two injections into each nasal passage twice a day. If necessary, the dose can be increased to four injections twice a day. As soon as the symptoms of the disease subside, the dosage is halved.
nasal polyps
For polyps in the nasal cavity, the drug is used only in patients who are 18 years of age. The standard dosage in such cases is two injections in each nasal passage once a day.
When is Nasonex contraindicated?
There are only a few conditions in which it is worth abandoning the intranasal use of mometasone. Nasonex and its analogues are categorically contraindicated if:
- you are hypersensitive to mometasone or any of the other ingredients of Nasonex spray;
- an active untreated infection progresses in the nasal cavity, affecting the mucous membrane. Glucocorticosteroids are able to suppress the healing of wounds resulting from trauma, surgery, etc. Therefore, patients after surgery or trauma to the nasal cavity should refuse Nasonex or other drugs with steroids, such as Avamys, until the nasal mucosa heals.
In all other cases, the drug is safe and approved for use (of course, within the age limits).
Side effects
Alas, in the process of using the Nasonex spray, despite all its safety, sometimes side effects cannot be avoided. However, we hasten to reassure potential consumers: adverse events during therapy with intranasal mometasone are rather an exception to the rule.
Adults may experience:
- nosebleeds, which can be either obvious or unexpressed and appear as mucus or blood-colored clots;
- pharyngitis - inflammation of the pharyngeal mucosa;
- burning sensation in the nasal cavity;
- irritation of the nasal mucosa.
- Of the four adverse effects, the first, nosebleeds, is the most common. They may appear in 5% of patients taking Nasonex.
However, nosebleeds are usually short-lived, minor, and stop on their own. Note that in the treatment of other intranasal corticosteroids, the risk of bleeding is the same as during the use of Nasonex.
The likelihood of developing other side effects does not differ from the chances of getting them as a result of treatment with a dummy drug - a placebo.
In the treatment of children, a headache is added to the list of undesirable manifestations, which nevertheless develops extremely rarely and does not require the abolition of Nasonex.
Nasonex during pregnancy: dangerous or not?
It is reliably known that with the intranasal use of Nasonex, the drug is not detected in the blood even by the most sensitive laboratory methods. Theoretically, this indicates the complete safety of the drug for all groups of patients, including pregnant women.
However, the principles of prescribing drugs in obstetrics are based on clinical confirmation of safety in accordance with the requirements of evidence-based medicine.
To give the "green light" to the use of the drug in pregnant and lactating women, it is necessary to conduct clinical trials on these groups of patients and prove in practice that there is no effect on the fetus, pregnancy or child (when breastfeeding).
For perfectly understandable ethical reasons, Schering Plow did not initiate such studies, therefore there is no official permission for the use of Nasonex during pregnancy and lactation and probably will not be. And yet, in case of severe allergies or extreme necessity, the drug is prescribed, hiding behind the wording of "the benefit to the mother, which exceeds the risk to the fetus."
Nasonex as part of complex treatment
Despite the fact that Nasonex is also used for inflammatory diseases of the nasal mucosa, including viral and bacterial rhinitis, adenoids and sinusitis, its main purpose is to resist an allergic reaction. It gives the best results and tolerability for allergies in adults and children. Leading allergists of the world, together with scientists who are engaged in clinical research, are unanimous in one thing.
Nasonex is the most effective modern drug for allergies, and pharmaceuticals do not yet know more effective and better means.
However, he, unfortunately, is not omnipotent. Depending on the severity of the disease, it can be used both as monotherapy and as part of complex treatment.
For mild allergies, as a rule, only intranasal mometasone is prescribed.
With moderate allergy or monotherapy failure, an antihistamine is included in the treatment regimen. The instructions indicate that Nasonex does not interact with the popular antihistamine loratadine, and patient reviews confirm the good tolerability of this combination.
In severe allergies that do not respond to complex treatment, oral corticosteroids are already used and plasmapheresis is often prescribed.
Replace the irreplaceable: analogues of Nasonex
Nasonex is an original drug, and, therefore, not the most economical. Unfortunately, its price can hurt your pocket, so many patients tend to replace Nasonex with a cheaper analogue. And he is, indeed, the only one.
This is a drug from the Israeli company Teva Dezrinit, which is of good quality at a fairly reasonable price.
Nasonex sinus
Often, consumers ask a logical question: what is the difference between Nasonex and Nasonex sinus? Turns out it's just a matter of price. Nasonex contains 120 doses, and Nasonex sinus according to the instructions for use - only 60. Thanks to the release of a more economical form, the drug has become more affordable. And, therefore, more Russians will be able to treat a runny nose with Nasonex.
Good articles to follow:
And if the course of taking GCS is over, and the runny nose, congestion and sneezing gradually return? Whether it is necessary to resume reception, or to be limited to vasoconstrictors? And if you resume the reception, then after what time?
Faced with any ailment, it is important to learn about it as much as possible. Forewarned is forearmed. Having a full range of information about pathology, a person knows when to see a doctor, what symptoms to focus on, whether it is possible to get rid of health problems on their own and what complications should be prepared for.
The site provides information about various diseases, their symptoms and methods of diagnosis, directions of therapy and a specific list of drugs. Publications are created by our own using reliable scientific sources and are presented in an easy-to-understand manner.
In the first section " traditional medicine» Information materials on various medical fields are published. The second section " cold health» is dedicated to ENT topics and colds, as the most common diseases in the world. The third section "" (abbreviated as N.I.P.) - the name speaks for itself.
We wish you happy reading and stay healthy!
Sincerely, Site Administration.
Runny nose is a symptom of many diseases. It occurs with colds, viral infections, allergies. Especially often, nasal discharge appears in preschoolers, whose immunity has not yet been strengthened. It is worth giving the baby to kindergarten, as he starts to get sick, and a runny nose can last for several weeks. In spring and summer, during the flowering period of allergenic plants, rhinitis does not go away as long as pollen is in the air. An effective remedy that helps fight a runny nose of various etiologies is the hormonal intranasal drug Nasonex for children.
Description of Nasonex
Nasonex is a hormonal drug that is designed to fight allergy symptoms. It also helps with inflammatory processes in the sinuses, which are caused by infectious diseases and are a complication of a simple cold or flu. The effect of the spray is due to its effect on the focus of inflammation, in addition, it prevents the development of an allergic reaction.
Composition and forms of release
Nasonex comes in the form of a spray. Drops are poured into a plastic bottle equipped with a dispenser tip for ease of use. Oily liquid, white.
The bottles come in different sizes. The smallest ones hold 10 g of liquid, and this is enough for about 60 doses. Another package is designed for 120 doses and contains 18 g of drops. The active substance is a glucocorticosteroid - micronized mometasone furoate. 1 dose includes 50 micrograms of mometasone.
Pharmacodynamics and pharmacokinetics
What causes the action of mometasone:
During inhalation, the bioavailability of mometasone is low, mainly due to low absorption. Absolute bioavailability is 16%, and in patients with bronchial asthma - only 10%. The substance is excreted from the body with urine and bile.
When spraying the agent into the nasal cavity, they are partially swallowed. You should not worry, because the drug is practically not absorbed in the intestines. It is extensively metabolized by the liver and excreted in the bile.
Indications for prescribing the drug to children
The main purpose of Nasonex is the treatment and prevention of the common cold. Nasonex is prescribed for children in the following cases:
Contraindications and side effects
It is forbidden to use Nasonex if the child has recently undergone surgery or a nose injury. It is necessary to wait for the complete healing of the mucosa, because mometasone prevents wound healing.
If treatment with this drug is necessary, then its use is allowed even during these diseases, but you must first consult with your doctor. Self-medication with Nasonex is strictly prohibited.
Sometimes the use of Nasonex spray in children causes adverse reactions:
- bleeding from the nose, the allocation of bloody clots of mucus - in 6% of cases;
- irritation of the mucous membranes of the nose and sneezing - 3%;
- headache - 3%.
Particular attention should be paid to young children who are treated with glucocorticosteroids, such as Nasonex, for a long time. They may experience growth retardation. In such cases, the spray dose must be reduced to a minimum.
Long-term treatment with drops can cause systemic side effects:
After prolonged therapy, withdrawal syndrome may occur. There are pains in the joints, muscles, lethargy, constant fatigue, bad mood. The child's immunity is reduced - it is susceptible to bacterial and fungal infections.
Method of application and dosage of Nasonex for children
The scheme for using Nasonex spray differs depending on what diseases are present in children. The duration of treatment, the dosage is selected by the doctor individually after the disease that caused rhinitis is diagnosed. In addition, the method of application depends on the age of the child.
Before use, you need to make sure that air has stopped coming out of the nozzle of the bottle, and the suspension has begun to flow. To do this, shake the bottle and press the dosing device several times until splashes appear.
How to use the spray bottle correctly? Instillation should be done in a position that is comfortable for the child, the medicine will not leak out immediately after it enters the nasal cavity. Since the suspension is sprayed with a nozzle, it is not necessary to tilt your head back. You can spray while standing or sitting.
The dosing nozzle must be cleaned periodically. To do this, carefully remove the cap from the dispenser, and then pull out the spray tip. These elements of the bottle should be washed with warm running water and then dried. After the system is assembled, you need to calibrate by pressing the dispenser until splashes come out. Cleaning should be carried out regularly, especially with prolonged use. Also, the system must be cleaned if the drops have not been used for more than 2 weeks.
With adenoids
With adenoids and polyposis in children, the use of Nasonex is not recommended. It is used mainly for the treatment of adults who have reached the age of majority. However, at the discretion of the attending physician, the spray can be used at an individual dosage.
Adult patients need to instill 2 times in each nostril twice a day. For one injection, about 50 micrograms of liquid is sprayed. The total dose for the whole day should not exceed 400 mcg.
As symptoms decrease, the dosage should be reduced. It is allowed to reduce the amount of the drug per day by half. Two injections of 50 mcg each are made into each nasal opening.
Runny nose treatment
To eliminate chronic rhinitis and sinusitis, Nasonex is used only in adolescence and older. The recommended age when you can use the spray is 12 years. For younger children, a different medicine is selected.
It is necessary to use the medicine strictly according to the instructions that are attached to the package. With the individual characteristics of the course of the disease in a small patient, the doctor can correct the method of application. The recommended therapeutic dose in the treatment of sinusitis is 400 micrograms per day. This amount of spray is divided into several approaches: twice a day, 2 injections into each nostril.
What to do if sinusitis does not go away? Doubling the dosage is allowed. The daily amount increases to 800 mcg. 2 applications per day, 4 sprays in each nasal opening are shown.
For allergies
The main purpose of Nasonex is the treatment of allergy symptoms and allergic rhinitis. The dosage is calculated according to the age of the small patient and is indicated in the instructions for the remedy.
If a teenager over 12 years of age has allergic rhinitis, then the daily dose of drops is 200 mcg. The treatment regimen is as follows: 2 injections (50 mcg) 1 time per day should be taken into each nostril. As a rule, the medicine begins to act 12 hours after the start of therapy.
Gradually, the dose can be reduced. If the child is relieved, there is no need to give him such a large dose of glucocorticosteroid. The amount of suspension can be halved and limited to one injection in each nostril 1 time per day. Thus, the daily amount of the drug will be 100 mcg.
What to do if the therapeutic effect does not occur, and the symptoms intensify? Doctors allow you to increase the dosage. During the day, it is necessary to do 4 sprays in each nostril, thereby increasing the total dose to 400 mcg.
How to treat children who are not yet 12 years old? The maximum amount of the drug should not exceed 100 mcg. Babies do one injection once a day. A single dose is 50 mcg. The age at which Nasonex is allowed to be used to eliminate allergic symptoms is 2 years.
How long can the spray be used? Preventive measures usually last 2-3 weeks. For medicinal purposes, it should be used until the symptoms are completely eliminated. The duration of treatment is determined by the attending physician.
Price and analogues of the drug
How much does Nasonex cost? On average, a bottle of spray can be purchased for 400 rubles, but the cost differs depending on the pricing policy of pharmacies.
What to do if there is no way to buy Nasonex or there is an individual intolerance to the components of the drug? Not everyone can afford to buy a tool for such a price and are looking for a cheaper replacement for it. The drug can be replaced by analogues, which are also glucocorticosteroids, but contain another active ingredient.
The table shows Nasonex analogs:
| Name of the drug | Release form | Active ingredient | Indications | What age is allowed? |
| Flixonase | Intranasal drops | Fluticasone | Allergic rhinitis, hay fever, nasal congestion, watery eyes, sneezing | 4 years |
| Avamys | Spray | fluticasone furoate | Symptoms of allergic rhinitis | 2 years |
| Nazarel | Spray | Fluticasone | Prevention and treatment of seasonal rhinitis |
